Lower phosphorylation of p38 MAPK blocks the oxidative stress-induced senescence in myeloid leukemic CD34+CD38- cells

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 32, Issue 3, 2012, Pages 328-333

  Xiao, Yin ^a   Zou, Ping ^a   Wang, Jie ^a   Song, Hui ^a   Zou, Jing ^a   Liu, Lingbo ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cellular senescence; DNA damage; Leukemia stem cells; Myeloid; P38 MAPK; Reactive oxygen species

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CANCER STEM CELL; CELL AGING; ENZYMOLOGY; FEMALE; HUMAN; MALE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL CULTURE;

ANTIGENS, CD34; ANTIGENS, CD38; CELL AGING; FEMALE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; NEOPLASTIC STEM CELLS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 84865583413     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-012-0057-z     Document Type: Article

References (20)

1. Chan WI, Huntly BJ. Leukemia stem cells in acute myeloid leukemia. Semin Oncol, 2008,35(4):326-335
2. Eppert K, Takenaka K, Lechman ER, et al. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med, 2011,17(9):1086-1093
3. Visconti R, Grieco D. New insights on oxidative stress in cancer. Curr Opin Drug Discov Devel, 2009,12(2): 240-245
4. Naka K, Muraguchi T, Hoshii T, et al. Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells. Antioxid Redox Signal, 2008,10(11):1883-1894
5. Wang Y, Schulte BA, LaRue AC, et al. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood, 2006,107(1):358-366 (Pubitemid 43053564)
6. Collado M, Serrano M. Senescence in tumours: Evidence from mice and humans. Nat Rev Cancer, 2010,10(1): 51-57
7. Collado M, Gil J, Efeyan A, et al. Tumour biology: Senescence in premalignant tumours. Nature, 2005,436 (7051):642 (Pubitemid 41117258)
8. Sallmyr A, Fan J, Datta K, et al. Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: Implications for poor prognosis in AML. Blood, 2008,111(6):3173-3182
9. Sattler M, Verma S, Shrikhande G, et al. The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J Biol Chem, 2000, 275(32):24273-24278 (Pubitemid 30626515)
10. Koptyra M, Falinski R, Nowicki MO, et al. BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Blood, 2006,108(1): 319-327 (Pubitemid 43990645)
11. Rassool FV, Gaymes TJ, Omidvar N, et al. Reactive oxygen species, DNA damage, and error-prone repair: A model for genomic instability with progression in myeloid leukemia? Cancer Res, 2007,67(18):8762-8771 (Pubitemid 47437452)
12. Ito K, Hirao A, Arai F, et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med, 2006,12(4):446-451
13. Wang Y, Liu L, Pazhanisamy SK, et al. Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radic Biol Med, 2010,48(2):348-356
14. Wang Y, Kellner J, Liu L, et al. Inhibition of p38 mitogen- activated protein kinase promotes ex vivo hematopoietic stem cell expansion. Stem Cells Dev, 2011,20(7):1143-1152
15. Zou J, Zou P, Lou Y, et al. The cross-talk between ROS and p38MAPKalpha in the ex vivo expanded human umbilical cord blood CD133(+) cells. J Huazhong Univ Sci Technolog Med Sci, 2011,31(5):591-595
16. Dolado I, Swat A, Ajenjo N, et al. p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell, 2007,11(2):191-205 (Pubitemid 46209847)
17. Ambrosino C, Nebreda AR. Cell cycle regulation by p38 MAP kinases. Biol Cell, 2001,93(1-2):47-51 (Pubitemid 33040859)
18. Zhou L, Opalinska J, Verma A. p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure. Cell Cycle, 2007,6(5):534-537 (Pubitemid 46440424)
19. Haq R, Brenton JD, Takahashi M, et al. Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res, 2002,62(17):5076-5082 (Pubitemid 34987550)
20. Bulavin DV, Fornace AJ. p38 MAP kinase's emerging role as a tumor suppressor. Adv Cancer Res, 2004, 92:95-118 (Pubitemid 39458114)