Histopathologic changes in the kidneys of male F344 rats from a 2-year inhalation carcinogenicity study of tetrahydrofuran: A pathology working group review and re-evaluation

Regulatory Toxicology and Pharmacology

Volumn 58, Issue 1, 2010, Pages 100-105

  Bruner, Richard H ^a   Greaves, Peter ^b   Hard, Gordon C ^c   Regan, Karen S ^d   Ward, Jerrold M ^c   David, Raymond M ^e  

^a Biotechnics Inc   (United States)

^b LEICESTER ROYAL INFIRMARY   (United Kingdom)

^c Regan Path/Tox Services ^*  (United States)

^d Regan Path/Tox Services   (United States)

^e The Tetrahydrofuran Task Force   (United States)

Author keywords

Atypical tubule hyperplasia; Chronic progressive nephropathy; Modes of action; Pathology Working Group; Renal tubule adenoma; Renal tubule hyperplasia; Risk assessment; Tetrahydrofuran

Indexed keywords

ALPHA 2 GLOBULIN; HYALIN; TETRAHYDROFURAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGEN TESTING; CARCINOGENICITY; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; FEMALE; FISCHER 344 RAT; HISTOPATHOLOGY; KIDNEY ADENOMA; KIDNEY CANCER; MALE; NEPHROTOXICITY; NONHUMAN; PRECANCER; PRIORITY JOURNAL; RAT; TISSUE REGENERATION;

AIR POLLUTANTS; ANIMALS; CARCINOGENICITY TESTS; FURANS; INHALATION EXPOSURE; KIDNEY; MALE; RATS; RATS, INBRED F344; RISK ASSESSMENT; SOLVENTS;

ANIMALIA; RATTUS;

EID: 77955927086     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2010.04.009     Document Type: Article

References (27)

1. Baetcke, K.P., Hard, G.C., Rodgers, I.S., McGaughy, R.E., Tahan, L.M., 1991. Alpha 2u-Globulin: Association with Chemically Induced Renal Toxicity and Neoplasia in the Male Rat. U.S. Environmental Protection Agency, Risk Assessment Forum, Washington, DC 20460 (EPA/625/3-91/09F).
2. Brenner B.M., Meyer T.W., Hostetter T.H. Dietary protein intake and the progressive nature of kidney disease. N. Engl. J. Med. 1983, 307:652-672.
3. Chhabra R.S., Herbert R.A., Roycroft J.H., Chou B., Miller R.A., Renne R.A. Carcinogenesis studies of tetrahydrofuran vapors in rats and mice. Toxicol. Sci. 1998, 41:183-188.
4. Fogo A., Ichikawa I. Evidence for the central role of glomerular growth promoters in the development of sclerosis. Sem. Nephrol. 1989, 9:329-342.
5. Gamer A.O., Jaeckh R., Leibold E., Kaufmann W., Gembardt C., Bahnemann R., Ravenzwaay B. Investigations on cell proliferation and enzyme induction in male rat kidney and female mouse liver caused by tetrahydrofuran. Toxicol. Sci. 2002, 70:140-149.
6. Greaves P. Urinary tract. Histopathology of Preclinical Toxicity Studies 2007, 570-660. Elsevier, Amsterdam. third ed.
7. Hard G.C. Mechanisms of chemically induced renal carcinogenesis in the laboratory rodent. Toxicol. Pathol. 1998, 26:104-112.
8. Hard G.C. Comparative kidney carcinogenesis in laboratory rodents and humans. Carcinogenicity. Testing, Predicting, and Interpreting Chemical Effects 1999, 439-466. Marcel Dekker, Inc., NY. K.T. Kitchen (Ed.).
9. Hard G.C. Significance of the renal effects of ethyl benzene in rodents for assessing human carcinogenic risk. Toxicol. Sci. 2002, 69:30-41.
10. Hard, G.C., 2005. Expert Report on Renal Histopathology Induced in F344 Rats in Subchronic Toxicity and Carcinogenicity Studies with Tetrahydrofuran. Report to Tetrahydrofuran Task Force, Synthetic and Organic Chemical Manufacturers Association (SOCMA), Washington, DC. March 14.
11. Hard G.C., Khan K.N. A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment. Toxicol. Pathol. 2004, 32:171-180.
12. Hard G.C., Seely J.C. Recommendations for the interpretation of renal tubule proliferative lesions occurring in rat kidneys with advanced chronic progressive nephropathy (CPN). Toxicol. Pathol. 2005, 33:641-649.
13. Hard G.C., Seely J.C. Histological investigation of diagnostically challenging tubule profiles in advanced chronic progressive nephropathy (CPN) in the Fischer 344 rat. Toxicol. Pathol. 2006, 34:941-948.
14. Hard G.C., Alden C.L., Stula E.F., Trump B.F. Proliferative lesions of the kidney in rats. Guides for Toxicologic Pathology 1995, 1-32. STP/ARP/AFIP, Washington, DC.
15. Hard G.C., Whysner J., English J.C., Zang E., Williams G.M. Relationship of hydroquinone-associated rat renal tumors with spontaneous chronic progressive nephropathy. Toxicol. Pathol. 1997, 25:132-143.
16. Hard G.C., Seely J.C., Betz L.J., Hayashi S.M. Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin. Food Chem. Toxicol. 2007, 45:600-608.
17. Hard G.C., Johnson K.J., Cohen S.M. A comparison of rat chronic progressive nephropathy (CPN) with human renal disease-implications for human risk assessment. Crit. Rev. Toxicol. 2009, 39:332-346.
18. Konishi N., Ward J.M. Increased levels of DNA synthesis in hyperplastic renal tubules of aging nephropathy in female F344/NCr rats. Vet. Pathol. 1989, 26:6-10.
19. Lock E.A., Hard G.C. Chemically-induced renal tubule tumors in the laboratory rat and mouse: review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information. Crit. Rev. Toxicol. 2004, 34:211-299.
20. 2u -globulin-nephropathy and chronic progressive nephropathy as modes of action for renal tubule tumor induction in rats, and their possible interaction. Cancer Risk Assessment - Chemical Carcinogenesis, Hazard Evaluation, and Risk Characterization 2010, 482-500. John Wiley and Sons, Inc., NY. C.-H. Hsu, T. Stedeford (Eds.).
21. NTP, 1998. Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CAS No. 109-99-9) in F344/N Rats and 86C3h Mice (inhalation studies). National Toxicology Program, National Institutes of Health, Research Triangle Park, NC. NTP TR-475, NIH Publication No. 98-3965.
22. Ott R.L. Introduction to Statistical Methods and Data Analysis 2002, Duxbury Press, Belmont, CA. fourth ed.
23. Rao G.N. Diet and kidney disease in rats. Toxicol. Pathol. 2002, 30:651-656.
24. Robertson J.L. Chemically induced glomerular injury: a review of basic mechanisms and specific xenobiotics. Toxicol. Pathol. 1998, 26:64-72.
25. Seely J.C., Haseman J.K., Nyska A., Wolf D.C., Everitt J.I., Hailey J.R. The effect of chronic progressive nephropathy on the incidence of renal tubule cell neoplasms in control male F344 rats. Toxicol. Pathol. 2002, 30:681-686.
26. 2u-globulin in F344 rats during chronic exposure to unleaded gasoline or 2,2,4-trimethylpentane. Toxicol. Appl. Pharmacol. 1989, 101:414-431.
27. USEPA, 2007. Toxicological Review of Tetrahydrofuran: In Support of Summary Information on the Integrated Risk Information System (IRIS). US Environmental Protection Agency, Washington, DC. External Review Draft, NCEA-S-1620.