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Volumn 2, Issue 4, 2008, Pages 1384-1408

Modeling long-term longitudinal HIV dynamics with application to an AIDS clinical study

(2)  Huang, Yangxin a   Lu, Tao a  

a NONE

Author keywords

AIDS; Antiretroviral drug therapy; Bayesian nonlinear mixed effects models; Long term HIV dynamics; Longitudinal data; Time varying drug efficacy

Indexed keywords


EID: 84865361734     PISSN: 19326157     EISSN: 19417330     Source Type: Journal    
DOI: 10.1214/08-AOAS192     Document Type: Article
Times cited : (15)

References (53)
  • 2
    • 0034027217 scopus 로고    scopus 로고
    • Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
    • Bangsberg, D. R. et al. (2000). Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS 14 357-366.
    • (2000) AIDS , vol.14 , pp. 357-366
    • Bangsberg, D.R.1
  • 3
    • 0028817206 scopus 로고
    • Compliance in clinical trials
    • Besch, C. L. (1995). Compliance in clinical trials. AIDS 9 1-10.
    • (1995) AIDS , vol.9 , pp. 1-10
    • Besch, C.L.1
  • 4
    • 0030711752 scopus 로고    scopus 로고
    • Evaluating treatment protocols to prevent antibiotic resistance
    • Bonhoeffer, S., Lipsitch, M. and Levin, B. R. (1997). Evaluating treatment protocols to prevent antibiotic resistance. Proc. Natl. Acad. Sci. USA 94 12106-12111.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 12106-12111
    • Bonhoeffer, S.1    Lipsitch, M.2    Levin, B.R.3
  • 5
    • 0036381110 scopus 로고    scopus 로고
    • HIV-1 infection and low steady state viral loads
    • Callaway, D. S. and Perelson, A. S. (2002). HIV-1 infection and low steady state viral loads. Bull. Math. Biol. 64 29-64.
    • (2002) Bull. Math. Biol , vol.64 , pp. 29-64
    • Callaway, D.S.1    Perelson, A.S.2
  • 7
    • 0018472841 scopus 로고
    • Identifiability of compartmental systems and related structural properties
    • Cobelli, C., Lepschy, A. and Jacur, G. R. (1979). Identifiability of compartmental systems and related structural properties. Math. Biosci. 44 1-18.
    • (1979) Math. Biosci , vol.44 , pp. 1-18
    • Cobelli, C.1    Lepschy, A.2    Jacur, G.R.3
  • 9
    • 0032864856 scopus 로고    scopus 로고
    • Relationships between antiviral treatment effects and biphasic viral decay rates in modeling HIV dynamics
    • Ding, A. A. and Wu, H. (1999). Relationships between antiviral treatment effects and biphasic viral decay rates in modeling HIV dynamics. Math. Biosci. 160 63-82.
    • (1999) Math. Biosci , vol.160 , pp. 63-82
    • Ding, A.A.1    Wu, H.2
  • 10
    • 34547249641 scopus 로고    scopus 로고
    • A comparison study of models and fitting procedures for biphasic viral decay rates in viral dynamic models
    • Ding, A. A. and Wu, H. (2000). A comparison study of models and fitting procedures for biphasic viral decay rates in viral dynamic models. Biometrics 56 16-23.
    • (2000) Biometrics , vol.56 , pp. 16-23
    • Ding, A.A.1    Wu, H.2
  • 11
    • 0002484095 scopus 로고    scopus 로고
    • Assessing antiviral potency of anti-HIV therapies in vivo by comparing viral decay rates in viral dynamic models
    • Ding, A. A. and Wu, H. (2001). Assessing antiviral potency of anti-HIV therapies in vivo by comparing viral decay rates in viral dynamic models. Biostatistics 2 13-29.
    • (2001) Biostatistics , vol.2 , pp. 13-29
    • Ding, A.A.1    Wu, H.2
  • 13
    • 84865262077 scopus 로고
    • Illustration of Bayesian inference in normal data models using Gibbs sampling
    • Gelfand, A. E., Hills, S. E., Racine-Poon, A. and Smith, A. F. M. (1990). Illustration of Bayesian inference in normal data models using Gibbs sampling. J. Amer. Statist. Assoc. 85 972-985.
    • (1990) J. Amer. Statist. Assoc , vol.85 , pp. 972-985
    • Gelfand, A.E.1    Hills, S.E.2    Racine-Poon, A.3    Smith, A.F.M.4
  • 14
    • 84950453304 scopus 로고
    • Sampling-based approaches to calculating marginal densities
    • Gelfand, A. E. and Smith, A. F. M. (1990). Sampling-based approaches to calculating marginal densities. J. Amer. Statist. Assoc. 85 398-409.
    • (1990) J. Amer. Statist. Assoc , vol.85 , pp. 398-409
    • Gelfand, A.E.1    Smith, A.F.M.2
  • 15
    • 0021518209 scopus 로고
    • Stochastic relaxation, Gibbs distributions, and the Bayesian restoration of images
    • Geman, S. and Geman, D. (1984). Stochastic relaxation, Gibbs distributions, and the Bayesian restoration of images. IEEE Trans. Pattern Recognition Machine Intelligence 6 721-741.
    • (1984) IEEE Trans. Pattern Recognition Machine Intelligence , vol.6 , pp. 721-741
    • Geman, S.1    Geman, D.2
  • 16
    • 0038102081 scopus 로고    scopus 로고
    • Bayesian analysis of a population HIV dynamic model
    • C. Gatsonis, A. Carriquiry, A. Gelman, et al., eds.), Springer, New York
    • Han, C., Chaloner, K. and Perelson, A. S. (2002). Bayesian analysis of a population HIV dynamic model. In Case Studies in Bayesian Statistics 6 (C. Gatsonis, A. Carriquiry, A. Gelman, et al., eds.) 223-237. Springer, New York.
    • (2002) Case Studies In Bayesian Statistics 6 , pp. 223-237
    • Han, C.1    Chaloner, K.2    Perelson, A.S.3
  • 17
    • 0030343462 scopus 로고    scopus 로고
    • Distinguishing "missing at random" and "missing completely at random"
    • Heitjan, D. F. and Basu, S. (1996). Distinguishing "missing at random" and "missing completely at random." Amer. Statist. 50 207-213.
    • (1996) Amer. Statist , vol.50 , pp. 207-213
    • Heitjan, D.F.1    Basu, S.2
  • 18
    • 0031511277 scopus 로고    scopus 로고
    • A two-step approach to measurement error in time-dependent covariates in nonlinear mixed-effects models, with application to IGF-I pharmacokinetics
    • Higgins, M., Davidian, M. and Giltinan, D. M. (1997). A two-step approach to measurement error in time-dependent covariates in nonlinear mixed-effects models, with application to IGF-I pharmacokinetics. J. Amer. Statist. Assoc. 92 436-448.
    • (1997) J. Amer. Statist. Assoc , vol.92 , pp. 436-448
    • Higgins, M.1    Davidian, M.2    Giltinan, D.M.3
  • 19
    • 0028874048 scopus 로고
    • Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
    • Ho, D. D., Neuman, A. U., Perelson, A. S., Chen, W., Leonard, J. M. and Markowitz, M. (1995). Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373 123-126.
    • (1995) Nature , vol.373 , pp. 123-126
    • Ho, D.D.1    Neuman, A.U.2    Perelson, A.S.3    Chen, W.4    Leonard, J.M.5    Markowitz, M.6
  • 20
    • 0037696057 scopus 로고    scopus 로고
    • Modeling HIV dynamics and antiviral responses with consideration of time-varying drug exposures, sensitivities and adherence
    • Huang, Y., Rosenkranz, S. L. and Wu, H. (2003). Modeling HIV dynamics and antiviral responses with consideration of time-varying drug exposures, sensitivities and adherence. Math. Biosci. 184 165-186.
    • (2003) Math. Biosci , vol.184 , pp. 165-186
    • Huang, Y.1    Rosenkranz, S.L.2    Wu, H.3
  • 21
    • 30844451991 scopus 로고    scopus 로고
    • A Bayesian approach for estimating antiviral efficacy in HIV dynamic model
    • Huang, Y. and Wu, H. (2006). A Bayesian approach for estimating antiviral efficacy in HIV dynamic model. J. Appl. Statist. 33 155-174.
    • (2006) J. Appl. Statist , vol.33 , pp. 155-174
    • Huang, Y.1    Wu, H.2
  • 22
    • 0011054587 scopus 로고    scopus 로고
    • Trough concentrations-EC50 relationship as a predictor of viral response for ABT-378/ritonavir in treatment-experienced patients
    • San Francisco, CA, Poster Session
    • Hsu, A., Issacson, J., Kempf, D. J. et al. (2000). Trough concentrations-EC50 relationship as a predictor of viral response for ABT-378/ritonavir in treatment-experienced patients. In 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, Poster Session 171.
    • (2000) 40th Interscience Conference On Antimicrobial Agents and Chemotherapy , pp. 171
    • Hsu, A.1    Issacson, J.2    Kempf, D.J.3
  • 23
    • 0030968251 scopus 로고    scopus 로고
    • Adherence in AIDS clinical trial: A framework for clinical research and clinical care
    • Ickovics, J. R. and Meisler, A. W. (1997). Adherence in AIDS clinical trial: A framework for clinical research and clinical care. J. Clinical Epidemiology 50 385-391.
    • (1997) J. Clinical Epidemiology , vol.50 , pp. 385-391
    • Ickovics, J.R.1    Meisler, A.W.2
  • 25
    • 0031403669 scopus 로고    scopus 로고
    • A pharmacokinetic-pharmacodynamic model of chemotherapy of human immunodeficiency virus infection that relates development of drug resistance to treatment intensity
    • Jackson, R. C. (1997). A pharmacokinetic-pharmacodynamic model of chemotherapy of human immunodeficiency virus infection that relates development of drug resistance to treatment intensity. J. Pharmacokinetics Pharmacodynamics 25 713-730.
    • (1997) J. Pharmacokinetics Pharmacodynamics , vol.25 , pp. 713-730
    • Jackson, R.C.1
  • 26
    • 0030463012 scopus 로고    scopus 로고
    • Cytotoxic T lymphocytes and viral turnover in HIV type 1 infrction
    • Klenernam, P., Phillips, R. E. et al. (1996). Cytotoxic T lymphocytes and viral turnover in HIV type 1 infrction. Proc. Natl. Acad. Sci. USA 93 15323-15328.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 15323-15328
    • Klenernam, P.1    Phillips, R.E.2
  • 27
    • 33745619788 scopus 로고    scopus 로고
    • A nonlinear mixed effect dynamic model incorporating prior exposure and adherence to treatment to describe long-term therapy outcome in HIV-patients
    • Labbé, L. and Verttoa, D. (2006). A nonlinear mixed effect dynamic model incorporating prior exposure and adherence to treatment to describe long-term therapy outcome in HIV-patients. J. Pharmacokinetics and Pharmacodynamics 33 519-542.
    • (2006) J. Pharmacokinetics and Pharmacodynamics , vol.33 , pp. 519-542
    • Labbé, L.1    Verttoa, D.2
  • 28
    • 0037385686 scopus 로고    scopus 로고
    • A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo
    • Markowitz, M., Louie, M., Hurley, A., Sun, E., Mascio, M. D., Perelson, A. S. and Ho, D. D. (2003). A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo. J. Virology 77 5037-5038.
    • (2003) J. Virology , vol.77 , pp. 5037-5038
    • Markowitz, M.1    Louie, M.2    Hurley, A.3    Sun, E.4    Mascio, M.D.5    Perelson, A.S.6    Ho, D.D.7
  • 29
    • 15444377672 scopus 로고    scopus 로고
    • Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
    • Molla, A. et al. (1996). Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nature Medicine 2 760-766.
    • (1996) Nature Medicine , vol.2 , pp. 760-766
    • Molla, A.1
  • 30
    • 0032552097 scopus 로고    scopus 로고
    • Rate of HIV-1 decline following antiretroviral therapy is related to viral load at baseline and drug regimen
    • Notermans, D. W., Goudsmit, J., Danner, S. A. et al. (1998). Rate of HIV-1 decline following antiretroviral therapy is related to viral load at baseline and drug regimen. AIDS 12 1483-1490.
    • (1998) AIDS , vol.12 , pp. 1483-1490
    • Notermans, D.W.1    Goudsmit, J.2    Danner, S.A.3
  • 31
    • 84984934413 scopus 로고
    • HIV results in the frame
    • Nowak, M. A., Bonhoeffer, S. et al. (1995). HIV results in the frame. Nature 375 193.
    • (1995) Nature , vol.375 , pp. 193
    • Nowak, M.A.1    Bonhoeffer, S.2
  • 33
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson, A. S., Essunger, P. et al. (1997). Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387 188-191.
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1    Essunger, P.2
  • 34
    • 0001918317 scopus 로고    scopus 로고
    • Mathematical analysis of HIV-1 dynamics in vivo
    • Perelson, A. S. and Nelson, P. W. (1999). Mathematical analysis of HIV-1 dynamics in vivo. SIAM Rev. 41 3-44.
    • (1999) SIAM Rev , vol.41 , pp. 3-44
    • Perelson, A.S.1    Nelson, P.W.2
  • 35
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson, A. S., Neumann, A. U., Markowitz, M., Leonard, J. M. and Ho, D. D. (1996). HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time. Science 271 1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 37
    • 0001974429 scopus 로고    scopus 로고
    • Markov chain concepts related to sampling algorithms
    • W. R. Gilks, S. Richardson and D. J. Spiegelhalter, eds.), Chapman and Hall, London
    • Roberts, G. O. (1996). Markov chain concepts related to sampling algorithms. In Markov Chain Monte Carlo in Practice (W. R. Gilks, S. Richardson and D. J. Spiegelhalter, eds.) 45-57. Chapman and Hall, London.
    • (1996) Markov Chain Monte Carlo In Practice , pp. 45-57
    • Roberts, G.O.1
  • 38
    • 0004282518 scopus 로고    scopus 로고
    • SAS institute inc, Version 8. SAS Publishing
    • SAS institute inc. (2000). SAS/STAT User's Guide, Version 8. SAS Publishing.
    • (2000) SAS/STAT User's Guide
  • 39
    • 0003022755 scopus 로고
    • Modeling pharmacodynamics: Parametric and nonparametric approaches
    • M. Rowland et al., eds. Raven Press, New York
    • Sheiner, L. B. (1985). Modeling pharmacodynamics: Parametric and nonparametric approaches. In Variability in Drug Therapy: Description, Estimation, and Control (M. Rowland et al., eds.) 139-152. Raven Press, New York.
    • (1985) Variability In Drug Therapy: Description, Estimation, and Control , pp. 139-152
    • Sheiner, L.B.1
  • 40
    • 0034615789 scopus 로고    scopus 로고
    • Modeling plasma virus concentration during primary HIV infection
    • Stafford, M. A. et al. (2000). Modeling plasma virus concentration during primary HIV infection. J. Theoret. Biol. 203 285-301.
    • (2000) J. Theoret. Biol , vol.203 , pp. 285-301
    • Stafford, M.A.1
  • 42
    • 23344442813 scopus 로고    scopus 로고
    • Models and estimation methods for clinical HIV-1 data
    • Verotta, D. (2005). Models and estimation methods for clinical HIV-1 data. J. Comput. Appl. Math. 184 275-300.
    • (2005) J. Comput. Appl. Math , vol.184 , pp. 275-300
    • Verotta, D.1
  • 43
    • 0034701490 scopus 로고    scopus 로고
    • Adherence and resistance: Predictions for therapy outcome
    • Wahl, L. M. and Nowak, M. A. (2000). Adherence and resistance: Predictions for therapy outcome. Proc. Roy. Soc. Biol. 267 835-843.
    • (2000) Proc. Roy. Soc. Biol , vol.267 , pp. 835-843
    • Wahl, L.M.1    Nowak, M.A.2
  • 44
    • 0030512725 scopus 로고    scopus 로고
    • Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substition in 3TC-resistant HIV-1 reverse transcriptase
    • Wainberg, M. A. et al. (1996). Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substition in 3TC-resistant HIV-1 reverse transcriptase. AIDS 10(suppl) S3-S10.
    • (1996) AIDS , vol.10 , Issue.SUPPL.
    • Wainberg, M.A.1
  • 45
    • 0001880068 scopus 로고    scopus 로고
    • The Bayesian analysis to population Pharmacokinetic models
    • Wakefield, J. C. (1996). The Bayesian analysis to population Pharmacokinetic models. J. Amer. Statist. Assoc. 91 62-75.
    • (1996) J. Amer. Statist. Assoc , vol.91 , pp. 62-75
    • Wakefield, J.C.1
  • 46
    • 0032492830 scopus 로고    scopus 로고
    • Mathematical analysis of antiretroviral therapy aimed at HIV-1 eradication or maintenance of low viral loads
    • Wein, L. M., Damato, R. M. and Perelson, A. S. (1998). Mathematical analysis of antiretroviral therapy aimed at HIV-1 eradication or maintenance of low viral loads. J. Theoret. Biol. 192 81-98.
    • (1998) J. Theoret. Biol , vol.192 , pp. 81-98
    • Wein, L.M.1    Damato, R.M.2    Perelson, A.S.3
  • 48
    • 0032967837 scopus 로고    scopus 로고
    • Population HIV-1 dynamics in vivo: Applicable models and inferential tools for virological data from AIDS clinical trials
    • Wu, H. and Ding, A. A. (1999). Population HIV-1 dynamics in vivo: Applicable models and inferential tools for virological data from AIDS clinical trials. Biometrics 55 410-418.
    • (1999) Biometrics , vol.55 , pp. 410-418
    • Wu, H.1    Ding, A.A.2
  • 49
    • 0011419832 scopus 로고    scopus 로고
    • Characterization of viral dynamics in Human Immunodeficiency Virus Type 1-infected patients treated with combination antiretroviral therapy: Relationships to host factors, cellular restoration and virological endpoints
    • Wu, H., Kuritzkes, D. R., Mcclernon, D. R. et al. (1999). Characterization of viral dynamics in Human Immunodeficiency Virus Type 1-infected patients treated with combination antiretroviral therapy: Relationships to host factors, cellular restoration and virological endpoints. J. Infectious Diseases 179 799-807.
    • (1999) J. Infectious Diseases , vol.179 , pp. 799-807
    • Wu, H.1    Kuritzkes, D.R.2    McClernon, D.R.3
  • 50
    • 0042126735 scopus 로고    scopus 로고
    • Viral Dynamics and their relations to baseline factors and logn-term virologic responses in treatment-naive HIV-1 infected patients receiving abacavir in combination with HIV-1 protease inhibitors
    • Wu, H., Mellors, J., Ruan, P. et al. (2003). Viral Dynamics and their relations to baseline factors and logn-term virologic responses in treatment-naive HIV-1 infected patients receiving abacavir in combination with HIV-1 protease inhibitors. JAIDS 32 557-564.
    • (2003) JAIDS , vol.32 , pp. 557-564
    • Wu, H.1    Mellors, J.2    Ruan, P.3
  • 51
    • 1442325333 scopus 로고    scopus 로고
    • Relationship of plasma HIV-1 RNA dynamics to baseline factors and virological responses to Highly Active Antiretroviral Therapy (HAART) in adolescents infected through risk behavior
    • Wu, H., Lathey, J., Ruan, P. et al. (2004). Relationship of plasma HIV-1 RNA dynamics to baseline factors and virological responses to Highly Active Antiretroviral Therapy (HAART) in adolescents infected through risk behavior. J. Infectious Diseases 189 593-601.
    • (2004) J. Infectious Diseases , vol.189 , pp. 593-601
    • Wu, H.1    Lathey, J.2    Ruan, P.3
  • 53
    • 0036970596 scopus 로고    scopus 로고
    • A joint model for nonlinear mixed-effects models with censoring and covariates measured with error, with application to AIDS studies
    • Wu, L. (2002). A joint model for nonlinear mixed-effects models with censoring and covariates measured with error, with application to AIDS studies. J. Amer. Statist. Assoc. 97 955-964.
    • (2002) J. Amer. Statist. Assoc , vol.97 , pp. 955-964
    • Wu, L.1


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