-
1
-
-
0028330005
-
Genetic susceptibility to death from coronary heart disease in a study of twins
-
DOI 10.1056/NEJM199404143301503
-
Marenberg ME, Risch N, Berkman LF, et al. Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med. 1994;330:1041-6. (Pubitemid 24106561)
-
(1994)
New England Journal of Medicine
, vol.330
, Issue.15
, pp. 1041-1046
-
-
Marenberg, M.E.1
Risch, N.2
Berkman, L.F.3
Floderus, B.4
De Faire, U.5
-
2
-
-
33846603166
-
Genetics and heritability of coronary artery disease and myocardial infarction
-
DOI 10.1007/s00392-006-0447-y
-
Mayer B, Erdmann J, Schunkert H. Genetics and heritability of coronary artery disease and myocardial infarction. Clin Res Cardiol: Official Journal of the German Cardiac Society. 2007;96:1-7. (Pubitemid 46175364)
-
(2007)
Clinical Research in Cardiology
, vol.96
, Issue.1
, pp. 1-7
-
-
Mayer, B.1
Erdmann, J.2
Schunkert, H.3
-
3
-
-
79957506175
-
Strategic approaches to unraveling genetic causes of cardiovascular diseases
-
This review article will bring the readers up-To-date with the current approaches to genetic studies of complex diseases, such as atherosclerosis
-
Marian AJ, Belmont J. Strategic approaches to unraveling genetic causes of cardiovascular diseases. Circ Res. 2011;108:1252-69. This review article will bring the readers up-To-date with the current approaches to genetic studies of complex diseases, such as atherosclerosis.
-
(2011)
Circ Res.
, vol.108
, pp. 1252-69
-
-
Marian, A.J.1
Belmont, J.2
-
5
-
-
34249788998
-
"Laminopathies": A wide spectrum of human diseases
-
DOI 10.1016/j.yexcr.2007.03.028, PII S0014482707001279
-
Worman HJ, Bonne G. "Laminopathies": A wide spectrum of human diseases. Exp Cell Res. 2007;313:2121-33. (Pubitemid 46850729)
-
(2007)
Experimental Cell Research
, vol.313
, Issue.10
, pp. 2121-2133
-
-
Worman, H.J.1
Bonne, G.2
-
6
-
-
13844313862
-
Whole-genome patterns of common DNA variation in three human populations
-
DOI 10.1126/science.1105436
-
Hinds DA, Stuve LL, Nilsen GB, et al. Whole-genome patterns of common DNA variation in three human populations. Science. 2005;307:1072-9. (Pubitemid 40262106)
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1072-1079
-
-
Hinds, D.A.1
Stuve, L.L.2
Nilsen, G.B.3
Halperin, E.4
Eskin, E.5
Ballinger, D.G.6
Frazer, K.A.7
Cox, D.R.8
-
7
-
-
18444396271
-
A first-generation linkage disequilibrium map of human chromosome 22
-
DOI 10.1038/nature00864
-
Dawson E, Abecasis GR, Bumpstead S, et al. A first-generation linkage disequilibrium map of human chromosome 22. Nature. 2002;418:544-8. (Pubitemid 34851401)
-
(2002)
Nature
, vol.418
, Issue.6897
, pp. 544-548
-
-
Dawson, E.1
Abecasis, G.R.2
Bumpstead, S.3
Chen, Y.4
Hunt, S.5
Beare, D.M.6
Pabial, J.7
Dibling, T.8
Tinsley, E.9
Kirby, S.10
Carter, D.11
Papaspyridonos, M.12
Livingstone, S.13
Ganske, R.14
Lohmussaar, E.15
Zernant, J.16
Tonisson, N.17
Remm, M.18
Magi, R.19
Puurand, T.20
Vilo, J.21
Kurg, A.22
Rice, K.23
Deloukas, P.24
Mott, R.25
Metspalu, A.26
Bentley, D.R.27
Cardon, L.R.28
Dunham, I.29
more..
-
8
-
-
0036208832
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Patterns of linkage disequilibrium in the human genome
-
DOI 10.1038/nrg777
-
Ardlie KG, Kruglyak L, Seielstad M Patterns of linkage disequilibrium in the human genome. Nat Rev Genet. 2002;3:299-309. (Pubitemid 34279798)
-
(2002)
Nature Reviews Genetics
, vol.3
, Issue.4
, pp. 299-309
-
-
Ardlie, K.G.1
Kruglyak, L.2
Seielstad, M.3
-
9
-
-
67349085063
-
Genome-wide association study identifies eight loci associated with blood pressure
-
Newton-Cheh C, Johnson T, Gateva V, et al. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 2009;41:666-76.
-
(2009)
Nat Genet
, vol.41
, pp. 666-676
-
-
Newton-Cheh, C.1
Johnson, T.2
Gateva, V.3
-
11
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80053907554
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
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This is a genome-wide association study that describes identification of multiple loci associated with systemic arterial hypertension and shows that the effect of each locus is very small
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Ehret GB, Munroe PB, Rice KM, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478:103-9. This is a genome-wide association study that describes identification of multiple loci associated with systemic arterial hypertension and shows that the effect of each locus is very small.
-
(2011)
Nature.
, vol.478
, pp. 103-9
-
-
Ehret, G.B.1
Munroe, P.B.2
Rice, K.M.3
-
12
-
-
80053452394
-
Large-scale gene-centric analysis identifies novel variants for coronary artery disease
-
Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS genetics 2011; 7:e1002260.
-
(2011)
PLoS genetics
, vol.7
-
-
-
13
-
-
34249996115
-
A common allele on chromosome 9 associated with coronary heart disease
-
DOI 10.1126/science.1142447
-
McPherson R, Pertsemlidis A, Kavaslar N, et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316:1488-91. (Pubitemid 46906617)
-
(2007)
Science
, vol.316
, Issue.5830
, pp. 1488-1491
-
-
McPherson, R.1
Pertsemlidis, A.2
Kavaslar, N.3
Stewart, A.4
Roberts, R.5
Cox, D.R.6
Hinds, D.A.7
Pennacchio, L.A.8
Tybjaerg-Hansen, A.9
Folsom, A.R.10
Boerwinkle, E.11
Hobbs, H.H.12
Cohen, J.C.13
-
14
-
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34250010480
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A common variant on chromosome 9p21 affects the risk of myocardial infarction
-
DOI 10.1126/science.1142842
-
Helgadottir A, Thorleifsson G, Manolescu A, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007;316:1491-3. (Pubitemid 46906618)
-
(2007)
Science
, vol.316
, Issue.5830
, pp. 1491-1493
-
-
Helgadottir, A.1
Thorleifsson, G.2
Manolescu, A.3
Gretarsdottir, S.4
Blondal, T.5
Jonasdottir, A.6
Jonasdottir, A.7
Sigurdsson, A.8
Baker, A.9
Palsson, A.10
Masson, G.11
Gudbjartsson, D.F.12
Magnusson, K.P.13
Andersen, K.14
Levey, A.I.15
Backman, V.M.16
Matthiasdottir, S.17
Jonsdottir, T.18
Palsson, S.19
Einarsdottir, H.20
Gunnarsdottir, S.21
Gylfason, A.22
Vaccarino, V.23
Hooper, W.C.24
Reilly, M.P.25
Granger, C.B.26
Austin, H.27
Rader, D.J.28
Shah, S.H.29
Quyyumi, A.A.30
Gulcher, J.R.31
Thorgeirsson, G.32
Thorsteinsdottir, U.33
Kong, A.34
Stefansson, K.35
more..
-
15
-
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34547623750
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Genomewide association analysis of coronary artery disease
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DOI 10.1056/NEJMoa072366
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Samani NJ, Erdmann J, Hall AS, et al. Genomewide association analysis of coronary artery disease. N Engl J Med. 2007;357:443-53. (Pubitemid 47204873)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.5
, pp. 443-453
-
-
Samani, N.J.1
Erdmann, J.2
Hall, A.S.3
Hengstenberg, C.4
Mangino, M.5
Mayer, B.6
Dixon, R.J.7
Meitinger, T.8
Braund, P.9
Wichmann, H.-E.10
Barrett, J.H.11
Konig, I.R.12
Stevens, S.E.13
Szymczak, S.14
Tregouet, D.-A.15
Iles, M.M.16
Pahlke, F.17
Pollard, H.18
Lieb, W.19
Cambien, F.20
Fischer, M.21
Ouwehand, W.22
Blankenberg, S.23
Balmforth, A.J.24
Baessler, A.25
Ball, S.G.26
Strom, T.M.27
Braenne, I.28
Gieger, C.29
Deloukas, P.30
Tobin, M.D.31
Ziegler, A.32
Thompson, J.R.33
Schunkert, H.34
more..
-
16
-
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34447543913
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Cellular senescence in cancer and aging
-
DOI 10.1016/j.cell.2007.07.003, PII S0092867407008902
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Collado M, Blasco MA, Serrano M Cellular senescence in cancer and aging. Cell. 2007;130:223-33. (Pubitemid 47081143)
-
(2007)
Cell
, vol.130
, Issue.2
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
17
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77949775636
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Targeted deletion of the 9p21 noncoding coronary artery disease risk interval in mice
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This is an interesting study that analyzes phenotypic consequences of deletion of the 9p21 analogous locus in mice and shows enhanced smooth muscle cell proliferation
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Visel A, Zhu Y, May D, et al. Targeted deletion of the 9p21 noncoding coronary artery disease risk interval in mice. Nature. 2010;464:409-12. This is an interesting study that analyzes phenotypic consequences of deletion of the 9p21 analogous locus in mice and shows enhanced smooth muscle cell proliferation.
-
(2010)
Nature.
, vol.464
, pp. 409-12
-
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Visel, A.1
Zhu, Y.2
May, D.3
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18
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79951473520
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9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response
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This study provides mechanistic data to explain association of the 9p21 locus with coronary atherosclerosis. The findings are notable for enhanced interferon gamma response of expression of an anti-sense RNACDKN2B-AS1 in the presence of the risk allele. The latter leads to suppression of cell cycle regulator CDKN2B and hence, anticipated increased proliferation of smooth muscle cells
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Harismendy O, Notani D, Song X, et al. 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response. Nature. 2011;470:264-8. This study provides mechanistic data to explain association of the 9p21 locus with coronary atherosclerosis. The findings are notable for enhanced interferon gamma response of expression of an anti-sense RNACDKN2B-AS1 in the presence of the risk allele. The latter leads to suppression of cell cycle regulator CDKN2B and hence, anticipated increased proliferation of smooth muscle cells.
-
(2011)
Nature.
, vol.470
, pp. 264-8
-
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Harismendy, O.1
Notani, D.2
Song, X.3
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19
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77955499945
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From noncoding variant to phenotype via sort1 at the 1p13 cholesterol locus
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This study identifies SORT1, coding for Sortilin 1, as the gene associated with coronary atherosclerosis in the GWAS. The authors perform a series of in vivo and in vitro mechanistic studies and discover that the risk alleles generate a binding site for C/EBP-A and increased expression of Sort1 is associated with lower plasma LDL-C level
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Musunuru K, Strong A, Frank-Kamenetsky M, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 2010;466:714-9. This study identifies SORT1, coding for Sortilin 1, as the gene associated with coronary atherosclerosis in the GWAS. The authors perform a series of in vivo and in vitro mechanistic studies and discover that the risk alleles generate a binding site for C/EBP-A and increased expression of Sort1 is associated with lower plasma LDL-C level.
-
(2010)
Nature.
, vol.466
, pp. 714-719
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Musunuru, K.1
Strong, A.2
Frank-Kamenetsky, M.3
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20
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77956327982
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Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export
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The authors study the mechanism by which Sort1 influences plasma LDL-C level and report that over-expression of Sort1 is associated with increased hepatic release of lipoproteins and plasma LDL level, a finding that seems to be in contrast to the study by Musunuru et al. [19••]
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Kjolby M, Andersen OM, Breiderhoff T, et al. Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab. 2010;12:213-23. The authors study the mechanism by which Sort1 influences plasma LDL-C level and report that over-expression of Sort1 is associated with increased hepatic release of lipoproteins and plasma LDL level, a finding that seems to be in contrast to the study by Musunuru et al. [19••].
-
(2010)
Cell Metab.
, vol.12
, pp. 213-23
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Kjolby, M.1
Andersen, O.M.2
Breiderhoff, T.3
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21
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84855853297
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Molecular genetic studies of complex phenotypes
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Marian AJ. Molecular genetic studies of complex phenotypes. Transl Res. 2012;159:64-79.
-
(2012)
Transl Res
, vol.159
, pp. 64-79
-
-
Marian, A.J.1
-
22
-
-
84859917347
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Elements of missing heritability
-
Marian AJ. Elements of missing heritability. Curr Opin Cardiol. 2012;27.
-
(2012)
Curr Opin Cardiol.
, vol.27
-
-
Marian, A.J.1
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