Multispecies-compatible antitumor effects of a cross-species small-interfering RNA against mammalian target of rapamycin

Cellular and Molecular Life Sciences

Volumn 69, Issue 18, 2012, Pages 3147-3158

  Ahn, Jeonghyun ^a   Woo, Ha Na ^a   Ko, Ara ^a   Khim, Maria ^a   Kim, Catherine ^a   Park, Nung Hwa ^a   Song, Ho Young ^a,b   Kim, Seong Who ^a   Lee, Heuiran ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Asan Medical Center   (South Korea)

Author keywords

CAPSID; Cross species activity; Mammalian target of rapamycin; Small interfering RNA; Tumor therapeutics

Indexed keywords

INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); S6 KINASE; SMALL INTERFERING RNA; SUCCINATE DEHYDROGENASE (UBIQUINONE); TRANSCRIPTION FACTOR FKHR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CONTROLLED STUDY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; MALE; MELANOMA; MITOSIS INHIBITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UTERINE CERVIX CANCER;

ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CELL LINE; DEPENDOVIRUS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION; GENE SILENCING; HAPLORHINI; HUMANS; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

ADENO-ASSOCIATED VIRUS; MAMMALIA;

EID: 84865658775     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-0998-1     Document Type: Article

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