Dibenzoylmethane, a natural dietary compound, induces HIF-1α and increases expression of VEGF

Biochemical and Biophysical Research Communications

Volumn 303, Issue 1, 2003, Pages 279-286

  Mabjeesh, Nicola J ^a   Willard, Margaret T ^a   Harris, Wayne B ^a   Sun, He Ying ^a   Wang, Ruoxiang ^a   Zhong, Hua ^a   Umbreit, Jay N ^a   Simons, Jonathan W ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiomyocyte; Dibenzoylmethane; HIF 1 ; Prostate cancer cells; VEGF

Indexed keywords

CHELATING AGENT; DIBENZOYLMETHANE DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1; IRON; VASCULOTROPIN; BENZOIC ACID DERIVATIVE; CHALCONE DERIVATIVE; DIBENZOYLMETHANE; ENDOTHELIAL CELL GROWTH FACTOR; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LYMPHOKINE; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR; UBIQUITIN; VASCULOTROPIN A;

ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; HUMAN; HUMAN CELL; HUMAN TISSUE; ISCHEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REPORTER GENE; SIGNAL TRANSDUCTION; TOXICITY; ANOXIA; BIOSYNTHESIS; CELL CULTURE; DIMERIZATION; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; METABOLISM; TIME; TRANSACTIVATION; WESTERN BLOTTING;

ANOXIA; BENZOATES; BLOTTING, WESTERN; CHALCONES; CHELATING AGENTS; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL GROWTH FACTORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENES, REPORTER; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; IRON; LYMPHOKINES; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; UBIQUITIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0037470774     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00336-X     Document Type: Article

References (43)

1. Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochem. Pharmacol. 64:2002;993-998.
2. Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., Simons J.W., Semenza G.L. Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 60:2000;1541-1545.
3. Stiehl D.P., Jelkmann W., Wenger R.H., Hellwig-Burgel T. Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the phosphatidylinositol 3-kinase pathway. FEBS Lett. 512:2002;157-162.
4. Laughner E., Taghavi P., Chiles K., Mahon P.C., Semenza G.L. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol. Cell Biol. 21:2001;3995-4004.
5. Jiang B.H., Jiang G., Zheng J.Z., Lu Z., Hunter T., Vogt P.K. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ. 12:2001;363-369.
6. ′ -kinase/Akt signaling pathway Cancer Res. 61:2001;7349-7355.
7. Berra E., Milanini J., Richard D.E., Le Gall M., Vinals F., Gothie E., Roux D., Pages G., Pouyssegur J. Signaling angiogenesis via p42/p44 MAP kinase and hypoxia. Biochem. Pharmacol. 60:2000;1171-1178.
8. Richard D.E., Berra E., Gothie E., Roux D., Pouyssegur J. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J. Biol. Chem. 274:1999;32631-32637.
9. Page E.L., Robitaille G.A., Pouyssegur J., Richard D.E. Induction of hypoxia-inducible factor-1α by transcriptional and translational mechanisms. J. Biol. Chem. 277:2002;48403-48409.
10. 2 -regulated prolyl hydroxylation Science. 292:2001;468-472.
11. 2 sensing Science. 292:2001;464-468.
12. Masson N., Willam C., Maxwell P.H., Pugh C.W., Ratcliffe P.J. Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J. 20:2001;5197-5206.
13. Epstein A.C., Gleadle J.M., McNeill L.A., Hewitson K.S., O'Rourke J., Mole D.R., Mukherji M., Metzen E., Wilson M.I., Dhanda A., Tian Y.M., Masson N., Hamilton D.L., Jaakkola P., Barstead R., Hodgkin J., Maxwell P.H., Pugh C.W., Schofield C.J., Ratcliffe P.J. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 107:2001;43-54.
14. Bruick R.K., McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science. 294:2001;1337-1340.
15. Jeong J.W., Bae M.K., Ahn M.Y., Kim S.H., Sohn T.K., Bae M.H., Yoo M.A., Song E.J., Lee K.J., Kim K.W. Regulation and destabilization of HIF-1α by ARD1-mediated acetylation. Cell. 111:2002;709-720.
16. Berra E., Roux D., Richard D.E., Pouyssegur J. Hypoxia-inducible factor-1α (HIF-1α) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm. EMBO Rep. 2:2001;615-620.
17. Brahimi-Horn C., Berra E., Pouyssegur J. Hypoxia: the tumor's gateway to progression along the angiogenic pathway. Trends Cell Biol. 11:2001;S32-36.
18. Maxwell P.H. Oxygen homeostasis and cancer: insights from a rare disease. Clin. Med. 2:2002;356-362.
19. 2 -regulated gene expression FASEB J. 16:2002;1151-1162.
20. Harris A.L. Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer. 2:2002;38-47.
21. Semenza G.L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 8:2002;S62-67.
22. Ivan M., Haberberger T., Gervasi D.C., Michelson K.S., Gunzler V., Kondo K., Yang H., Sorokina I., Conaway R.C., Conaway J.W., Kaelin W.G. Jr. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc. Natl. Acad. Sci. USA. 99:2002;13459-13464.
23. Semenza G.L., Roth P.H., Fang H.M., Wang G.L. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269:1994;23757-23763.
24. Chong T.W., Horwitz L.D., Moore J.W., Sowter H.M., Harris A.L. A mycobacterial iron chelator, desferri-exochelin, induces hypoxia-inducible factors 1 and 2, NIP3, and vascular endothelial growth factor in cancer cell lines. Cancer Res. 62:2002;6924-6927.
25. Shibata S. Antitumor-promoting and anti-inflammatory activities of licorice principles and their modifies compounds. Ho C.-T., Osawa T., Huang M.-T., Rosen R.T. Food Phytochemicals for Cancer Prevention II. Teas, Spices, and HerbsACS Symposium Series. 1994;309-321 American Chemical Society, Washington, DC.
26. Yuki H., Hirano N., Kawasaki H., Yajima T. Analysis of serum iron by gel permeation high-performance liquid chromatography. J. Chromatogr. 221:1980;271-277.
27. Simpson P., Savion S. Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol. Circ. Res. 50:1982;101-116.
28. 2 tension Am. J. Physiol. 271:1996;C1172-1180.
29. Mabjeesh N.J., Post D.E., Willard M.T., Kaur B., Van Meir E.G., Simons J.W., Zhong H. Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells. Cancer Res. 62:2002;2478-2482.
30. Post D.E., Van Meir E.G. Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells. Gene Ther. 8:2001;1801-1807.
31. Zhong H., Hanrahan C., van der Poel H., Simons J.W. Hypoxia-inducible factor 1α and 1β proteins share common signaling pathways in human prostate cancer cells. Biochem. Biophys. Res. Commun. 284:2001;352-356.
32. Wang G.L., Semenza G.L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood. 82:1993;3610-3615.
33. Wanner R.M., Spielmann P., Stroka D.M., Camenisch G., Camenisch I., Scheid A., Houck D.R., Bauer C., Gassmann M., Wenger R.H. Epolones induce erythropoietin expression via hypoxia-inducible factor-1α activation. Blood. 96:2000;1558-1565.
34. Dalle B., Payen E., Beuzard Y. Modulation of transduced erythropoietin expression by iron. Exp. Hematol. 28:2000;760-764.
35. Lin C.C., Lu Y.P., Lou Y.R., Ho C.T., Newmark H.H., MacDonald C., Singletary K.W., Huang M.T. Inhibition by dietary dibenzoylmethane of mammary gland proliferation, formation of DMBA-DNA adducts in mammary glands, and mammary tumorigenesis in Sencar mice. Cancer Lett. 168:2001;125-132.
36. Huang M.T., Lou Y.R., Xie J.G., Ma W., Lu Y.P., Yen P., Zhu B.T., Newmark H., Ho C.T. Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice. Carcinogenesis. 19:1998;1697-1700.
37. Singletary K., MacDonald C., Iovinelli M., Fisher C., Wallig M. Effect of the β-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12-dimethylbenz[a]anthracene. Carcinogenesis. 19:1998;1039-1043.
38. Shibata S. Anti-tumorigenic chalcones. Stem Cells. 12:1994;44-52.
39. Jackson K.M., DeLeon M., Verret C.R., Harris W.B. Dibenzoylmethane induces cell cycle deregulation in human prostate cancer cells. Cancer Lett. 178:2002;161-165.
40. Patro B.S., Rele S., Chintalwar G.J., Chattopadhyay S., Adhikari S., Mukherjee T. Protective activities of some phenolic 1,3-diketones against lipid peroxidation: possible involvement of the 1,3-diketone moiety. Chembiochem. 3:2002;364-370.
41. Creighton-Gutteridge M., Tyrrell R.M. A novel iron chelator that does not induce HIF-1 activity. Free Radic. Biol. Med. 33:2002;356-363.
42. Huang M.T., Lou Y.R., Xie J.G., Ma W., Lu Y.P., Yen P., Zhu B.T., Newmark H., Ho C.T. Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice. Carcinogenesis. 19:1998;1697-1700.
43. Singletary K., MacDonald C., Iovinelli M., Fisher C., Wallig M. Effect of the β-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12-dimethylbenz[a]anthracene. Carcinogenesis. 19:1998;1039-1043.