Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase

Tuberculosis

Volumn 92, Issue 5, 2012, Pages 434-439

  Krátký, Martin ^a   Vinová, Jarmila ^a   Novotná, Eva ^a   Mandíková, Jana ^a   Wsól, Vladimír ^a   Trejtnar, Frantiek ^a   Ulmann, Vít ^b   Stolaíková, Jiina ^b   Fernandes, Steve ^c   Bhat, Shridhar ^c   Liu, Jun O ^c  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b Zdravotniho ustavu se sidlem v Ostrave   (Czech Republic)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Isocitrate lyase; Methionine aminopeptidase; Salicylanilide derivative; Targeting; Tuberculosis

Indexed keywords

3 NITROPROPIONIC ACID; 4 BROMO 2 [4 (TRIFLUOROMETHYL)PHENYLCARBAMOYL]PHENYL 2 ACETAMIDO 3 PHENYLPROPANOATE; 4 BROMO 2 [4 (TRIFLUOROMETHYL)PHENYLPHENYLCARBAMOYL]PHENYL PYRAZINE 2 CARBOXYLATE; 4 CHLORO 2 [4 (TRIFLUOROMETHYL)PHENYLCARBAMOYL]PHENYL PYRAZINE 2 CARBOXYLATE; 5 CHLORO 2 HYDROXY N [4 (TRIFLUOROMETHYL)PHENYL]BENZAMIDE; ANTIMYCOBACTERIAL AGENT; ISOCITRATE LYASE; METHIONYL AMINOPEPTIDASE; SALICYLANILIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LATENT TUBERCULOSIS; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANTITUBERCULAR AGENTS; CZECH REPUBLIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; ISOCITRATE LYASE; MALE; METHIONYL AMINOPEPTIDASES; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; SALICYLANILIDES; SOCIOECONOMIC FACTORS; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 84865510687     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2012.06.001     Document Type: Article

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