Anti-influenza Drug Discovery: Identification of an Orally Bioavailable Quinoline Derivative through Activity- and Property-Guided Lead Optimization

ChemMedChem

Volumn 7, Issue 9, 2012, Pages 1546-1550

  Yeh, Jiann Yih ^a   Coumar, Mohane Selvaraj ^b   Shiao, Hui Yi ^a   Lin, Ta Jen ^c   Lee, Yen Chun ^a   Hung, Hui Chen ^a   Ko, Shengkai ^a   Kuo, Fu Ming ^a   Fang, Ming Yu ^a   Huang, Yu Lin ^a   Hsu, John T A ^a   Yeh, Teng Kuang ^a   Shih, Shin Ru ^c   Chao, Yu Sheng ^a   Horng, Jim Tong ^c   Hsieh, Hsing Pang ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b PONDICHERRY UNIVERSITY   (India)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Drug discovery; Hit to lead optimization; Influenza; Pharmacokinetics; Structure activity relationships

Indexed keywords

AMANTADINE; ANGELICIN DERIVATIVE; HYDRAZONE DERIVATIVE; OSELTAMIVIR; QUINOLINE 4 CABOXYLIC ACID DERIVATIVE; QUINOLONE DERIVATIVE; RIMANTADINE; UNCLASSIFIED DRUG; ZANAMIVIR;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOPATHOGENIC EFFECT; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; INFLUENZA A (H1N1); INFLUENZA VACCINATION; INFLUENZA VIRUS; NONHUMAN; PANDEMIC; PRIORITY JOURNAL; VIRUS STRAIN;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DRUG DISCOVERY; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MALE; ORTHOMYXOVIRIDAE INFECTIONS; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865598860     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200259     Document Type: Article

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