Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 18, 2012, Pages 5839-5844

  Bandgar, Babasaheb P ^a   Adsul, Laxman K ^a   Chavan, Hemant V ^a   Jalde, Shivkumar S ^a   Shringare, Sadanand N ^a   Shaikh, Rafique ^b   Meshram, Rohan J ^b   Gacche, Rajesh N ^b   Masand, Vijay ^c  

^a SOLAPUR UNIVERSITY   (India)

^b SWAMI RAMANAND TEERTH MARATHWADA UNIVERSITY   (India)

^c Camp Amravati ^*  (India)

Author keywords

Anti inflammatory activity; Antioxidant; Carbazole; Molecular docking; Pyrazoline

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 3 [3 (3,4 DIFLUOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 9 METHYL 9H CARBAZOLE; 3 [3 (3,4 DIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 9 METHYL 9H CARBAZOLE; 3 [3 (4 BROMOPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 9 METHYL 9H CARBAZOLE; 3 [3 (4 CHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 9 METHYL 9H CARBAZOLE; 3 [3 (4 FLUOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 9 METHYL 9H CARBAZOLE; 3 [3 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 9 METHYL 9H CARBAZOLE; 9 METHYL 3 (3 PHENYL 4,5 DIHYDRO 1H PYRAZOL 5 YL) 9H CARBAZOLE; 9 METHYL 3 [3 (4 NITROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 9H CARBAZOLE; 9 METHYL 3 [3 (THIOPHEN 2 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL] 9H CARBAZOLE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ASCORBIC ACID; CARRAGEENAN; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; BIPHENYL COMPOUNDS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FREE RADICAL SCAVENGERS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PICRATES; PYRAZOLES; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES;

PUFFINUS AURICULARIS; RATTUS;

EID: 84865471777     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.080     Document Type: Article

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