Inhalative vs. systemic IL-10 administration: Differences in the systemic inflammatory response and end-organ inflammation following hemorrhagic shock

Cytokine

Volumn 60, Issue 1, 2012, Pages 266-270

  Pfeifer, Roman ^a   Lichte, Philipp ^a   Schreiber, Helen ^a   Sellei, Richard M ^a   Schmidt, Joachim ^b   Dombroski, Derek ^c   Pape, Hans Christoph ^a   Kobbe, Philipp ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c Parkland Health and Hospital Systems   (United States)

Author keywords

End organ inflammation; Hemorrhagic shock; Inhalation; Interleukin 10; Systemic inflammation

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; LIPOPOLYSACCHARIDE BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RECOMBINANT INTERLEUKIN 10;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMORRHAGIC SHOCK; HEPATITIS; INHALER; MALE; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESUSCITATION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ACUTE-PHASE PROTEINS; ADMINISTRATION, INHALATION; ANIMALS; CARRIER PROTEINS; CHEMOKINE CCL2; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATITIS; INFLAMMATION; INJECTIONS, INTRA-ARTERIAL; INTERLEUKIN-10; INTERLEUKIN-6; LIVER; LUNG; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; PEROXIDASE; PNEUMONIA; SHOCK, HEMORRHAGIC; TIME FACTORS;

ANIMALIA; MUS;

EID: 84865409475     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.05.028     Document Type: Article

References (31)

1. Akkose S., Ozgurer A., Bulut M., Koksal O., Ozdemir F., Ozguc H. Relationships between markers of inflammation, severity of injury, and clinical outcomes in hemorrhagic shock. Adv Ther 2007, 24:955-962.
2. Bivas-Benita M., Zwier R., Junginger H.E., Borchard G. Non-invasive pulmonary aerosol delivery in mice by the endotracheal route. Eur J Pharm Biopharm 2005, 61:214-218.
3. Dentener M.A., Vreugdenhil A.C., Hoet P.H., Vernooy J.H., Nieman F.H., Heumann D., et al. Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implication for local defense to bacterial endotoxins. Am J Respir Cell Mol Biol 2000, 23:146-153.
4. Dhingra S., Sharma A.K., Arora R.C., Slezak J., Singal P.K. IL-10 attenuated TNF-alpha-induced NFkB pathway activation and cardiomyocyte apoptosis. Cardiovasc Res 2009, 82:59-66.
5. Fan J., Li Y., Levy R.M., Fan J.J., Hackam D.J., Vodovotz Y., et al. Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. J Immunol 2007, 178:6573-6580.
6. Fan J., Li Y., Vodovotz Y., Billiar T.R., Wilson M.A. Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation. Am J Physiol Lung Cell Mol Physiol 2006, 290:L738-L746.
7. Gebhard F., Pfetsch H., Steinbach G., Stecker W., Kinzl L., Brückner U.B. Is interleukin 6 an early marker of injury severity following major trauma in humans. Arch Surg 2000, 135:291-295.
8. Giannoudis P., Smith R.M., Perry S.L., Windsor A.J., Dickson R.A., Bellamy M.C. Immediate IL-10 expression following major orthopaedic trauma: relationship to anti-inflammatory response and subsequent development of sepsis. Intersive Care Med 2000, 26:1076-1081.
9. Goodman R.B., Pugin J., Lee J.S., Matthay M.A. Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev 2003, 14:523-535.
10. Hofstetter C., Flondor M., Hoegl S., Muhl H., Zwissler B. Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat. Crit Care Med 2005, 33:2317-2322.
11. Kobbe P., Lichte P., Schreiber H., Reiss L.K., Uhlig S., Pape H.C., et al. Inhalative IL-10 attenuates pulmonary inflammation following hemorrhagic shock without major alterations of the systemic inflammatory response. Mediators Inflamm. 2012, 2012:512974. [Epub 2011 Oct 20].
12. Kobbe P., Schmidt J., Stoffels B., Chanthaphavong R.S., Bauer A.J., Pape H.C. IL-10 administration attenuates pulmonary neutrophil infiltration and alters pulmonary iNOS activation following hemorrhagic shock. Inflamm Res 2009, 58:170-174.
13. Kobbe P., Stoffels B., Schmidt J., Tsukamoto T., Gutkin D.W., Bauer A.J., et al. IL-10 deficiency augments acute lung but not liver injury in hemorrhagic shock. Cytokine 2008.
14. Kobbe P., Vodovotz Y., Kaczorowski D., Mollen K.P., Billiar T.R., Pape H.C. Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture. Shock 2008, 30:43-47.
15. Kobbe P., Vodovotz Y., Kaczorowski D.J., Billiar T.R., Pape H.C. The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture. J Orthop Trauma 2008, 22:385-390.
16. Levy R.M., Mollen K.P., Prince J.M., Kaczorowski D.J., Vallabhaneni R., Liu S., et al. Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol 2007, 293:R1538-R1544.
17. Neidhardt R., Keel M., Steckholzer U., Safret A., Ungethuem U., Trenz O., et al. Relationship of interleukin-10 plasma levels to severity of injury and clinical outcome in injured patients. J Trauma 1997, 42:863-871.
18. Ouyang W., Rutz S., Crellin N.K., Valdez P.A., Hymowitz S.G. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol 2011, 29:71-109.
19. Pfeifer R., Kobbe P., Darwiche S., Billiar T.R., Pape H.C. Role of hemorrhage in the induction of systemic inflammation and remote organ damage: analysis of combined pseudo-fracture and hemorrhagic shock. J Orthop Res 2011, 29:270-274.
20. Prucha M., Herold I., Zazula R., Dubska L., Dostal M., Hildebrand T., et al. Significance of lipopolysaccharide-binding protein (an acute phase protein) in monitoring critically ill patients. Crit Care 2003, 7:154-159.
21. Rosseau S., Selhorst J., Wiechmann K., Leissner K., Maus U., Mayer K., et al. Monocyte migration through the alveolar epithelial barrier: adhesion molecule mechanisms and impact of chemokines. J Immunol 2000, 164:427-435.
22. Sabat R. IL-10 family of cytokines. Cytokine Growth Factor Rev 2010, 21:315-324.
23. Sabat R., Grütz G., Warszawska K., Kirsch S., Witte E., Wolk K., et al. Biology of interleukin 10. Cytokine Growth Factor Rev 2010, 21:331-344.
24. Sandhir R., Gregory E., He Y., Berman N.E. Upregulation of inflammatory mediators in a model of chronic pain after spinal cord injury. Neurochem Res 2011, 36:856-862.
25. Sherry R.M., Cue J.I., Goddard J.K., Parramore J.B., DiPiro J.T. Interleukin 10 is associated with the development of sepsis in trauma patients. J Trauma 1996, 40:613-616.
26. Speyer C.L., Gao H., Rancilio N.J., Heff T.A., Huffnagle G.B., Sarma J.V., et al. Novel chemokine responsiveness and mobilization of neutrophils during sepsis. Am J Pathol 2004, 165:2187-2196.
27. Thorley A.J., Ford P.A., Giembycz M.A., Goldstraw P., Young A., Tetley T.D. Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages. J Immunol 2007, 178:463-473.
28. van Zoelen M.A.D., Verstege M.I., Draing C ., de Beer R., van't Veer C., Florguin S., et al. Endogenous MCP-1 promotes lung inflammation induced by LPS and LTA. Mol Immunol 2011, 48:1468-1476.
29. Vreugdenhil A.C., Dentener M.A., Snoek A.M., Greve J.W., Buurman W.A. Lipopolysaccharide binding protein and serum amyloid A secretion by human intestinal epithelial cells during the acute phase response. J Immunol 1999, 163:2798.
30. Wright S.D., Ramos R.A., Tobias P.S., Ulevitch R.J., Mathison J.C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990, 249:1433.
31. Zimmerman M.A., Reznikov L.L., Raeburn C.D., Selzman C.H. Interleukin-10 Attenuates the Response to Vascular Injury. J Surg Res 2004, 121:206-213.