Serum dioxin-like activity is associated with reproductive parameters in young men from the general flemish population

Environmental Health Perspectives

Volumn 114, Issue 11, 2006, Pages 1670-1676

  Dhooge, Willem ^a   Van Larebeke, Nicolas ^a   Koppen, Gudrun ^b   Nelen, Vera ^c   Schoeters, Greet ^b   Vlietinck, Robert ^d   Kaufman, Jean Marc ^a   Comhaire, Frank ^a   Buntinx, F ^d   Callens, S ^d   Den Hond, E ^d   Fagard, R ^d   Nawrot, T ^d   Thijs, L ^d   Staessen, J A ^d   Vanderschueren, D ^d   Van Hecke, E ^d   Van Loon, H ^d   Viaene, M K ^d   De Ceuster, T ^b   Goelen, E ^b   Van Den Heuvel, R ^b   Verheyen, G ^b   Verschaeve, L ^b   Loots, I ^e   Herremans, M ^e   Mertens, P ^e   Vermeire, P ^e   Weyler, J ^e   Roels, H A ^f   more..

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

^c Provincial Institute of Hygiene   (Belgium)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSITY OF ANTWERP   (Belgium)

^f UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Dioxin; DR CALUX; Egg consumption; Hormones; Male fertility; Semen volume; Sperm concentration; TCDD; Testosterone

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON; LUCIFERASE; POLYCHLORINATED BIPHENYL; TESTOSTERONE;

ADULT; ANIMAL CELL; ARTICLE; BELGIUM; EJACULATION; ENZYME ACTIVITY; FOOD CONTAMINATION; HORMONE DETERMINATION; HORMONE RELEASE; HUMAN; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; MEN'S HEALTH; NONHUMAN; NUTRITIONAL ASSESSMENT; POLLUTANT; PRIORITY JOURNAL; RAT; REPORTER GENE; REPRODUCTIVE TOXICITY; SEMEN ANALYSIS; SEMINAL VESICLE; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON DENSITY;

ADULT; ANIMALS; BELGIUM; BIOLOGICAL MARKERS; CELL LINE, TUMOR; DIET; DIOXINS; ENVIRONMENTAL POLLUTANTS; ESTRADIOL; FOLLICLE STIMULATING HORMONE; HUMANS; INHIBINS; LUTEINIZING HORMONE; MALE; RATS; RECEPTORS, ARYL HYDROCARBON; SEX HORMONE-BINDING GLOBULIN; SPERM COUNT; TESTOSTERONE;

ANIMALIA;

EID: 33750874054     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.9224     Document Type: Article

References (63)

1. ATSDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs). Atlanta, GA:Agency for Toxic Substances and Disease Registry.
2. Andersson AM, Jørgensen N, Frydelund-Larsen L, Rajpert-DeMeyts E, Skakkebaek NE. 2004. Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controls. J Clin Endocrinol Metab 89:3161-3167.
3. Andersson AM, Müller J, Skakkebaek NE. 1998. Different roles of prepubertal and postpubertal germ cells and Sertoli cells in the regulation of serum inhibin B levels. J Clin Endocrinol Metab 83:4451-4458.
4. Aümuller G, Riva A. 1992. Morphology and functions of the human seminal vesicle. Andrologia 24:183-196.
5. Aümuller G, Seitz J. 1990. Protein secretion and secretory processes in male accessory sex glands. Int Rev Cytol 121:127-231.
6. Aylward LL, Brunet RC, Carrier G, Hays SM, Cushing CA, Needham LL, et al. 2005. Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort. J Expo Anal Environ Epidemiol 15:51-65.
7. Bergman A, Klasson-Wehler E, Kuroki H. 1994. Selective retention of hydroxylated PCB metabolites in blood. Environ Health Perspect 102:464-469.
8. Bernard A, Hermans C, Broeckaert F, De Poorter G, De Cock A, Houins G. 1999. Food contamination by PCBs and dioxins. Nature 401:231-232.
9. Birnbaum LS, Tuomisto J. 2000. Non-carcinogenic effects of TCDD in animals. Food Addit Contam 17:275-288.
10. Bookstaff RC, Kamel F, Moore RW, Bjerke DL, Peterson RE. 1990. Altered regulation of pituitary gonadotropin-releasing hormone (GnRH) receptor number and pituitary responsiveness to GnRH in 2,3,7,8-tetrachlorodibenzo-pdioxin-treated male rats. Toxicol Appl Pharmacol 105:78-92.
11. Bush B, Bennett AH, Snow JT. 1986. Polychlorobiphenyl congeners, p,p′-DDE, and sperm function in humans. Arch Environ Contam Toxicol 15:333-341.
12. Dallinga JW, Moonen EJ, Dumoulin JC, Evers JL, Geraedts JP, Kleinjans JC. 2002. Decreased human semen quality and organochlorine compounds in blood. Hum Reprod 17:1973-1979.
13. Den Hond E, Roels HA, Hoppenbrouwers K, Nawrot T, Thijs L, Vandermeulen C, et al. 2002. Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek's hypothesis revisited. Environ Health Perspect 110:771-776.
14. Egeland GM, Sweeney MH, Fingerhut MA, Wille KK, Schnorr TM, Halperin WE. 1994. Total serum testosterone and gonadotropins in workers exposed to dioxin. Am J Epidemiol 139:272-281.
15. Elzanaty S, Richthoff J, Malm J, Giwercman A. 2002. The impact of epididymal and accessory sex gland function on sperm motility. Hum Reprod 17:2904-2911.
16. Focant JF, Eppe G, Scippo ML, Massart AC, Pirard C, Maghuin-Rogister G, et al. 2005. Comprehensive two-dimensional gas chromatography with isotope dilution time-of-flight mass spectrometry for the measurement of dioxins and polychlorinated biphenyls in foodstuffs. Comparison with other methods. J Chromatogr A 1086:45-60.
17. Fukuzawa NH, Ohsako S, Wu Q, Sakaue M, Fujii-Kuriyama Y, Baba T, et al. 2004. Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse. Mol Cell Endocrinol 221:87-96.
18. Gray LE, Ostby J, Furr J, Wolf CJ, Lambright C, Parks L, et al. 2001. Effects of environmental antiandrogens on reproductive development in experimental animals. Hum Reprod Update 7:248-264.
19. Grubbs WD, Wolfe WH, Michalek JE, Williams DE, Lustik MB, Brockman AS, et al. 1995. The Air Force Health Study: An Epidemiologic Investigation of Health Effects in Air Force Personnel following Exposure to Herbicides. 1992 Followup Examination Results. AL-TR-920107. Brooks Air Force Base, TX:Epidemiologic Research Division, Armstrong Laboratory.
20. Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C, et al. 2001. Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 345:1388-1393.
21. Hamm JT, Chen CY, Birnbaum LS. 2003. A mixture of dioxins, furans, and non-ortho PCBs based upon consensus toxic equivalency factors produces dioxin-like reproductive effects. Toxicol Sci 74:182-191.
22. Hauser R, Chen Z, Pothier L, Ryan L, Altshul L. 2003. The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p′-DDE. Environ Health Perspect 111:1505-1511.
23. Henriksen GL, Michalek JE. 1996. Serum dioxin, testosterone, and gonadotropins in veterans of Operation Ranch Hand. Epidemiology 7:454-455.
24. Hsu PC, Huang W, Yao WJ, Wu MH, Guo YL, Lambert GH. 2003. Sperm changes in men exposed to polychlorinated biphenyls and dibenzofurans. JAMA 289:2943-2944.
25. Johnson L, Dickerson R, Safe SH, Nyberg CL, Lewis RP, Welsh TH Jr. 1992. Reduced Leydig cell volume and function in adult rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin without a significant effect on spermatogenesis. Toxicology 76:103-118.
26. Johnson E, Shorter C, Bestervelt L, Patterson D, Needham L, Piper W, et al. 2001. Serum hormone levels in humans with low serum concentrations of 2,3,7,8-TCDD. Toxicol Ind Health 17:105-112.
27. Jørgensen N, Carlsen E, Nermoen I, Punab M, Suominen J, Andersen AG, et al. 2002. East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland. Hum Reprod 17:2199-2208.
28. Judd N, Griffith WC, Faustman EM. 2004. Contribution of PCB exposure from fish consumption to total dioxin-like dietary exposure. Regul Toxicol Pharmacol 40:125-135.
29. Kaufman JM, Vermeulen A. 2005. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 26:833-876.
30. Keel BA. 2004. How reliable are results from the semen analysis? Fertil Steril 82:41-44.
31. Kern PA, Said S, Jackson WG Jr, Michalek JE. 2004. Insulin sensitivity following Agent Orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Clin Endocrinol Metab 89:4665-4672.
32. Kidd SA, Eskenazi B, Wyrobek AJ. 2001. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 75:237-248.
33. Kogevinas M. 2001. Human health effects of dioxins: cancer, reproductive and endocrine system effects. Hum Reprod Update 7:331-339.
34. Koppen G, Covaci A, Van Cleuvenbergen R, Schepens P, Winneke G, Nelen V, et al. 2001. Comparison of CALUXTEQ values with PCB and PCDD/F measurements in human serum of the Flanders Environmental and Health Study (FLEHS). Toxicol Lett 123:59-67.
35. Koppen G, Covaci A, Van Cleuvenbergen R, Schepens P, Winneke G, Nelen V, et al. 2002. Persistent organochlorine pollutants in human serum of 50-65 years old women in the Flanders Environmental and Health Study (FLEHS). Part 1: concentrations and regional differences. Chemosphere 48:811-825.
36. Lemcke B, Behre HM, Nieschlag E. 1997. Frequently subnormal semen profiles of normal volunteers recruited over 17 years. Int J Androl 20:144-152.
37. Liem AK, Furst P, Rappe C. 2000. Exposure of populations to dioxins and related compounds. Food Addit Contam 17:241-259.
38. Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M, Olafsdottir K. 2005. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod 20:208-215.
39. Mocarelli P, Gerthoux PM, Ferrari E, Patterson DG, Kieszak SM, Brambilla P, et al. 2000. Paternal concentrations of dioxin and sex ratio of offspring. Lancet 355:1858-1863.
40. Moore RW, Jefcoate CR, Peterson RE. 1991. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits steroidogenesis in the rat testis by inhibiting the mobilization of cholesterol to cytochrome P450scc. Toxicol Appl Pharmacol 109:85-97.
41. Moore RW, Peterson RE. 1988. Androgen catabolism and excretion in 2,3,7,8-tetrachlorodibenzo- p-dioxin-treated rats. Biochem Pharmacol 37:560-562.
42. Moore RW, Potter CL, Theobald HM, Robinson JA, Peterson RE. 1985. Androgenic deficiency in male rats treated with 2,3,7,8-tetrachlorodibenzo- p-dioxin. Toxicol Appl Pharmacol 79:99-111.
43. Muller A, De La Rochebrochard E, Labbé-Declèves C, Jouannet P, Bujan L, Mieusset R, et al. 2004. Selection bias in semen studies due to self-selection of volunteers. Hum Reprod 19:2838-2844.
44. Murk AJ, Legler J, Denison MS, Giesy JP, van de Guchte C, Brouwer A. 1996. Chemical-activated luciferase gene expression (CALUX): a novel in vitro bioassay for Ah receptor active compounds in sediments and pore water. Fundam Appl Toxicol 33:149-160.
45. Nawrot TS, Staessen JA, Den Hond E, Koppen G, Schoeters G, Fagard R, et al. 2002. Host and environmental determinants of polychlorinated aromatic hydrocarbons in serum of adolescents. Environ Health Perspect 110:583-589.
46. Richthoff J, Rylander L, Jönsson BAG, Åkesson H, Hagmar L, Nilsson-Ehle P, et al. 2003. Serum levels of 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population. Environ Health Perspect 111:409-413.
47. Rignell-Hydbom A, Rylander L, Giwercman A, Jönsson BAG, Nilsson-Ehle P, Hagmar L. 2004. Exposure to CB-153 and p,p′-DDE and male reproductive function. Hum Reprod 19:2066-2075.
48. Safe S. 1990. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit Rev Toxicol 21:51-88.
49. Safe SH. 1995. Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharmacol Ther 67:247-281.
50. Simon AM, Brochard D, Morel L, Veyssiere G, Jean C. 1997. The androgen-dependent mouse seminal vesicle secretory protein of 99 amino acids (MSVSP99): regulation of the mRNA and preliminary characterization of the promoter. J Steroid Biochem Mol Biol 61:87-95.
51. Slama R, Eustache F, Ducot B, Jensen TK, Jørgensen N, Horte A, et al. 2002. Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities. Hum Reprod 17:503-515.
52. Staessen JA, Nawrot T, Den Hond E, Thijs L, Fagard R, Hoppenbrouwers K, et al. 2001. Renal function, cytogenetic measurements, and sexual development in adolescents in relation to environmental pollutants: a feasibility study of biomarkers. Lancet 357:1660-1669.
53. Stichting Nevo. 1993. NEVO-tabel: Nederlands Voedingsstoffenbestand [in Dutch]. 1st ed. Den Haag, the Netherlands: Voorlichtingsbureau voor de Voeding.
54. Swan SH, Elkin EP, Fenster L. 2000. The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ Health Perspect 108:961-966.
55. Toft G, Hagmar L, Giwercman A, Bonde JP. 2004. Epidemiological evidence on reproductive effects of persistent organochlorines in humans. Reprod Toxicol 19:5-26.
56. van den Berg M, Peterson RE, Schrenk D. 2000. Human risk assessment and TEFs. Food Addit Contam 17:347-358.
57. van Larebeke N, Hens L, Schepens P, Covaci A, Baeyens J, Everaert K, et al. 2001. The Belgian PCB and dioxin incident of January-June 1999: exposure data and potential impact on health. Environ Health Perspect 109:265-273.
58. Vermeulen A, Verdonck L, Kaufman JM. 1999. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672.
59. Wevers M, Van Gerven T, Van Hooste H. 2004. MIRA (2004) Milieuen natuurrapport Vlaanderen, Verspreiding van PCB's [in Dutch]. Achtergronddocument 2004. Erembodegem, Belgium:Vlaamse Milieumaatschappij. Available: http://www.milieurapport.be/ [accessed 27 January 2005].
60. Wevers M, Van Hooste H. 2004. MIRA (2004) Milieu- en natuurrapport Vlaanderen. Verspreiding van producten van onvolledige verbranding (POV's) [in Dutch]. Achtergrond-document 2004, Erembodegem, Belgium:Vlaamse Milieumaatschappij. Available: http://www.milieurapport.be/ [accessed 27 January 2005].
61. WHO (World Health Organization). 1992. WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. 3rd ed. Cambridge, UK:Cambridge University Press.
62. WHO (World Health Organization). 1999. WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. 4th ed. Cambridge, UK:Cambridge University Press.
63. Zhuang YH, Bläuer M, Pekki A, Tuohimaa P. 1992. Subcellular location of androgen receptor in rat prostate, seminal vesicle and human osteosarcoma MG-63 cells. J Steroid Biochem Mol Biol 41:693-696.