Novel CCK-dependent vasorelaxing dipeptide, Arg-Phe, decreases blood pressure and food intake in rodents

Molecular Nutrition and Food Research

Volumn 56, Issue 9, 2012, Pages 1456-1463

  Kagebayashi, Tomomi ^a   Kontani, Noriyasu ^a   Yamada, Yuko ^a   Mizushige, Takafumi ^a   Arai, Toshinobu ^b   Kino, Kuniki ^b   Ohinata, Kousaku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b WASEDA UNIVERSITY   (Japan)

Author keywords

Blood pressure; Cholecystokinin; Dipeptide; Food intake; l amino acid ligase; Vasorelaxation

Indexed keywords

ANTIHYPERTENSIVE AGENT; CHOLECYSTOKININ; CHOLECYSTOKININ RECEPTOR; DIPEPTIDE; DRUG DERIVATIVE; ENZYME INHIBITOR; INDOMETACIN; LORGLUMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHENYLALANYLARGININE; PROGLUMIDE; PROSTAGLANDIN; VASODILATOR AGENT;

ANIMAL; ARTICLE; BLOOD PRESSURE; DRUG ANTAGONISM; DRUG EFFECT; EATING; ENTEROENDOCRINE CELL; MALE; MESENTERIC ARTERY; METABOLISM; MOUSE; MOUSE STRAIN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CHOLECYSTOKININ; DIPEPTIDES; EATING; ENTEROENDOCRINE CELLS; ENZYME INHIBITORS; INDOMETHACIN; MALE; MESENTERIC ARTERIES; MICE; MICE, INBRED STRAINS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; PROGLUMIDE; PROSTAGLANDINS; RATS; RATS, INBRED SHR; RECEPTORS, CHOLECYSTOKININ; VASODILATOR AGENTS;

RATTUS; RODENTIA;

EID: 84865760817     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200168     Document Type: Article

References (42)

1. Brantl, V., Teschemacher, H., Henschen, A., Lott-speich, F., Novel opioid peptides derived from casein (β-casomorphins). I. Isolation from bovine casein peptone. Hoppe Seylers Z. Physiol. Chem. 1979, 360, 1211-1216.
2. Yoshikawa, M., Yoshimatsu, T., Chiba, H., Opioid peptides from human β-casein. Agric. Biol. Chem. 1984, 48, 3185-3187.
3. Fukudome, S., Yoshikawa, M., Opioid peptides derived from wheat gluten: their isolation and characterization. FEBS Lett. 1992, 296, 107-111.
4. Matoba, N., Usui, H., Fujita, H., Yoshikawa, M., A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery. FEBS Lett. 1999, 452, 181-184.
5. 2-dependent vasorelaxation in spontaneously hypertensive rats. Peptides 2008, 29, 345-349.
6. Marczak, E. D., Usui, H., Fujita, H., Yang, Y. et al., New antihypertensive peptides isolated from rapeseed. Peptides 2003, 24, 791-798.
7. Yoshikawa, M., Fujita, H., Matoba, N., Takenaka, Y. et al., Bioactive peptides derived from food proteins preventing lifestyle-related diseases. Biofactors 2000, 12, 143-146.
8. 1 receptor. Peptides 2010, 31, 909-914.
9. 1 receptor in male ddY mice. Peptides 2008, 29, 629-632.
10. Schror, K., Prostaglandins, other eicosanoids and endothelial cells. Basic Res. Cardiol. 1985, 80, 502-514.
11. Kino, K., Nakazawa, Y., Yagasaki, M., Dipeptide synthesis by L-amino acid ligase from Ralstonia solanacearum. Biochem. Biophys. Res. Commun. 2008, 371, 536-540.
12. Kino, K., Kotanaka, Y., Arai, T., Yagasaki, M., A novel L-amino acid ligase from Bacillus subtilis NBRC3134, a microorganism producing peptide-antibiotic rhizocticin. Biosci. Biotechnol. Biochem. 2009, 73, 901-907.
13. Marczak, E. D., Ohinata, K., Lipkowski, A. W., Yoshikawa, M., Arg-Ile-Tyr (RIY) derived from rapeseed protein decreases food intake and gastric emptying after oral administration in mice. Peptides 2006, 27, 2065-2068.
14. Hou, I.-C., Yoshikawa, M., Ohinata, K., β-Lactotensin derived from bovine β-lactoglobulin suppresses food intake via the CRF system followed by the CGRP system in mice. Peptides 2009, 30, 2228-2232.
15. 2-dependent mechanism in mice. Peptides 2009, 30, 1105-1108.
16. 5]-oryzatensin(5-9). Peptides 2007, 28, 602-606.
17. 4)-dermorphin(1-4) on gastrointestinal transit. Peptides 2000, 21, 295-299.
18. B systems. Am. J. Physiol. Gastrointest. Liver. Physiol. 2010, 299, G799-805.
19. Nakajima, S., Hira, T., Eto, Y., Asano, K. et al., Soybean β51-63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells. Regul. Pept. 2010, 159, 148-155.
20. Hira, T., Nakajima, S., Eto, Y., Hara, H., Calcium-sensing receptor mediates phenylalanine-induced cholecystokinin secretion in enteroendocrine STC-1 cells. FEBS J. 2008, 275, 4620-4626.
21. Strader, A. D., Woods, S. C., Gastrointestinal hormones and food intake.2288; Gastroenterology 2005, 128, 175-191.
22. Moran, T. H., Kinzig, K. P., Gastrointestinal satiety signals II. Cholecystokinin. Am. J. Physiol. Gastrointest. Liver. Physiol. 2004, 286, G183-188.
23. Ruiz-Gayo, M., González, M. C., Fernández-Alfonso, S., Vasodilatory effects of cholecystokinin: new role for an old peptide? Regul Pept. 2006, 137, 179-184.
24. Sartor, D. M., Verberne, A. J., Abdominal vagal signalling: a novel role for cholecystokinin in circulatory control? Brain Res. Rev. 2008, 59, 140-154.
25. Premen, A. J., Kvietys, P. R., Granger, D. N., Postprandial regulation of intestinal blood flow: role of gastrointestinal hormones. Am. J. Physiol. 1985, 249, G250-255.
26. Chou, C. C., Hsieh, C. P., Dabney, J. M., Comparison of vascular effects of gastrointestinal hormones on various organs. Am. J. Physiol. 1977, 232, H103-109.
27. Fara, J. W., Madden, K. S., Effect of secretin and cholecystokinin on small intestinal blood flow distribution. Am. J. Physiol. 1975, 229, 1365-1370.
28. Fara, J. W., Rubinstein, E. H., Sonnenschein, R. R., Intestinal hormones in mesenteric vasodilation after intraduodenal agents. Am. J. Physiol. 1972, 223, 1058-1067.
29. Janssen, P. J., Gardiner, S. M., Compton, A. M., Bennett, T., Mechanisms contributing to the differential haemodynamic effects of bombesin and cholecystokinin in conscious, Long Evans rats. Br. J. Pharmacol. 1991, 102, 123-134.
30. 3 receptors in the effects of CCK on presympathetic vasomotor neuronal discharge in the rat. Br. J. Pharmacol. 2003, 139, 415-423.
31. Price, D. A., Greenberg, M. J., Structure of a molluscan cardioexcitatory neuropeptide. Science 1977, 197, 670-671.
32. Bechtold, D. A., Luckman, S. M., The role of RFamide peptides in feeding. J. Endocrinol. 2007, 192, 3-15.
33. Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H. et al., A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Proc. Natl. Acad. Sci. USA 2006, 103, 7438-7443.
34. Ma, L., MacTavish, D., Simonin, F., Bourguignon, J. J. et al., Prolactin-releasing peptide effects in the rat brain are mediated through the Neuropeptide FF receptor. Eur. J. Neurosci. 2009, 30, 1585-1593.
35. Fang, Q., Liu, Q., Li, N., Jiang, T. N. et al., Cardiovascular effects of intravenous administered 26RFa, a novel RFamide peptide ligand for GPR103, in anaesthetised rats. Eur. J. Pharmacol. 2009, 621, 61-66.
36. Chartrel, N., Dujardin, C., Anouar, Y., Leprince, J. et al., Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc. Natl. Acad. Sci. USA 2003, 100, 15247-15252.
37. Takayanagi, Y., Onaka, T., Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake. FEBS J. 2010, 277, 4998-5005.
38. Cline, M. A., Newmyer, B. A, Smith, M. L., The anorectic effect of neuropeptide AF is associated with satiety-related hypothalamic nuclei. J. Neuroendocrinol. 2009, 21, 595-601.
39. Hayes, M. R., Miller, C. K., Ulbrecht, J. S., Mauger, J. L. et al., A carbohydrate-restricted diet alters gut peptides and adiposity signals in men and women with metabolic syndrome. J. Nutr. 2007, 137, 1944-1950.
40. Zwirska-Korczala, K., Konturek, S. J., Sodowski, M., Wylezol, M. et al., Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome. J. Physiol. Pharmacol. 2007, 58, 13-35.
41. 2+-sensing receptor. Proc. Natl. Acad. Sci. USA 2000, 97, 4814-4819.
42. Wellendorph, P., Hansen, K. B., Balsgaard, A., Greenwood, J. R. et al., Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol. Pharmacol. 2005, 67, 589-597.