Low-density lipoprotein receptor gene transfer in hypercholesterolemic mice improves cardiac function after myocardial infarction

Gene Therapy

Volumn 19, Issue 8, 2012, Pages 860-871

  Van Craeyveld, E ^a   Jacobs, F ^a   Gordts, S C ^a   De Geest, B ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

cardiac function; hypercholesterolemia; lipid lowering; low density lipoprotein receptor gene transfer; myocardial infarction; remodeling

Indexed keywords

ADENOVIRUS VECTOR; ANGIOTENSIN RECEPTOR; ATRIAL NATRIURETIC FACTOR; CHOLESTEROL; CONNECTIVE TISSUE GROWTH FACTOR; COPPER ZINC SUPEROXIDE DISMUTASE; EXTRACELLULAR SUPEROXIDE DISMUTASE; GELATINASE A; GELATINASE B; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MANGANESE SUPEROXIDE DISMUTASE; NATRIURETIC PEPTIDE RECEPTOR A; NATRIURETIC PEPTIDE RECEPTOR B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR GENE THERAPY; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENDOTHELIAL PROGENITOR CELL; EX VIVO STUDY; FEMALE; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE RELAXATION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HYPERCHOLESTEROLEMIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LEUKOCYTE; MORTALITY; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME;

ADENOVIRIDAE; ANIMALS; CHOLESTEROL; FEMALE; HYPERCHOLESTEROLEMIA; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, LDL; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

MUS;

EID: 84864887891     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.147     Document Type: Article

References (51)

1. Sutton MG, Sharpe N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 2000; 101: 2981-2988.
2. He J, Ogden LG, Bazzano LA, Vupputuri S, Loria C, Whelton PK. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic followup study. Arch Intern Med 2001; 161: 996-1002.
3. Wang TD, Wu CC, Chen WJ, Lee CM, Chen MF, Liau CS et al. Dyslipidemias have a detrimental effect on left ventricular systolic function in patients with a first acute myocardial infarction. Am J Cardiol 1998; 81: 531-537.
4. Aronow HD, Lincoff AM, Quinn MJ, McRae AT, Gurm HS, Houghtaling PL et al. Relation between previous lipid-lowering therapy and infarct size (creatine kinase-MB level) in patients presenting with acute myocardial infarction. Am J Cardiol 2008; 102: 1119-1124.
5. Hoffmann R, Haager P, Suliman H, Christott P, Radke P, Blindt R et al. Effect of statin therapy before Q-wave myocardial infarction on myocardial perfusion. Am J Cardiol 2008; 101: 139-143.
6. Jones SP, Gibson MF, Rimmer 3rd DM, Gibson TM, Sharp BR, Lefer DJ. Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor. J Am Coll Cardiol 2002; 40: 1172-1178.
7. Wolfrum S, Dendorfer A, Schutt M, Weidtmann B, Heep A, Tempel K et al. Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway. J Cardiovasc Pharmacol 2004; 44: 348-355.
8. Jacobs F, Van Craeyveld E, Feng Y, Snoeys J, De Geest B. Adenoviral low density lipoprotein receptor attenuates progression of atherosclerosis and decreases tissue cholesterol levels in a murine model of familial hypercholesterolemia. Atherosclerosis 2008; 201: 289-297.
9. Yeagle PL. Cholesterol and the cell membrane. Biochim Biophys Acta 1985; 822: 267-287.
10. Huang Y, Walker KE, Hanley F, Narula J, Houser SR, Tulenko TN. Cardiac systolic and diastolic dysfunction after a cholesterol-rich diet. Circulation 2004; 109: 97-102.
11. Luo TY, Su MJ, Yang YF, Liu YB, Liang HC, Wu CC et al. Effect of hypercholesterolemia on myocardial function in New Zealand white rabbits. J Biomed Sci 2004; 11: 829-837.
12. Bastiaanse EM, Atsma DE, Kuijpers MM, Van der Laarse A. The effect of sarcolemmal cholesterol content on intracellular calcium ion concentration in cultured cardiomyocytes. Arch Biochem Biophys 1994; 313: 58-63.
13. Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N et al. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Invest 2010; 120: 1506-1514.
14. Hoshida S, Yamashita N, Otsu K, Kuzuya T, Hori M. Cholesterol feeding exacerbates myocardial injury in Zucker diabetic fatty rats. Am J Physiol Heart Circ Physiol 2000; 278: H256-H262.
15. Hoshida S, Nishida M, Yamashita N, Igarashi J, Hori M, Kamada T et al. Amelioration of severity of myocardial injury by a nitric oxide donor in rabbits fed a cholesterol-rich diet. J Am Coll Cardiol 1996; 27: 902-909.
16. Osipov RM, Bianchi C, Feng J, Clements RT, Liu Y, Robich MP et al. Effect of hypercholesterolemia on myocardial necrosis and apoptosis in the setting of ischemia-reperfusion. Circulation 2009; 120: S22-S30.
17. Gao XM, Xu Q, Kiriazis H, Dart AM, Du XJ. Mouse model of post-infarct ventricular rupture: time course, strain-and gender-dependency, tensile strength, and histopathology. Cardiovasc Res 2005; 65: 469-477.
18. Wang F, Keimig T, He Q, Ding J, Zhang Z, Pourabdollah-Nejad S et al. Augmented healing process in female mice with acute myocardial infarction. Gend Med 2007; 4: 230-247.
19. Wang B, Ansari R, Sun Y, Postlethwaite AE, Weber KT, Kiani MF. The scar neovasculature after myocardial infarction in rats. Am J Physiol Heart Circ Physiol 2005; 289: H108-H113.
20. Virag JI, Murry CE. Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair. Am J Pathol 2003; 163: 2433-2440.
21. Rehman J, Li J, Orschell CM, March KL. Peripheral blood 'endothelial progenitor cells' are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 2003; 107: 1164-1169.
22. Cho HJ, Lee N, Lee JY, Choi YJ II M, Wecker A et al. Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. J Exp Med 2007; 204: 3257-3269.
23. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 1990; 81: 1161-1172.
24. Tirziu D, Chorianopoulos E, Moodie KL, Palac RT, Zhuang ZW, Tjwa M et al. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. J Clin Invest 2007; 117: 3188-3197.
25. van den Borne SW, Isobe S, Verjans JW, Petrov A, Lovhaug D, Li P et al. Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction. J Am Coll Cardiol 2008; 52: 2017-2028.
26. Langenickel T, Pagel I, Hohnel K, Dietz R, Willenbrock R. Differential regulation of cardiac ANP and BNP mRNA in different stages of experimental heart failure. Am J Physiol 2000; 278: H1500-H1506.
27. Sun Y. Intracardiac renin-angiotensin system and myocardial repair/remodeling following infarction. J Mol Cell Cardiol 2010: 483-489.
28. Lax CJ, Domenighetti AA, Pavia JM, Di Nicolantonio R, Curl CL, Morris MJ et al. Transitory reduction in angiotensin AT2 receptor expression levels in postinfarct remodelling in rat myocardium. Clin Exp Pharmacol Physiol 2004; 31: 512-517.
29. Haywood GA, Gullestad L, Katsuya T, Hutchinson HG, Pratt RE, Horiuchi M et al. AT1 and AT2 angiotensin receptor gene expression in human heart failure. Circulation 1997; 95: 1201-1206.
30. Asano K, Dutcher DL, Port JD, Minobe WA, Tremmel KD, Roden RL et al. Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium. Circulation 1997; 95: 1193-1200.
31. Lassegue B, Alexander RW, Nickenig G, Clark M, Murphy TJ, Griendling KK. Angiotensin II down-regulates the vascular smooth muscle AT1 receptor by transcriptional and post-transcriptional mechanisms: evidence for homologous and heterologous regulation. Mol Pharmacol 1995; 48: 601-609.
32. Looi YH, Grieve DJ, Siva A, Walker SJ, Anilkumar N, Cave AC et al. Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction. Hypertension 2008; 51: 319-325.
33. Hill MF, Singal PK. Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats. Am J Pathol 1996; 148: 291-300.
34. Sorescu D, Griendling KK. Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure. Congest Heart Fail 2002; 8: 132-140.
35. Oliveira HC, Cosso RG, Alberici LC, Maciel EN, Salerno AG, Dorighello GG et al. Oxidative stress in atherosclerosis-prone mouse is due to low antioxidant capacity of mitochondria. FASEB J 2005; 19: 278-280.
36. Doerries C, Grote K, Hilfiker-Kleiner D, Luchtefeld M, Schaefer A, Holland SM et al. Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction. Circ Res 2007; 100: 894-903.
37. Qin F, Simeone M, Patel R. Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction. Free Radic Biol Med 2007; 43: 271-281.
38. van Deel ED, Lu Z, Xu X, Zhu G, Hu X, Oury TD et al. Extracellular superoxide dismutase protects the heart against oxidative stress and hypertrophy after myocardial infarction. Free Radic Biol Med 2008; 44: 1305-1313.
39. Hayashidani S, Tsutsui H, Shiomi T, Suematsu N, Kinugawa S, Ide T et al. Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation 2002; 105: 868-873.
40. Tulenko TN, Chen M, Mason PE, Mason RP. Physical effects of cholesterol on arterial smooth muscle membranes: evidence of immiscible cholesterol domains and alterations in bilayer width during atherogenesis. J Lipid Res 1998; 39: 947-956.
41. Zhu Y, Liao HL, Wang N, Yuan Y, Ma KS, Verna L et al. Lipoprotein promotes caveolin-1 and Ras translocation to caveolae: role of cholesterol in endothelial signaling. Arterioscler Thromb Vasc Biol 2000; 20: 2465-2470.
42. Okamoto T, Schlegel A, Scherer PE, Lisanti MP. Caveolins, a family of scaffolding proteins for organizing 'preassembled signaling complexes' at the plasma membrane. J Biol Chem 1998; 273: 5419-5422.
43. Kutryk MJ, Pierce GN. Stimulation of sodium-calcium exchange by cholesterol incorporation into isolated cardiac sarcolemmal vesicles. J Biol Chem 1988; 263: 13167-13172.
44. Jacobs F, Snoeys J, Feng Y, Van Craeyveld E, Lievens J, Armentano D et al. Direct comparison of hepatocyte-specific expression cassettes following adenoviral and nonviral hydrodynamic gene transfer. Gene Therapy 2008; 15: 594-603.
45. Van Linthout S, Lusky M, Collen D, De Geest B. Persistent hepatic expression of human apo A-I after transfer with a helper-virus independent adenoviral vector. Gene Therapy 2002; 9: 1520-1528.
46. Van Craeyveld E, Gordts SC, Nefyodova E, Jacobs F, De Geest B. Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies. J Mol Med 2011; 89: 555-567.
47. Hadjantonakis AK, Gertsenstein M, Ikawa M, Okabe M, Nagy A. Generating green fluorescent mice by germline transmission of green fluorescent ES cells. Mech Dev 1998; 76: 79-90.
48. Weiss JL, Frederiksen JW, Weisfeldt ML. Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. J Clin Invest 1976; 58: 751-760.
49. Feng Y, Jacobs F, Van Craeyveld E, Brunaud C, Snoeys J, Tjwa M et al. Human ApoA-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2008; 28: 278-283.
50. Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y et al. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area-and length-based approaches. J Appl Physiol 2007; 102: 2104-2111.
51. Virag JA, Rolle ML, Reece J, Hardouin S, Feigl EO, Murry CE. Fibroblast growth factor-2 regulates myocardial infarct repair: effects on cell proliferation, scar contraction, and ventricular function. Am J Pathol 2007; 171: 1431-1440.