Posttransplant metabolic syndrome in children and adolescents after liver transplantation: A systematic review

Liver Transplantation

Volumn 18, Issue 9, 2012, Pages 1009-1028

  Rothbaum Perito, Emily ^a   Lau, Audrey ^a   Rhee, Sue ^a   Roberts, John P ^a   Rosenthal, Philip ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; AZATHIOPRINE; CALCINEURIN INHIBITOR; CHOLESTEROL; CYCLOSPORIN A; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; PREDNISONE; STEROID; TACROLIMUS; TRIACYLGLYCEROL;

ADOLESCENCE; ADOLESCENT; CARDIOVASCULAR DISEASE; CHILD; CHILDHOOD; DIABETES MELLITUS; DISEASE SEVERITY; DYSLIPIDEMIA; GLUCOSE INTOLERANCE; GRAFT RECIPIENT; HUMAN; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; INSULIN RESISTANCE; LIVER TRANSPLANTATION; METABOLIC SYNDROME X; MORBIDITY; NEPHROTOXICITY; NONALCOHOLIC FATTY LIVER; OBESITY; OUTCOME ASSESSMENT; POSTOPERATIVE COMPLICATION; POSTTRANSPLANT METABOLIC SYNDROME; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SYSTEMATIC REVIEW; UNITED STATES;

ADOLESCENT; AGE FACTORS; CHILD; DYSLIPIDEMIAS; FEMALE; GLUCOSE INTOLERANCE; HUMANS; HYPERTENSION; IMMUNOSUPPRESSIVE AGENTS; LIVER TRANSPLANTATION; MALE; METABOLIC SYNDROME X; OBESITY; PREVALENCE; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS;

EID: 84865583111     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.23478     Document Type: Review

References (86)

1. Dick AA, Perkins JD, Spitzer AL, Lao OB, Healey PJ, Reyes JD,. Impact of obesity on children undergoing liver transplantation. Liver Transpl 2010; 16: 1296-1302.
2. Perito ER, Glidden D, Roberts JP, Rosenthal P,. Overweight and obesity in pediatric liver transplant recipients: prevalence and predictors before and after transplant, United Network for Organ Sharing data, 1987-2010. Pediatr Transplant 2012; 16: 41-49.
3. Anastácio LR, Ferreira LG, de Sena Ribeiro H, Lima AS, Vilela EG, Toulson Davisson Correia MI,. Body composition and overweight of liver transplant recipients. Transplantation 2011; 92: 947-951.
4. Pagadala M, Dasarathy S, Eghtesad B, McCullough AJ,. Posttransplant metabolic syndrome: an epidemic waiting to happen. Liver Transpl 2009; 15: 1662-1670.
5. Everhart JE, Lombardero M, Lake JR, Wiesner RH, Zetterman RK, Hoofnagle JH,. Weight change and obesity after liver transplantation: incidence and risk factors. Liver Transpl Surg 1998; 4: 285-296. (Pubitemid 28323748)
6. Laryea M, Watt KD, Molinari M, Walsh MJ, McAlister VC, Marotta PJ, et al. Metabolic syndrome in liver transplant recipients: prevalence and association with major vascular events. Liver Transpl 2007; 13: 1109-1114. (Pubitemid 47305029)
7. Bianchi G, Marchesini G, Marzocchi R, Pinna AD, Zoli M,. Metabolic syndrome in liver transplantation: relation to etiology and immunosuppression. Liver Transpl 2008; 14: 1648-1654.
8. Anastácio LR, Ferreira LG, Ribeiro Hde S, Liboredo JC, Lima AS, Correia MI,. Metabolic syndrome after liver transplantation: prevalence and predictive factors. Nutrition 2011; 27: 931-937.
9. Laish I, Braun M, Mor E, Sulkes J, Harif Y, Ben Ari Z,. Metabolic syndrome in liver transplant recipients: prevalence, risk factors, and association with cardiovascular events. Liver Transpl 2011; 17: 15-22.
10. Watt KD, Charlton MR,. Metabolic syndrome and liver transplantation: a review and guide to management. J Hepatol 2010; 53: 199-206.
11. Pletcher MJ, Bibbins-Domingo K, Liu K, Sidney S, Lin F, Vittinghoff E, Hulley SB,. Nonoptimal lipids commonly present in young adults and coronary calcium later in life: the CARDIA (Coronary Artery Risk Development in Young Adults) study. Ann Intern Med 2010; 153: 137-146.
12. Pletcher MJ, Bibbins-Domingo K, Lewis CE, Wei GS, Sidney S, Carr JJ, et al. Prehypertension during young adulthood and coronary calcium later in life. Ann Intern Med 2008; 149: 91-99. (Pubitemid 352035334)
13. Morrison JA, Friedman LA, Gray-McGuire C,. Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton Lipid Research Clinics follow-up study. Pediatrics 2007; 120: 340-345. (Pubitemid 47219504)
14. Morrison JA, Glueck CJ, Horn PS, Yeramaneni S, Wang P,. Pediatric triglycerides predict cardiovascular disease events in the fourth to fifth decade of life. Metabolism 2009; 58: 1277-1284.
15. Juonala M, Magnussen CG, Venn A, Dwyer T, Burns TL, Davis PH, et al. Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine Study for the International Childhood Cardiovascular Cohort (i3C) consortium. Circulation 2010; 122: 2514-2520.
16. Morrison JA, Glueck CJ, Wang P,. Childhood risk factors predict cardiovascular disease, impaired fasting glucose plus type 2 diabetes mellitus, and high blood pressure 26 years later at a mean age of 38 years: the Princeton-Lipid Research Clinics follow-up study. Metabolism 2012; 61: 531-541.
17. Franks PW, Hanson RL, Knowler WC, Sievers ML, Bennett PH, Looker HC,. Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med 2010; 362: 485-493.
18. Barlow SE,; for Expert Committee. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007; 120 (suppl 4): S164-S192.
19. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents of the National Heart, Lung, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics 2011; 128 (suppl 5): S213-S256.
20. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-Analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283: 2008-2012. (Pubitemid 30214957)
21. Manchikanti L, Datta S, Smith HS, Hirsch JA,. Evidence-based medicine, systematic reviews, and guidelines in interventional pain management: part 6. Systematic reviews and meta-analyses of observational studies. Pain Physician 2009; 12: 819-850.
22. McDiarmid SV, Busuttil RW, Ascher NL, Burdick J, D'Alessandro AM, Esquivel C, et al. FK506 (tacrolimus) compared with cyclosporine for primary immunosuppression after pediatric liver transplantation. Results from the U.S. multicenter trial. Transplantation 1995; 59: 530-536.
23. Ng VL, Fecteau A, Shepherd R, Magee J, Bucuvalas J, Alonso E, et al. Outcomes of 5-year survivors of pediatric liver transplantation: report on 461 children from a North American multicenter registry. Pediatrics 2008; 122: e1128-e1135.
24. Hathout E, Alonso E, Anand R, Martz K, Imseis E, Johnston J, et al.; for SPLIT Study Group. Post-transplant diabetes mellitus in pediatric liver transplantation. Pediatr Transplant 2009; 13: 599-605.
25. Ng VL, Alonso EM, Bucuvalas JC, Cohen G, Limbers CA, Varni JW, et al.; for Studies of Pediatric Liver Transplantation (SPLIT) Research Group. Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the Studies of Pediatric Liver Transplantation experience. J Pediatr 2012; 160: 820-826.e3.
26. Sundaram SS, Alonso EM, Zeitler P, Yin W, Anand R,; for SPLIT Research Group. Obesity after pediatric liver transplant: prevalence and risk factors. Am J Transplant 2011; 11: 95.
27. McLin VA, Anand R, Daniels SR, Yin W, Alonso EM,; for SPLIT Research Group. Blood pressure elevation in long-term survivors of pediatric liver transplantation. Am J Transplant 2012; 12: 183-190.
28. Holt RI, Broide E, Buchanan CR, Miell JP, Baker AJ, Mowat AP, Mieli-Vergani G,. Orthotopic liver transplantation reverses the adverse nutritional changes of end-stage liver disease in children. Am J Clin Nutr 1997; 65: 534-542. (Pubitemid 27130764)
29. McDiarmid SV, Gornbein JA, DeSilva PJ, Goss JA, Vargas JH, Martín MG, et al. Factors affecting growth after pediatric liver transplantation. Transplantation 1999; 67: 404-411. (Pubitemid 29094011)
30. Saito T, Mizuta K, Hishikawa S, Kawano Y, Sanada Y, Fujiwara T, et al. Growth curves of pediatric patients with biliary atresia following living donor liver transplantation: factors that influence post-transplantation growth. Pediatr Transplant 2007; 11: 764-770. (Pubitemid 47512319)
31. Alonso EM, Shepherd R, Martz KL, Yin W, Anand R,; for SPLIT Research Group. Linear growth patterns in prepubertal children following liver transplantation. Am J Transplant 2009; 9: 1389-1397.
32. Ogden CL, Carroll MD, Kit BK, Flegal KM,. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA 2012; 307: 483-490.
33. Harambat J, Dubourg L, Ranchin B, Hadj-Aïssa A, Fargue S, Rivet C, et al. Hyperuricemia after liver transplantation in children. Pediatr Transplant 2008; 12: 847-853.
34. Hasenbein W, Albani J, Englert C, Spehr A, Grabhorn E, Kemper MJ, et al. Long-term evaluation of cyclosporine and tacrolimus based immunosuppression in pediatric liver transplantation. Pediatr Transplant 2006; 10: 938-942. (Pubitemid 44683640)
35. Campbell K, Bucuvalas J, Anand R, Zeng L,; for SPLIT Research Group. Renal function in pediatric liver transplant survivors-a report from the SPLIT database. Am J Transplant 2004; 4: 419.
36. Herzog D, Martin S, Turpin S, Alvarez F,. Normal glomerular filtration rate in long-term follow-up of children after orthotopic liver transplantation. Transplantation 2006; 81: 672-677.
37. Kaliciński P, Szymczak M, Smirska E, Pawłowska J, Teisseyre M, Kamiński A, et al. Longitudinal study of renal function in pediatric liver transplant recipients. Ann Transplant 2005; 10: 53-58.
38. McCulloch MI, Burger H, Spearman CW, Cooke L, Goddard E, Gajjar P, et al. Nephrotoxic effects of immunosuppressant therapy in pediatric liver transplant recipients. Transplant Proc 2005; 37: 1220-1223. (Pubitemid 40590842)
39. McLin VA, Girardin E, Lecoultre C, Mentha G, Belli DC,. Glomerular and tubular function following orthotopic liver transplantation in children. Pediatr Transplant 2005; 9: 512-519. (Pubitemid 41153273)
40. Del Compare ME, D'Agostino D, Ferraris JR, Boldrini G, Waisman G, Krmar RT,. Twenty-four-hour ambulatory blood pressure profiles in liver transplant recipients. Pediatr Transplant 2004; 8: 496-501. (Pubitemid 39279021)
41. Avitzur Y, De Luca E, Cantos M, Jimenez-Rivera C, Jones N, Fecteau A, et al. Health status ten years after pediatric liver transplantation-looking beyond the graft. Transplantation 2004; 78: 566-573. (Pubitemid 39097103)
42. Berg UB, Ericzon BG, Nemeth A,. Renal function before and long after liver transplantation in children. Transplantation 2001; 72: 631-637. (Pubitemid 32802744)
43. Bartosh SM, Alonso EM, Whitington PF,. Renal outcomes in pediatric liver transplantation. Clin Transplant 1997; 11 (pt 1): 354-360. (Pubitemid 27460427)
44. Jain A, Mazariegos G, Kashyap R, Green M, Gronsky C, Starzl TE, et al. Comparative long-term evaluation of tacrolimus and cyclosporine in pediatric liver transplantation. Transplantation 2000; 70: 617-625. (Pubitemid 30662068)
45. Reyes J, Jain A, Mazariegos G, Kashyap R, Green M, Iurlano K, Fung J,. Long-term results after conversion from cyclosporine to tacrolimus in pediatric liver transplantation for acute and chronic rejection. Transplantation 2000; 69: 2573-2580. (Pubitemid 30482024)
46. Hansen ML, Gunn PW, Kaelber DC,. Underdiagnosis of hypertension in children and adolescents. JAMA 2007; 298: 874-879. (Pubitemid 47311293)
47. McNiece KL, Poffenbarger TS, Turner JL, Franco KD, Sorof JM, Portman RJ,. Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr 2007; 150: 640-644.e1.
48. Sorof JM, Lai D, Turner J, Poffenbarger T, Portman RJ,. Overweight, ethnicity, and the prevalence of hypertension in school-aged children. Pediatrics 2004; 113 (pt 1): 475-482. (Pubitemid 38280786)
49. Seifeldin R, Marcos-Alvarez A, Lewis WD, Gordon FD, Jenkins RL,. Effect of nifedipine on renal function in liver transplant recipients receiving tacrolimus. Clin Ther 1996; 18: 491-496. (Pubitemid 26248909)
50. Chan C, Maurer J, Cardella C, Cattran D, Pei Y,. A randomized controlled trial of verapamil on cyclosporine nephrotoxicity in heart and lung transplant recipients. Transplantation 1997; 63: 1435-1440. (Pubitemid 27237448)
51. McDiarmid SV, Gornbein JA, Fortunat M, Saikali D, Vargas JH, Busuttil RW, Ament ME,. Serum lipid abnormalities in pediatric liver transplant patients. Transplantation 1992; 53: 109-115.
52. Siirtola A, Antikainen M, Ala-Houhala M, Koivisto AM, Solakivi T, Virtanen SM, et al. Insulin resistance, LDL particle size, and LDL susceptibility to oxidation in pediatric kidney and liver recipients. Kidney Int 2005; 67: 2046-2055. (Pubitemid 40577744)
53. Siirtola A, Solakivi T, Jokela H, Ala-Houhala M, Antikainen M, Holmberg C, et al. Hypertriglyceridemia and low serum HDL cholesterol are common in children after liver transplantation. Transplant Proc 2001; 33: 2449. (Pubitemid 32830179)
54. Becker J, Huber WD, Aufricht C,. Short- and long-time effects of pediatric liver transplantation on serum cholesterol and triglyceride levels-the Vienna cohort. Pediatr Transplant 2008; 12: 883-888.
55. Siirtola A, Antikainen M, Ala-Houhala M, Koivisto AM, Solakivi T, Jokela H, et al. Serum lipids in children 3 to 5 years after kidney, liver, and heart transplantation. Transpl Int 2004; 17: 109-119. (Pubitemid 38660686)
56. Law YM, Yim R, Agatisa P, Boyle GJ, Miller SA, Lawrence K, Webber SA,. Lipid profiles in pediatric thoracic transplant recipients are determined by their immunosuppressive regimens. J Heart Lung Transplant 2006; 25: 276-282. (Pubitemid 43290656)
57. Filler G, Webb NJ, Milford DV, Watson AR, Gellermann J, Tyden G, et al. Four-year data after pediatric renal transplantation: a randomized trial of tacrolimus vs. cyclosporin microemulsion. Pediatr Transplant 2005; 9: 498-503. (Pubitemid 41153271)
58. Taylor DO, Barr ML, Radovancevic B, Renlund DG, Mentzer RM Jr, Smart FW, et al. A randomized, multicenter comparison of tacrolimus and cyclosporine immunosuppressive regimens in cardiac transplantation: decreased hyperlipidemia and hypertension with tacrolimus. J Heart Lung Transplant 1999; 18: 336-345. (Pubitemid 29205269)
59. Centers for Disease Control and Prevention (CDC). Prevalence of abnormal lipid levels among youths-United States, 1999-2006. MMWR Morb Mortal Wkly Rep 2010; 59: 29-33.
60. Lamb MM, Ogden CL, Carroll MD, Lacher DA, Flegal KM,. Association of body fat percentage with lipid concentrations in children and adolescents: United States, 1999-2004. Am J Clin Nutr 2011; 94: 877-883.
61. Kuo HT, Poommipanit N, Sampaio M, Reddy P, Cho YW, Bunnapradist S,. Risk factors for development of new-onset diabetes mellitus in pediatric renal transplant recipients: an analysis of the OPTN/UNOS database. Transplantation 2010; 89: 434-439.
62. Högler W, Baumann U, Kelly D,. Growth and bone health in chronic liver disease and following liver transplantation in children. Pediatr Endocrinol Rev 2010; 7: 266-274.
63. Kerkar N, Akler G, Annunziato R, Miloh T, Arnon R, Rapaport R, et al. Diabetes in pediatric liver transplant recipients: endocrine perspective. Am J Transplant 2011; 11: 497.
64. Yazigi N, Ryckman F, Alonso M, Tiao G, Balistreri W, Bucuvalas J,. Glucose intolerance in long-term pediatric liver transplant survivors. Am J Transplant 2004; 4: 385.
65. Romero R, Melde K, Pillen T, Smallwood GA, Heffron T,. Persistent hyperglycemia in pediatric liver transplant recipients. Transplant Proc 2001; 33: 3617-3618. (Pubitemid 34044152)
66. Gökçe S, Durmaz O, Celtik C, AydoÄan A, Baş F, TürkoÄlu U, et al. Investigation of impaired carbohydrate metabolism in pediatric liver transplant recipients. Pediatr Transplant 2009; 13: 873-880.
67. Williams DE, Cadwell BL, Cheng YJ, Cowie CC, Gregg EW, Geiss LS, et al. Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents, 1999-2000. Pediatrics 2005; 116: 1122-1126. (Pubitemid 46056417)
68. Duncan GE,. Prevalence of diabetes and impaired fasting glucose levels among US adolescents: National Health and Nutrition Examination Survey, 1999-2002. Arch Pediatr Adolesc Med 2006; 160: 523-528.
69. Jonas MM, Krawczuk LE, Kim HB, Lillehei C, Perez-Atayde A,. Rapid recurrence of nonalcoholic fatty liver disease after transplantation in a child with hypopituitarism and hepatopulmonary syndrome. Liver Transpl 2005; 11: 108-110. (Pubitemid 40136476)
70. Jankowska I, Socha P, Pawlowska J, Teisseyre M, Gliwicz D, Czubkowski P, et al. Recurrence of non-alcoholic steatohepatitis after liver transplantation in a 13-yr-old boy. Pediatr Transplant 2007; 11: 796-798. (Pubitemid 47512324)
71. Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, Angulo P,. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 2009; 58: 1538-1544.
72. Lykavieris P, van Mil S, Cresteil D, Fabre M, Hadchouel M, Klomp L, et al. Progressive familial intrahepatic cholestasis type 1 and extrahepatic features: no catch-up of stature growth, exacerbation of diarrhea, and appearance of liver steatosis after liver transplantation. J Hepatol 2003; 39: 447-452. (Pubitemid 37070265)
73. Tümgör G, Ankan C, Nart D, Kihiç M, AydoÄdu S,. Fatty liver due to high levels of serum tacrolimus after liver transplantation. Turk J Pediatr 2007; 49: 223-225. (Pubitemid 47299811)
74. Hori T, Egawa H, Takada Y, Ueda M, Oike F, Ogura Y, et al. Progressive familial intrahepatic cholestasis: a single-center experience of living-donor liver transplantation during two decades in Japan. Clin Transplant 2011; 25: 776-785.
75. Miyagawa-Hayashino A, Egawa H, Yorifuji T, Hasegawa M, Haga H, Tsuruyama T, et al. Allograft steatohepatitis in progressive familial intrahepatic cholestasis type 1 after living donor liver transplantation. Liver Transpl 2009; 15: 610-618.
76. Nicastro E, Stephenne X, Smets F, Fusaro F, de Magnée C, Reding R, Sokal EM,. Recovery of graft steatosis and protein-losing enteropathy after biliary diversion in a PFIC 1 liver transplanted child. Pediatr Transplant; doi:10.1111/j.1399-3046.2011.01514.x.
77. Zahmatkeshan M, Geramizadeh B, Eshraghian A, Nikeghbalian S, Bahador A, Salahi H, Malek-Hosseini SA,. De novo fatty liver due to vascular complications after liver transplantation. Transplant Proc 2011; 43: 615-617.
78. Ramirez-Cortes G, Fuentes-Velasco Y, García-Roca P, Guadarrama O, Lõpez M, Valverde-Rosas S, et al. Prevalence of metabolic syndrome and obesity in renal transplanted Mexican children. Pediatr Transplant 2009; 13: 579-584.
79. Maduram A, John E, Hidalgo G, Bottke R, Fornell L, Oberholzer J, Benedetti E,. Metabolic syndrome in pediatric renal transplant recipients: comparing early discontinuation of steroids vs. steroid group. Pediatr Transplant 2010; 14: 351-357.
80. Dumortier J, Giostra E, Belbouab S, Morard I, Guillaud O, Spahr L, et al. Non-alcoholic fatty liver disease in liver transplant recipients: another story of "seed and soil". Am J Gastroenterol 2010; 105: 613-620.
81. Steinberger J, Daniels SR, Eckel RH, Hayman L, Lustig RH, McCrindle B, Mietus-Snyder ML,; for American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young, Council on Cardiovascular Nursing, and Council on Nutrition, Physical Activity, and Metabolism. Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation 2009; 119: 628-647.
82. Satapathy SK, Charlton MR,. Posttransplant metabolic syndrome: new evidence of an epidemic and recommendations for management. Liver Transpl 2011; 17: 1-6.
83. Cook S, Auinger P, Huang TT,. Growth curves for cardio-metabolic risk factors in children and adolescents. J Pediatr 2009; 155: S6.e15-S6.e26.
84. Nobili V, Dhawan A,. Are children after liver transplant more prone to non-alcoholic fatty liver disease? Pediatr Transplant 2008; 12: 611-613.
85. Codoñer-Franch P, Valls-Bellés V, Arilla-Codoñer A, Alonso-Iglesias E,. Oxidant mechanisms in childhood obesity: the link between inflammation and oxidative stress. Transl Res 2011; 158: 369-384.
86. Shoelson SE, Herrero L, Naaz A,. Obesity, inflammation, and insulin resistance. Gastroenterology 2007; 132: 2169-2180. (Pubitemid 46693756)