Impaired small-bowel barrier integrity in the presence of lumenal pancreatic digestive enzymes leads to circulatory shock

Shock

Volumn 38, Issue 3, 2012, Pages 262-267

  Kistler, Erik B ^a,b   Alsaigh, Tom ^b   Chang, Marisol ^b   Schmid Schönbein, Geert W ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Autodigestion; inflammatory mediators; pancreatic enzymes; small intestine permeability

Indexed keywords

ACETYLCYSTEINE; AMYLASE; ATROPINE; CHYMOTRYPSIN; ELASTASE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; MUCIN; MUCOLYTIC AGENT; PANCREAS ENZYME; PROTEINASE INHIBITOR; TRIACYLGLYCEROL LIPASE; TRYPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEATH; ENZYME ACTIVITY; ENZYME INHIBITION; HEMODYNAMICS; HYPOTENSION; INFUSION; INTESTINE ISCHEMIA; INTESTINE MUCOSA PERMEABILITY; MALE; MUCOLYSIS; NONHUMAN; RAT; SHOCK; SMALL INTESTINE; SMALL INTESTINE MUCOSA;

ANIMALS; BLOTTING, WESTERN; ENZYMES; EXPECTORANTS; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; INTESTINE, SMALL; MALE; PANCREAS; PANCREATIC ELASTASE; PEPTIDE HYDROLASES; PERMEABILITY; RATS; RATS, WISTAR; SHOCK; TRYPSIN;

EID: 84865529678     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31825b1717     Document Type: Article

References (27)

1. Rocker G, Cook D, Sjokvist P, Weaver B, Finfer S, McDonald E, Marshall J, Kirby A, Levy M, Dodek P, et al.: Clinician predictions of intensive care unit mortality. Crit Care Med 32:1149-1154, 2004. (Pubitemid 38620983)
2. Gustot T: Multiple organ failure in sepsis: prognosis and role of systemic inflammatory response. Curr Opin Crit Care 17:153-159, 2011.
3. Mitsuoka H, Kistler EB, Schmid-Schonbein GW: Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes. Proc Natl Acad Sci USA 97:1772-1777, 2000. (Pubitemid 30118518)
4. Pusztai A: Transport of proteins through the membranes of the adult gastrointestinal tract-a potential for drug delivery? Adv Drug Deliv Rev 3: 215-228, 1989. (Pubitemid 19146031)
5. Godl K, Johansson ME, Lidell ME, Morgelin M, Karlsson H, Olson FJ, Gum JR Jr, Kim YS, Hansson GC: The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment. J Biol Chem 277:47248-47256, 2002. (Pubitemid 36163373)
6. Chang M, Kistler EB, Schmid-Schonbein GW: Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wall. Shock 37:297-305, 2012.
7. Mitsuoka H, Kistler EB, Schmid-Schonbein GW: Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. Shock 17:205-209, 2002.
8. Kistler EB, Lefer AM, Hugli TE, Schmid-Schonbein GW: Plasma activation during splanchnic arterial occlusion shock. Shock 14:30-34, 2000.
9. Rosario HS, Waldo SW, Becker SA, Schmid-Schonbein GW: Pancreatic trypsin increases matrix metalloproteinase-9 accumulation and activation during acute intestinal ischemia-reperfusion in the rat. Am J Pathol 164: 1707-1716, 2004. (Pubitemid 38529773)
10. Waldo SW, Rosario HS, Penn AH, Schmid-Schonbein GW: Pancreatic digestive enzymes are potent generators of mediators for leukocyte activation and mortality. Shock 20:138-143, 2003.
11. Corne SJ, Morrissey SM, Woods RJ: Proceedings: a method for the quantitative estimation of gastric barrier mucus. J Physiol 242:116PY117P, 1974.
12. Bounous G, McArdle AH, Hodges DM, Hampson LG, Gurd FN: Biosynthesis of intestinal mucin in shock: relationship to tryptic hemorrhagic enteritis and permeability to curare. Ann Surg 164:13-22, 1966.
13. Berlin SC, Goske MJ, Obuchowski N, Alexander F, Zepp RC, Goldblum JR, Godec K: Small bowel obstruction in rats: diagnostic accuracy of sonography versus radiography. J Ultrasound Med 17:497-504, 1998. (Pubitemid 28355271)
14. Celli JP, Turner BS, Afdhal NH, Ewoldt RH, McKinley GH, Bansil R, Erramilli S: Rheology of gastric mucin exhibits a pH-dependent sol-gel transition. Biomacromolecules 8:1580-1586, 2007. (Pubitemid 46865131)
15. Kistler EB, Hugli TE, Schmid-Schonbein GW: The pancreas as a source of cardiovascular cell activating factors. Microcirculation 7:183-192, 2000.
16. Rubin BK: Mucolytics, expectorants, and mucokinetic medications. Respir Care 52:859-865, 2007.
17. Doucet JJ, Hoyt DB, Coimbra R, Schmid-Schonbein GW, Junger WG, Paul LW, Loomis WH, Hugli TE: Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock. J Trauma 56:501-510, 2004; discussion 501-510.
18. Sharpe SM, Qin X, Lu Q, Feketeova E, Palange DC, Dong W, Sheth SU, Lee MA, Reino D, Xu DZ, et al.: Loss of the intestinal mucus layer in the normal rat causes gut injury but not toxic mesenteric lymph nor lung injury. Shock 34:475-481, 2010.
19. Qin X, Sheth SU, Sharpe SM, Dong W, Lu Q, Xu D, Deitch EA: The mucus layer is critical in protecting against ischemia-reperfusionYmediated gut injury and in the restitution of gut barrier function. Shock 35:275-281, 2011.
20. Sheth SU, Lu Q, Twelker K, Sharpe SM, Qin X, Reino DC, Lee MA, Xu DZ, Deitch EA: Intestinal mucus layer preservation in female rats attenuates gut injury after trauma-hemorrhagic shock. J Trauma 68:279-288, 2010.
21. Deitch EA, Shi HP, Lu Q, Feketeova E, Xu DZ: Serine proteases are involved in the pathogenesis of trauma-hemorrhagic shockYinduced gut and lung injury. Shock 19:452-456, 2003. (Pubitemid 44305172)
22. Chang RW, Chang JB, Longo WE: Update in management of mesenteric ischemia. World J Gastroenterol 12:3243-3247, 2006. (Pubitemid 43881350)
23. Leaphart CL, Tepas JJ 3rd: The gut is a motor of organ system dysfunction. Surgery 141:563-569, 2007. (Pubitemid 46621132)
24. Malinoski DJ, Hadjizacharia P, Salim A, Kim H, Dolich MO, Cinat M, Barrios C, Lekawa ME, Hoyt DB: Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death. J Trauma 67: 445-449, 2009.
25. Fitzal F, DeLano FA, Young C, Rosario HS, Schmid-Schonbein GW: Pancreatic protease inhibition during shock attenuates cell activation and peripheral inflammation. J Vasc Res 39:320-329, 2002. (Pubitemid 34983863)
26. Hansson GC: Role of mucus layers in gut infection and inflammation. Curr Opin Microbiol 15:57-62, 2012.
27. Kim HD, Malinoski DJ, Borazjani B, Patel MS, Chen J, Slone J, Nguyen XM, Steward E, Schmid-Schonbein GW, Hoyt DB: Inhibition of intraluminal pancreatic enzymes with nafamostat mesilate improves clinical outcomes after hemorrhagic shock in swine. J Trauma 68:1078-1083, 2010.