Induction of the cell cycle arrest and apoptosis by flavonoids isolated from Korean Citrus aurantium L. in non-small-cell lung cancer cells

Food Chemistry

Volumn 135, Issue 4, 2012, Pages 2728-2735

  Park, Kwang Il ^a   Park, Hyeon Soo ^a   Nagappan, Arulkumar ^a   Hong, Gyeong Eun ^a   Lee, Do Hoon ^a   Kang, Sang Rim ^b   Kim, Jin A ^a   Zhang, Jue ^c   Kim, Eun Hee ^d   Lee, Won Sup ^e   Shin, Sung Chul ^a   Hah, Young Sool ^a   Kim, Gon Sup ^a  

^a Gyeongsang National University   (South Korea)

^b Kyonggi University   (South Korea)

^c BEIJING HOSPITAL   (China)

^d International University of Korea   (South Korea)

^e Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Apoptosis; Cell cycle arrest; Flavonoid; Human lung cancer cells; Korean Citrus aurantium L.

Indexed keywords

A549 CELLS; ANTI-PROLIFERATIVE; APOPTOTIC EFFECTS; CASPASE-3; CASPASES; CELL-CYCLE ARREST; CELLULAR PATHWAY; CITRUS AURANTIUM; DOSE-DEPENDENT MANNER; EXPRESSION LEVELS; FLAVONOID; HUMAN LUNG CANCER CELLS; INDUCED APOPTOSIS; INHIBITORY EFFECT; LUNG CANCER CELLS; NON SMALL CELL LUNG CANCER; WESTERN-BLOT ANALYSIS;

DRUG PRODUCTS; FLOW CYTOMETRY; HARDWOODS;

CELL DEATH;

3 HYDROXYNOBILETIN; 3,5,6,7,3',4',5' HEPTAMETHOXYFLAVONE; ANTINEOPLASTIC AGENT; AURANTIIN; CASPASE; CDC25C PROTEIN; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1; FLAVONOID; HESPERIDIN; HEXAMETHOXYFLAVONE; HYDROXYPENTAMETHOXYFLAVONE; ISOSINESETIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NOBILETIN; PONCIRIN; PROTEIN BAX; PROTEIN BCL XL; SINESETIN; SOUR ORANGE EXTRACT; TANGERETIN; TETRAMETHYL O ISOSCUTELLAREIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; ENZYME ACTIVITY; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; M PHASE CELL CYCLE CHECKPOINT; PROTEIN EXPRESSION; WESTERN BLOTTING;

APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CITRUS; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; PLANT EXTRACTS;

CITRUS AURANTIUM;

EID: 84865341668     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.06.097     Document Type: Article

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