Cellular actions of testosterone in vascular cells: Mechanism independent of aromatization to estradiol

Steroids

Volumn 77, Issue 11, 2012, Pages 1033-1040

  Campelo, Adrián E ^a,b   Cutini, Pablo H ^a,b   Massheimer, Virginia L ^a,b  

^a UNIVERSIDAD NACIONAL DEL SUR   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Aromatase; Nitric oxide; Proliferation; Testosterone; Vascular

Indexed keywords

ANASTROZOLE; ANDROSTANOLONE; AROMATASE INHIBITOR; BACTERIUM LIPOPOLYSACCHARIDE; ESTRADIOL; FINASTERIDE; FLUTAMIDE; FULVESTRANT; NITRIC OXIDE; TESTOSTERONE;

ANIMAL TISSUE; AROMATIZATION; ARTICLE; BIOTRANSFORMATION; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; MONOCYTE; MUSCLE CELL; NONHUMAN; RAT; SMOOTH MUSCLE FIBER; SYNTHESIS; VASCULAR SMOOTH MUSCLE CELL;

5-ALPHA REDUCTASE INHIBITORS; ANDROGEN ANTAGONISTS; ANIMALS; AORTA; AROMATASE INHIBITORS; CELL ADHESION; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; FINASTERIDE; FLUTAMIDE; MONOCYTES; MYOCYTES, SMOOTH MUSCLE; NITRIC OXIDE; NITRILES; RATS; RATS, WISTAR; TESTOSTERONE; TRIAZOLES;

BACTERIA (MICROORGANISMS); RATTUS;

EID: 84865500007     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.05.008     Document Type: Article

References (47)

1. P. Ouyang, E.D. Michos, and R.H. Karas Hormone replacement therapy and the cardiovascular system learned and unanswered questions J Am Coll Cardiol 47 2006 1741 1753
2. J.M. Orshal, and R.A. Khalil Gender, sex hormones, and vascular tone Am J Physiol Regul Integr Comp Physiol 286 2004 R233 R249
3. P.Y. Liu, A.K. Death, and D.J. Handelsman Androgens and cardiovascular disease Endocr Rev 24 2003 313 340
4. J. Li, and F. Al-Azzawi Mechanism of androgen receptor action Maturitas 63 2009 142 148
5. M. Perusquía, and J.N. Stallone Do androgens play a beneficial role in the regulation of vascular tone? Nongenomic vascular effect of testosterone metabolites Am J Physiol Heart Cir Physiol 298 2010 H1301 H1307
6. S. Ling, A. Dai, M.R. Williams, K. Myles, R.J. Dilley, P. Komesaroff, and K. Sudhir Testosterone (T) enhances apoptosis-related damage in human vascular endothelial cells Endocrinology 143 2002 1119 1125
7. T.K. Mukherjee, H. Dinh, G. Chaudhuri, and L. Nathan Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis Proc Nat Acad Sci USA 99 2002 4055 4060
8. N. Harada, H. Sasano, H. Murakami, T. Ohkuma, H. Nagura, and Y. Takagi Localized expression of aromatase in human vascular tissues Circ Res 84 1999 1285 1291
9. M.E. Mendelsohn, and G.M. Rosano Hormonal regulation of normal vascular tone in males Circ Res 93 2003 1142 1145
10. R.J. Gonzales, S. Ansar, S.P. Duckles, and D.N. Krause Androgenic/estrogenic balance in the male rat cerebral circulation: metabolic enzymes and sex steroid receptors J Cereb Blood Flow Metab 27 2007 1841 1852
11. R. Fujimoto, I. Morimoto, E. Morita, H. Sugimoto, Y. Ito, and S. Eto Androgen receptors, 5 alpha-reductase activity and androgen-dependent proliferation of vascular smooth muscle cells J Steroid Biochem Mol Biol 50 1994 169 174
12. S. Aggarwal, S. Thareja, A. Verma, T.R. Bhardwaj, and M. Kumar An overview on 5alpha-reductase inhibitors Steroids 75 2010 109 153
13. R. Ross Atherosclerosis, an inflammatory disease N Engl J Med 340 1999 115 126
14. P. Libby, P.M. Ridker, and A. Maseri Inflammation and atherosclerosis Circulation 105 2002 1135 1143
15. R.M. Rao, L. Yang, G. Garcia-Cardena, and F.W. Luscinskas Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall Circ Res 101 2007 234 247
16. R. Ross The pathogenesis of atherosclerosis: a perspective for the 1990s Nature 362 1993 801 809
17. R.R. Pauly, A. Passaniti, C. Bilato, R. Monticone, L. Cheng, and N. Papadopoulos Migration of cultured vascular smooth cells through a basement membrane barrier requires type IV collagenase activity and is inhibited by cellular differentiation Circ Res 75 1994 41 54
18. M.L. Bochatan-Piallat, F. Gabbiani, M. Redard, A. Desmouliere, and G. Gabbiani Apoptosis participates in cellularity regulation during rat aortic intimal thickening Am J Pathol 146 1995 1059 1064
19. A.E. Campelo, P.H. Cutini, and V. Massheimer Testosterone modulates platelet aggregation and endothelial cell growth through nitric oxide pathway J Endocrinol 213 2012 77 87
20. P. Cutini, and V. Massheimer Role of progesterone on the regulation of vascular muscle cells proliferation, migration and apoptosis Steroids 75 2010 355 361
21. T. Bachetti, and L. Morbidelli Endothelial cells in culture: a model for studying vascular functions Pharmacol Res 42 2000 9 19
22. M.B. Rauschemberger, J. Selles, and V. Massheimer The direct action of estrone on vascular tissue involves genomic and non-genomic actions Life Sci 82 2008 115 123
23. P. Cutini, J. Sellés, and V. Massheimer Cross-talk between rapid and long term effects of progesterone on vascular tissue J Steroid Biochem Mol Biol 115 2009 36 43
24. M.J. Sandoval, P.H. Cutini, M.B. Rauschemberger, and V.L. Massheimer The soyabean isoflavone genistein modulates endothelial cell behaviour Br J Nutr 104 2010 171 179
25. M. Mendelsohn Estrogen actions in the cardiovascular system Climacteric 12 2009 18 21
26. K. Chamblis, and P. Shaul Estrogen modulation of endothelial nitric oxide synthase End Rev 23 2002 665 686
27. K. Chamblis, I. Yuhanna, C. Mineo, P. Liu, Z. German, and T. Sheman Estrogen receptor α and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae Circ Res 87 2000 e44 e52
28. Z. Chen, I. Yuhanna, Z. Galcheva-Gargova, R. Karas, M. Mendelsohn, and P. Shaul Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen J Clin Invest 1999 401 406
29. P. Tep-areenan, D.A. Kendall, and M.D. Randall Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels Br J Pharmacol 135 2002 735 740
30. R.D. Jones, K.M. English, T.H. Jones, and K.S. Channer Testosterone-induced coronary vasodilatation occurs via a non-genomic mechanism: evidence of a direct calcium antagonism action Clin Sci (Lond) 107 2004 149 158
31. L. Nathan, W. Shi, H. Dinh, T.K. Mukherjee, X. Wang, and A. Lusis Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase Proc Nat Acad Sci USA 98 2001 3585 3593
32. M. Kimura, K. Sudhir, M. Jones, E. Simpson, A.M. Jefferis, and J.P. Chin-Dusting Impaired acetylcholine induced release of nitric oxide in the aorta of male aromatase-knockout mice. regulation of nitric oxide production by endogenous sex hormones in males Cir Res 93 2003 1267 1271
33. R. Lew, P. Komesaroff, M. Williams, T. Dawood, and K. Sudhir Endogenous estrogens influence endothelial function in young men Cir Res 93 2003 1127 1133
34. C.U. Chae, and C.A. Derby The menopausal transition and cardiovascular risk Obstet Gynecol Clin North Am 38 2011 477 488
35. V.M. Miller, and S.L. Mulvagh Sex steroids and endothelial function: translating basic science to clinical practice Trends Pharmacol Sci 28 2007 263 270
36. K. Higashiura, B. Blaney, E. Morgan, R.S. Mathur, and P.V. Halushka Inhibition of testosterone 5 alpha-reductase: evidence for tissue-specific regulation of thromboxane A2 receptors J Pharmacol Exp Ther 279 1996 1386 1391
37. L. Goglia, V. Tosi, A.M. Sanchez, M.I. Flamini, X.D. Fu, S. Zullino, A.R. Genazzani, and T. Simoncini Endothelial regulation of eNOS, PAI-1 and t-PA by testosterone and dihydrotesterone in vitro and in vivo Mol Hum Reprod 16 2010 761 769
38. H. Zhang, C. Facemire, A. Banes, and J. Faber Different α-adrenoceptors mediate migration of vascular smooth muscle cells and adventitial fibroblasts in vitro Am J Physiol Heart Circ Physiol 282 2002 H2364 H2370
39. 1-adrenoceptor-induced smooth muscle cell proliferation and migration Br J Pharmacol 121 1997 665 670
40. M.R. Williams, S. Ling, T. Dawood, K. Hashimura, A. Dai, and H. Li Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs J Clin Endocrinol Metab 87 2002 176 181
41. L. Nheu, L. Nazareth, G.Y. Xu, F.Y. Xiao, R.Z. Luo, and P. Komesaroff Physiological effects of androgens on human vascular endothelial and smooth muscle cells in culture Steroids 76 2011 1590 1596
42. D.K. Bowles, K.K. Maddali, V.C. Dhulipala, and D.H. Korzick PKCdelta mediates anti-proliferative, pro-apoptic effects of testosterone on coronary smooth muscle Am J Physiol Cell Physiol 293 2007 C805 C813
43. H. Hao, G. Gabbiani, and M.L. Bochaton-Piallat Arterial smooth muscle cell heterogeneity: implications for atherosclerosis and restenosis development Arterioscler Thromb Vasc Biol 23 2003 1510 1520
44. C. Vitale, M. Fini, G. Speziale, and S. Chierchia Gender differences in the cardiovascular effects of sex hormones Fundam Clin Pharmacol 24 2010 675 685
45. K.J. Woollard, and F. Geissmann Monocytes in atherosclerosis: subsets and functions Nat Rev Cardiol 7 2010 77 86
46. B.S. Cho, D.T. Woodrum, K.J. Roelofs, J.C. Stanley, P.K. Henke, and G.R. Upchurch Jr. Differential regulation of aortic growth in male and female rodents is associated with AAA development J Surg Res 155 2009 330 338
47. V. Mirone, C. Imbimbo, F. Fusco, P. Verze, M. Creta, and G. Tajana Androgens and morphologic remodeling at penile and cardiovascular levels: a common piece in complicated puzzles? Eur Urol 56 2009 309 316