-
1
-
-
33846289198
-
Excess of rare cancers in Werner syndrome (adult progeria)
-
Goto, M. et al. (1996) Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiol. Biomarkers Prev., 5, 239-46.
-
(1996)
Cancer Epidemiol. Biomarkers Prev.
, vol.5
, pp. 239-46
-
-
Goto, M.1
-
2
-
-
0020028472
-
Werner's syndrome with associated malignant neoplasms
-
Hrabko, R.P. et al. (1982) Werner's syndrome with associated malignant neoplasms. Arch. Dermatol., 118, 106-8.
-
(1982)
Arch. Dermatol.
, vol.118
, pp. 106-8
-
-
Hrabko, R.P.1
-
3
-
-
0034626770
-
Lessons from human progeroid syndromes
-
Martin, G.M. et al. (2000) Lessons from human progeroid syndromes. Nature, 408, 263-6.
-
(2000)
Nature
, vol.408
, pp. 263-6
-
-
Martin, G.M.1
-
4
-
-
0033771208
-
The Werner syndrome protein: an update
-
Oshima, J. (2000) The Werner syndrome protein: an update. Bioessays, 22, 894-901.
-
(2000)
Bioessays
, vol.22
, pp. 894-901
-
-
Oshima, J.1
-
5
-
-
0021778354
-
In vitro studies of Werner syndrome cells: aberrant growth and chromosome behavior
-
Salk, D. (1985) In vitro studies of Werner syndrome cells: aberrant growth and chromosome behavior. Basic Life Sci., 35, 419-26.
-
(1985)
Basic Life Sci.
, vol.35
, pp. 419-26
-
-
Salk, D.1
-
6
-
-
0024465870
-
Mutator phenotype of Werner syndrome is characterized by extensive deletions
-
Fukuchi, K. et al. (1989) Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl. Acad. Sci. U.S.A., 86, 5893-7.
-
(1989)
Proc. Natl. Acad. Sci. U.S.A.
, vol.86
, pp. 5893-7
-
-
Fukuchi, K.1
-
7
-
-
0023712434
-
Spontaneous and induced chromosomal instability in Werner syndrome
-
Gebhart, E. et al. (1988) Spontaneous and induced chromosomal instability in Werner syndrome. Hum. Genet., 80, 135-9.
-
(1988)
Hum. Genet.
, vol.80
, pp. 135-9
-
-
Gebhart, E.1
-
8
-
-
0034194139
-
Genetic instability and hematologic disease risk in Werner syndrome patients and heterozygotes
-
Moser, M.J. et al. (2000) Genetic instability and hematologic disease risk in Werner syndrome patients and heterozygotes. Cancer Res., 60, 2492-6.
-
(2000)
Cancer Res.
, vol.60
, pp. 2492-6
-
-
Moser, M.J.1
-
9
-
-
0034578446
-
DNA helicases, genomic instability, and human genetic disease
-
van Brabant, A.J. et al. (2000) DNA helicases, genomic instability, and human genetic disease. Annu. Rev. Genomics Hum. Genet., 1, 409-59.
-
(2000)
Annu. Rev. Genomics Hum. Genet.
, vol.1
, pp. 409-59
-
-
van Brabant, A.J.1
-
10
-
-
0032573157
-
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
-
Lebel, M. et al. (1998) A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc. Natl. Acad. Sci. U.S.A., 95, 13097-102.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 13097-102
-
-
Lebel, M.1
-
11
-
-
0034736294
-
Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage
-
Pichierri, P. et al. (2000) Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage. Mutat. Res., 456, 45-57.
-
(2000)
Mutat. Res.
, vol.456
, pp. 45-57
-
-
Pichierri, P.1
-
12
-
-
0035169035
-
Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle
-
Pichierri, P. et al. (2001) Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle. Mol. Biol. Cell, 12, 2412-21.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 2412-21
-
-
Pichierri, P.1
-
13
-
-
38749136967
-
Werner syndrome helicase activity is essential in maintaining fragile site stability
-
Pirzio, L.M. et al. (2008) Werner syndrome helicase activity is essential in maintaining fragile site stability. J. Cell Biol., 180, 305-14.
-
(2008)
J. Cell Biol.
, vol.180
, pp. 305-14
-
-
Pirzio, L.M.1
-
14
-
-
0035349905
-
Werner syndrome cells are sensitive to DNA cross-linking drugs
-
Poot, M. et al. (2001) Werner syndrome cells are sensitive to DNA cross-linking drugs. FASEB J., 15, 1224-6.
-
(2001)
FASEB J.
, vol.15
, pp. 1224-6
-
-
Poot, M.1
-
15
-
-
0142043288
-
RecQ helicases: multiple roles in genome maintenance
-
Khakhar, R.R. et al. (2003) RecQ helicases: multiple roles in genome maintenance. Trends Cell Biol., 13, 493-501.
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 493-501
-
-
Khakhar, R.R.1
-
16
-
-
0036787870
-
Homologous recombination resolution defect in werner syndrome
-
Saintigny, Y. et al. (2002) Homologous recombination resolution defect in werner syndrome. Mol. Cell. Biol., 22, 6971-8.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 6971-8
-
-
Saintigny, Y.1
-
17
-
-
77956881105
-
ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery
-
Ammazzalorso, F. et al. (2010) ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery. EMBO J., 29, 3156-69.
-
(2010)
EMBO J.
, vol.29
, pp. 3156-69
-
-
Ammazzalorso, F.1
-
18
-
-
2942637828
-
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
-
Opresko, P.L. et al. (2004) The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol. Cell, 14, 763-74.
-
(2004)
Mol. Cell
, vol.14
, pp. 763-74
-
-
Opresko, P.L.1
-
19
-
-
0034283889
-
Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA
-
Shen, J.C. et al. (2000) Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. Nucleic Acids Res., 28, 3260-8.
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 3260-8
-
-
Shen, J.C.1
-
20
-
-
0141740425
-
WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair
-
Chen, L. et al. (2003) WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell, 2, 191-9.
-
(2003)
Aging Cell
, vol.2
, pp. 191-9
-
-
Chen, L.1
-
21
-
-
62849091779
-
The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation
-
Opresko, P.L. et al. (2009) The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation. PLoS ONE, 4, e4825.
-
(2009)
PLoS ONE
, vol.4
-
-
Opresko, P.L.1
-
22
-
-
1842685207
-
The Werner syndrome protein has separable recombination and survival functions
-
Swanson, C. et al. (2004) The Werner syndrome protein has separable recombination and survival functions. DNA Repair (Amst.), 3, 475-82.
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 475-82
-
-
Swanson, C.1
-
23
-
-
0041324850
-
Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein
-
Bai, Y. et al. (2003) Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein. Hum. Genet., 113, 337-47.
-
(2003)
Hum. Genet.
, vol.113
, pp. 337-47
-
-
Bai, Y.1
-
24
-
-
2442660468
-
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1
-
Cheng, W.H. et al. (2004) Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J. Biol. Chem., 279, 21169-76.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 21169-76
-
-
Cheng, W.H.1
-
25
-
-
55949108120
-
Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway
-
Franchitto, A. et al. (2008) Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway. J. Cell Biol., 183, 241-52.
-
(2008)
J. Cell Biol.
, vol.183
, pp. 241-52
-
-
Franchitto, A.1
-
26
-
-
84873412967
-
The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation
-
Mar 12. doi: 10.1038/onc.2012.80. [Epub ahead of print]
-
Murfuni, I., et al. (2012) The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation. Oncogene, Mar 12. doi: 10.1038/onc.2012.80. [Epub ahead of print]
-
(2012)
Oncogene
-
-
Murfuni, I.1
-
27
-
-
0034462093
-
Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1
-
Boddy, M.N. et al. (2000) Damage tolerance protein Mus81 associates with the FHA1domain of checkpoint kinase Cds1. Mol. Cell. Biol., 20, 8758-66.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 8758-66
-
-
Boddy, M.N.1
-
28
-
-
0035886690
-
Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease
-
Kaliraman, V. et al. (2001) Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev., 15, 2730-40.
-
(2001)
Genes Dev.
, vol.15
, pp. 2730-40
-
-
Kaliraman, V.1
-
29
-
-
0035148955
-
Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae
-
Mullen, J.R. et al. (2001) Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics, 157, 103-18.
-
(2001)
Genetics
, vol.157
, pp. 103-18
-
-
Mullen, J.R.1
-
30
-
-
77954025436
-
WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations
-
Friedrich, K. et al. (2010) WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations. Hum. Genet., 128, 103-11.
-
(2010)
Hum. Genet.
, vol.128
, pp. 103-11
-
-
Friedrich, K.1
-
31
-
-
0025988295
-
DNA double-strand breaks measured in individual cells subjected to gel electrophoresis
-
Olive, P.L. et al. (1991) DNA double-strand breaks measured in individual cells subjected to gel electrophoresis. Cancer Res., 51, 4671-76.
-
(1991)
Cancer Res.
, vol.51
, pp. 4671-76
-
-
Olive, P.L.1
-
32
-
-
0037168658
-
Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication
-
Fabre, F. et al. (2002) Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication. Proc. Natl. Acad. Sci. U.S.A., 99, 16887-92.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 16887-92
-
-
Fabre, F.1
-
33
-
-
84861964325
-
The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling
-
Oct 17. doi: 10.1038/onc.2011.468. [Epub ahead of print]
-
Pichierri, P., et al. (2011) The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling. Oncogene, Oct 17. doi: 10.1038/onc.2011.468. [Epub ahead of print]
-
(2011)
Oncogene
-
-
Pichierri, P.1
-
34
-
-
0034231844
-
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest
-
Constantinou, A. et al. (2000) Werner's syndrome protein (WRN) migrates Holliday junctionsand co-localizes with RPA upon replication arrest. EMBO Rep., 1, 80-4.
-
(2000)
EMBO Rep.
, vol.1
, pp. 80-4
-
-
Constantinou, A.1
-
35
-
-
78549251695
-
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis
-
Hashimoto, Y. et al. (2010) Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat. Struct. Mol. Biol., 17, 1305-311.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1305-311
-
-
Hashimoto, Y.1
-
36
-
-
0141480945
-
WRN interacts physically and functionally with the recombination mediator protein RAD52
-
Baynton, K. et al. (2003) WRN interacts physically and functionally with the recombination mediator protein RAD52. J. Biol. Chem., 278, 36476-86.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 36476-86
-
-
Baynton, K.1
-
37
-
-
0345824623
-
Asymmetry of DNA replication fork progression in Werner's syndrome
-
Rodríguez-López, A.M. et al. (2002) Asymmetry of DNA replication fork progression in Werner's syndrome. Aging Cell, 1, 30-9.
-
(2002)
Aging Cell
, vol.1
, pp. 30-9
-
-
Rodríguez-López, A.M.1
-
38
-
-
0035009356
-
Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51
-
Sakamoto, S. et al. (2001) Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51. Genes Cells, 6, 421-30.
-
(2001)
Genes Cells
, vol.6
, pp. 421-30
-
-
Sakamoto, S.1
-
39
-
-
42049116919
-
The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest
-
Sidorova, J.M. et al. (2008) The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest. Cell Cycle, 7, 796-807.
-
(2008)
Cell Cycle
, vol.7
, pp. 796-807
-
-
Sidorova, J.M.1
-
40
-
-
0030218834
-
A YAC, P1, and cosmid contig and 17 new polymorphic markers for the Werner syndrome region at 8p12-p21
-
Yu, C.E. et al. (1996) A YAC, P1, and cosmid contig and 17 new polymorphic markers for the Werner syndrome region at 8p12-p21. Genomics, 35, 431-40.
-
(1996)
Genomics
, vol.35
, pp. 431-40
-
-
Yu, C.E.1
-
41
-
-
79952779558
-
Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage
-
Machwe, A. et al. (2011) Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage. J. Biol. Chem., 286, 3497-508.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 3497-508
-
-
Machwe, A.1
-
42
-
-
34848880201
-
Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity
-
Machwe, A. et al. (2007) Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity. Nucleic Acids Res., 35, 5729-47.
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 5729-47
-
-
Machwe, A.1
-
43
-
-
0035976963
-
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein
-
Opresko, P.L. et al. (2001) Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein. J. Biol. Chem., 276, 44677-87.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 44677-87
-
-
Opresko, P.L.1
-
44
-
-
0037137177
-
The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro
-
Orren, D.K. et al. (2002) The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro. Biochemistry, 41, 13483-8.
-
(2002)
Biochemistry
, vol.41
, pp. 13483-8
-
-
Orren, D.K.1
-
45
-
-
34249942213
-
Exploring the roles of Mus81-Eme1/Mms4 at perturbed replication forks
-
Osman, F. et al. (2007) Exploring the roles of Mus81-Eme1/Mms4 at perturbed replication forks. DNA Repair (Amst.), 6, 1004-17.
-
(2007)
DNA Repair (Amst.)
, vol.6
, pp. 1004-17
-
-
Osman, F.1
-
46
-
-
77953590923
-
Delineation of WRN helicase function with EXO1 in the replicational stress response
-
Aggarwal, M. et al. (2010) Delineation of WRN helicase function with EXO1 in the replicational stress response. DNA Repair (Amst.), 9, 765-76.
-
(2010)
DNA Repair (Amst.)
, vol.9
, pp. 765-76
-
-
Aggarwal, M.1
-
47
-
-
39449123590
-
Cleavage of stalled forks by fission yeast Mus81/ Eme1 in absence of DNA replication checkpoint
-
Froget, B. et al. (2008) Cleavage of stalled forks by fission yeast Mus81/ Eme1 in absence of DNA replication checkpoint. Mol. Biol. Cell, 19, 445-56.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 445-56
-
-
Froget, B.1
-
48
-
-
79953239469
-
Aberrant chromosome morphology in human cells defective for Holliday junction resolution
-
Wechsler, T. et al. (2011) Aberrant chromosome morphology in human cells defective for Holliday junction resolution. Nature, 471, 642-6.
-
(2011)
Nature
, vol.471
, pp. 642-6
-
-
Wechsler, T.1
-
49
-
-
38049162608
-
Chromosome fragile sites
-
Durkin, S.G. et al. (2007) Chromosome fragile sites. Annu. Rev. Genet., 41, 169-92.
-
(2007)
Annu. Rev. Genet.
, vol.41
, pp. 169-92
-
-
Durkin, S.G.1
-
50
-
-
0021278143
-
DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes
-
Glover, T.W. et al. (1984) DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum. Genet., 67, 136-42.
-
(1984)
Hum. Genet.
, vol.67
, pp. 136-42
-
-
Glover, T.W.1
-
51
-
-
0035844242
-
Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence
-
Kamath-Loeb, A.S. et al. (2001) Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence. J. Biol. Chem., 276, 16439-46.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 16439-46
-
-
Kamath-Loeb, A.S.1
-
52
-
-
30144439370
-
Common fragile sites
-
Glover, T.W. (2006) Common fragile sites. Cancer Lett., 232, 4-12.
-
(2006)
Cancer Lett.
, vol.232
, pp. 4-12
-
-
Glover, T.W.1
|