Novel anti-acne actions of nadifloxacin and clindamycin that inhibit the production of sebum, prostaglandin E2 and promatrix metalloproteinase-2 in hamster sebocytes

Journal of Dermatology

Volumn 39, Issue 9, 2012, Pages 774-780

  Sato, Takashi ^a   Shirane, Tatsuhiko ^a   Noguchi, Norihisa ^a   Sasatsu, Masanori ^a   Ito, Akira ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

acne vulgaris; antimicrobial agents; matrix metalloproteinase; prostaglandin E2; sebum production

Indexed keywords

CLINDAMYCIN; DIACYLGLYCEROL ACYLTRANSFERASE 1; FAT DROPLET; GELATINASE A; NADIFLOXACIN; PERILIPIN; PROSTAGLANDIN E2; TRIACYLGLYCEROL;

ACNE VULGARIS; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL TYPE; CONTROLLED STUDY; ENZYME SYNTHESIS; HAMSTER; IN VITRO STUDY; LIPOGENESIS; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; SEBACEOUS CELL; SEBACEOUS GLAND; SEBUM SECRETION;

ACNE VULGARIS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRIER PROTEINS; CELLS, CULTURED; CLINDAMYCIN; CRICETINAE; DIACYLGLYCEROL O-ACYLTRANSFERASE; DINOPROSTONE; ENZYME PRECURSORS; FLUOROQUINOLONES; GELATINASES; GENE EXPRESSION; HUMANS; LIPOGENESIS; PEPTIDOGLYCAN; PHOSPHOPROTEINS; QUINOLIZINES; SEBACEOUS GLANDS; SEBUM;

EID: 84865639425     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2012.01525.x     Document Type: Article

References (38)

1. Farrar MD, Ingham E,. Acne: inflammation. Clin Dermatol 2004; 22: 380-384.
2. Zouboulis CC, Eady A, Philopott M, et al. What is the pathogenesis of acne? Exp Dermatol 2005; 14: 143-152.
3. Kurokawa I, Danby FW, Ju Q, et al. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol 2009; 18: 821-832.
4. Pawin H, Beylot C, Chivot M, et al. Physiopathology of acne vulgaris: recent data, new understanding of the treatments. Eur J Dermatol 2004; 14: 4-12.
5. Rivera AE,. Acne scarring: a review and current treatment modalities. J Am Acad Dermatol 2008; 59: 659-676.
6. Papakonstantinou E, Aletras AJ, Glass E, et al. Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin. J Invest Dermatol 2005; 125: 673-684.
7. Trivedi NR, Gilliland KL, Zhao W, et al. Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling. J Invest Dermatol 2006; 126: 1071-1079.
8. Jalian HR, Liu PT, Kanchanapoomi M, et al. All-trans retinoic acid shifts Propionibacterium acnes-induced matrix degradation expression profile toward matrix preservation in human monocytes. J Invest Dermatol 2008; 128: 2777-2782.
9. Choi JY, Piao MS, Lee JB, et al. Propionibacterium acnes stimulates pro-matrix metalloproteinase-2 expression through tumor necrosis factor-α in human dermal fibroblasts. J Invest Dermatol 2008; 128: 846-854.
10. Graham GM, Farrar MD, Crusse-Sawyar JE, et al. Proinflammatory cytokine production by human keratinocytes stimulated with Propionibacterium acnes and P. acnes GroEL. Br J Dermatol 2004; 150: 421-428.
11. Vowels BR, Yang S, Leyden JJ,. Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne. Infect Immun 1995; 63: 3158-3165.
12. Chen Q, Koga T, Uchi H, et al. Propionibacterium acnes-induced IL-8 production may be mediated by NF-ÎB activation in human monocytes. J Dermatol Sci 2002; 29: 97-103.
13. Basal E, Jain A, Kaushal GP,. Antibody response to crude cell lysate of propionibacterium acnes and induction of pro-inflammatory cytokines in patients with acne and normal healthy subjects. J Microbiol 2004; 42: 117-125.
14. Sugisaki H, Yamanaka K, Kakeda M, et al. Increased interferon-Î, interleukin-12p40 and IL-8 production in Propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris: host response but not bacterial species is the determinant factor of the disease. J Dermatol Sci 2009; 55: 47-52.
15. Iinuma K, Sato T, Akimoto N, et al. Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. J Invest Dermatol 2009; 129: 2113-2119.
16. Sato T, Kurihara H, Akimoto N, et al. Augmentation of gene expression and production of promatrix metalloproteinase 2 by Propionibacterium acnes-derived factors in hamster sebocytes and dermal fibroblasts: a possible mechanism for acne scarring. Biol Pharm Bull 2011; 34: 295-299.
17. Thiboutot D, Gollnick H, Bettoli V, et al. Global Alliance to Improve Outcomes in Acne. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol 2009; 60: S1-S50.
18. Nishijima S, Kurokawa I, Kawabata S,. Sensitivity of Propionibacterium acnes isolated from acne patients: comparative study of antimicrobial agents. J Int Med Res 1996; 24: 473-477.
19. Leyden JJ,. Current issues in antimicrobial therapy for the treatment of acne. J Eur Acad Dermatol Venereol 2001; 15: 51-55.
20. Kuwahara K, Kitazawa T, Kitagaki H, et al. Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes. J Dermatol Sci 2005; 38: 47-55.
21. Akamatsu H, Sasaki H, Kurokawa I, et al. Effect of nadifloxacin on neutrophil functions. J Int Med Res 1995; 23: 19-26.
22. 3 suppress lipogenesis in hamster sebaceous gland cells in vitro. J Invest Dermatol 2001; 117: 965-970.
23. Zouboulis CC, Seltmann H, Neitzel H, Orfanos CE,. Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol 1999; 113: 1011-1020.
24. 2 production. J Invest Dermatol 2005; 125: 865-872.
25. Akimoto N, Sato T, Iwata C, et al. Expression of perilipin A on the surface of lipid droplets increases along with the differentiation of hamster sebocytes in vivo and in vitro. J Invest Dermatol 2005; 124: 1127-1133.
26. Smith TM, Cong Z, Gilliland KL, et al. Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1. J Invest Dermatol 2006; 126: 1226-1232.
27. Melnik BC, Schmitz G,. Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. Exp Dermatol 2009; 18: 833-841.
28. Turkish A, Sturley SL,. Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: "Many ways to skin ACAT or a DGAT". Am J Physiol Gastrointest Liver Physiol 2007; 292: G953-G957.
29. 2 are active in sebaceous glands. J Mol Med 2006; 84: 75-87.
30. 2 production. Exp Dermatol 2006; 15: 769-774.
31. 2 does not affect testosterone production. Br J Dermatol 2009; 161: 674-677.
32. Cunliffe WJ, Holland DB, Jeremy A,. Comedone formation: etiology, clinical presentation, and treatment. Clin Dermatol 2004; 22: 367-374.
33. Cappel M, Mauger D, Thiboutot D,. Correlation between serum levels of insulin-like growth factor 1, dehydroepiandrosterone sulfate, and dihydrotestosterone and acne lesion counts in adult women. Arch Dermatol 2005; 141: 333-338.
34. Inui S, Nakao T, Itami S,. Modulation of androgen receptor transcriptional activity by anti-acne reagents. J Dermatol Sci 2004; 36: 97-101.
35. Romics L Jr, Dolganiuc A, Velayudham A, et al. Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propionibacterium acnes. J Leukoc Biol 2005; 78: 1255-1264.
36. Gill SE, Parks WC,. Metalloproteinases and their inhibitors: regulators of wound healing. Int J Biochem Cell Biol 2008; 40: 1334-1347.
37. Jinnin M,. Mechanisms of skin fibrosis in systemic sclerosis. J Dermatol 2010; 37: 11-25.
38. Visse R, Nagase H,. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 2003; 92: 827-839.