Repeated exposure to water immersion stress reduces the Muc2 gene level in the rat colon via two distinct mechanisms

Brain, Behavior, and Immunity

Volumn 26, Issue 7, 2012, Pages 1061-1065

  Shigeshiro, Mizuki ^a   Tanabe, Soichi ^a   Suzuki, Takuya ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Goblet cell; Intestine; Mucin; Water immersion stress

Indexed keywords

KRUPPEL LIKE FACTOR 4; MUCIN 2; NOTCH RECEPTOR; TRANSCRIPTION FACTOR CDX2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL STRESS; CONTROLLED STUDY; GENE EXPRESSION; GOBLET CELL; MALE; MENTAL STRESS; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WATER IMMERSION;

ANIMALS; CELL COUNT; CELL DIFFERENTIATION; COLON; GENE EXPRESSION REGULATION; GOBLET CELLS; IMMERSION; IMMUNOHISTOCHEMISTRY; MALE; MUCIN-2; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; STRESS, PSYCHOLOGICAL; TRANSCRIPTION FACTORS;

EID: 84865647210     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2012.05.016     Document Type: Article

References (20)

1. Chatzaki E., Crowe P.D., Wang L., Million M., Tache Y., Grigoriadis D.E. CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon. J. Neurochem. 2004, 90:309-316.
2. Collins S.M. Stress and the Gastrointestinal Tract IV. Modulation of intestinal inflammation by stress: basic mechanisms and clinical relevance. Am. J. Physiol. Gastrointest. Liver Physiol. 2001, 280:G315-G318.
3. Estienne M., Claustre J., Clain-Gardechaux G., Paquet A., Tache Y., Fioramonti J., Plaisancie P. Maternal deprivation alters epithelial secretory cell lineages in rat duodenum: role of CRF-related peptides. Gut 2010, 59:744-751.
4. Gerbe F., van Es J.H., Makrini L., Brulin B., Mellitzer G., Robine S., Romagnolo B., Shroyer N.F., Bourgaux J.F., Pignodel C., Clevers H., Jay P. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J. Cell Biol. 2011, 192:767-780.
5. Johansson M.E., Ambort D., Pelaseyed T., Schutte A., Gustafsson J.K., Ermund A., Subramani D.B., Holmen-Larsson J.M., Thomsson K.A., Bergstrom J.H., van der Post S., Rodriguez-Pineiro A.M., Sjovall H., Backstrom M., Hansson G.C. Composition and functional role of the mucus layers in the intestine. Cell Mol. Life Sci. 2011, 68:3635-3641.
6. Katz J.P., Perreault N., Goldstein B.G., Lee C.S., Labosky P.A., Yang V.W., Kaestner K.H. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development 2002, 129:2619-2628.
7. Kawahito Y., Sano H., Kawata M., Yuri K., Mukai S., Yamamura Y., Kato H., Chrousos G.P., Wilder R.L., Kondo M. Local secretion of corticotropin-releasing hormone by enterochromaffin cells in human colon. Gastroenterology 1994, 106:859-865.
8. Matsuo K., Zhang X., Ono Y., Nagatomi R. Acute stress-induced colonic tissue HSP70 expression requires commensal bacterial components and intrinsic glucocorticoid. Brain Behav. Immun. 2009, 23:108-115.
9. McGuckin M.A., Linden S.K., Sutton P., Florin T.H. Mucin dynamics and enteric pathogens. Nat. Rev. Microbiol. 2011, 9:265-278.
10. Mesquita P., Jonckheere N., Almeida R., Ducourouble M.P., Serpa J., Silva E., Pigny P., Silva F.S., Reis C., Silberg D., Van Seuningen I., David L. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J. Biol. Chem. 2003, 278:51549-51556.
11. Muramatsu Y., Fukushima K., Iino K., Totsune K., Takahashi K., Suzuki T., Hirasawa G., Takeyama J., Ito M., Nose M., Tashiro A., Hongo M., Oki Y., Nagura H., Sasano H. Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa. Peptides 2000, 21:1799-1809.
12. Saunders P.R., Kosecka U., McKay D.M., Perdue M.H. Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine. Am. J. Physiol. 1994, 267:G794-G799.
13. Soderholm J.D., Perdue M.H. Stress and gastrointestinal tract. II. Stress and intestinal barrier function. Am. J. Physiol. Gastrointest. Liver Physiol. 2001, 280:G7-G13.
14. Soderholm J.D., Yang P.C., Ceponis P., Vohra A., Riddell R., Sherman P.M., Perdue M.H. Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine. Gastroenterology 2002, 123:1099-1108.
15. Theodossi A., Spiegelhalter D.J., Jass J., Firth J., Dixon M., Leader M., Levison D.A., Lindley R., Filipe I., Price A., et al. Observer variation and discriminatory value of biopsy features in inflammatory bowel disease. Gut 1994, 35:961-968.
16. Turner J.R. Intestinal mucosal barrier function in health and disease. Nat. Rev. Immunol. 2009, 9:799-809.
17. Van der Sluis M., De Koning B.A., De Bruijn A.C., Velcich A., Meijerink J.P., Van Goudoever J.B., Buller H.A., Dekker J., Van Seuningen I., Renes I.B., Einerhand A.W. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 2006, 131:117-129.
18. van der Sluis M., Melis M.H., Jonckheere N., Ducourouble M.P., Buller H.A., Renes I., Einerhand A.W., Van Seuningen I. The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells. Biochem. Biophys. Res. Commun. 2004, 325:952-960.
19. Vooijs M., Liu Z., Kopan R. Notch: architect, landscaper, and guardian of the intestine. Gastroenterology 2011, 141:448-459.
20. Yuan P.Q., Wu S.V., Wang L., Tache Y. Corticotropin releasing factor in the rat colon: expression, localization and upregulation by endotoxin. Peptides 2010, 31:322-331.