Concurrent blockade of free radical and microsomal prostaglandin e synthase-1-mediated PGE 2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis

Journal of Neurochemistry

Volumn 122, Issue 5, 2012, Pages 952-961

  Shin, Jin Hee ^a,b   Lee, Young Ae ^b   Lee, Jae Keun ^c   Lee, Yong Beom ^a,b   Cho, Woong ^b   Im, Doo Soon ^a,b   Lee, Jin Hwan ^a,b   Yun, Bok Sun ^b   Springer, Joe E ^d   Gwag, Byoung Joo ^a,b  

^a Ajou University School of Medicine   (South Korea)

^b GNT Pharma   (South Korea)

^c Korea University   (South Korea)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

ALS; inflammation; mPGES 1; oxidative stress; PGE 2; SOD1 G93A

Indexed keywords

2 HYDROXY 5 [2 (4 TRIFLUOROMETHYLPHENYL)ETHYLAMINOBENZOIC ACID]; AAD 2004; ACETYLSALICYLIC ACID DERIVATIVE; ADENINE; FREE RADICAL; GUANINE; IBUPROFEN; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; RECOMBINANT HUMAN MPGES 1 PROTEIN; RECOMBINANT PROTEIN; RILUZOLE; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; AUTOPHAGOSOME; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; IC 50; IN VITRO STUDY; LIFESPAN; MALE; MICROGLIA; MICROSOME; MOTONEURON; MOTOR PERFORMANCE; MOUSE; NERVE CELL DEGENERATION; NERVE CELL STIMULATION; NERVOUS SYSTEM INFLAMMATION; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; SPINAL CORD; STOMACH HEMORRHAGE; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CALCIUM-BINDING PROTEINS; CEREBRAL CORTEX; DEOXYGUANOSINE; DINOPROSTONE; DISEASE MODELS, ANIMAL; ENCEPHALITIS; FREE RADICAL SCAVENGERS; FREE RADICALS; GENE EXPRESSION REGULATION; HUMANS; IBUPROFEN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; MICROGLIA; MOTOR NEURONS; OXIDATIVE STRESS; RILUZOLE; SPINAL CORD; SULFASALAZINE; SUPEROXIDE DISMUTASE; TYROSINE;

MUS MUSCULUS;

EID: 84865342363     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07771.x     Document Type: Article

References (52)

1. Almer G., Guegan C., Teismann P., Naini A., Rosoklija G., Hays A. P., Chen C., and, Przedborski S., (2001) Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. Ann. Neurol. 49, 176-185. (Pubitemid 32157993)
2. Andreassen O. A., Dedeoglu A., Klivenyi P., Beal M. F., and, Bush A. I., (2000) N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. NeuroReport 11, 2491-2493. (Pubitemid 30622295)
3. Babu G. N., Kumar A., Chandra R., Puri S. K., Kalita J., and, Misra U. K., (2008) Elevated inflammatory markers in a group of amyotrophic lateral sclerosis patients from northern India. Neurochem. Res. 33, 1145-1149.
4. Beal M. F., Ferrante R. J., Browne S. E., Matthews R. T., Kowall N. W., and, Brown R. H. Jr, (1997) Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann. Neurol. 42, 644-654. (Pubitemid 27439028)
5. Benatar M., (2007) Lost in translation: treatment trials in the SOD1 mouse and in human ALS. Neurobiol. Dis. 26, 1-13. (Pubitemid 46437445)
6. Bowling A. C., Schulz J. B., Brown R. H. Jr, and, Beal M. F., (1993) Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J. Neurochem. 61, 2322-2325. (Pubitemid 23354097)
7. Chaudhry U. A., Zhuang H., Crain B. J., and, Dore S., (2008) Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease. Alzheimers Dement. 4, 6-13.
8. Chen Y., and, Gibson S. B., (2008) Is mitochondrial generation of reactive oxygen species a trigger for autophagy? Autophagy 4, 246-248. (Pubitemid 351231192)
9. Collier H. O., (1971) Prostaglandins and aspirin. Nature 232, 17-19.
10. Crow J. P., Calingasan N. Y., Chen J., Hill J. L., and, Beal M. F., (2005) Manganese porphyrin given at symptom onset markedly extends survival of ALS mice. Ann. Neurol. 58, 258-265. (Pubitemid 41098883)
11. Cudkowicz M. E., Shefner J. M., Schoenfeld D. A., Zhang H., Andreasson K. I., Rothstein J. D., and, Drachman D. B., (2006) Trial of celecoxib in amyotrophic lateral sclerosis. Ann. Neurol. 60, 22-31.
12. De Boer A. G., and, Gaillard P. J., (2007) Drug targeting to the brain. Annu. Rev. Pharmacol. Toxicol. 47, 323-355.
13. Desnuelle C., Dib M., Garrel C., and, Favier A., (2001) A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. ALS riluzole-tocopherol study group. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2, 9-18. (Pubitemid 32472143)
14. Dinis T. C., Maderia V. M., and, Almeida L. M., (1994) Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Arch. Biochem. Biophys. 315, 161-169. (Pubitemid 24351051)
15. Drachman D. B., Frank K., Dykes-hoberg M., Teismann P., Almer G., Przedborski S., and, Rothstein J. D., (2002) Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS. Ann. Neurol. 52, 771-778. (Pubitemid 35403187)
16. Ek M., Engblom D., Saha S., Blomqvist A., Jakobsson P. J., and, Ericsson-dahlstrand A., (2001) Inflammatory response: pathway across the blood-brain barrier. Nature 410, 430-431. (Pubitemid 32240034)
17. Engblom D., Saha S., Ericsson-dahlstrand A., Jakobsson P. J., and, Blomqvist A., (2002) Prostaglandins as inflammatory messengers across the blood-brain barrier. J. Mol. Med. 80, 5-15. (Pubitemid 34143403)
18. Engblom D., Saha S., Engstorm L., Westman M., Audoly L. P., Jakobsson P. J., and, Blomqvist A., (2003) Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. Nat. Neurosci. 6, 1137-1138. (Pubitemid 37346030)
19. Eriksen J. L., Sagi S. A., Smith T. E., et al. (2003) NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J. Clin. Invest. 112, 440-449. (Pubitemid 38063773)
20. Evans G., Packham M. A., Nishzawa E. E., Mustard J. F., and, Murphy E. A., (1968) The effect of acetylsalicyclic acid on platelet function. J. Exp. Med. 128, 877-894.
21. Ferrante R. J., Browne S. E., Shinobu L. A., et al. (1997) Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J. Neurochem. 69, 2064-2074. (Pubitemid 27452754)
22. Fesharaki M., Nasimi A., Mokhtari S., Mokhtari R., Moradian R., and, Amirpoor N., (2006) Reactive oxygen metabolites and anti-oxidative defenses in aspirin-induced gastric damage in rats: gastroprotection by vitamin E. Pathophysiology 13, 237-243. (Pubitemid 44602421)
23. Fischer L. R., Culver D. G., Tennant P., Davis A. A., Wang M., Castellano-sanchez A., Khan J., Polak M. A., and, Glass J. D., (2004) Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp. Neurol. 185, 232-240. (Pubitemid 38084849)
24. Gordon P. H., Cheung Y. K., Levin B., et al. (2008) A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS. Amyotroph. Lateral Scler. 9, 212-222.
25. Graf M., Ecker D., Horowski R., et al. (2005) High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study. J. Neural Transm. 112, 649-660. (Pubitemid 40591197)
26. Gurney M. E., Pu H., Chiu A. Y., et al. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264, 1772-1775. (Pubitemid 24227760)
27. Gurney M. E., Fleck T. J., Himes C. S., and, Hall E. D., (1998) Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis. Neurology 50, 62-66. (Pubitemid 28106020)
28. He Y., Hua Y., Song S., Liu W., Keep R. F., and, Xi G., (2008) Induction of autophagy in rat hippocampus and cultured neurons by iron. Acta Neurochir. Suppl. 105, 29-32.
29. Ihara Y., Nobukuni K., Takata H., and, Hayabara T., (2005) Oxidative stress and metal content in blood and cerebrospinal fluid of amyotrophic lateral sclerosis patients with and without a Cu, Zn-superoxide dismutase mutation. Neurol. Res. 27, 105-108. (Pubitemid 40189615)
30. Ikeda-matsuo Y., Ikegaya Y., Matsuki N., Uematsu S., Akira S., and, Sasaki Y., (2005) Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production. J. Neurochem. 94, 1546-1558. (Pubitemid 41324637)
31. Ilieva H., Polymenidou M., and, Cleveland D. W., (2009) Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J. Cell Biol. 187, 761-772.
32. Ilzecka J., (2003) Prostaglandin E2 is increased in amyotrophic lateral sclerosis patients. Acta Neurol. Scand. 108, 125-129. (Pubitemid 36920662)
33. Keizman D., Rogowski O., Berliner S., Ish-shalom M., Maimon N., Nefussy B., Artamonov I., and, Drory V. E., (2009) Low-grade systemic inflammation in patients with amyotrophic lateral sclerosis. Acta Neurol. Scand. 119, 383-389.
34. Komatsu M., Wang Q. J., Holstein G. R., et al. (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc. Natl Acad. Sci. USA 104, 14489-14494. (Pubitemid 350010651)
35. Li L., Zhang X., and, Le W., (2008) Altered macroautophagy in the spinal cord of SOD1 mutant mice. Autophagy 4, 290-293. (Pubitemid 351458089)
36. Liu R., Althaus J. S., Ellerbrock B. R., Becker D. A., and, Gurney M. E., (1998) Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis. Ann. Neurol. 44, 763-770. (Pubitemid 28516047)
37. Maihofner C., Probst-cousin S., Bergmann M., Neuhuber W., Neundorfer B., and, Heuss D., (2003) Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis. Eur. J. Neurosci. 18, 1527-1534. (Pubitemid 37215106)
38. Martinez-gonzalez J., and, Badimon L., (2007) Mechanisms underlying the cardiovascular effects of COX-inhibition: benefits and risks. Curr. Pharm. Des. 13, 2215-2227. (Pubitemid 47321572)
39. Morimoto N., Nagai M., Ohta Y., et al. (2007) Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res. 1167, 112-117. (Pubitemid 47302432)
40. Orrell R. W., (2010) Motor neuron disease: systematic reviews of treatment for ALS and SMA. Br. Med. Bull. 93, 145-159.
41. Orrell R. W., Lane R. J., and, Ross M., (2008) A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease. Amyotroph. Lateral Scler. 9, 195-211.
42. Ozaki-okayama Y., Matsumura K., Ibuki T., Ueda M., Yamazaki Y., Tanaka Y., and, Kobayashi S., (2004) Burn injury enhances brain prostaglandin E2 production through induction of cyclooxygenase-2 and microsomal prostaglandin E synthase in cerebral vascular endothelial cells in rats. Crit. Care Med. 32, 795-800. (Pubitemid 38340079)
43. Pedersen W. A., Fu W., Keller J. N., Markesbery W. R., Appel S., Smith R. G., Kasarskis E., and, Mattson M. P., (1998) Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Ann. Neurol. 44, 819-824. (Pubitemid 28516055)
44. Reilly I. A., and, Fitzgerald G. A., (1988) Aspirin in cardiovascular disease. Drugs 35, 154-176. (Pubitemid 18057430)
45. Rimm E. B., and, Stampfer M. J., (1997) The role of antioxidants in preventive cardiology. Curr. Opin. Cardiol. 12, 188-194. (Pubitemid 27220124)
46. Ryu B. R., Lee Y. A., Won S. J., et al. (2003) The novel neuroprotective action of sulfasalazine through blockade of NMDA receptors. J. Pharmacol. Exp. Ther. 305, 48-56. (Pubitemid 36373835)
47. Samuelsson B., Morgenstern R., and, Jakobsson P. J., (2007) Membrane prostaglandin E synthase-1: a novel therapeutic target. Pharmacol. Rev. 59, 207-224. (Pubitemid 47481434)
48. Shadick N. A., Karlson E. W., Cook N. R., Maher N. E., Buring J. E., and, Lee I. M., (2010) Low-dose aspirin in the primary prevention of rheumatoid arthritis: the women's health study. Arthritis Care Res. (Hoboken) 62, 545-550.
49. Shin J. H., Cho S. I., Lim H. R., et al. (2007) Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis. Mol. Pharmacol. 71, 965-975.
50. Udassin R., Ariel I., Haskel Y., Kitrossky N., and, Chevion M., (1991) Salicylate as an in vivo free radical trap: studies on ischemic insult to the rat intestine. Free Radic. Biol. Med. 10, 1-6. (Pubitemid 121003204)
51. Yamagata K., Matsumura K., Inoue W., et al. (2001) Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J. Neurosci. 21, 2669-2677. (Pubitemid 32298209)
52. Yasojima K., Tourtellotte W. W., Mcgeer E. G., and, Mcgeer P. L., (2001) Marked increase in cyclooxygenase-2 in ALS spinal cord: implications for therapy. Neurology 57, 952-956. (Pubitemid 32880185)