Mechanisms of (2-methyl-n-butyl) shikonin induced apoptosis of gastric cancer SGC-7901 cells

Yaoxue Xuebao

Volumn 47, Issue 6, 2012, Pages 816-821

  Wang, Hai Bing ^a   Ma, Xiao Qiong ^a  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

(2 methyl n butyl) shikonin; Apoptosis; ERK1 2 signal pathway; SGC 7901 cell

Indexed keywords

(2 METHYL N BUTYL)SHIKONIN; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; SURVIVIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA CONDENSATION; DNA STRUCTURE; DOSE RESPONSE; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IMMUNOCYTOCHEMISTRY; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH CANCER; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; HUMANS; INHIBITORY CONCENTRATION 50; LITHOSPERMUM; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR STRUCTURE; NAPHTHOQUINONES; PLANT ROOTS; PLANTS, MEDICINAL; PROTO-ONCOGENE PROTEINS C-BCL-2; STOMACH NEOPLASMS;

EID: 84865326678     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Shen CC, Syu WJ, Li SY, et al. Antimicrobial activities of naphthazarins from Arnebia euchroma [J]. J Nat Prod, 2002, 65: 1857-1862.
2. Tanaka S, Tajima M, Tsukada M, et al. A comparative study on anti-inflammatory activities of the enantiomers, shikonin and alkannin [J]. J Nat Prod, 1986, 49: 466-469.
3. Chen X, Yang L, Oppenheim JJ, et al. Cellular pharmacology studies of shikonin derivatives [J]. Phytother Res, 2002, 16: 199-209.
4. Yoon Y, Kim YO, Lim NY, et al. Shikonin, an ingredient of Lithospermum erythrorhizon induced apoptosis in HL60 human premyelocytic leukemia cell line [J]. Planta Med, 1999, 65: 532-535.
5. Wu Z, Wu LJ, Li LH, et al. Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis [J]. J Asian Nat Prod Res, 2004, 6: 155-166.
6. Yeh CC, Kuo HM, Li TM, et al. Shikonin-induced apoptosis involves caspase-3 activity in a human bladder cancer cell line (T24) [J]. In Vivo, 2007, 21: 1011-1019.
7. Wu Z, Wu L, Li L, et al. p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells [J]. J Pharmacol Sci, 2004, 94: 166-176.
8. Hisa T, Kimura Y, Takada K, et al. Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro [J]. Anticancer Res, 1998, 18: 783-790.
9. Danial NN, korsmeyer SJ. Cell death: critical control points [J]. Cell, 2004, 116: 205-219.
10. Wang XT, Martindale JL, Holbrook NJ. Requirement for ERK activation in cisplatin-induced apoptosis [J]. J Biol Chem, 2000, 275: 39435-39443.
11. Zhu MY, Wang RB, Zhou W, et al. Antitumor effect research progress of shikonin and its derivatives [J]. Acta Pharm Sin, 2012, 47: 588-593.
12. Papageorgiou V, Assimopoulou AN, Couladouros EA, et al. The chemistry and biology of alkannin, shikonin, and related naphthazarin natural products [J]. Angew Chem Int Ed Engl, 1999, 38: 270-300.
13. Gao D, Hiromura M, Yasui H, et al. Direct reaction between shikonin and thiols induces apoptosis in HL60 cells [J]. Biol Pharm Bull, 2002, 25: 827-832.
14. Mao X, Yu CR, Li WH, et al. Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells [J]. Cell Res, 2008, 18:879-888.
15. Hsu PC, Huang YT, Tsai ML, et al. Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells [J]. J Agric Food Chem, 2004, 52: 6330-6337.
16. McGill A, Frank A, Emmett N, et al. The anti-psoriatic drug anthralin accumulates in keratinocyte mitochondria, dissipates mitochondrial membrane potential, induces apoptosis through a pathway dependent on respiratory competent mitochondria [J]. FASEB J, 2005, 19: 1012-1014.
17. Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs [J]. Oncogene, 2007, 26: 3100-3112.
18. Lim ES, Rhee YH, Park MK, et al. DMMQ S-64 induces apoptosis via caspase activation and cyclooxygenase-2 inhibition in human nonsmall lung cancer cells [J]. Ann N Y Acad Sci, 2007, 1095: 7-18.
19. Tournier C, Hess P, Yang DD, et al. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway [J]. Science, 2000, 288: 870-874.
20. Xia Z, Dickens M, Raingeaud J, et al. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis [J]. Science, 1995, 270: 1326-1331.
21. Park JM, Greten FR, Li ZW, et al. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition [J]. Science, 2002, 297: 2048-2051.
22. Jeong JC, Kim MS, Kim TH, et al. Kaempferol induces cell death through ERK and Akt-dependent down-regulation of XIAP and surviving in human glioma cells [J]. Neurochem Res, 2009, 34: 991-1001.
23. Chen MF, Qi L, Li Y, et al. Icaritin induces growth inhibition and apoptosis of human prostatic smooth muscle cells in an estrogen receptor-independent manner [J]. Amino Acids, 2010, 38: 1505-1513.