Phase I-II study of hypofractionated simultaneous integrated boost using volumetric modulated arc therapy for adjuvant radiation therapy in breast cancer patients: a report of feasibility and early toxicity results in the first 50 treatments

Radiation Oncology

Volumn 7, Issue 1, 2012, Pages

  Scorsetti, Marta ^a   Alongi, Filippo ^a   Fogliata, Antonella ^b   Pentimalli, Sara ^a   Navarria, Pierina ^a   Lobefalo, Francesca ^a   Garcia Etienne, Carlos ^a   Clivio, Alessandro ^b   Cozzi, Luca ^b   Mancosu, Pietro ^a   Nicolini, Giorgia ^b   Vanetti, Eugenio ^b   Eboli, Marco ^a   Rossetti, Carlo ^a   Rubino, Arianna ^a   Sagona, Andrea ^a   Arcangeli, Stefano ^a   Gatzemeier, Wolfgang ^a   Masci, Giovanna ^a   Torrisi, Rosalba ^a   Testori, Alberto ^a   Alloisio, Marco ^a   Santoro, Armando ^a   Tinterri, Corrado ^a   more..

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

Author keywords

Breast cancer; Hypofractionation; Simultaneous integrated boost; Volumetric modulated arc therapy

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER STAGING; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MORBIDITY; RADIATION DOSE; SKIN TOXICITY; VOLUMETRY;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; DOSE FRACTIONATION; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM STAGING; PROGNOSIS; RADIATION INJURIES; RADIOTHERAPY, ADJUVANT; RADIOTHERAPY, INTENSITY-MODULATED;

EID: 84865344362     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-7-145     Document Type: Article

References (22)

1. Veronesi U, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E. Twenty year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002, 347:1227-1232. 10.1056/NEJMoa020989, 12393819.
2. American College of Radiology Practice guideline for the breast conservation therapy in the management of invasive breast carcinoma. J Am Coll Surg 2007, 205:362-376. American College of Radiology.
3. Qi XS, White J, Li XA. Is α/β for breast cancer really low?. Radiother Oncol 2011, 100:282-288. 10.1016/j.radonc.2011.01.010, 21367477.
4. Bentzen SM, Agrawal RK, Aird EG, Barrett JM, Barrett-Lee PJ, Bliss JM, Brown J, Dewar JA, Dobbs HJ, Haviland JS, Hoskin PJ, Hopwood P, Lawton PA, Magee BJ, Mills J, Morgan DA, Owen JR, Simmons S, Sumo G, Sydenham MA, Venables K, Yarnold JR. The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial. Lancet Oncol 2008, 9:331-341. 2323709, 18356109.
5. Bentzen SM, Agrawal RK, Aird EG, Barrett JM, Barrett-Lee PJ, Bentzen SM, Bliss JM, Brown J, Dewar JA, Dobbs HJ, Haviland JS, Hoskin PJ, Hopwood P, Lawton PA, Magee BJ, Mills J, Morgan DA, Owen JR, Simmons S, Sumo G, Sydenham MA, Venables K, Yarnold JR. The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial. Lancet 2008, 371:1098-1107. 2277488, 18355913.
6. Owen JR, Ashton A, Bliss JM, Homewood J, Harper C, Hanson J, Haviland J, Bentzen SM, Yarnold JR. Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial. Lancet Oncol 2006, 7:467-471. 10.1016/S1470-2045(06)70699-4, 16750496.
7. Whelan TJ, Pignol JP, Levine MN, Julian JA, MacKenzie R, Parpia S, Shelley W, Grimard L, Bowen J, Lukka H, Perera F, Fyles A, Schneider K, Gulavita S, Freeman C. Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med 2010, 362:513-520. 10.1056/NEJMoa0906260, 20147717.
8. Smith BD, Bentzen SM, Correa CR, Hahn CA, Hardenbergh PA, Ibbott GS, McCormick B, McQueen JR, Pierce LJ, Powell SN, Recht A, Taghian AG, Vicini FA, White JR, Haffty BG. Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Int J Radiat Oncol Biol Phys 2011, 81:59-68. 10.1016/j.ijrobp.2010.04.042, 20638191.
9. Otto K. Volumetric modulated arc therapy: IMRT in a single arc. Med Phys 2008, 35:310-317. 10.1118/1.2818738, 18293586.
10. Bignardi M, Cozzi L, Fogliata A, Lattuada P, Mancosu P, Navarria P, Urso G, Vigorito S, Scorsetti M. Critical appraisal of volumetric modulated arc therapy in stereotactic body radiation therapy for metastases to abdominal lymph nodes. Int J Radiat Oncol Biol Phys 2009, 75:1570-1577. 10.1016/j.ijrobp.2009.05.035, 19880261.
11. Clivio A, Fogliata A, Franzetti-Pellanda A, Nicolini G, Vanetti E, Wyttenbach R, Cozzi L. Volumetric-modulated arc radiotherapy for carcinomas of the anal canal: A treatment planning comparison with fixed field IMRT. Radiother Oncol 2009, 92:118-124. 10.1016/j.radonc.2008.12.020, 19181409.
12. Verbakel W, Senan S, Cuijpers JP, Slotman BJ, Lagerwaard FJ. Rapid delivery of stereotactic radiotherapy for peripheral lung tumors using volumetric intensity-modulated arcs. Radiother Oncol 2009, 93:122-124. 10.1016/j.radonc.2009.05.020, 19552979.
13. Vanetti E, Clivio A, Nicolini G, Fogliata A, Ghosh-Laskar S, Agarwal JP, Upreti RR, Budrukkar A, Murthy V, Deshpande DD, Shrivastava SK, Dinshaw DA, Cozzi L. Volumetric modulated arc radiotherapy for carcinomas of the oro-pharynx, hypo-pharynx: A treatment planning comparison with fixed field IMRT. Radiother Oncol 2009, 92:111-117. 10.1016/j.radonc.2008.12.008, 19157609.
14. Formenti SC, Gidea-Addeo D, Goldberg JK, Roses DF, Guth A, Rosenstein BS, DeWyngaert KJ. Phase I-II Trial of Prone Accelerated Intensity Modulated Radiation Therapy to the Breast to Optimally Spare Normal Tissue. J Clin Oncol 2007, 25:2236-2242. 10.1200/JCO.2006.09.1041, 17470849.
15. Harris JR, Levene MB, Svensson G, Hellman S. Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast. Int J Radiat Oncol Biol Phys 1979, 5:257-261. 10.1016/0360-3016(79)90729-6, 110740.
16. Arthur DW, Cuttino LW, Neuschatz AC, Koo DT, Morris MM, Bear HD, Kaplan BJ, Dawson K, Wazer DE. Tumor bed boost omission after negative re-excision in breast-conservation treatment. Ann Surg Oncol 2006, 13:794-801. 10.1245/ASO.2006.04.002, 16614879.
17. Romestaing P, Lehingue Y, Carrie C, Coquard R, Montbarbon X, Ardiet JM, Mamelle N, Gérard JP. Role of a 10-Gy boost in the conservative treatment of early breast cancer: Results of a randomized clinical trial in Lyon, France. J Clin Oncol 1997, 15:963-968.
18. Plataniotis A, Dale RG. Biologically Effective Dose-Response Relationship for Breast Cancer Treated by Conservative Surgery and Postoperative Radiotherapy. Int J Radiat Oncol Biol Phys 2009, 75:512-517. 10.1016/j.ijrobp.2009.05.013, 19625139.
19. Oh KS, Kong FM, Griffith KA, Yanke B, Pierce LJ. Planning the breast tumour bed boost: changes in the excision cavity volume and surgical scar location after breast-conserving surgery and whole-breast irradiation. Int J Radiat Oncol Biol Phys 2006, 66:680-686. 10.1016/j.ijrobp.2006.04.042, 16863683.
20. Solin LJ, Danoff BF, Schwartz GF, Galvin JM, Goodman RL. A practical technique for the localization of the tumour volume in definitive irradiation of the breast. Int J Radiat Oncol Biol Phys 1985, 11:1215-1220. 10.1016/0360-3016(85)90072-0, 3997603.
21. Freedman GM, Anderson PR, Goldstein LJ, Ma CM, Li J, Swaby RF, Litwin S, Watkins-Bruner D, Sigurdson ER, Morrow M. Four-week course of radiation for breast cancer using hypofractionated intensity modulated radiation therapy with an incorporated boost. Int J Radiat Oncol Biol Phys 2007, 68:347-353. 10.1016/j.ijrobp.2006.12.035, 17379430.
22. Chadha M, Vongtama D, Friedmann P, Parris C, Boolbol SK, Woode R, Harrison LB. Comparative Acute Toxicity from Whole Breast Irradiation Using 3-Week Accelerated Schedule With Concomitant Boost and the 6.5-Week Conventional Schedule With Sequential Boost for Early-Stage Breast Cancer. Clin Breast Cancer 2012, 12:57-62. 10.1016/j.clbc.2011.09.002, 22056970.