Relationship of interleukin-10 plasma levels to severity of injury and clinical outcome in injured patients

Journal of Trauma - Injury, Infection and Critical Care

Volumn 42, Issue 5, 1997, Pages 863-871

  Neidhardt, Regula ^a   Keel, Marius ^a   Steckholzer, Ursula ^a   Safret, Alexandra ^a   Ungethuem, Udo ^a   Trentz, Otmar ^a   Ertel, Wolfgang ^a,b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

ARDS; Interleukin 10; MODS; Multiple injury; Sepsis; Trauma

Indexed keywords

INTERLEUKIN 10;

ADULT; CONFERENCE PAPER; DISEASE SEVERITY; EMERGENCY TREATMENT; FEMALE; HUMAN; IMMUNE RESPONSE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; PATHOGENESIS; PRIORITY JOURNAL; SEPSIS;

EID: 0030910849     PISSN: 00225282     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005373-199705000-00017     Document Type: Conference Paper

References (45)

1. Ho AY, Moore KW. Interleukin-10 and its receptor. Ther Immunol. 1994;1:173.
2. Mosmann TR. Properties and functions of Interleukin-10. Adv Immunol. 1994;56:1.
3. Bogdan C, Vodovotz Y, Nathan C. Macrophage deactivation by Interleukin 10. J Exp Med. 1991;174:1549.
4. Geng Y, Gulbins E, Altman A, et al. Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway. Proc Natl Acad Sci USA. 1994;91:8602.
5. Wang P, Wu P, Siegel MI, et al. Interleukin (IL)-10 inhibits Nuclear Factor κB (NFκB) activation in human monocytes. J Biol Chem. 1995;270:9558.
6. Fiorentino DF, Zlotnik A, Vieira P, et al. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol. 1991;146:3444.
7. De Waal Malefyt R, Haanen J, Spits H, et al. Interleukin-10 (IL-10) and viral-IL-10 strongly reduce antigen-specific human T-cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class-II major histocompatibility complex expression. J Exp Med. 1991;174:915.
8. Cassatella MA, Meda L, Bonora S, et al. Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1β in mediating the production of IL-8 triggered by lipopolysaccharide. J Exp Med. 1993;178:2207.
9. D'Andrea A, Aste-Amezaga M, Valiante NM, et al. Interleukin 10 (IL-10) inhibits human interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med. 1993; 178:1041.
10. Chan SH, Perussia B, Gupta JW, et al. Induction of Interferon γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med. 1991;173: 869.
11. Oswald IP, Gazzinelli RT, Sher A, et al. IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity. J Immunol. 1992;148:3578.
12. Gazzinelli RT, Oswald IP, James SL, et al. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages. J Immunol. 1992;148:1792.
13. Cunha FQ, Moncada S, Liew FY. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthetase by interferon-gamma in murine macrophages. Biochem Biophys Res Commun. 1992;182:1155.
14. Sherry RM, Cué JI, Goddard JK, et al.. Interleukin-10 is associated with the development of sepsis in trauma patients. J Trauma. 1996;40:613.
15. Marchant A, Devière J, Byl B, et al. Interleukin-10 production during septicaemia. Lancet. 1994;343:707.
16. Gomez-Jimenez J, Martin MC, Sauri R, et al. Interleukin-10 and the monocyte/macrophage-induced inflammatory response in septic shock. J Infect Dis. 1995;171:472.
17. Marchant A, Alegre ML, Hakim A, et al. Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock. J Clin Immunol 1995;15:266.
18. Derkx B, Marchant A, Goldman M, et al. High levels of interleukin-10 during the initial phase of fulminant meningococcal septic shock. J Infect Dis. 1995;171:229.
19. Hauser CJ, Joshi P, Xinchun Z, et al. Production of interleukin-10 in human fracture soft-tissue hematomas. Shock. 1996;6:3.
20. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864.
21. Greenspan L, McLellan BA, Greig H. Abbreviated injury scale and injury severity score: a scoring chart. J Trauma. 1985;25:60.
22. Ertel W, Friedl HP, Trentz O. Multiple organ dysfunction syndrome (MODS) following multiple trauma: rationale and concept of therapeutic approach. Eur J Pediatr Surg. 1994; 4:243.
23. Goris RJA, Te Boekhorst TPA, Nuytinck JKS, et al. Multiple-Organ Failure-Generalized autodestructive inflammation? Arch Surg. 1985;120:1109.
24. Murray JF, Matthay MA, Luce JM, et al. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988;138:720.
25. Van Deventer SJH, Buller HR, ten Cate JW, et al. Endotoxaemia: an early predictor of septicaemia in febrile patients. Lancet. 1988;i:605.
26. De Groote D, Marchant A, Fauchet F, et al. Characterization of monoclonal antibodies against human interleukin-10 and their use in an ELISA for the measurement of this cytokine. J Immunol Methods. 1994;177:225.
27. Ertel W, Keel M, Bonaccio M, et al. Release of anti-inflammatory mediators following mechanical trauma correlates with severity of injury and clinical outcome. J Trauma. 1995;39:879.
28. Knaus WA, Draper EA, Wagner DP, et al. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818.
29. Joyce DA, Gibbons DP, Green P, et al. Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes. Eur J Immunol. 1994;24:2699.
30. Jenkins JK, Mark M, Arend WP. The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1β production in human monocytes and neutrophils. Lvmphokine Cytok Res. 1994;13:47.
31. O'Mahony JB, Palder SB, Wood JJ, et al. Depression of cellular immunity after multiple trauma in the absence of sepsis. J Trauma. 1984;24:869.
32. Keel M, Schregenberger N. Steckholzer U, et al. Endotoxin tolerance after severe injury and its regulatory mechanisms. J Trauma. 1996;41:430.
33. Hauser CJ, Lagoo S, Lagoo A, et al. Human peripheral mononuclear cells do not show proinflammatory patterns of cytokine transcription in early trauma: a preliminary report. Shock. 19954:247.
34. Bone RC. The pathogenesis of sepsis. Ann Intern Med. 1991;115:457.
35. Tracey KJ, Vlassara H, Cerami A. Cachectin/Tumour necrosis factor. Lancet. 1989;i:1122.
36. Gérard C, Bruyns C, Marchant A, et al. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med. 1993; 177:547.
37. Howard M, Muchamuel T, Andrade S, et al. Interleukin 10 protects mice from lethal endotoxemia. J Exp Med. 1993; 177:1205.
38. Randow F, Syrbe U, Meisel C, et al. Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor β. J Exp Med. 1995;181:1887.
39. De Waal Malefyt R, Abrams J, Bennett B, et al. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med. 1991;174:1209.
40. Standiford TJ, Strieter RM, Lukacs NW, et al. Neutralization of IL-10 increases lethality in endotoxemia. J Immunol. 1995;155:2222.
41. Kusske AM, Rongione AJ, Ashley SW, et al. Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice. Surgery. 1996;120:284.
42. Taga K, Tosato G. IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol. 1992;148:1143.
43. O'Sullivan ST, Lederer JA, Horgan AF, et al. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann Surg. 1995;222:482.
44. Knolle P, Schlaak J, Uhrig A, et al. Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge. J Hepatol. 1995;22:226.
45. Ertel W, Keel M, Steckholzer U, et al. Interleukin-10 attenuates the release of proinflammatory cytokines but depresses splenocyte functions in murine endotoxemia. Arch Surg. 1996;131:51.