Synthesis, antimycobacterial and antibacterial activity of ciprofloxacin derivatives containing a N-substituted benzyl moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 18, 2012, Pages 5971-5975

  Wang, Shuo ^a   Jia, Xue Dong ^a   Liu, Ming Liang ^a   Lu, Yu ^b   Guo, Hui Yuan ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Antibacterial activity; Antimycobacterial activity; Ciprofloxacin derivatives; Synthesis

Indexed keywords

ANTIBIOTIC AGENT; ANTIMYCOBACTERIAL AGENT; CIPROFLOXACIN; CIPROFLOXACIN DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BENZYL DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIMYCOBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; LIPOPHILICITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROCYSTIS AERUGINOSA; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SUBSTITUTION REACTION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GROWTH, DEVELOPMENT AND AGING; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MYCOBACTERIUM TUBERCULOSIS; NEGIBACTERIA; POSIBACTERIA;

ANTI-BACTERIAL AGENTS; BENZYL COMPOUNDS; CIPROFLOXACIN; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865483801     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.040     Document Type: Article

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