DMNQ S-64 induces apoptosis via caspase activation and cyclooxygenase-2 inhibition in human nonsmall lung cancer cells

Annals of the New York Academy of Sciences

Volumn 1095, Issue , 2007, Pages 7-18

  Lim, Eu Soo ^a   Rhee, Yun Hee ^a   Park, Min Kyu ^a   Shim, Beom Sang ^a   Ahn, Kyoo Seok ^a   Kang, Hee ^a   Yoo, Hwa Seung ^b   Kim, Sung Hoon ^a  

^a Kyung Hee University   (South Korea)

^b Daejeon University   (South Korea)

Author keywords

Apoptosis; COX 2; DMNQ S 64; Shikonin

Indexed keywords

2 PHENYLINDOLE DERIVATIVE; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYCLOOXYGENASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROSTAGLANDIN E2; PROTEIN BAX; PROTEIN BCL 2; SHIKONIN DERIVATIVE; 6 (1 PROPOXYIMINOALKYL) 5,8 DIMETHOXY 1,4 NAPHTHOQUINONE S 64; 6-(1-PROPOXYIMINOALKYL)-5,8-DIMETHOXY-1,4-NAPHTHOQUINONE S-64; ANTINEOPLASTIC AGENT; CYCLOOXYGENASE 2 INHIBITOR; HYDROXYLAMINE; MEMBRANE PROTEIN; NAPHTHOQUINONE; PTGS2 PROTEIN, HUMAN; SHIKONIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; COLORIMETRY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LUNG NON SMALL CELL CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; STAINING; WESTERN BLOTTING; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; LUNG TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL LINE, TUMOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; ENZYME ACTIVATION; HUMANS; HYDROXYLAMINES; LUNG NEOPLASMS; MEMBRANE PROTEINS; NAPHTHOQUINONES;

EID: 34247885910     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1397.002     Document Type: Conference Paper

References (28)

1. HSU, P.C., Y.T. HUANG, M.L. TSAI, et al. 2004. Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells. J. Agric. Food Chem. 52: 6330-6337.
2. TOUNO, K., J. TAMAOKA, Y. OHASHI, et al. 2005. Ethylene induced shikonin biosynthesis in shoot culture of Lithospermum erythorhizon. Plant Physiol. Biochem. 43: 101-105.
3. WU, Z., L. WU, L. LI, et al. 2004. p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells. J. Pharmacol. Sci. 94: 166-176.
4. PIETROSIUK, A., E. SKOPINSKA-ROZEWSKA, M. FURMANOWA, et al. 2004. Immunomodulatory effect of shikonin derivatives isolated from Lithospermum canescens on cellular and humoral immunity in Balb/c mice. Pharmazie 59: 640-642.
5. HEMMI, H., K. SHIBUYA, Y. TAKAHASHI, et al. 2004. (S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids. J. Biol. Chem. 279: 50197-50203.
6. SINGH, F., D. GAO, M.G. LEBWOHL, et al. 2003. Shikonin modulates cell proliferation by inhibiting epidermal growth factor receptor signaling in human epidermoid carcinoma cells. Cancer Lett. 200: 115-121.
7. SHIN, Y.K., J.S. PARK, H.S. KIM, et al. 2005. Radiosensitivity enhancement by celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, via COX-2-dependent cell cycle regulation on human cancer cells expressing differential COX-2 levels. Cancer Res. 15: 9501-9509.
8. LIU, X.H., A. KIRSCHENBAUM, K. YU, et al. 2005. Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. J. Biol. Chem. 4: 3817-3823.
9. HUSSAIN, T., S. GUPTA, V.M. ADHAMI, et al. 2005. Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells. Int. J. Cancer 10: 660-669.
10. KIM, S.H., I.C. KANG, T.J. YOON, et al. 2001. Antitumor activities of a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33. Cancer Lett. 172: 171-175.
11. GERLIER, D. & N. THOMASSET. 1986. Use of MTT colorimetric assay to measure cell activation. J. Immunol. Methods 94: 57-63.
12. PARK, E.M., I.J. LEE, S.H. KIM, et al. 2003. Inhibitory effect of a naphthazarin derivative, S64, on heat shock factor (Hsf) activation and glutathione status following hypoxia. Cell. Biol. Toxicol. 19: 273-284.
13. GEE, J., I.L. LEE, D. JENDIRPBA, et al. 2006. Selective cyclooxygenase-2 inhibitors inhibit growth and induce apoptosis of bladder cancer. Oncol. Rep. 15: 471-477.
14. TAKAHASHI, T., M. BABA & H. NISHINO. 2006. Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells. Cancer Lett. 231: 319-325.
15. IGNATIU, A.A. & L.E. CLAES. 1996. In vitro biocompatibility of bioresorbable polymers: poly (l, dl-lactide) and poly(l-lactide-co-glycolide). Biomaterials 17: 831-839.
16. KAUFMANN, S.H. & W.C. EARNSHAW. 2000. Induction of apoptosis by cancer chemotherapy. Exp. Cell. Res. 256: 42-49.
17. BAMFORD, M., G. WAKINSHAW & R. BROWN. 2000. Therapeutic applications of apoptosis research. Exp. Cell. Res. 256: 1-11.
18. BENNETT, A., R.L. CARTER, I.F. STANFORD, et al. 1980. Prostaglandin-like material extracted from squamous cell carcinomas of the head and neck. Br. J. Cancer 41: 204-208.
19. SANO, H., Y. KAWAHITO, R.L. WILDER, et al. 1995. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res. 55: 3785-3789.
20. TSUJII, M. & R.N. DUBOIS. 1995. Alteration in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthesis-2. Cell 83: 493-501.
21. JANG, T.J. 2004. Expression of proteins related to prostaglandin E2 biosynthesis is increased in human gastric cancer and during gastric carcinogenesis. Virchows Arch. 445: 564-571.
22. MAJNO, G. & L. JORIS. 1995. Apoptosis and necrosis: an overview of cell death. Am. J. Pathol. 46: 3-15.
23. DENECKER, G., D. VERCAMMEN, W. DECLEROQ, et al. 2001. Apoptotic and necrotic cell death induced by death domain receptors. Cell. Mol. Life Sci. 58: 356-370.
24. BOSSY-WETZEL, E., D.D. NEWMETER & D.R. GREEN. 1998. Mitochondria cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J. 17: 37-49.
25. CHANG, H.Y. & X. YANG. 2000. Proteases for suicide: functions and regulation of caspases. Microbiol. Mol. Biol. Rev. 64: 621-646.
26. WHITMARSH, A.J., P. SHORE, A.D. SHARROCKS, et al. 1996. Integration of MAP kinase signal transduction pathways at the serum response element. Science 269: 403-407.
27. HAN, S., N. SIDELL, S. ROSER-PAGE, et al. 2004. Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression. Int. J. Cancer 111: 322-331.
28. LIU, N.B., T. PENG, C. PAN, et al. 2005. Overexpression of cyclooxygenase-2 in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell lines and mechanism of cyclooxygenase-2 selective inhibitor celecoxib-induced cell growth inhibition and apoptosis. World J. Gastroenterol. 11: 6281-6287.