Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein - Potential novel positron emitting tomography imaging agents

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 18, 2012, Pages 5795-5800

  Wadsworth, Harry ^a   Jones, Paul A ^a   Chau, Wai Fung ^a   Durrant, Clare ^a   Morisson Iveson, Véronique ^a   Passmore, Joanna ^a   O'Shea, Dennis ^a   Wynn, Duncan ^a   Khan, Imtiaz ^a   Black, Andrew ^a   Avory, Michelle ^a   Trigg, William ^a  

^a GE HEALTHCARE   (United Kingdom)

Author keywords

Neuroinflammation; PBR; PET; Synthesis; TSPO

Indexed keywords

ANILIDE; BENZODIAZEPINE RECEPTOR; DAA 1106; DIARYL ANILIDE; FE DAA 1106; FE PPA; FLUORINE 18; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; PBR 06; PBR 28; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG SYNTHESIS; GENETIC POLYMORPHISM; ISOTOPE LABELING; LIGAND BINDING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN DOMAIN; RAT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE;

ANILIDES; ANIMALS; BRAIN; CARRIER PROTEINS; FLUORINE RADIOISOTOPES; HEART; LIGANDS; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, WISTAR; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 84865499184     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.093     Document Type: Article

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