Plasma soluble α-klotho protein levels in premature and term neonates: Correlations with growth and metabolic parameters

European Journal of Endocrinology

Volumn 167, Issue 3, 2012, Pages 433-440

  Siahanidou, Tania ^a   Garatzioti, Maria ^a   Lazaropoulou, Christina ^b   Kourlaba, Georgia ^a   Papassotiriou, Ioannis ^b   Kino, Tomoshige ^c   Imura, Akihiro ^d   Nabeshima, Yo Ichi ^d   Chrousos, George ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d INSTITUTE OF BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA KLOTHO PROTEIN; CALCITRIOL; GLUCOSE; INSULIN; KLOTHO PROTEIN; MALONALDEHYDE; UNCLASSIFIED DRUG;

ARTICLE; BODY HEIGHT; BODY WEIGHT; CHILD GROWTH; CLINICAL ARTICLE; FEMALE; GESTATIONAL AGE; HUMAN; INFANT; INSULIN RESISTANCE; MALE; METABOLISM; NEWBORN; OXIDATIVE STRESS; PERINATAL PERIOD; PREMATURITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL;

AGE FACTORS; BIOLOGICAL MARKERS; CHILD DEVELOPMENT; ENERGY METABOLISM; FEMALE; GLUCURONIDASE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; MALE; OXIDATIVE STRESS;

EID: 84865761557     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-12-0476     Document Type: Article

References (38)

1. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R & Nabeshima YI. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997 390 45-51. (doi:10.1038/36285)
2. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP &Kuro-o M. Suppression of aging in mice by the hormone klotho. Science 2005 309 1829-1833. (doi:10.1126/science.1112766)
3. Lorenzi O, Veyrat-Durebex C, Wollheim CB, Villemin P, Rohner-Jeanrenaud F, Zanchi A & Vischer UM. Evidence against a direct role of klotho in insulin resistance. Pflügers Archives: European Journal of Physiology 2010 459 465-473. (doi:10.1007/s00424-009-0735-2)
4. Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y &Ozono K. Circulating levels of soluble α-klotho are markedly elevated in human umbilical cord blood. Journal of Clinical Endocrinology and Metabolism 2011 96 E943-E947. (doi:10.1210/jc.2010-2357)
5. Chen CD, Podvin S, Gillespie E, Leeman SE & Abraham CR. Insulin stimulates the cleavage and release of the extracellular domain of klotho by ADAM10 and ADAM17. PNAS 2007 104 19796-19801. (doi:10.1073/pnas.0709805104)
6. Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N, Fujimori T & Nabeshima Y. Secreted klotho protein in sera and CSF: implication for post-translational cleavage in release of klotho protein from cell membrane. FEBS Letters 2004 565 143-147. (doi:10.1016/j.febslet.2004.03.090)
7. Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ &Hoenderop JG. The β-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 2005 310 490-493. (doi:10.1126/science.1114245)
8. Tsujikawa H, Kurotaki Y, Fujimori T, Fukuda K & Nabeshima Y. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Molecular Endocrinology 2003 17 2393-2403. (doi:10.1210/me.2003-0048)
9. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S & Yamashita T. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006 444 770-774. (doi:10.1038/nature05315)
10. Nabeshima Y. Discovery of α-klotho unveiled new insights into calcium and phosphate homeostasis. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences 2009 85 125-141. (doi:10.2183/pjab.85.125)
11. Martin A, David V & Quarles LD. Regulation and function of the FGF23/klotho endocrine pathways. Physiological Reviews 2012 92 131-135. (doi:10.1152/physrev.00002.2011)
12. Kuro-o M. Klotho. Pflugers Archives: European Journal of Physiology 2010 459 333-343. (doi:10.1007/s00424-009-0722-7)
13. Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A, Obuse C, Togashi K, Tominaga M, Kita N, Tomiyama K, Iijima J, Nabeshima Y, Fujioka M, Asato R, Tanaka S, Kojima K, Ito J, Nozaki K, Hashimoto N, Ito T, Nishio T, Uchiyama T, Fujimori T & Nabeshima Y. α-Klotho as a regulator of calcium homeostasis. Science 2007 316 1615-1618. (doi:10.1126/science.1135901)
14. Brownstein CA, Adler F, Nelson-Williams C, Iijima J, Li P, Imura A, Nabeshima Y, Reyes-Mugica M, Carpenter TO & Lifton RP. A translocation causing increased α-klotho level results in hypophosphatemic rickets and hyperparathyroidism. PNAS 2008 105 3455-3460. (doi:10.1073/pnas.0712361105)
15. Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A, Kurosu H, Miyoshi M, Ogawa Y, Castrillon DH, Rosenblatt KP & Kuro-o M. Regulation of oxidative stress by the anti-aging hormone klotho. Journal of Biological Chemistry 2005 280 38029-38034. (doi:10.1074/jbc.M509039200)
16. Saito Y, Nakamura T, Ohyama Y, Suzuki T, Iida A, Shiraki-Iida T, Kuro-o M, Nabeshima Y, Kurabayashi M & Nagai R. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochemical and Biophysical Research Communications 2000 276 767. (doi:10.1006/bbrc.2000.3470)
17. Chihara Y, Rakugi H, Ishikawa K, Ikushima M, Maekawa Y, Ohta J, Kida I & Ogihara T. Klotho protein promotes adipocyte differentiation. Endocrinology 2006 147 3835-3842. (doi:10.1210/en.2005-1529)
18. Tsuji K, Maeda T, Kawane T, Matsunuma A & Horiuchi N. Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1α,25-dihydroxyvitamin D3 synthesis in leptin-deficient mice. Journal of Bone and Mineral Research 2010 25 1711-1723. (doi:10.1002/jbmr.65)
19. Georgeson GD, Szony BJ, Streitman K, Varga IS, Kovacs A, Kovacs L & Laszlo A. Antioxidant enzymes activities are decreased in preterm infants and in neonates born via caesarean section. European Journal of Obstetrics, Gynecology, and Reproductive Biology 2002 103 136-139. (doi:10.1016/S0301- 2115(02)00050-7)
20. Robles R, Palomino N & Robles A. Oxidative stress in the neonate. Early Human Development 2001 65 Suppl S75-S81. (doi:10.1016/S0378-3782(01)00209- 2)
21. Hofman PL, Regan F & Cutfield WS. Prematurity - another example of perinatal metabolic programming? Hormone Research 2006 66 33-39. (doi:10.1159/000093230)
22. Hofman PL, Regan F, Jackson WE, Jefferies C, Knight DB, Robinson EM & Cutfield WS. Premature birth and later insulin resistance. New England Journal of Medicine 2004 351 2179-2186. (doi:10.1056/NEJMoa042275)
23. Martos-Moreno GA, Barrios V, Sáenz de Pipaón M, Pozo J, Dorronsoro I, Martínez-Biarge M, Quero J & Argente J. Influence of prematurity and growth restriction on the adipokine profile, IGF1 and ghrelin levels in cord blood: relationship with glucose metabolism. European Journal of Endocrinology 2009 161 381-389. (doi:10.1530/EJE-09-0193)
24. Ballard JL, Khoury JC, Wedig K, Wang L, Eilers-Walsman BL & Lipp R. New Ballard score, expanded to include extremely premature infants. Journal of Pediatrics 1991 119 417-423. (doi:10.1016/S0022-3476(05)82056-6)
25. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF & Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 412-419. (doi:10.1007/BF00280883)
26. Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, Aono Y, Hasegawa H, Yamashita T, Nakatani K, Saito Y, Okamoto N, Kurumatani N, Namba N, Kitaoka T, Ozono K, Sakai T, Hataya H, Ichikawa S, Imel EA, Econs MJ & Nabeshima Y. Establishment of sandwich ELISA for soluble α-klotho measurement: age-dependent change of soluble α-klotho levels in healthy subjects. Biochemical and Biophysical Research Communications 2010 398 513-518. (doi:10.1016/j.bbrc.2010.06.110)
27. Ohyama Y, Kurabayashi M, Masuda H, Nakamura T, Aihara Y, Kaname T, Suga T, Arai M, Aizawa H, Matsumura Y, Kuro-o M, Nabeshima Y & Nagail R. Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress. Biochemical and Biophysical Research Communications 1998 251 920-925. (doi:10.1006/bbrc.1998.9576)
28. Gubhaju L, Sutherland MR & Black MJ. Preterm birth and the kidney: implications for long-term renal health. Reproductive Sciences 2011 18 322-333. (doi:10.1177/1933719111401659)
29. Davidson AJ. Uncharted waters: nephrogenesis and renal regeneration in fish and mammals. Pediatric Nephrology 2011 26 1435-1443. (doi:10.1007/s00467- 011-1795-z)
30. Shimada T, Yamazaki Y, Takahashi M, Hasegawa H, Urakawa I, Oshima T, Ono K, Kakitani M, Tomizuka K, Fujita T, Fukumoto S &Yamashita T. Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. American Journal of Physiology. Renal Physiology 2005 289 F1088-F1095. (doi:10.1152/ajprenal.00474.2004)
31. Lim K, Lu TS, Molostvov G, Lee C, Lam FT, Zehnder D & Hsiao LL. Vascular klotho deficiency potentiates the development of human artery calcification and mediates resistance to FGF-23. Circulation 2012 125 2243-2255. (doi:10.1161/CIRCULATIONAHA.111.053405)
32. Kuro-o M. Klotho as a regulator of oxidative stress and senescence. Biological Chemistry 2008 389 233-241. (doi:10.1515/BC.2008.028)
33. Luycky VA & Brenner BM. The clinical importance of nephron mass. Journal of the American Society of Nephrology 2010 21 898-910. (doi:10.1681/ASN.2009121248)
34. Koo WW, Walters JC & Hockman EM. Body composition in neonates: relationship between measured and derived anthropometry with dual-energy X-ray absorptiometry measurements. Pediatric Research 2004 56 694-700. (doi:10.1203/01.PDR.0000142587.59238.BD)
35. Kawaguchi H, Manabe N, Miyaura C, Chikuda H, Nakamura K &Kuro-o M. Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia. Journal of Clinical Investigation 1999 104 229-237. (doi:10.1172/JCI5705)
36. Suzuki H, Amizuka N, Oda K, Noda M, Ohshima H & Maeda T. Histological and elemental analyses of impaired bone mineralization in klotho-deficient mice. Journal of Anatomy 2008 212 275-285. (doi:10.1111/j.1469-7580.2008.00859. x)
37. Shalhoub V, Ward SC, Sun B, Stevens J, Renshaw L, Hawkins N & Richards WG. Fibroblast growth factor 23 (FGF23) and α-klotho stimulate osteoblastic MC3T3.E1 cell proliferation and inhibit mineralization. Calcified Tissue International 2011 89 140-150. (doi:10.1007/s00223-011-9501-5)
38. Yamagishi T, Saito Y, Nakamura T, Takeda S, Kanai H, Sumino H, Kuro-o M, Nabeshima Y, Kurabayashi M & Nagai R. Troglitazone improves endothelial function and augments renal klotho mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factors. Hypertension Research 2001 24 705-709. (doi:10.1291/hypres.24.705)