Inhibitory effect of intracerebroventricularly-administered [D-Arg2, β-Ala4]-dermorphin (1-4) on gastrointestinal transit

Peptides

Volumn 21, Issue 2, 2000, Pages 295-299

  Niijima, Fukie ^a   Tan No, Koichi ^a   Esashi, Akihisa ^a   Nakagawasai, Osamu ^a   Tadano, Takeshi ^a   Takahashi, Norio ^a   Yonezawa, Akihiko ^a   Sakurada, Shinobu ^a   Kisara, Kensuke ^a  

^a Tohoku Pharmaceutical U ^*  (Japan)

Author keywords

D Ala2; Dermorphin analog; Gastrointestinal transit; Gly5 ol enkephalin; Morphine; Mouse; N methyl Phe4

Indexed keywords

BETA FUNALTREXAMINE; CHARCOAL; DELTA OPIATE RECEPTOR ANTAGONIST; DERMORPHIN DERIVATIVE; DERMORPHIN[1-4][2 DEXTRO ARGININE 4 BETA ALANINE]; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; KAPPA OPIATE RECEPTOR ANTAGONIST; MORPHINE; MU 1 OPIATE RECEPTOR; MU 1 OPIATE RECEPTOR AGONIST; MU 1 OPIATE RECEPTOR ANTAGONIST; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; NALOXONAZINE; NALOXONE; NALTRINDOLE; NORBINALTORPHIMINE; OPIATE ANTAGONIST; OPIATE RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; GASTROINTESTINAL TRANSIT; MALE; MEAL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANALGESICS; ANIMALS; CHARCOAL; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; FEMALE; GASTROINTESTINAL TRANSIT; INJECTIONS, INTRAVENTRICULAR; MICE; MICE, INBRED STRAINS; MORPHINE; NALOXONE; NALTREXONE; NARCOTIC ANTAGONISTS; OLIGOPEPTIDES; RECEPTORS, OPIOID;

EID: 0034027038     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(99)00195-3     Document Type: Article

References (34)

1. Broccardo M., Erspamer V., Erspamer G.F., Improta G., Linari G., Melchiorri P., Montecucchi P.C. Pharmacological data on dermorphins, a new class of potent opioid peptides from amphibian skin. Br J Pharmacol. 73:1981;625-631.
2. Brown G.P., Yang K., King M.A., Rossi G.C., Leventhal L., Chang A., Pasternak G.W. 3-Methoxynaltrexone, a selective heroin/morphine-6β-glucuronide antagonist. FEBS Lett. 412:1997;35-38.
3. 2]-dermophin tetrapeptide analogs and morphine in mice. Pharmacol Biochem Behav. 31:1988;439-444.
4. 2]-dermophin tetrapeptide analogs and morphine in rats. Br J Pharmacol. 95:1988;15-22.
5. 4]-dermophin tetrapeptide; physical dependence liability in mice. Neuropeptides. 13:1989;83-88.
6. 2]-dermorphin tetrapeptide analogs and morphine. Peptides. 11:1990;139-144.
7. De Castiglione R., Faoro F., Perseo G., Erspamer G.F., Erspamer V., Guglietta A. Synthetic peptides related to dermorphins. I. Synthesis and biological activity of the shorter homologues and of analogues of the heptapeptides. Peptides. 2:1981;265-269.
8. Erspamer V., Melchiorri P., Broccardo M., Erspamer G.F., Falaschi P., Improta G., Negri R., Renda T. The brain-gut-skin triangle new peptides . Peptides. 2:(suppl. 2):1981;7-16.
9. Fujita H., Sasaki Y., Kohno H., Ohkubo Y., Ambo A., Suzuki K., Hino M. Studies on analgesic oligopeptides. VI. Further studies of synthesis and biological properties of tripeptide alkylamides, Tyr-D-Arg-Phe-X. Chem Pharm Bull. 38:1990;2197-2200.
10. Galligan J.J., Mosberg H.I., Hurst R., Hruby V.J., Burks T.F. Cerebral delta opioid receptors mediated analgesia but not the intestinal motility effects of intracerebroventricularly administered opioids. J Pharmacol Exp Ther. 229:1984;641-648.
11. Haley T.J., McCormick W.G. Pharmacological effects produced by intracerebral injections of drugs in the conscious mouse. Br J Pharmacol. 12:1957;12-15.
12. Heyman J.S., Williams C.L., Burks T.F., Mosberg H.I., Porreca F. Dissosiation of opioid antinociception and central gastrointestinal propulsion in the mouse studies with naloxonazine . J Pharmacol Exp Ther. 245:1988;238-243.
13. Improta G., Broccardo M. Effect of selective mu1, mu2 and delta2 opioid receptor agonists on gastric function in the rat. Neuropharmacology. 33:1994;977-981.
14. Kisara K., Sakurada S., Sakurada T., Sasaki Y., Sato T., Suzuki K., Watanabe H. Dermorphin analogues containing D-kyotorphin structure-antinociceptive relationships in mice . Br J Pharmacol. 87:1986;183-189.
15. Litchfield J.T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther. 96:1949;99-113.
16. Massi P., Giagnoni G., Basilico L., Gori E., Rubino T., Parolaro D. Intestinal effect of morphine 6β-glucuronide in vivo and in vitro characterization . Eur J Pharmacol. 253:1994;269-274.
17. 6-dermorphin in skin extracts of Brazilian frog Phyllomedusa rhodei. Int J Pept Prot Res. 17:1981;316-321.
18. 4]-dermorphin (1-4) and morphine on small intestinal transit and electrically evoked contraction of guinea pig ileum. Meth Find Exp Clin Pharmacol. 20:1998;193-198.
19. 3H-opioid binding further evidence for μ1 sites . Mol Pharmacol. 25:1984;29-37.
20. Porreca F., Mosberg H.I., Hurst R., Hruby V.J., Burks T.F. Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse. J Pharmacol Exp Ther. 230:1984;341-348.
21. Reisine T., Bell G.I. Molecular biology of opioid receptors. Trends Neurosci. 16:1993;506-510.
22. Rossi G.C., Pan Y.-X., Brown G.P., Pasternak G.W. Antisense mapping the MOR-1 opioid receptor evidence for alternative splicing and a novel morphine-6β-glucuronide receptor . FEBS Lett. 369:1995;192-196.
23. Rossi G.C., Brown G.P., Leventhal L., Yang K., Pasternak G.W. Novel receptor mechanisms for heroin and morphine-6β-glucuronide analgesia. Neurosci Lett. 216:1996;1-4.
24. Rossi G.C., Leventhal L., Pan Y.-X., Cole J., Su W., Bodnar R.J., Pasternak G.W. Antisense mapping of MOR-1 in rats distinguishing between morphine and morphine-6β-glucuronide antinociception . J Pharmacol Exp Ther. 281:1997;109-114.
25. 2]-dermophin tripeptide analogs. J Pharmacol Exp Ther. 263:1992;793-799.
26. Sakurada S., Zadina J.E., Kastin A.J., Katsuyama S., Fujimura T., Murayama K., Yuki M., Ueda H., Sakurada T. Differential involvement of μ-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception. Eur J Pharmacol. 372:1999;25-30.
27. Sakurada S, Takeda S, Sato T, Hayashi T, Yuki M, Kutsuwa T, Tan-No K, Sakurada C, Kisara K, Sakurada T. Selective antagonism by naloxonazine of antinociception of Tyr-D-Arg-Phe-β-Ala, a novel dermorphin analogue with high affinity at μ-opioid receptors. Eur J Pharmacol (in press).
28. Salvadori S., Sarto G., Tomatis R. Synthesis and pharmacological activity of dermorphin and its N-terminal sequence. Int J Pept Prot Res. 19:1982;536-542.
29. Sato T., Sakurada S., Sakurada T., Kisara K., Sasaki Y., Suzuki K. A comparison of the antinociceptive and behavioral effects of D-Arg substituted dipeptides and tetrapeptides in mice. Peptides. 6:1985;35-40.
30. 2-substituted tetrapeptides. J Pharmacol Exp Ther. 242:1987;654-659.
31. Sato T., Takahashi N., Tan-No K., Kisara K., Sakurada T., Sakurada S. Comparison of opioid activity between a N-terminal tetrapeptide analogue of dermorphin, H-Tyr-D-Arg-Phe-β-Ala-OH and morphine. Meth Find Exp Clin Pharmacol. 20:1998;581-586.
32. Schuller A.G.P., King M.A., Zhang J., Bolan E., Pan Y.-X., Morgan D.J., Chang A., Czick M.E., Unterwald E.M., Pasternak G.W., Pintar J.E. Retention of heroin and morphine-6β-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1. Nature Neurosci. 2:1999;151-156.
33. Takagi H., Shiomi H., Ueda H., Amano H. Morphine-like analgesia by a new dipeptide, L-tyrosyl-L-arginine (kyotorphin) and its analogue. Eur J Pharmacol. 55:1979;109-111.
34. Uhl G.R., Childers S., Pasternak G. An opiate-receptor gene family reunion. Trends Neurosci. 17:1994;89-93.