Pharmacological stimulation of type 5 adenylyl cyclase stabilizes heart rate under both microgravity and hypergravity induced by parabolic flight

Journal of Pharmacological Sciences

Volumn 119, Issue 4, 2012, Pages 381-389

  Bai, Yunzhe ^a   Tsunematsu, Takashi ^a   Jiao, Qibin ^a   Ohnuki, Yoshiki ^b   Mototani, Yasumasa ^b   Shiozawa, Kouichi ^b   Jin, Meihua ^a   Cai, Wenqian ^a   Jin, Hui Ling ^a   Fujita, Takayuki ^a   Ichikawa, Yasuhiro ^a   Suita, Kenji ^a   Kurotani, Reiko ^a,c   Yokoyama, Utako ^a   Sato, Motohiko ^a   Iwatsubo, Kousaku ^d   Ishikawa, Yoshihiro ^a,d   Okumura, Satoshi ^a,b  

^a YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TSURUMI UNIVERSITY   (Japan)

^c YAMAGATA UNIVERSITY   (Japan)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Adenylyl cyclase isoform; Autonomic nerve activity; Heart rate variability; Microgravity; Parabolic flight

Indexed keywords

6 (3 DIMETHYLAMINOPROPIONYL)FORSKOLIN; ADENYLATE CYCLASE; TYPE 5 ADENYLATE CYCLASE; UNCLASSIFIED DRUG; VIDARABINE;

ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC DYSFUNCTION; AUTONOMIC NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; FLIGHT; GRAVITATIONAL STRESS; HEART RATE; HEART RATE VARIABILITY; MALE; MICROGRAVITY; MOUSE; NONHUMAN; PARABOLIC FLIGHT; PHARMACOLOGICAL STIMULATION; REGULATORY MECHANISM; RR INTERVAL; WEIGHTLESSNESS;

EID: 84865410254     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12102FP     Document Type: Article

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