Chemically exacerbated chronic progressive nephropathy not associated with renal tubular tumor induction in rats: An evaluation based on 60 carcinogenicity studies by the national toxicology program

Toxicological Sciences

Volumn 128, Issue 2, 2012, Pages 346-356

  Melnick, Ronald L ^a   Burns, Kathleen M ^b   Ward, Jerrold M ^c   Huff, James ^d  

^a Ron Melnick Consulting   (United States)

^b Sciencecorps   (United States)

^c Global VetPathology   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Aging nephropathy; Carcinogenicity studies; Chronic progressive nephropathy.; Kidney; Nephropathy severity; Rats; Renal tubule tumors

Indexed keywords

1 PHENYLETHANOL; 2 AMINO 4 NITROPHENOL; 4 NITROPHENOL; ANTHRAQUINONE; BENZOFURAN DERIVATIVE; CLOROFENE; COUMARIN; CUMENE; DECALIN; DIETHANOLAMINE; ETHYLBENZENE; FURAN; FUROSEMIDE; ISOPRENE; MANGANESE SULFATE; MERCURIC CHLORIDE; METHOXSALEN; METHYLEUGENOL; MIREX; NITROFURANTOIN; NITROMETHANE; OXAZEPAM; OXYMETHOLONE; PARACETAMOL; PHENYLBUTAZONE; PULEGONE; TETRAHYDROFURAN; TOLUENE; TRIAMTERENE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CHRONIC KIDNEY DISEASE; CHRONIC PROGRESSIVE NEPHROPATHY; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; EVALUATION; FEMALE; FISCHER 344 RAT; HISTOPATHOLOGY; INCIDENCE; KIDNEY TUMOR; MALE; NONHUMAN; RAT; RENAL CARCINOGENICITY; RENAL TUBULAR TUMOR; RISK ASSESSMENT;

ANIMALS; CARCINOGENICITY TESTS; CHRONIC DISEASE; DISEASE PROGRESSION; FEMALE; KIDNEY DISEASES; KIDNEY NEOPLASMS; KIDNEY TUBULES; MALE; RATS; RATS, INBRED F344;

EID: 84865356350     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs156     Document Type: Article

References (43)

1. Bruner, R. H., Greaves, P., Hard, G. C., Regan, K. S., Ward, J. M., and David, R. M. (2010). Histopathologic changes in the kidneys of male F344 rats from a 2-year inhalation carcinogenicity study of tetrahydrofuran: A pathology working group review and re-evaluation. Regul. Toxicol. Pharmacol. 58, 100-105.
2. Brüning, T., Chronz, C., Their, R., Havelka, J., Ko, Y., and Bolt, H. M. (1999). Occurrence of urinary tract tumors in miners highly exposed to dinitrotoluene. J. Occup. Environ. Med. 41, 144-149.
3. Brüning, T., Their, R., Mann, H., Melzer, H., Bröde, P., Dallner, G., and Bolt, H. M. (2001). Pathological excretion patterns of urinary proteins in miners highly exposed to dinitrotoluene. J. Occup. Environ. Med. 43, 610-615.
4. Buzio, L., Tondel, M., De Palma, G., Buzio, C., Franchini, I., Mutti, A., and Axelson, O. (2002). Occupational risk factors for renal cell cancer. An Italian case-control study. Med. Lav. 93, 303-309.
5. Cernaro, V., Lacquaniti, A., Donato, V., Fazio, M. R., Buemi, A., and Buemi, M. (2012). Fibrosis, regeneration and cancer: What is the link? Nephrol. Dial. Transplant. 27, 21-27.
6. Doi, A. M., Hill, G., Seely, J., Hailey, J. R., Kissling, G., and Bucher, J. R. (2007). a2u-Globulin nephropathy and renal tumors in National Toxicology Program studies. Toxicol. Pathol. 35, 533-540.
7. Dominick, M. A., Robertson, D. G., Bleavins, M. R., Sigler, R. E., Borrowski, W. F., and Gough, A. W. (1991). a2u-Globulin nephropathy without nephrocarcinogenesis in male Wistar rats administered 1-(aminomethyl) cyclohexaneacetic acid. Toxicol. Appl. Pharmacol. 111, 375-387.
8. Eustis, S. L., Hailey, J. R., Boorman, G. A., and Haseman, J. K. (1994). The utility of multiple-section sampling in the histopathological evaluation of the kidney for carcinogenicity studies. Toxicol. Pathol. 22, 457-472.
9. Franchini, I., Cavatorta, A., Falzol, M., Lucertini, S., and Mutti, A. (1983). Early indicators of renal damage in workers exposed to organic solvents. Int. Arch. Occup. Environ. Health 52, 1-9.
10. Hard, G. C. (2002). Significance of the renal effects of ethyl benzene in rodents for assessing human carcinogenic risk. Toxicol. Sci. 69, 30-41.
11. Hard, G. C., Bruner, R. H., Cohen, S. M., Pletcher, J. M., and Regan, K. S. (2011). Renal histopathology in toxicity and carcinogenicity studies with tert-butyl alcohol administered in drinking water to F344 rats: A pathology working group review and re-evaluation. Regul. Toxicol. Pharmacol. 59, 430-436.
12. Hard, G. C., Johnson, K. J., and Cohen, S. M. (2009). A comparison of rat chronic progressive nephropathy with human renal disease-Implications for human risk assessment. Crit. Rev. Toxicol. 39, 332-346.
13. Hard, G. C., and Khan, K. N. (2004). A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment. Toxicol. Pathol. 32, 171-180.
14. Hard, G. C., Seely, J. C., Betz, L. J., and Hayashi, S. M. (2007). Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin. Food Chem. Toxicol. 45, 600-608.
15. Hard, G. C., Whysner, J., English, J. C., Zang, E., and Williams, G. M. (1997). Relationship of hydroquinone-associated rat renal tumors with spontaneous chronic progressive nephropathy. Toxicol. Pathol. 25, 132-143.
16. Haseman, J. K., Ney, E., Nyska, A., and Rao, G. N. (2003). Effect of diet and animal care/housing protocols on body weight, survival, tumor incidences, and nephropathy severity of F344 rats in chronic studies. Toxicol. Pathol. 31, 674-681.
17. Hoel, D. G., Haseman, J. K., Hogan, M. D., Huff, J., and McConnell, E. E. (1988). The impact of toxicity on carcinogenicity studies: Implications for risk assessment. Carcinogenesis 9, 2045-2052.
18. Huff, J. (1992). A historical perspective on the classification developed and used for chemical carcinogens by the National Toxicology Program during 1983-1992. Scand. J. Work Environ. Health 18(Suppl. 1), 74-82.
19. Huff, J., Melnick, R., Tomatis, L., LaDou, J., and Teitelbaum, D. (2004). Trichloroethylene and cancers in humans. Toxicology 197, 185-187.
20. Keenan, K. P., Coleman, J. B., McCoy, C. L., Hoe, C. M., Soper, K. A., and Laroque, P. (2000). Chronic nephropathy in ad libitum overfed Sprague-Dawley rats and its early attenuation by increasing degrees of dietary (caloric) restriction to control growth. Toxicol. Pathol. 28, 788-798.
21. Konishi, N., and Ward, J. M. (1989). Increased levels of DNA synthesis in hyperplastic renal tubules of aging nephropathy in female F344/NCr rats. Vet. Pathol. 26, 6-10.
22. Liu, Y. (2011). Cellular and molecular mechanisms of renal fibrosis. Nat. Rev. Nephrol. 7, 684-696.
23. Malley, L. A., Kennedy, G. L., Elliott, G. S., Slone, T. W., Mellert, W., Deckardt, K., Kuttler, K., Hildebrand, B., Banton, M. I., Parod, R. J., and Griffiths, J. C. (2001). Chronic toxicity and oncogenicity of N-methylpyrrolidone (NMP) in rats and mice by dietary administration. Drug Chem. Toxicol. 24, 315-338.
24. Malley, L. A., Slone, T. W. Jr, Makovec, G. T., Elliott, G. S., and Kennedy, G. L. Jr. (1995). Chronic toxicity/oncogenicity of dimethylacetamide in rats and mice following inhalation exposure. Fundam. Appl. Toxicol. 28, 80-93.
25. Melnick, R. L., Huff, J., Barrett, J. C., Maronpot, R. R., Lucier, G., and Portier, C. J. (1993). Cell proliferation and chemical carcinogenesis: Symposium overview. Environ. Health Perspect. 101(Suppl. 5), 3-7.
26. National Toxicology Program. (1990). NTP toxicology and carcinogenesis studies of toluene (CAS No.108-88-3) in F344/N rats and B6C3F1 mice (inhalation studies). Natl. Toxicol. Program Tech. Rep. Ser. 371, 1-253.
27. Nortier, J. L., and Vanherweghem, J. L. (2002). Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). Toxicology 27, 181-182, 577-580.
28. Nyska, A., Haseman, J. K., Hailey, J. R., Smetana, S., and Maronpot, R. R. (1999). The association between severe nephropathy and pheochromocytoma in the male F344 rat-The National Toxicology Program experience. Toxicol. Pathol. 27, 456-462.
29. Pesch, B., Haerting, J., Ranft, U., Klimpel, A., Oelschlägel, B., and Schill, W. (2000). Occupational risk factors for renal cell carcinoma: Agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter urothelial and renal cancer study. Int. J. Epidemiol. 29, 1014-1024.
30. Rao, G. N. (1996). New diet (NTP-2000) for rats in the National Toxicology Program toxicity and carcinogenicity studies. Fundam. Appl. Toxicol. 32, 102-108.
31. Rao, G. N., Morris, R. W., and Seely, J. C. (2001). Beneficial effects of NTP-2000 diet on growth, survival, and kidney and heart diseases of Fischer 344 rats in chronic studies. Toxicol. Sci. 63, 245-255.
32. Seely, J. C., Haseman, J. K., Nyska, A., Wolf, D. C., Everitt, J. I., and Hailey, J. R. (2002). The effect of chronic progressive nephropathy on the incidence of renal tubule cell neoplasms in control male F344 rats. Toxicol. Pathol. 30, 681-686.
33. Short, B. G., Burnett, V. L., and Swenberg, J. A. (1989). Elevated proliferation of proximal tubule cells and localization of accumulated alpha 2u-globulin in F344 rats during chronic exposure to unleaded gasoline or 2,2,4-trimethylpentane. Toxicol. Appl. Pharmacol. 101, 414-431.
34. Siegel, R., Naishadham, D., and Jemal, A. (2012). Cancer Statistics, 2012. CA Cancer J. Clin. 62, 10-29.
35. Simard, E. P., Ward, E. M., Siegel, R., and Jemal, A. (2012). Cancers with increasing incidence trends in the United States: 1999 through 2008. CA Cancer J. Clin. 62, 118-128.
36. Soderland, P., Lovekar, S., Weiner, D. E., Brooks, D. R., and Kaufman, J. S. (2010). Chronic kidney disease associated with environmental toxins and exposures. Adv. Chronic Kidney Dis. 17, 254-264.
37. Solleveld, H. A., Haseman, J. K., and McConnell, E. E. (1984). Natural history of body weight gain, survival, and neoplasia in the F344 rat. J. Natl. Cancer Inst. 72, 929-940.
38. Travlos, G. S., Hard, G. C., Betz, L. J., and Kissling, G. E. (2011). Chronic progressive nephropathy in male F344 rats in 90-day toxicity studies: Its occurrence and association with renal tubule tumors in subsequent 2-year bioassays. Toxicol. Pathol. 39, 381-389.
39. United States Environmental Protection Agency (U.S. EPA). (2005). Guidelines for carcinogen risk assessment. EPA/630/P-03/001F. Available at: http://www.epa.gov/cancerguidelines/. Accessed March 20, 2012.
40. United States Environmental Protection Agency (U.S. EPA). (2011). Toxicological review of trichloroethylene (CAS No. 79-01-6). EPA/635/R-09/011F. Available at: http://www.epa.gov/iris/supdocs/0199index.html. Accessed March 20, 2012.
41. Van Vleet, T. R., and Schnellmann, R. G. (2003). Toxic nephropathy: Environmental chemicals. Semin. Nephrol. 23, 500-508.
42. Voss, J. U., Roller, M., Brinkmann, E., and Mangelsdorf, I. (2005). Nephrotoxicity of organic solvents: Biomarkers for early detection. Int. Arch. Occup. Environ. Health 78, 475-485.
43. Ward, J. M., Uno, H., Kurata, Y., Weghorst, C. M., and Jang, J. J. (1993). Cell proliferation not associated with carcinogenesis in rodents and humans. Environ. Health Perspect. 101(Suppl. 5), 125-135.