Effect of injection routes on pharmacokinetics and lactone/carboxylate equilibrium of 9-Nitrocamptothecin in rats

International Journal of Pharmaceutics

Volumn 340, Issue 1-2, 2007, Pages 29-33

  Chen, Jun ^a,b   Ping, Qineng ^b   Guo, Jianxin ^c   Liu, Minling ^b   Cai, Baochang ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

9 Nitrocamptothecin; Intramuscular injection; Intravenous injection; Lactone; Pharmacokinetics; Rats

Indexed keywords

CARBOXYLATE 9 NITROCAMPTOTHECIN; CARBOXYLIC ACID; LACTONE; LACTONE 9 NITROCAMPTOTHECIN; RUBITECAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AREA UNDER CURVE; BIOTRANSFORMATION; CAMPTOTHECIN; CARBOXYLIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; LACTONES; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 34447275732     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.03.008     Document Type: Article

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