Modeling formamide denaturation of probe-target hybrids for improved microarray probe design in microbial diagnostics

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Yilmaz, L Safak ^a   Loy, Alexander ^c   Wright, Erik S ^b   Wagner, Michael ^c   Noguera, Daniel R ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b University of Wisconsin Madison   (United States)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

FORMAMIDE; RIBOSOME RNA;

ACCURACY; AMPLICON; ARTICLE; BACTERIAL GENE; CONCENTRATION (PARAMETERS); DENATURATION; EQUIPMENT DESIGN; ESCHERICHIA COLI; FLUORESCENCE; GENE TARGETING; LINEAR FREE ENERGY MODEL; MICROARRAY ANALYSIS; MICROBIAL COMMUNITY; MICROBIAL IDENTIFICATION; MOLECULAR MODEL; NONHUMAN; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDE SEQUENCE; OLIGONUCLEOTIDE PROBE; PREDICTIVE VALIDITY; PROCESS OPTIMIZATION; RHODOBACTER SPHAEROIDES; RNA STRUCTURE; SENSITIVITY AND SPECIFICITY; SIMULATION; THERMODYNAMICS;

BASE SEQUENCE; ESCHERICHIA COLI K12; FORMAMIDES; MODELS, STATISTICAL; NUCLEIC ACID DENATURATION; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGONUCLEOTIDE PROBES; RHODOBACTER SPHAEROIDES; RNA, BACTERIAL; RNA, RIBOSOMAL, 16S; THERMODYNAMICS; TRANSITION TEMPERATURE;

EID: 84865426331     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043862     Document Type: Article

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