메뉴 건너뛰기




Volumn 48, Issue SUPPL. B, 2012, Pages 1-17

Liraglutide: New results in the treatment of type 2 diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C; LIPID; LIRAGLUTIDE; ORAL ANTIDIABETIC AGENT; ANTIDIABETIC AGENT; DRUG DERIVATIVE; GLIMEPIRIDE; GLUCAGON LIKE PEPTIDE 1; GLYCOSYLATED HEMOGLOBIN; INCRETIN; PYRAZINE DERIVATIVE; SITAGLIPTIN; SULFONYLUREA DERIVATIVE; TRIAZOLE DERIVATIVE;

EID: 84865619716     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2012.48(Suppl.A).1876681     Document Type: Review
Times cited : (2)

References (81)
  • 1
    • 70349207817 scopus 로고    scopus 로고
    • Projecting the future diabetes population size and related costs for the US
    • Huang É, Basu A, O'Grady M, Capretta JC. Projecting the future diabetes population size and related costs for the US. Diabetes Care. 2009; 32:2225-2229.
    • (2009) Diabetes Care. , vol.32 , pp. 2225-2229
    • Huang, É.1    Basu, A.2    O'Grady, M.3    Capretta, J.C.4
  • 2
    • 84872365409 scopus 로고    scopus 로고
    • National Diabetes Statistics, 2007
    • US Department of Health and Human Services, Last updated: June 2008. Accessed October 19, 2010
    • US Department of Health and Human Services, National Diabetes Information Clearinghouse. National Diabetes Statistics, 2007. NIH Publication No. 08-3892. Em: http://diabetes.niddk.nih.gov/dm/pubs/statistics/DM-Statistics. Last updated: June 2008. Accessed October 19, 2010.
    • NIH Publication No. 08-3892
  • 3
    • 78650117385 scopus 로고    scopus 로고
    • International Diabetes Federation. International Diabetes Federation Website. Em: Accessed October 19, 2010
    • International Diabetes Federation. Diabetes and impaired glucose tolerance: global burden: prevalence and projections, 2010 and 2030. International Diabetes Federation Website. Em: http://www.diabetesatlas.org /content/diabetesand-impaired-glucose-tolerance. Accessed October 19, 2010.
    • Diabetes and Impaired Glucose Tolerance: Global Burden: Prevalence and Projections, 2010 and 2030
  • 4
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009; 32:193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 5
    • 73949146152 scopus 로고    scopus 로고
    • Current views on type 2 diabetes
    • Lin E, Sun Z. Current views on type 2 diabetes. J Endocrinol. 2010; 204:1-11.
    • (2010) J Endocrinol. , vol.204 , pp. 1-11
    • Lin, E.1    Sun, Z.2
  • 6
    • 64649104158 scopus 로고    scopus 로고
    • Banting Lecture: From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • DeFronzo RA. Banting Lecture: from the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009; 58:773-795.
    • (2009) Diabetes. , vol.58 , pp. 773-795
    • DeFronzo, R.A.1
  • 7
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001; 285:2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 8
    • 75749115884 scopus 로고    scopus 로고
    • The role of basal insulin and glucagon-like peptide-1 agonists in the therapeutic management of type 2 diabetes - A comprehensive review
    • Garg SK. The role of basal insulin and glucagon-like peptide-1 agonists in the therapeutic management of type 2 diabetes - a comprehensive review. Diabetes Technol Therapeutics 2010; 12:11-24.
    • (2010) Diabetes Technol Therapeutics , vol.12 , pp. 11-24
    • Garg, S.K.1
  • 10
    • 79958743689 scopus 로고    scopus 로고
    • Clinical pharmacology of incretin therapies for type 2 diabetes mellitus: Implications for treatment
    • Neumiller JJ. Clinical pharmacology of incretin therapies for type 2 diabetes mellitus: implications for treatment. Clinical Therapeutics 2011; 33:528-576.
    • (2011) Clinical Therapeutics , vol.33 , pp. 528-576
    • Neumiller, J.J.1
  • 12
    • 73349083198 scopus 로고    scopus 로고
    • Reduced insulin secretion/insulin resistance (disposition) index is the primary determinant of glucose intolerance in the pre-diabetic state: Results from ACT NOW
    • Paper presented at
    • DeFronzo R, Banerji MA, Bray G, et al. Reduced insulin secretion/insulin resistance (disposition) index is the primary determinant of glucose intolerance in the pre-diabetic state: results from ACT NOW. Paper presented at: American Diabetes Association 68th Scientific Session; June 6-10, 2008; San Francisco, CA.
    • American Diabetes Association 68th Scientific Session; June 6-10, 2008; San Francisco, CA
    • DeFronzo, R.1    Banerji, M.A.2    Bray, G.3
  • 13
    • 0028817815 scopus 로고
    • UK Prospective Diabetes Study 16. Overview of 6 years' therapy of type II diabetes: A progressive disease
    • United Kingdom Prospective Diabetes Study Group
    • United Kingdom Prospective Diabetes Study Group. UK Prospective Diabetes Study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes. 1995; 44: 1249-1258.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 15
    • 77950891085 scopus 로고    scopus 로고
    • Effect of noninsulin antidiabetic drugs added to metformin therapy on glycaemic controle, weight gain, and hypoglycaemia in type 2 diabetes
    • Phung OJ, Scholle JM, Talwar M, Coleman CI. Effect of noninsulin antidiabetic drugs added to metformin therapy on glycaemic controle, weight gain, and hypoglycaemia in type 2 diabetes. JAMA 2010; 303:1410-1418.
    • (2010) JAMA , vol.303 , pp. 1410-1418
    • Phung, O.J.1    Scholle, J.M.2    Talwar, M.3    Coleman, C.I.4
  • 16
    • 79959774265 scopus 로고    scopus 로고
    • Therapy in the early stage: Incretins
    • Cernea S, Raz MD. Therapy in the early stage: incretins. Diabetes Care 2011; 34 (Suppl 2):S264-S271.
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 2
    • Cernea, S.1    Raz, M.D.2
  • 17
    • 33845344395 scopus 로고
    • Plasma insulin response to oral and intravenous glucose administration
    • Elrick H, Stimmler L, Hlad CJ Jr, Arai E. Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab. 1964; 24:1076-1082.
    • (1964) J Clin Endocrinol Metab. , vol.24 , pp. 1076-1082
    • Elrick, H.1    Stimmler, L.2    Hlad Jr., C.J.3    Arai, E.4
  • 18
    • 51949112509 scopus 로고    scopus 로고
    • An overview of incretin hormones
    • Holst JJ, LaSalle JR. An overview of incretin hormones. J Fam Prac. 2008; 57:S4-S9.
    • (2008) J Fam Prac , vol.57
    • Holst, J.J.1    LaSalle, J.R.2
  • 19
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab. 2006; 3:153-165.
    • (2006) Cell Metab. , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 22
    • 0037312818 scopus 로고    scopus 로고
    • Glucagon-like peptides: Regulators of cell proliferation, differentiation, and apoptosis
    • DOI 10.1210/me.2002-0306
    • Drucker DJ. Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol. 2003; 17:161-171. (Pubitemid 36183142)
    • (2003) Molecular Endocrinology , vol.17 , Issue.2 , pp. 161-171
    • Drucker, D.J.1
  • 23
    • 57149083860 scopus 로고    scopus 로고
    • The incretins: From the concept to their use in the treatment of type 2 diabetes. Part A: incretins: concept and physiological functions
    • Girard J. The incretins: from the concept to their use in the treatment of type 2 diabetes. Part A: incretins: concept and physiological functions. Diabetes Metab. 2008; 34:550-559.
    • (2008) Diabetes Metab. , vol.34 , pp. 550-559
    • Girard, J.1
  • 24
    • 0022617246 scopus 로고
    • Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes
    • DOI 10.1007/BF02427280
    • Nauck M, Stockmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes. Diabetologia 1986; 29:46-52. (Pubitemid 16162741)
    • (1986) Diabetologia , vol.29 , Issue.1 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 25
    • 0037312821 scopus 로고    scopus 로고
    • The influence of GLP-1 on glucose-stimulated insulin secretion: Effects on -cell sensitivity in type 2 and nondiabetic subjects
    • DOI 10.2337/diabetes.52.2.380
    • Kjems LL, Holst JJ, Volund A, Madsbad S. The influence of GLP-1 on glucose stimulated insulin secretion: effects on - cell sensitivity in Type 2 and nondiabetic subjects. Diabetes 2003; 52:380-386. (Pubitemid 36173193)
    • (2003) Diabetes , vol.52 , Issue.2 , pp. 380-386
    • Kjems, L.L.1    Holst, J.J.2    Volund, A.3    Madsbad, S.4
  • 26
    • 40949090627 scopus 로고    scopus 로고
    • Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance
    • Vollmer K, Holst JJ, Baller B, et al. Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance. Diabetes. 2008; 57:678-687.
    • (2008) Diabetes. , vol.57 , pp. 678-687
    • Vollmer, K.1    Holst, J.J.2    Baller, B.3
  • 27
    • 67049155251 scopus 로고    scopus 로고
    • Unraveling the science of incretin biology
    • Nauck MA. Unraveling the science of incretin biology. Am J Med. 2009; 122:S3-S10.
    • (2009) Am J Med , vol.122
    • Nauck, M.A.1
  • 28
    • 65949122087 scopus 로고    scopus 로고
    • One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: A randomized, controlled trial
    • Bunck MC, Diamant M, Corner A, et al. One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial. Diabetes Care. 2009; 32:762-768.
    • (2009) Diabetes Care. , vol.32 , pp. 762-768
    • Bunck, M.C.1    Diamant, M.2    Corner, A.3
  • 29
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet. 2009; 374:39-47.
    • (2009) Lancet. , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 30
    • 77951793008 scopus 로고    scopus 로고
    • Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function
    • Meier JJ, Nauck MA. Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function Diabetes. 2010; 59:1117-1125.
    • (2010) Diabetes. , vol.59 , pp. 1117-1125
    • Meier, J.J.1    Nauck, M.A.2
  • 31
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: Systematic review and meta-analysis
    • DOI 10.1001/jama.298.2.194
    • Amori RE, Lau J, Pittas AG. Efficacy and safety of incretin therapy in type 2 diabetes: Systematic review and metaanalysis. JAMA 2007, 298:194-206. (Pubitemid 47057766)
    • (2007) Journal of the American Medical Association , vol.298 , Issue.2 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 32
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • DOI 10.1007/s00125-001-0719-z
    • Agersø H, Jensen LB, Elbrønd B, et al. The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 2002, 45:195-202. (Pubitemid 34208381)
    • (2002) Diabetologia , vol.45 , Issue.2 , pp. 195-202
    • Agerso, H.1    Jensen, L.B.2    Elbrond, B.3    Rolan, P.4    Zdravkovic, M.5
  • 34
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • DOI 10.1210/jc.2002-021053
    • Vilsboll, T. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab 2003; 88:220-224. (Pubitemid 36115169)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.1 , pp. 220-224
    • Vilsboll, T.1    Agerso, H.2    Krarup, T.3    Holst, J.J.4
  • 35
    • 70349093453 scopus 로고    scopus 로고
    • The effect of three different injection sites on the pharmacokinetics of the once-daily human GLP-1 analogue liraglutide
    • Abstr
    • Kapitza C, Flint A, Spitzer H, Hindsberger C, Zdravkovic M. The effect of three different injection sites on the pharmacokinetics of the once-daily human GLP-1 analogue liraglutide. (Abstr). Diabetes. 2008; 57:A593.
    • (2008) Diabetes , vol.57
    • Kapitza, C.1    Flint, A.2    Spitzer, H.3    Hindsberger, C.4    Zdravkovic, M.5
  • 36
    • 78049365082 scopus 로고    scopus 로고
    • Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase
    • Malm-Erjefält M, Bjørnsdottir I, Vanggaard J, Helleberg H, Larsen U, Oosterhuis B, et al. Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Drug Metab Dispos 2010; 38: 1944-1953.
    • (2010) Drug Metab Dispos , vol.38 , pp. 1944-1953
    • Malm-Erjefält, M.1    Bjørnsdottir, I.2    Vanggaard, J.3    Helleberg, H.4    Larsen, U.5    Oosterhuis, B.6
  • 37
    • 70849096647 scopus 로고    scopus 로고
    • Effect of renal impairment on the pharmacokinetics of the GLP-1 analog liraglutide
    • Jacobsen L, Hindsberger C, Robson, R, et al. Effect of renal impairment on the pharmacokinetics of the GLP-1 analog liraglutide. Br J Clin Pharmacol. 2009; 68:898-905.
    • (2009) Br J Clin Pharmacol. , vol.68 , pp. 898-905
    • Jacobsen, L.1    Hindsberger, C.2    Robson, R.3
  • 38
    • 67549112400 scopus 로고    scopus 로고
    • Insights from the liraglutide clinical development program - The Liraglutide Effect and Action in Diabetes (LEAD) studies
    • McGill J. Insights from the liraglutide clinical development program - the Liraglutide Effect and Action in Diabetes (LEAD) studies. Postgrad Med. 2009; 121:16-25.
    • (2009) Postgrad Med. , vol.121 , pp. 16-25
    • McGill, J.1
  • 39
    • 69949110258 scopus 로고    scopus 로고
    • Influence of hepatic impairment on pharmacokinetics of the long-acting human GLP-1 analog liraglutide
    • Flint A, Nazzal K, Jagielski P, et al. Influence of hepatic impairment on pharmacokinetics of the long-acting human GLP-1 analog liraglutide. Diabetes. 2007; 56:A145.
    • (2007) Diabetes , vol.56
    • Flint, A.1    Nazzal, K.2    Jagielski, P.3
  • 40
    • 72749125264 scopus 로고    scopus 로고
    • A randomized, double-blind, cross-over trial investigating the effect of liraglutide on the absorption pharmacokinetics of concomitantly administered oral drugs in healthy subjects
    • Abstr
    • Malm-Erjelfalt M, Ekblom M, Brondsted L, et al. A randomized, double-blind, cross-over trial investigating the effect of liraglutide on the absorption pharmacokinetics of concomitantly administered oral drugs in healthy subjects. (Abstr). Diabetes. 2008; 57:A130.
    • (2008) Diabetes , vol.57
    • Malm-Erjelfalt, M.1    Ekblom, M.2    Brondsted, L.3
  • 43
    • 0036784675 scopus 로고    scopus 로고
    • The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice
    • Rolin B, Larsen MO, Gotfredsen CF. The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice. Am J Physiol Endocrinol Metab 2002; 283:E745-E752.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Rolin, B.1    Larsen, M.O.2    Gotfredsen, C.F.3
  • 46
    • 79954631160 scopus 로고    scopus 로고
    • The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes
    • Shimoda M, Kanda E, Hamamoto S, et al. The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes. Diabetologia 2011; 54:1098-1108.
    • (2011) Diabetologia , vol.54 , pp. 1098-1108
    • Shimoda, M.1    Kanda, E.2    Hamamoto, S.3
  • 47
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brändle M, Bebakar WM, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabet Med 2009; 26:268-278.
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3    Bebakar, W.M.4
  • 50
    • 34249869806 scopus 로고    scopus 로고
    • Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes
    • DOI 10.2337/dc06-2593
    • Visbøll T, Zdravkovik M, Le-Thi T. Liraglutide, a long-acting human GLP-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes mellitus. Diabetes Care. 2007; 30:1608-1610. (Pubitemid 46871185)
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1608-1610
    • Vilsboll, T.1    Zdravkovic, M.2    Le-Thi, T.3    Krarup, T.4    Schmitz, O.5    Courreges, J.-P.6    Verhoeven, R.7    Buganova, I.8    Madsbad, S.9
  • 51
    • 69949129023 scopus 로고    scopus 로고
    • The once-daily human GLP-1 analog liraglutide reduces systolic blood pressure in patients with type 2 diabetes
    • Colagiuri S, Frid A, Zdravkovic M, Le-Thi T, Vaag A. The once-daily human GLP-1 analog liraglutide reduces systolic blood pressure in patients with type 2 diabetes. Diabetes. 2008; 57:A164-A165.
    • (2008) Diabetes , vol.57
    • Colagiuri, S.1    Frid, A.2    Zdravkovic, M.3    Le-Thi, T.4    Vaag, A.5
  • 52
    • 75549091263 scopus 로고    scopus 로고
    • Glycemic control algorithm. Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: An algorithm for glycemic control
    • Rodbard HW, Jellinger PS, Davidson JA, et al. Glycemic control algorithm. Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. Endocr Pract 2009; 15(6): 513-655.
    • (2009) Endocr Pract , vol.15 , Issue.6 , pp. 513-655
    • Rodbard, H.W.1    Jellinger, P.S.2    Davidson, J.A.3
  • 54
    • 0036066641 scopus 로고    scopus 로고
    • Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes
    • Juhl CB, Hollingdal M, Sturis J, et al. Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes. Diabetes. 2002; 51:424-429. (Pubitemid 34764798)
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 424-429
    • Juhl, C.B.1    Hollingdal, M.2    Sturis, J.3    Jakobsen, G.4    Agerso, H.5    Veldhuis, J.6    Porksen, N.7    Schmitz, O.8
  • 55
    • 3342984674 scopus 로고    scopus 로고
    • The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes
    • DOI 10.2337/diacare.27.8.1915
    • Harder H, Nielsen L, Thi TD, Astrup A. The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes. Diabetes Care. 2004; 27:1915-1921. (Pubitemid 38989232)
    • (2004) Diabetes Care , vol.27 , Issue.8 , pp. 1915-1921
    • Harder, H.1    Nielsen, L.2    Thi, T.D.T.3    Astrup, A.4
  • 56
    • 0038353630 scopus 로고    scopus 로고
    • The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose
    • Chang AM, Jakobsen G, Sturis J, et al. The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose. Diabetes. 2003; 52:1786-1791. (Pubitemid 36792471)
    • (2003) Diabetes , vol.52 , Issue.7 , pp. 1786-1791
    • Chang, A.M.1    Jakobsen, G.2    Sturis, J.3    Smith, M.J.4    Bloem, C.J.5    An, B.6    Galecki, A.7    Halter, J.B.8
  • 58
    • 2542451393 scopus 로고    scopus 로고
    • Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): A 12-week, double-blind, randomized, controlled trial
    • DOI 10.2337/diacare.27.6.1335
    • Madsbad S, Schmitz OU, Ranstam J, et al. Improved glycemic controle with não weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): A 12-week, double-blind, randomized, controlled trial. Diabetes Care 2004; 27:1335-1342. (Pubitemid 38679980)
    • (2004) Diabetes Care , vol.27 , Issue.6 , pp. 1335-1342
    • Madsbad, S.1    Schmitz, O.2    Ranstam, J.3    Jakobsen, G.4    Matthews, D.R.5
  • 59
    • 22644444292 scopus 로고    scopus 로고
    • Effects of liraglutide (NN2211), a long-acting GLP-1 analogue, on glycaemic control and bodyweight in subjects with Type 2 diabetes
    • DOI 10.1111/j.1464-5491.2005.01567.x
    • Feinglos MN, Saad MF, Pi-Sunyer FX, An B, Santiago OU. Effects of liraglutide (NN2211), a long-acting GLP-1 analogue, on glycaemic controle and bodyweight in subjects with type 2 diabetes. Diabet Med 2005; 22:1016-1023. (Pubitemid 41025998)
    • (2005) Diabetic Medicine , vol.22 , Issue.8 , pp. 1016-1023
    • Feinglos, M.N.1    Saad, M.F.2    Pi-Sunyer, F.X.3    An, B.4    Santiago, O.5
  • 60
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD- 3 Mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, Garcia-Hernandez PA, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD- 3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009; 373:473-81.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3    Garcia-Hernandez, P.A.4
  • 61
    • 77954184211 scopus 로고    scopus 로고
    • Patient-reported outcomes following treatment with the human GLP-1 analogue liraglutide or glimepiride in monotherapy: Results from a randomized controlled trial in patients with type 2 diabetes
    • Bode BW, Testa MA, Magwire M, et al. Patient-reported outcomes following treatment with the human GLP-1 analogue liraglutide or glimepiride in monotherapy: results from a randomized controlled trial in patients with type 2 diabetes. Diabetes Obes Metab 2011; 12:604-612.
    • (2011) Diabetes Obes Metab , vol.12 , pp. 604-612
    • Bode, B.W.1    Testa, M.A.2    Magwire, M.3
  • 62
    • 79951906623 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic controle and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes
    • Garber A, Henry RR, Ratner R, et al. Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic controle and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes. Diabetes Obes Metab 2011; 13:348-356.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 348-356
    • Garber, A.1    Henry, R.R.2    Ratner, R.3
  • 63
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes (LEAD-2)
    • Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes (LEAD-2). Diabetes Care 2009; 32:84-90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 64
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial
    • Pratley R, Nauck M, Bailey T, et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet 2010; 375: 1447-56.
    • (2010) Lancet , vol.375 , pp. 1447-1456
    • Pratley, R.1    Nauck, M.2    Bailey, T.3
  • 65
    • 79952755181 scopus 로고    scopus 로고
    • One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: A randomised, parallel-group, open-label trial
    • Pratley R, Nauck M, Bailey T, et al. One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial. Int J Clin Pract 2011; 65:397-407.
    • (2011) Int J Clin Pract , vol.65 , pp. 397-407
    • Pratley, R.1    Nauck, M.2    Bailey, T.3
  • 66
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse JB, et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 2009; 32:1224-30.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3
  • 67
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutine vs insulin glargine and placebo combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU):a randomised controlled trial
    • Russell-Jones D, Vaag A, Scmitz OU, et al. Liraglutine vs insulin glargine and placebo combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU):a randomised controlled trial. Diabetologia 2009; 52: 2046-2055.
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Scmitz, O.U.3
  • 68
    • 77956076972 scopus 로고    scopus 로고
    • Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents
    • Liraglutide Effect Action in Diabetes-6 Study Group
    • Buse JB, Sesti G, Schmidt WE et al. Liraglutide Effect Action in Diabetes-6 Study Group. Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents. Diabetes Care 2010; 33:1300-3.
    • (2010) Diabetes Care , vol.33 , pp. 1300-1303
    • Buse, J.B.1    Sesti, G.2    Schmidt, W.E.3
  • 69
    • 79955950106 scopus 로고    scopus 로고
    • Patient-reported outcomes are superior in patients with Type 2 diabetes treated with liraglutide as compared with exenatide, when added to metformin, sulphonylurea or both: Results from a randomized, open-label study
    • Schmidt WE, Christiansen JS, Hammer M, et al. Patient-reported outcomes are superior in patients with Type 2 diabetes treated with liraglutide as compared with exenatide, when added to metformin, sulphonylurea or both: results from a randomized, open-label study. Diabet Med 2011; 28:715-723.
    • (2011) Diabet Med , vol.28 , pp. 715-723
    • Schmidt, W.E.1    Christiansen, J.S.2    Hammer, M.3
  • 71
    • 77649294607 scopus 로고    scopus 로고
    • Weighing risks and benefits of liraglutide - The FDA's review of a new antidiabetic therapy
    • Parks M and Rosebraugh C. Weighing risks and benefits of liraglutide - The FDA's review of a new antidiabetic therapy. N Eng J Med 2010; 362:774-7.
    • (2010) N Eng J Med , vol.362 , pp. 774-777
    • Parks, M.1    Rosebraugh, C.2
  • 72
    • 77950228684 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    • Knudsen LB, Madsen LW, Andersen S, et al. Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology 2010; 151:1473-86.
    • (2010) Endocrinology , vol.151 , pp. 1473-1486
    • Knudsen, L.B.1    Madsen, L.W.2    Andersen, S.3
  • 73
    • 84878709382 scopus 로고    scopus 로고
    • Liraglutida en el tratamiento del diabetes tipo 2: Recomendaciones para una mejor selección de los pacientes desde uma visión multidisciplinar
    • Ampudia-Balsco FJ, Calvo Gómez C, Cos Claramunt X, et al. Liraglutida en el tratamiento del diabetes tipo 2: recomendaciones para una mejor selección de los pacientes desde uma visión multidisciplinar. SEMG 2010; 130:549-559.
    • (2010) SEMG , vol.130 , pp. 549-559
    • Ampudia-Balsco, F.J.1    Calvo Gómez, C.2    Cos Claramunt, X.3
  • 75
    • 79953724619 scopus 로고    scopus 로고
    • Consensus Panel on Type 2 diabetes mellitus an algorithm for glycemic control
    • AACE/ACE Consensus Statement. American Association of Clinical Endocrinologists/ American College of Endocrinology.
    • AACE/ACE Consensus Statement. American Association of Clinical Endocrinologists/ American College of Endocrinology. Consensus Panel on Type 2 diabetes mellitus an algorithm for glycemic control. Endocrine Pract 2009; 15:541-559.
    • (2009) Endocrine Pract , vol.15 , pp. 541-559
  • 76
    • 72449154207 scopus 로고    scopus 로고
    • Adding liraglutide to oral antidiabetic drug therapy: Onset of treatment effects over time
    • Gallwitz B, Vaag A, Falahati A, et al. Adding liraglutide to oral antidiabetic drug therapy: onset of treatment effects over time. Int J Clin Pract 2010; 64:267-76.
    • (2010) Int J Clin Pract , vol.64 , pp. 267-276
    • Gallwitz, B.1    Vaag, A.2    Falahati, A.3
  • 77
    • 67049122423 scopus 로고    scopus 로고
    • Liraglutide, a human GLP-1 analogue, reduces bodyweight in subjects with type 2 diabetes, irrespective of body mass index at baseline
    • Schmitz OU, Russell-Jones D, Shaw J, et al. Liraglutide, a human GLP-1 analogue, reduces bodyweight in subjects with type 2 diabetes, irrespective of body mass index at baseline. Diabetologia 2008; 51 (Suppl.1):S354-S5.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Schmitz, O.U.1    Russell-Jones, D.2    Shaw, J.3
  • 78
    • 64649102619 scopus 로고    scopus 로고
    • GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction inmice
    • Noyan-Ashraf MH, Momen MA, Ban K et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction inmice. Diabetes 2009; 58: 975-983.
    • (2009) Diabetes , vol.58 , pp. 975-983
    • Noyan-Ashraf, M.H.1    Momen, M.A.2    Ban, K.3
  • 79
    • 1442311383 scopus 로고    scopus 로고
    • Effects of Glucagon-Like Peptide-1 in Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction after Successful Reperfusion
    • DOI 10.1161/01.CIR.0000120505.91348.58
    • Nikolaidis A, Mankad S, Sokos GG et al. Effects of glucagon- like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004; 109: 962-965. (Pubitemid 38282847)
    • (2004) Circulation , vol.109 , Issue.8 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3    Miske, G.4    Shah, A.5    Elahi, D.6    Shannon, R.P.7
  • 81
    • 80052039077 scopus 로고    scopus 로고
    • Cardiovascular safety of liraglutide assessed in a patient-level pooled analysis of phase 2-3 liraglutide clinical development studies
    • Available in: dvr.sagepub.com
    • Marso SP, Lindsey JB, Stolker JM, et al. Cardiovascular safety of liraglutide assessed in a patient-level pooled analysis of phase 2-3 liraglutide clinical development studies. Diabetes Vasc Dis Res 2011. Available in: dvr.sagepub.com
    • (2011) Diabetes Vasc Dis Res
    • Marso, S.P.1    Lindsey, J.B.2    Stolker, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.