Synthesis of various 3-nitropropionamides as Mycobacterium tuberculosis isocitrate lyase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5149-5154

  Sriram, Dharmarajan ^a   Yogeeswari, Perumal ^a   Methuku, Swetha ^a   Vyas, Devambatla Ravi Kumar ^a   Senthilkumar, Palaniappan ^a   Alvala, Mallika ^a   Jeankumar, Variam Ullas ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Antitubercular activity; Latent tuberculosis; Mycobacterium tuberculosis; Nitropropionic acid derivatives

Indexed keywords

1 CYCLOPROPYL 7 (3,5 DIMETHYL 4 (3 NITROPROPANOYL)PIPERAZIN 1 YL) 6 FLUORO 8 METHOXY 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 3 NITROPROPIONIC ACID; ISOCITRATE LYASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG BINDING SITE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

ANILIDES; CATALYTIC DOMAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ISOCITRATE LYASE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NITRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM TUBERCULOSIS;

EID: 80051933535     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.062     Document Type: Article

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