Chronic Progressive Nephropathy in Male F344 Rats in 90-Day Toxicity Studies:Its Occurrence and Association with Renal Tubule Tumors in Subsequent 2-Year Bioassays

Toxicologic Pathology

Volumn 39, Issue 2, 2011, Pages 381-389

  Travlos, Greg S ^a   Hard, Gordon C ^b   Betz, Laura J ^c   Kissling, Grace E ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b SRA International Inc ^*  (New Zealand)

^c SRA International Inc   (United States)

Author keywords

chronic progressive nephropathy; CPN; CPN exacerbation; NIH 07 and NTP 2000 diets; renal tubule neoplasia; toxicity and carcinogenicity studies

Indexed keywords

1 NITROPYRENE; 1,2 DICHLOROETHYLENE; 2 BUTOXYETHANOL; 3,3',4,4' TETRACHLOROAZOBENZENE; ACROLEIN; ALLYL ALCOHOL; ANTHRAQUINONE; BENZOPHENONE; BENZYLTRIMETHYLAMMONIUM; CHEMICAL COMPOUND; CHROMIUM PICOLINATE MONOHYDRATE; CITRAL; COCONUT OIL DIETHANOLAMINE; DECALIN; DICYCLOHEXYLCARBODIIMIDE; DIISOPROPYLCARBODIIMIDE; ESTRAGOLE; INDIUM PHOSPHIDE; ISOBUTYLENE; METHYLENE BLUE TRIHYDRATE; N,N BIS(2 HYDROXYETHYL)LAURAMIDE; O CHLOROANILINE; OLEIC ACID DIETHANOLAMIDE; OXYMETHOLONE; PENTAERYTHRITOL TRIACRYLATE; PENTOSAN POLYSULFATE; TETRACHLOROETHANE; TRIMETHYLOLPROPANE TRIACRYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URETHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CHRONIC KIDNEY DISEASE; CHRONIC PROGRESSIVE NEPHROPATHY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; HISTOPATHOLOGY; KIDNEY TUMOR; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL TUBULE TUMOR;

ACROLEIN; ANIMAL FEED; ANIMALS; BENZOPHENONES; BIOLOGICAL ASSAY; DIET; INDIUM; KIDNEY FAILURE, CHRONIC; KIDNEY NEOPLASMS; KIDNEY TUBULES; MALE; MODELS, ANIMAL; PHOSPHINES; RATS; RATS, INBRED F344; TOXICITY TESTS; URETHANE;

RATTUS;

EID: 79954549224     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623310388432     Document Type: Article

References (37)

1. Anver M. R. Cohen B. J. Lattuada C. P. Foster C. J. (1982). Age associated lesions in barrier-reared male Sprague-Dawley rats: A comparison between Hap:(SD) and Crl:COBS[R]CD[R]SD stocks. Exp Aging Res 8, 3–24.
2. Bailer A. J. Portier C. J. (1988). Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples. Biometrics 44, 417–31.
3. Baylis C. (1994). Age-dependent glomerular damage in the rat. Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor. J Clin Invest 94, 1823–29.
4. Boobis A. R. Cohen S. M. Doerrer N. G. Galloway S. M. Haley P. J. Hard G. C. Hess F. G. (2009). A data-based assessment of alternative strategies for identification of potential human cancer hazards. Toxicol Pathol 37, 714–32.
5. Chhabra R. S. Huff J. E. Schwetz B. S. Selkirk J. (1990). An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program. Environ Health Perspect 86, 313–21.
6. Coleman G. L. Barthold S. W. Osbaldiston G. W. Foster S. J. Jonas A. (1977). Pathological changes during aging in barrier-reared Fischer 344 male rats. J Gerontol 32, 258–78.
7. Dietrich D. R. Swenberg J. A. (1991). Preneoplastic lesions in rodent kidney induced spontaneously or by non-genotoxic agents: predictive nature and comparison to lesions induced by genotoxic carcinogens. Mutation Res 248, 239–60.
8. Dixon D. Heider K. Elwell M. R. (1995). Incidence of nonneoplastic lesions in historical control male and female Fischer-344 rats from 90-day toxicity studies. Toxicol Pathol 23, 338–48.
9. Doi A. Hill G. Seely J. Hailey J. R. Kissling G. Bucher J. R. (2007). α2u-globulin nephropathy and renal tumors in National Toxicology Program studies. Toxicol Pathol 35, 533–40.
10. Eustis S. L. Hailey J. R. Boorman G. A. Haseman J. K. (1994). The utility of multiple-section sampling in the histopathological evaluation of the kidney for carcinogenesis studies. Toxicol Pathol 22, 457–72.
11. Gray J. E. (1977). Chronic progressive nephrosis in the albino rat. Crit Rev Toxicol 5, 115–44.
12. Hard G. C. (1987). Chemically induced epithelial tumours and carcinogenesis of the renal parenchyma. In Nephrotoxicity in the Experimental and Clinical Situation (Bach P. H. Lock E. A., eds.), pp. 211–50. Martinus Nijhoff Publishers, Dordrecht, the Netherlands.
13. Hard G. C. (1998). Mechanisms of chemically induced renal carcinogenesis in the laboratory rodent. Toxicol Pathol 26, 104–12.
14. Hard G. C. (2002). Significance of the renal effects of ethyl benzene in rodents for assessing human carcinogenic risk. Toxicol Sci 69, 30–41.
15. Hard G. C. Johnson K. J. Cohen S. M. (2009). A comparison of rat chronic progressive nephropathy (CPN) with human renal disease—implications for human risk assessment. Crit Rev Toxicol 39, 332–46.
16. Hard G. C. Khan K. N. (2004). A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment. Toxicol Pathol 32, 171–80.
17. Hard G. C. Rodgers I. S. Baetcke K. P. Richards W. L. McGaughy R. E. Valcovic L. R. (1993). Hazard evaluation of chemicals that cause accumulation of α2u-globulin, hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats. Environ Health Perspect 99, 313–49.
18. Hard G. C. Seely J. C. Betz L. J. Hayashi S. (2007). Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin. Food Chem Toxicol 45, 600–8.
19. Hard G. C. Whysner J. English J. C. Zang E. Williams G. M. (1997). Relationship of hydroquinone-associated rat renal tumors with spontaneous chronic progressive nephropathy. Toxicol Pathol 25, 132–43.
20. Hollander M. Wolfe D. A. (1973). Nonparametric Statistical Methods. John Wiley & Sons, New York.
21. Keenan K. P. Coleman J. B. McCoy C. L. Hoe C.-M. Soper K. A. Laroque P. (2000). Chronic nephropathy in ad libitum overfed Sprague-Dawley rats and its early attenuation by increasing degrees of dietary (caloric) restriction to control growth. Toxicol Pathol 28, 788–98.
22. Lipsky M. M. Trump B. F. (1988). Chemically induced renal epithelial neoplasia in experimental animals. Int Rev Exp Pathol 30, 357–83.
23. Lock E. A. Hard G. C. (2004). Chemically induced renal tubule tumors in the laboratory rat and mouse: Review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information. Crit Rev Toxicol 34, 211–99.
24. Lock E. A. Hard G. C. (in press). Alpha 2u-globulin-nephropathy and chronic progressive nephropathy as modes of action for renal tubule tumor induction in rats, and their possible interaction. In Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quatification (Hsu C.-H. Stedeford T., eds.). John Wiley & Sons, New York.
25. Maeda K. Gleiser C. A. Masoro E. J. Murata I. McMahan C. A. Yu B. P. (1985). Nutritional influences on aging of Fischer 344 rats: II. Pathology. J Gerontol 40, 671–88.
26. Montgomery C. A. Seely J. C. (1990). Kidney. In Pathology of the Fischer Rat (Boorman G. A. Eustis S. L. Elwell M. R. Montgomery C. A. MacKenzie W. F., eds.), pp. 127–53. Academic Press, San Diego, CA.
27. National Toxicology Program. (2005). Toxicology and Carcinogenicity Studies of Anthraquinone (CAS No. 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies). National Toxicology Program, NIH, Research Triangle Park, NC. NTP TR 494, NIH Publication No. 05-3953.
28. National Toxicology Program. (2006). Toxicology and Carcinogenesis Studies of Divinylbenzene-HP (CAS No. 1321-74-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). National Toxicology Program, NIH, Research Triangle Park, NC. NTP TR 534, NIH Publication No. 07-4470.
29. National Toxicology Program. (2010a). Historical Controls. National Toxicology Program, Research Triangle Park, NC. http://ntp-server.niehs.nih.gov/go/14692. Accessed April 15, 2010.
30. National Toxicology Program. (2010b). Summaries & Associations of Study Results: Organ Sites Associated with Neoplasia. National Toxicology Program, Research Triangle Park, NC. http://ntp.niehs.nih.gov/go/SApos. Accessed April 15, 2010.
31. National Toxicology Program. (2010c). Summaries & Associations of Study Results: List of 2-yr Studies by Report No. National Toxicology Program, Research Triangle Park, NC. http://ntp-server.niehs.nih.gov/go/9433. Accessed April 15, 2010.
32. Nogueira E. Cardesa A. Mohr U. (1993). Experimental models of kidney tumors. J Cancer Res Clin Oncol 119, 190–98.
33. Peddada S. D. Dinse G. E. Kissling G. E. (2007). Incorporating historical control data when comparing tumor incidence rates. J Am Stat Assoc 102, 1212–20.
34. Rao G. N. Edmondson J. Elwell M. R. (1993). Influence of dietary protein concentration on severity of nephropathy in Fischer-344 (F-344/N) rats. Toxicol Pathol 21, 353–61.
35. Seely J. C. Haseman J. K. Nyska A. Wolf D. C. Everitt J. I. Hailey J. R. (2002). The effect of chronic progressive nephropathy on the incidence of renal tubule cell neoplasms in control male F344 rats. Toxicol Pathol 30, 681–86.
36. Short B. G. Burnett V. L. Swenberg J. A. (1989). Elevated proliferation of proximal tubule cells and localization of accumulation of α2u-globulin in F344 rats during chronic exposure to unleaded gasoline or 2, 2, 4-trimethylpentane. Toxicol Appl Pharmacol 101, 414–31.
37. Swenberg J. A. Lehman-McKeeman L. D. (1999). α2–Urinary globulin-associated nephropathy as a mechanism of renal tubule cell carcinogenesis in male rats. In Species Differences in Thyroid, Kidney and Urinary Bladder Carcinogenesis (Capen C. C. Dybing E. Rice J. M. Wilbourn J. D., eds.), pp. 95–118. IARC Publications No. 147, International Agency for Research on Cancer, Lyon.