High cholesterol diet effects on ischemia- reperfusion injury of the heart

Canadian Journal of Physiology and Pharmacology

Volumn 90, Issue 9, 2012, Pages 1185-1196

  D'Annunzio, Verónica ^a   Donato, Martín ^a   Buchholz, Bruno ^a   Pérez, Virginia ^a   Miksztowicz, Verónica ^a   Berg, Gabriela ^a   Gelpi, Ricardo J ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Hypercholesterolemia; Ischemia reperfusion injury; Ischemic postconditioning; Ischemic preconditioning; Myocardial infarction; Statins; Ventricular function

Indexed keywords

ATORVASTATIN; DOXYCYCLINE; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

CHOLESTEROL DIET; DRUG EFFECT; HEART INFARCTION SIZE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE OXYGEN CONSUMPTION; HEART PROTECTION; HEART VENTRICLE FAILURE; HEART VENTRICLE FUNCTION; HYPERCHOLESTEROLEMIA; ISCHEMIC POSTCONDITIONING; ISCHEMIC PRECONDITIONING; NONHUMAN; PATHOPHYSIOLOGY; PLEIOTROPY; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; STUNNED HEART MUSCLE;

ANIMALS; CHOLESTEROL, DIETARY; DIET, HIGH-FAT; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; ISCHEMIC POSTCONDITIONING; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MYOCARDIAL REPERFUSION INJURY; SPECIES SPECIFICITY; TREATMENT OUTCOME; VENTRICULAR FUNCTION;

EID: 84865405351     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y2012-085     Document Type: Review

References (70)

1. Adameova, A., Harcarova, A., Matejikova, J., Pancza, D., Kuzelova, M., Carnicka, S., et al. 2009. Simvastatin alleviates myocardial contractile dysfunction and lethal ischemic injury in rat heart independent of cholesterol-lowering effects. Physiol. Res. 58(3): 449-454. PMID:19627175.
2. Ali, F., Zakkar, M., Karu, K., Lidington, E.A., Hamdulay, S.S., Boyle, J.J., et al. 2009. Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow. J. Biol. Chem. 284(28): 18882-18892. doi:10.1074/jbc.M109. 009886. PMID:19457866.
3. Anitschkow, N., and Chalatow, S. 1983. On experimental cholesterin steatosis and its significant in the origin of some pathological procceses. Arterioscler. Thromb. Vasc. Biol. 3: 178-182. doi:10. 1161/01.ATV.3.2.178. PMID:6340651.
4. Balakumar, P., Kathuria, S., Taneja, G., Kalra, S., and Mahadevan, N. 2012. Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins? J. Mol. Cell. Cardiol. 52(1): 83-92. PMID:21968328.
5. Bauersachs, J., Hiss, K., Fraccarollo, D., Laufs, U., and Ruetten, H. 2006. Simvastatin improves left ventricular function after myocardial infarction in hypercholesterolemic rabbits by anti-inflammatory effects. Cardiovasc. Res. 72(3): 438-446. doi:10. 1016/j.cardiores.2006.08.014. PMID:17026973.
6. Bell, R.M., and Yellon, D.M. 2003. Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by upregulating a pro-survival pathway. J. Am. Coll. Cardiol. 41(3): 508-515. doi:10.1016/S0735-1097(02) 02816-4. PMID:12575984.
7. Birnbaum, Y., Lin, Y., Ye, Y., Merla, R., Perez-Polo, J.R., and Uretsky, B.F. 2008. Pretreatment with high-dose statin, but not low-dose statin, ezetimibe, or the combination of low-dose statin and ezetimibe, limits infarct size in the rat. J. Cardiovasc. Pharmacol. Ther. 13(1): 72-79. doi:10.1177/1074248407312839. PMID:18287593.
8. Bulgarelli, A., Martins Dias, A.A., Caramelli, B., and Maranhão, R.C. 2012. Treatment with methotrexate inhibits atherogenesis in cholesterol-fed rabbits. J. Cardiovasc. Pharmacol. 59(4): 308-314. doi:10.1097/FJC.0b013e318241c385. PMID:22113347.
9. Calabresi, L., Gomaraschi, M., Villa, B., Omoboni, L., Dmitrieff, C., and Franceschini, G. 2002. Elevated soluble cellular adhesion molecules in subjects with low HDL-cholesterol. Arterioscler. Thromb. Vasc. Biol. 22(4): 656-661. doi:10.1161/hq0402.105901. PMID:11950706.
10. Čarnická, S., Adameová, A., Nemčeková, M., Matejíková, J., Pancza, D., and Ravingerová, T. 2011. Distinct effects of acute pretreatment with lipophilic and hydrophilic statins on myocardial stunning, arrhythmias and lethal injury in the rat heart subjected to ischemia/reperfusion. Physiol. Res. 60(5): 825-830. PMID: 22106818.
11. Ciruzzi, M., Schargrodsky, H., Rozlosnik, J., Pramparo, P., Delmonte, H., Rudich, V., et al. (Argentine FRICAS (Factores de Riesgo Coronario en America del Sur) Investigators). 1997. Frequency of family history of acute myocardial infarction in patients with acute myocardial infarction. Am. J. Cardiol. 80(2): 122-127. doi:10.1016/S0002-9149(97)00304-4. PMID:9230145.
12. D'Annunzio, V., Donato, M., Sabán, M., Sanguinetti, S.M., Wikinski, R.L., and Gelpi, R.J. 2005. Hypercholesterolemia attenuates postischemic ventricular dysfunction in the isolated rabbit heart. Mol. Cell. Biochem. 273(1-2): 137-143. doi:10.1007/s11010-005-8264-6. PMID:16013448.
13. D'Annunzio, V., Donato, M., Erni, L., Miksztowicz, V., Buchholz, B., Carrión, C.L., et al. 2009. Rosuvastatin given during reperfusion decreases infarct size and inhibits matrix metalloproteinase-2 activity in normocholesterolemic and hypercholesterolemic rabbits. J. Cardiovasc. Pharmacol. 53(2): 137-144. doi:10.1097/FJC. 0b013e318197c5e9. PMID:19188835.
14. Dawber, T.R., Meadors, G.F., and Moore, F.E., Jr. 1951. Epidemio-logical approaches to heart disease: the Framingham Study. Am. J. Public Health Nations Health, 41(3): 279-286. doi:10.2105/AJPH. 41.3.279. PMID:14819398.
15. Di Napoli, P., Taccardi, A.A., Grilli, A., De Lutiis, M.A., Barsotti, A., Felaco, M., and Decaterina, R. 2005. Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts. Cardiovasc. Res. 66(3): 462-471. doi:10.1016/j.cardiores.2005.02.008. PMID: 15914111.
16. +(ATP) channels in both normal and hypercholesterolemic rabbits. J. Cardiovasc. Pharmacol. 49(5): 287-292. doi:10.1097/FJC.0b013e31803c55fe. PMID: 17513947.
17. Dworakowski, R., Dworakowska, D., Kocic, I., Wirth, T., Gruchała, M., Kamiński, M., et al. 2008. Experimental hyperlipidaemia does not prevent preconditioning and it reduces ischemia-induced apoptosis. Int. J. Cardiol. 126(1): 62-67. doi:10.1016/j.ijcard. 2007.03.117. PMID:17482295.
18. Dworschak, M., d'Uscio, L.V., Breukelmann, D., and Hannon, J.D. 2005. Increased tolerance to hypoxic metabolic inhibition and reoxygenation of cardiomyocytes from apolipoprotein E-deficient mice. Am. J. Physiol. Heart Circ. Physiol. 289(1): H160-H167. doi:10.1152/ajpheart.00895.2004. PMID:15734885.
19. Ferdinandy, P., Szilvássy, Z., Horváth, L.I., Csont, T., Csonka, T., Nagy, C., et al. 1997. Loss of pacing-induced preconditioning in rat hearts: role of nitric oxide and cholesterol-enriched diet. J. Mol. Cell. Cardiol. 29(12): 3321-3333. doi:10.1006/jmcc.1997.0557. PMID:9441838.
20. Ginsberg, H.N. 1995. Update on the treatment of hypercholester-olemia, with a focus on HMG-CoA reductase inhibitors and combination regimens. Clin. Cardiol. 18(6): 307-315. doi:10. 1002/clc.4960180605. PMID:7664504.
21. Golino, P., Maroko, P.R., and Carew, T.E. 1987. The effect of acute hypercholesterolemia on myocardial infarct size and the no-reflow phenomenon during coronary occlusion-reperfusion. Circulation, 75(1): 292-298. doi:10.1161/01.CIR.75.1.292. PMID:3791611.
22. Görbe, A., Varga, Z.V., Kupai, K., Bencsik, P., Kocsis, G.F., Csont, T., et al. 2011. Cholesterol diet leads to attenuation of ischemic preconditioning-induced cardiac protection: the role of connexin 43. Am. J. Physiol. Heart Circ. Physiol. 300(5): H1907-H1913. doi:10.1152/ajpheart.01242.2010. PMID:21398600.
23. Hadi, N.R., Al-Amran, F., Hussein, M.A.A., and Rezeg, F.A. 2012. Evaluation of the effects of glimepiride (Amaryl) and repaglinide (novoNorm) on atherosclerosis progression in high cholesterol-fed male rabbits. J. Cardiovasc. Dis. Res. 3(1): 5-11. doi:10.4103/ 0975-3583.91592. PMID:22346138.
24. Hoeg, J.M., and Brewer, H.B., Jr. 1987. 3-Hydroxy-3-methylglu-taryl-coenzyme A reductase inhibitors in the treatment of hypercholesterolemia. JAMA, 258(24): 3532-3536. doi:10.1001/ jama.1987.03400240064025. PMID:3316727.
25. Huang, Y., Walker, K.E., Hanley, F., Narula, J., Houser, S.R., and Tulenko, T.N. 2004. Cardiac systolic and diastolic dysfunction after a cholesterol-rich diet. Circulation, 109(1): 97-102. doi:10. 1161/01.CIR.0000109213.10461.F6. PMID:14676147.
26. Ikeda, Y., Young, L.H., and Lefer, A.M. 2003. Rosuvastatin, a new HMG-CoA reductase inhibitor, protects ischemic reperfused myocardium in normocholesterolemic rats. J. Cardiovasc. Pharmacol. 41(4): 649-656. doi:10.1097/00005344-200304000-00019. PMID:12658068.
27. Iliodromitis, E.K., Zoga, A., Vrettou, A., Andreadou, I., Paraskevai-dis, I.A., Kaklamanis, L., and Kremastinos, D.T. 2006. The effectiveness of postconditioning and preconditioning on infarct size in hypercholesterolemic and normal anesthetized rabbits. Atherosclerosis, 188(2): 356-362. doi:10.1016/j.atherosclerosis. 2005.11.023. PMID:16376892.
28. Iliodromitis, E.K., Andreadou, I., Prokovas, E., Zoga, A., Farmakis, D., Fotopoulou, T., et al. 2010. Simvastatin in contrast to postconditioning reduces infarct size in hyperlipidemic rabbits: possible role of oxidative/nitrosative stress attenuation. Basic Res. Cardiol. 105(2): 193-203. doi:10.1007/s00395-009-0078-3. PMID:20066537.
29. Ishibashi, S., Goldstein, J.L., Brown, M.S., Herz, J., and Burns, D.K. 1994. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J. Clin. Invest. 93(5): 1885-1893. doi:10.1172/JCI117179. PMID:8182121.
30. Jennings, R., Steenbergen, C., and Reimer, K. 1995. Myocardial Ischemia and Reperfusion. Cardiovascular Pathology International Academy of Pathology Monograph. Edited by Schoen and Gimbrone. Williams & Wilkins. pp. 47-79.
31. Jones, S.P., Trocha, A.D., and Lefer, D.J. 2001. Pre-treatment with simvastatin attenuates myocardial dysfunction after ischemia and chronic reperfusion. Arterioscler. Thromb. Vasc. Biol. 21(12): 2059-2064. doi:10.1161/hq1201.099509. PMID:11742885.
32. Juhasz, B., Der, P., Turoczi, T, Bacskay, I., Varga, E., and Tosaki, A. 2004. Preconditioning in intact and previously diseased myocardium: laboratory or clinical dilemma?. Antioxid Redox Signal.6 (2): 325-333. doi:10.1089/152308604322899396. PMID: 15025934.
33. Jung, O., Jung, W., Malinski, T., Wiemer, G., Schoelkens, B.A., and Linz, W. 2000. Ischemic preconditioning and infarct mass: the effect of hypercholesterolemia and endothelial dysfunction. Clin. Exp. Hypertens. 22(2): 165-179. doi:10.1081/CEH-100100070. PMID:10744357.
34. Kalaivanisailaja, J., Manju, V., and Nalini, N. 2003. Lipid profile in mice fed a high-fat diet after exogenous leptin administration. Pol. J. Pharmacol. 55(5): 763-769. PMID:14704473.
35. Kannel, W.B., DAwber, T.R., Kagan, A., Revotskie, N., and Stokes, J., III. 1961. Factors of risk in the development of coronary heart disease-six year follow-up experience.The Framingham Study. Ann. Intern. Med. 55: 33-50. PMID:13751193.
36. Keys, A., Aravanis, C., Blackburn, H.W., Van Buchem, F.S., Buzina, R., Djordjević, B.D., et al. 1966. Epidemiological studies related to coronary heart disease: characteristics of men aged 40-59 in seven countries. Acta Med. Scand. Suppl. 460: 1-392. PMID: 5226858.
37. Kocsis, G.F., Csont, T., Varga-Orvos, Z., Puskas, L.G., Murlasits, Z., and Ferdinandy, P. 2010. Expression of genes related to oxidative/ nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. Med. Sci. Monit. 16(1): BR32-BR39. PMID: 20037483.
38. Kremastinos, D.T., Bofilis, E., Karavolias, G.K., Papalois, A., Kaklamanis, L., and Iliodromitis, E.K. 2000. Preconditioning limits myocardial infarct size in hypercholesterolemic rabbits. Atherosclerosis, 150(1): 81-89. doi:10.1016/S0021-9150(99) 00389-5. PMID:10781638.
39. Kupai, K., Csonka, C., Fekete, V., Odendaal, L., Van Rooyen, J., Marais, D.W., et al. 2009. Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitrite. Am. J. Physiol. Heart Circ. Physiol. 297(5): H1729-H1735. doi:10.1152/ajpheart.00484.2009. PMID:19734363.
40. Kyriakides, Z.S., Psychari, S., Iliodromitis, E.K., Kolettis, T.M., Sbarouni, E., and Kremastinos, D.T. 2002. Hyperlipidemia prevents the expected reduction of myocardial ischemia on repeated balloon inflations during angioplasty. Chest, 121(4): 1211-1215. doi:10.1378/chest.121.4.1211. PMID:11948055.
41. Le Grand, B., Vié, B., Fauré, P., Degryse, A.-D., Mouillard, P., and John, G.W. 1995. Increased resistance to ischaemic injury in the isolated perfused atherosclerotic heart of the cholesterol-fed rabbit. Cardiovasc. Res. 30(5): 689-696. PMID:8595614.
42. Luo, T.Y., Su, M.J., Yang, Y.F., Liu, Y.B., Liang, H.C., Wu, C.C., and Lee, Y.-T. 2004. Effect of hypercholesterolemia on myocardial function in New Zealand white rabbits. J. Biomed. Sci. 11(6): 829-837. doi:10.1007/BF02254368. PMID:15591780.
43. Mosca, L., and Biviano, A. National Cholesterol Education Program. 2002. Lipid-lowering therapies in the management of acute coronary syndromes. Curr. Cardiol. Rep. 4(4): 320-326. doi:10. 1007/s11886-002-0068-7. PMID:12052271.
44. Osipov, R.M., Bianchi, C., Feng, J., Clements, R.T., Liu, Y., Robich, M.P., et al. 2009. Effect of hypercholesterolemia on myocardial necrosis and apoptosis in the setting of ischemia-reperfusion. Circulation, 120(11 Suppl.): S22-S30. doi:10.1161/ CIRCULATIONAHA.108.842724. PMID:19752371.
45. Penna, C., Mancardi, D., Raimondo, S., Geuna, S., and Pagliaro, P. 2008. The paradigm of postconditioning to protect the heart. J. Cell. Mol. Med. 12(2): 435-458. doi:10.1111/j.1582-4934.2007. 00210.x. PMID:18182064.
46. Peterson, D.W., Napolitano, C.A., and Griffith, D.W., Jr. 1980. Spontaneous mechanical alternans in papillary muscles from atherosclerotic rabbits. Am. J. Physiol. 239(5): H674-H680. PMID:7435642.
47. Roger, V.L., Go, A.S., Lloyd-Jones, D.M., Adams, R.J., Berry, J.D., Brown, T.M., et al. (American Heart Association Statistics Committee and Stroke Statistics Subcommittee). 2011. Heart disease and stroke statistics-2011 update: a report from the American Heart Association. Circulation, 123(4): e18-e209. doi:10.1161/CIR.0b013e3182009701. PMID:21160056.
48. Rubinstein, J., Pelosi, A., Vedre, A., Kotaru, P., and Abela, G.S. 2009. Hypercholesterolemia and myocardial function evaluated via tissue doppler imaging. Cardiovasc. Ultrasound, 7(1): 56. doi:10.1186/1476-7120-7-56. PMID:19943937.
49. Sakamoto, S., Kashiki, M., Imai, N., Liang, C.S., and Hood, W.B., Jr. 1991. Effects of short-term, diet-induced hypercholesterolemia on systemic hemodynamics, myocardial blood flow, and infarct size in awake dogs with acute myocardial infarction. Circulation, 84(1): 378-386. PMID:2060108.
50. Satoh, K., Takaguri, A., Itagaki, M., Kano, S., and Ichihara, K. 2008. Effects of rosuvastatin and pitavastatin on ischemia-induced myocardial stunning in dogs. J. Pharmacol. Sci. 106(4): 593-599. doi:10.1254/jphs.08017FP. PMID:18403900.
51. Scalia, R., Gooszen, M.E., Jones, S.P., Hoffmeyer, M., Rimmer, D. M., 3rd, Trocha, S.D., et al. 2001. Simvastatin exerts both anti-inflammatory and cardioprotective effects in apolipoprotein E-deficient mice. Circulation, 103(21): 2598-2603. PMID: 11382730.
52. Schwartz, L.M., and Lagranha, C.J. 2006. Ischemic postconditioning during reperfusion activates Akt and ERK without protecting against lethal myocardial ischemia-reperfusion injury in pigs. Am. J. Physiol. Heart Circ. Physiol. 290(3): H1011-H1018. doi:10. 1152/ajpheart.00864.2005. PMID:16214840.
53. Shah, K.R., Kolar, F., Beamish, R.E., and Dhalla, N.S. 1990. Depression in cardiac contractile force induced by cholesterol. Cardioscience, 1(4): 255-259. PMID:2151760.
54. Shkliar, T.F., Bliakhman, F.A., and Aretinski V.B. 1991. Otsenka sokratimosti miokarda pri éksperimental'nom ateroskleroze [An assessment of myocardial contractility in experimental atherosclerosis]. Fiziol. Zh. SSSR Im. I M Sechenova, 77(11): 48-54. PMID:1668667.
55. Song, G., Tian, H., Qin, S., Sun, X., Yao, S., Zong, C., et al. 2012. Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice. Atherosclerosis, 221(1): 55-65. doi:10.1016/j. atherosclerosis.2011.11.043. PMID:22209213.
56. Szilvassy, Z., Ferdinandy, P., Nagy, I., Jakab, I., and Koltai, M. 1997. The effect of continuous versus intermittent treatment with transdermal nitroglycerin on pacing-induced preconditioning in conscious rabbits. Br. J. Pharmacol. 121(3): 491-496. doi:10. 1038/sj.bjp.0701163. PMID:9179391.
57. Szucs, G., Bester, D.J., Kupai, K., Csont, T., Csonka, C., Esterhuyse, A.J., et al. 2011. Dietary red palm oil supplementation decreases infarct size in cholesterol fed rats. Lipids Health Dis. 10(1): 103. doi:10.1186/1476-511X-10-103. PMID:21689423.
58. Talini, E., Di Bello, V., Bianchi, C., Palagi, C., Delle Donne, M.G., Penno, G., et al. 2008. Early impairment of left ventricular function in hypercholesterolemia and its reversibility after short term treatment with rosuvastatin: a preliminary echocardiographic study. Atherosclerosis, 197(1): 346-354. doi:10.1016/j. atherosclerosis.2007.05.024. PMID:17631295.
59. Tang, X.L., Stein, A.B., Shirk, G., and Bolli, R. 2004. Hypercho-lesterolemia blunts NO donor-induced late preconditioning against myocardial infarction in conscious rabbits. Basic Res. Cardiol. 99 (6): 395-403. doi:10.1007/s00395-004-0485-4. PMID:15372283.
60. Thuc, L.C., Teshima, Y., Takahashi, N., Nagano-Torigoe, Y., Ezaki, K., Yufu, K., et al. 2010. Mitochondrial K(ATP) channels-derived reactive oxygen species activate pro-survival pathway in pravas-tatin-induced cardioprotection. Apoptosis, 15(6): 669-678. doi:10. 1007/s10495-010-0473-0. PMID:20151195.
61. Tiefenbacher, C.P., Kapitza, J., Dietz, V., Lee, C.-H., and Niroomand, F. 2003. Reduction of myocardial infarct size by fluvastatin. Am. J. Physiol. Heart Circ. Physiol. 285(1): H59-H64. PMID: 12623790.
62. Tilton, R.G., Cole, P.A., Zions, J.D., Daugherty, A., Larson, K.B., Sutera, S.P., et al. 1987. Increased ischemia-reperfusion injury to the heart associated with short-term, diet-induced hypercholester-olemia in rabbits. Circ. Res. 60(4): 551-559. PMID:3594739.
63. Toleikis, P.M., and Tomlinson, C.W. 1987. Improved functional recovery of the atherosclerotic rabbit heart subjected to nor-mothermic global ischemia. Can. J. Cardiol. 3(7): 345-350. PMID:3427533.
64. Ueda, Y., Kitakaze, M., Komamura, K., Minamino, T., Asanuma, H., Sato, H., et al. 1999. Pravastatin restored the infarct size-limiting effect of ischemic preconditioning blunted by hypercholesterolemia in the rabbit model of myocardial infarction. J. Am. Coll. Cardiol. 34(7): 2120-2125. doi:10.1016/S0735-1097(99)00440-4. PMID:10588233.
65. Van Craeyveld, E., Jacobs, F., Gordts, S.C., and De Geest, B. 2011. Low-density lipoprotein receptor gene transfer in hypercholester-olemic mice improves cardiac function after myocardial infarction. Gene Ther. In press doi:10.1038/gt.2011.147. PMID:21975462.
66. Van de Velde, M., DeWolff, M., Leather, H.A., and Wouters, P.F. 2000. Effects of lipids on the functional and metabolic recovery from global myocardial stunning in isolated rabbit hearts. Cardiovasc. Res. 48(1): 129-137. doi:10.1016/S0008-6363(00) 00151-6. PMID:11033115.
67. Vinten-Johansen, J., Yellon, D.M., and Opie, L.H. 2005. Postconditioning: a simple, clinically applicable procedure to improve revascularization in acute myocardial infarction. Circulation, 112 (14): 2085-2088. doi:10.1161/CIRCULATIONAHA.105.569798. PMID:16203924.
68. Wang, T.D., Chen, W.J., Su, S.S., Lo, S.C., Lin, W.W., and Lee, Y.T. 2002a. Increased cardiomyocyte apoptosis following ischemia and reperfusion in diet-induced hypercholesterolemia: relation to Bcl-2 and Bax proteins and caspase-3 activity. Lipids, 37(4): 385-394. doi:10.1007/s1145-002-0906-2. PMID:12030319.
69. Wang, W., Schulze, C.J., Suarez-Pinzon, W.L., Dyck, J.R., Sawicki, G., and Schulz, R. 2002b. Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury. Circulation, 106(12): 1543-1549. doi:10.1161/ 01.CIR.0000028818.33488.7B. PMID:12234962.
70. Zhai, Y., Gao, X., Wu, Q., Peng, L., Lin, J., and Zuo, Z. 2008. Fluvastatin decreases cardiac fibrosis possibly through regulation of TGF-beta(1)/Smad 7 expression in the spontaneously hypertensive rats. Eur. J. Pharmacol. 587(1-3): 196-203. doi:10.1016/j. ejphar.2008.03.006. PMID:18430418.