Pharmacokinetics, tissue distribution, and the lactone/carboxylate equilibrium of hydroxycamptothecin delivered via aerosol in mice

Fitoterapia

Volumn 83, Issue 7, 2012, Pages 1291-1298

  Hu, Wei ^a   Zhang, Chao ^b   Hu, Wenjin ^b   Fang, Yun ^a   Hou, Wenjie ^b  

^a NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Aerosol; HCPT; HPLC; Lactone carboxylate equilibrium; Pharmacokinetics; Tissue distribution

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN DERIVATIVE; CARBOXYLIC ACID; HYDROXYCAMPTOTHECIN; LACTONE; UNCLASSIFIED DRUG;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; AREA UNDER CURVE; CAMPTOTHECIN; CARBOXYLIC ACIDS; FEMALE; LACTONES; LUNG; MICE; MICE, INBRED C57BL; TISSUE DISTRIBUTION;

MUS;

EID: 84865477637     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2011.12.005     Document Type: Article

References (29)

1. M.E. Wall, M.C. Wani, and C.E. Cook Plant antitumor agent. 1. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from camptotheca acumianta J Am Chem Soc 88 1966 3888 3890
2. M.D. Seo, K.W. Lee, J.H. Lim, H.G. Yi, D.Y. Kim, and D.Y. Oh Irinotecan combined with 5-Fluorouracil and leucovorin as second-line chemotherapy for metastatic or relapsed gastric cancer Jpn J Clin Oncol 38 2008 589 595
3. A. Wallin, J. Svanvik, B. Holmlund, L. Ferreud, and X.F. Sun Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential Oncol Rep 19 2008 1493 1498
4. H.B. Shen, Y.K. Zeng, Z.Q. Gu, L. Zhang, J. Kang, and J. Pan Hydroxycamptothecin induced apoptosis in 5637 cells line: an in-vitro model for high-risk superficial bladder cancer J Clin Urol 24 2009 306 310
5. Y.H. Hsiang, R. Hertzberg, S. Hecht, and L.F. Liu Camptothecin induces proteinlinked DNA breaks via mammalian DNA topoisomerase-I J Biol Chem 260 1985 14873 14878
6. H. Ulukan, and P.W. Swaan Camptothecins: a review of their chemotherapeutic potential Drugs 62 2002 2039 2057
7. R.P. Hertzberg, M.J. Caranfa, K.G. Holden, D.R. Jakas, G. Gallagher, and M.R. Mat-tern Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity J Med Chem 32 1989 715 720
8. Z. Mi, and T.G. Burke Differential interactions of camptothecin lactone and carboxylate forms with human blood components Biochemistry 33 1994 10325 10336
9. J. Chen, Q.N. Ping, J.X. Guo, M.L. Liu, and B.C. Cai Effect of injection routes on pharmacokinetics and lactone/carboxylate equilibrium of 9-Nitrocamptothecin in rats Int J Pharm 340 2007 29 33
10. J. Chen, Q.N. Ping, J.X. Guo, X.Z. Chu, and M.M. Song Pharmacokinetics of lactone, carboxylate and total 9-nitrocamptothecin with different doses and administration routes in rats Biopharm Drug Dispos 27 2006 53 59
11. N.V. Koshkina, J.C. Waldrep, and V. Knight Camptothecins and lung cancer: improved delivery systems by aerosol Curr Cancer Drug Targets 3 2003 251 264
12. L.T. Xu, and H. Xie The pharmacological action and clinical application of hydroxycamptothecin Herald Med 21 2002 302
13. J. Chen, Y. Fang, H.X. Zhang, L.L. Huang, X.P. Qian, and B.R. Liu Distribution of hydroxycamptothecin after aerosol inhalation in rabbits Acta Pharmacol Sin 39 2004 747 751
14. N.V. Koshkina, B.E. Gilbert, J.C. Waldrep, A. Seryshev, and V. Knight Distribution of camptothecin after delivery as a liposome aerosol or following intramuscular injection in mice Cancer Chem Pharm 44 1999 187 192
15. F. Gagnadoux, J. Hureaux, L. Vecellio, T. Urban, A.L. Pape, and I. Valo Aerosolized chemotherapy J Aerosol Med Pulm Drug Deliv 21 2008 61 69
16. N.V. Koshkina, E.S. Kleinerman, C. Waldrep, S.F. Jia, L.L. Worth, and B.E. Gilbert 9-Nitrocamptothecin liposome aerosol treatment of melanoma and osteosarcoma lung metastases in mice Clin Cancer Res 6 2000 2876 2880
17. N.V. Koshkina, J.C. Waldrep, L.E. Roberts, E. Golunski, S. Melton, and V. Knight Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model Clin Cancer Res 7 2001 3258 3262
18. W. Hu, Y. Fang, and S.S. Zhang Investigation of distribution on lactone/carboxylate of hydroxycamptothecin after aerosol inhalation in cavia cobay Chin Hosp Pharm J 29 2009 1280 1283
19. S.S. Zhang, Y. Fang, and W. Hu Determination of two forms of hydroxycamptothecin concentration in hepat-tumor tissues by HPLC-FLD Res Pract Chin Med 23 2009 48 51
20. T.J. Brown, and B.R. Nelson Malignant melanoma: a clinical review Cutis 63 1999 275 278 281-4
21. Z. Mi, and T.G. Burke Marked interspecies variations concerning the interactions of camptothecin with serum albumins: a frequency-domain fluorescence spectroscopic study Biochemistry 33 1994 12540 12545
22. J. O'Leary, and F.M. Muggia Camptothecins: a review of their development and schedules of administration Eur J Cancer 34 1998 1500 1508
23. Y. Yao, H. Zhao, Y.J. Sun, F. Lin, L.L. Tang, and P. Chen Combined chemotherapy of hydroxycamptothecin with oxaliplatin as an adjuvant treatment for human colorectal cancer Tohoku J Exp Med 215 2008 267 278
24. P. Zhou, and S.Q. Zheng Clinical observation of hydroxycamptothecin combined with oxaliplatin and capecitabine in the treatment of advanced gastric cancer Chin Clin Oncol 16 2011 739 741
25. Y.C. Lin, H.B. Wang, and W. Lin Preliminary study of lyophilized 10-Hydroxycamptothecin (Tuoxi) combine with cisplatin in advanced or recurrent malignancies Chin J Cancer Prev Treat 12 2005 1655 1657
26. W.Y. Xiang, and C. Fu Observation on efficacy of intraoperative submucosal injection of HCPT and postoperative bladder irrigation in treatment of bladder cancer Chin J Clin Oncol Rehabil 14 2007 433 434
27. W. Hu, C. Zhang, Y. Fang, and C.H. Lou Anticancer properties of 10-Hydroxycamptothecin in a murine melanoma pulmonary metastasis model in vitro and in vivo Toxicol In Vitro 25 2011 513 520
28. L. Zhang, S. Li, H. Liao, W.Q. Jiang, and Z.Z. Guan Phase I trial of pharmacokinetics and human tolerability to 10-Hydroxycamptothecin in patients with advanced malignancy Chin J Cancer 20 2001 1391 1395
29. J.A. Hersey, and P.C. Cook Homogeneity of pharmaceutical dispersed systems J Pharm Pharmacol 26 1974 126 133