Memory t cells in the chronic inflammatory microenvironment of nasal polyposis are hyporesponsive to signaling through the t cell receptor

JARO - Journal of the Association for Research in Otolaryngology

Volumn 13, Issue 3, 2012, Pages 423-435

  Lehman, Heather K ^a   Simpson Abelson, Michelle R ^a,b   Conway Jr , Thomas F ^a   Kelleher Jr , Raymond J ^a   Bernstein, Joel M ^a   Bankert, Richard B ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Anergy; Inflammation; Suppression; Tolerance

Indexed keywords

CD28 ANTIGEN; CD3 ANTIBODY; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IONOMYCIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN SLP 76; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ARTICLE; CELL INFILTRATION; CELL SURFACE; CHRONIC INFLAMMATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; MEMORY T LYMPHOCYTE; MICROENVIRONMENT; NOSE POLYP; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE;

ANTIGENS, CD28; ANTIGENS, CD3; CALCIUM IONOPHORES; CASE-CONTROL STUDIES; FLOW CYTOMETRY; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; IONOMYCIN; LYMPHOCYTE ACTIVATION; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; NASAL POLYPS; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; PHENOTYPE; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84865501855     PISSN: 15253961     EISSN: 14387573     Source Type: Journal    
DOI: 10.1007/s10162-012-0313-8     Document Type: Article

References (44)

1. AGNELLINI P, WOLINT P, REHR M, CAHENZLI U, KARRER U, OXENIUS A (2007) Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection. Proc Natl Acad Sci USA 104:4564-4570
2. AGRAWAL S, MARQUET J, DELFAU-LARUE MH, COPIE-BERGMAN C, JOUAULT H, REYES F, BENSUSSAN A, FARCET JP (1998) CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and nonmalignant secondary lymphoid organs. J Clin Invest 102:1715-1723
3. AHMED R, GRAY D (1996) Immunological memory and protective immunity: understanding their relation. Science 272:54-60
4. BARBER DL, WHERRY EJ, MASOPUST D, ZHU B, ALLISON JP, SHARPE AH, FREEMAN GJ, AHMED R (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439:682-687
5. BERNSTEIN JM, BALLOW M, RICH G, ALLEN C, SWANSON M, DMOCHOWSKI J (2004) Lymphocyte subpopulations and cytokines in nasal polyps: is there a local immune system in the nasal polyp? Otolaryngol Head Neck Surg 130:526-535
6. BETTS MR, BRENCHLEY JM, PRICE DA, DE ROSA SC, DOUEK DC, ROEDERER M, KOUP RA (2003) Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 281:65-78
7. BLACKBURN SD, SHIN H, HAINING WN, ZOU T, WORKMAN CJ, POLLEY A, BETTS MR, FREEMAN GJ, VIGNALI DA, WHERRY EJ (2009) Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 10:29-37
8. BRODERICK L, BANKERT RB (2006) Membrane-associated TGF-beta1 inhibits human memory T cell signaling in malignant and nonmalignant inflammatory microenvironments. J Immunol 177:3082-3088
9. BRODERICK L, BROOKS SP, TAKITA H, BAER AN, BERNSTEIN JM, BANKERT RB (2006) IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells. Clin Immunol 118:159-169
10. BRODERICK L, YOKOTA SJ, REINEKE J, MATHIOWITZ E, STEWART CC, BARCOS M, KELLEHER RJ JR, BANKERT RB (2005) Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells. J Immunol 174:898-906
11. CHIODETTI L, CHOI S, BARBER DL, SCHWARTZ RH (2006) Adaptive tolerance and clonal anergy are distinct biochemical states. J Immunol 176:2279-2291
12. DAGUR PK, SHARMA B, KUMAR G, KHAN NA, KATOCH VM, SENGUPTA U, JOSHI B (2010) Mycobacterial antigen(s) induce anergy by altering TCR-and TCR/CD28-induced signalling events: insights into T-cell unresponsiveness in leprosy. Mol Immunol 47:943-952
13. FEUNOU P, POULIN L, HABRAN C, LE MOINE A, GOLDMAN M, BRAUN MY (2003) CD4+CD25+ and CD4+CD25? T cells act respectively as inducer and effector T suppressor cells in superantigen-induced tolerance. J Immunol 171:3475-3484
14. GEORGE TC, BASIJI DA, HALL BE, LYNCH DH, ORTYN WE, PERRY DJ, SEO MJ, ZIMMERMAN CA, MORRISSEY PJ (2004) Distinguishing modes of cell death using the ImageStream multispectral imaging flow cytometer. Cytometry A 59:237-245
15. GEORGE TC, FANNING SL, FITZGERALD-BOCARSLY P, MEDEIROS RB, HIGHFILL S, SHIMIZU Y, HALL BE, FROST K, BASIJI D, ORTYN WE ET AL (2006) Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow. J Immunol Methods 311:117-129
16. GRAY-OWEN SD, BLUMBERG RS (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol 6:433-446
17. HU HL, CORNWELL WD, ROGERS TJ, LIN YS (1996) In vivo analysis of a superantigen-induced T cell suppressor factor. Cell Immunol 167:285-292
18. JARNICKI AG, FITZPATRICK DR, ROBINSON BW, BIELEFELDT-OHMANN H (1996) Altered CD3 chain and cytokine gene expression in tumor infiltrating T lymphocytes during the development of mesothelioma. Cancer Lett 103:1-9
19. JELLEY-GIBBS DM, DIBBLE JP, FILIPSON S, HAYNES L, KEMP RA, SWAIN SL (2005) Repeated stimulation of CD4 effector T cells can limit their protective function. J Exp Med 201:1101-1112
20. LETVIN NL, WALKER BD (2003) Immunopathogenesis and immunotherapy in AIDS virus infections. Nat Med 9:861-866
21. LI H, PAUZA DC (2011) Interplay of T-cell receptor and interleukin-2 signalling in V?2V?2 T-cell cytotoxicity. Immunology 132:96-103
22. LUXENBERGER W, POSCH U, BERGHOLD A, HOFMANN T, LANG-LOIDOLT D (2000) HLA patterns in patients with nasal polyposis. Eur Arch Otorhinolaryngol 257:137-139
23. MACCALLI C, PISARRA P, VEGETTI C, SENSI M, PARMIANI G, ANICHINI A (1999) Differential loss of T cell signaling molecules in metastatic melanoma patients' T lymphocyte subsets expressing distinct TCR variable regions. J Immunol 163:6912-6923
24. MACIAN F, GARCIA-COZAR F, IM SH, HORTON HF, BYRNE MC, RAO A (2002) Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109:719-731
25. MARKEL G, SEIDMAN R, STERN N, COHEN-SINAI T, IZHAKI O, KATZ G, BESSER M, TREVES AJ, BLUMBERG RS, LOEWENTHAL R ET AL (2006) Inhibition of human tumor-infiltrating lymphocyte effector functions by the homophilic carcinoembryonic cell adhesion molecule 1 interactions. J Immunol 177:6062-6071
26. MARTENS PB, GORONZY JJ, SCHAID D, WEYAND CM (1997) Expansion of unusual CD4+ T cells in severe rheumatoid arthritis. Arthritis Rheum 40:1106-1114
27. MEDEIROS RB, BURBACH BJ, MUELLER KL, SRIVASTAVA R, MOON JJ, HIGHFILL S, PETERSON EJ, SHIMIZU Y (2007) Regulation of NFkappaB activation in T cells via association of the adapter proteins ADAP and CARMA1. Science 316:754-758
28. MIGUELES SA, OSBORNE CM, ROYCE C, COMPTON AA, JOSHI RP, WEEKS KA, ROOD JE, BERKLEY AM, SACHA JB, COGLIANO-SHUTTA NA ET AL (2008) Lytic granule loading of CD8+ T cells is required for HIVinfected cell elimination associated with immune control. Immunity 29:1009-1021
29. MOLNAR-GABOR E, ENDREFFY E, ROZSASI A (2000) HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis. Laryngoscope 110:422-425
30. MOOSIG F, CSERNOK E, WANG G, GROSS WL (1998) Costimulatory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells. Clin Exp Immunol 114:113-118
31. MUELLER SN, AHMED R (2009) High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci USA 106:8623-8628
32. NEL AE, SLAUGHTER N (2002) T-cell activation through the antigen receptor. Part 2: role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy. J Allergy Clin Immunol 109:901-915
33. PEGGS KS, QUEZADA SA, ALLISON JP (2008) Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy. Immunol Rev 224:141-165
34. RAMÍREZ-ANGUIANO J, YAMAMOTO-FURUSHO JK, BARQUERA R, BELTRÁN O, GRANADOS J (2006) Association of HLA-DR3 and HLA-DR4 with sinonasal polyposis in Mexican Mestizos. Otolaryngol Head Neck Surg 135:90-93
35. SANCHEZ-SEGURA A, BRIEVA JA, RODRIGUEZ C (1998) T lymphocytes that infiltrate nasal polyps have a specialized phenotype and produce a mixed TH1/TH2 pattern of cytokines. J Allergy Clin Immunol 102:953-960
36. SCHIRMER M, GOLDBERGER C, WURZNER R, DUFTNER C, PFEIFFER KP, CLAUSEN J, NEUMAYR G, FALKENBACH A (2002) Circulating cytotoxic CD8(+) CD28(?) T cells in ankylosing spondylitis. Arthritis Res 4:71-76
37. SCHOOLEY K, ZHU P, DOWER SK, QWARNSTROM EE (2003) Regulation of nuclear translocation of nuclear factor-kappaB relA: evidence for complex dynamics at the single-cell level. Biochem J 369:331-339
38. SIMPSON-ABELSON MR, PUROHIT VS, PANG WM, IYER V, ODUNSI K, DEMMY TL, YOKOTA SJ, LOYALL JL, KELLEHER RJ JR, BALU-IYER S, BANKERT RB (2009) IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments. Clin Immunol 132:71-82
39. SLOAN-LANCASTER J, SHAW AS, ROTHBARD J, ALLEN PM (1994) Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy. Cell 79:913-922
40. SOMMER J (1977) To cationize glass. J Cell Biol 75:745a
41. SUNDSTEDT A, SIGVARDSSON M, LEANDERSON T, HEDLUND G, KALLAND T, DOHLSTEN M (1996) In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors. Proc Natl Acad Sci USA 93:979-984
42. VALLEJO AN, WEYAND CM, GORONZY JJ (2004) T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection. Trends Mol Med 10:119-124
43. WONG RM, SCOTLAND RR, LAU RL, WANG C, KORMAN AJ, KAST WM, WEBER JS (2007) Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs. Intl Immunol 19:1223-1234
44. ZHA Y, MARKS R, HO AW, PETERSON AC, JANARDHAN S, BROWN I, PRAVEEN K, STANG S, STONE JC, GAJEWSKI TF (2006) T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-?. Nature Immunol 7:1166-1173