Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 35, 2012, Pages 14182-14187

  Lai, Bo Shiun ^a   Witola, William H ^a,b   El Bissati, Kamal ^a   Zhou, Ying ^a   Mui, Ernest ^a   Fomovska, Alina ^a   McLeod, Rima ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b TUSKEGEE UNIVERSITY   (United States)

Author keywords

Apicomplexan; Protein translation; Protozoan; Toxoplasmosis

Indexed keywords

DIHYDROFOLATE REDUCTASE; ENOYL ACP REDUCTASE; FATTY ACID; FOLIC ACID; MORPHOLINO OLIGONUCLEOTIDE; OXIDOREDUCTASE; PEPTIDE DERIVATIVE; PLANT LIKE APETELA 2 PROTEIN; PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR XI 3; UNCLASSIFIED DRUG;

ANTISENSE THERAPY; ARTICLE; CELL DIVISION; DRUG DELIVERY SYSTEM; FATTY ACID SYNTHESIS; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; PARASITE CONTROL; PARASITE DEVELOPMENT; PARASITE LOAD; PARASITE REPLICATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; TACHYZOITE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; APICOMPLEXA; BACTERIAL PROTEINS; CELLS, CULTURED; FEMALE; FIBROBLASTS; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; HUMANS; LUCIFERASES; LUMINESCENT PROTEINS; MICE; MICE, INBRED C57BL; MORPHOLINOS; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA; TOXOPLASMOSIS;

MAMMALIA; MUS; PROTOZOA; TOXOPLASMA GONDII;

EID: 84865573083     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1208775109     Document Type: Article

References (9)

1. Moulton HM, Nelson MH, Hatlevig SA, Reddy MT, Iversen PL (2004) Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides. Bioconjug Chem 15:290-299. (Pubitemid 38365188)
2. Samuel BU, et al. (2003) Delivery of antimicrobials into parasites. Proc Natl Acad Sci USA 100:14281-14286. (Pubitemid 37499228)
3. Kumar P, et al. (2007) Transvascular delivery of small interfering RNA to the central nervous system. Nature 448:39-43. (Pubitemid 47037001)
4. Svasti S, et al. (2009) RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice. Proc Natl Acad Sci USA 106:1205-1210.
5. Behnke MS, et al. (2010) Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii. PLoS ONE 5:e12354.
6. De Silva EK, et al. (2008) Specific DNA-binding by apicomplexan AP2 transcription factors. Proc Natl Acad Sci USA 105:8393-8398. (Pubitemid 351904766)
7. Augagneur Y, Wesolowski D, Tae HS, Altman S, Ben Mamoun C (2012) Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum. Proc Natl Acad Sci USA 109:6235-6240.
8. Moulton HM (2012) Cell-penetrating peptides enhance systemic delivery of antisense morpholino oligomers. Methods Mol Biol 867:407-414.
9. Fomovska A, et al. (2012) Novel N -benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway. Antimicrob Agents Chemother 56:2666-2682.