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Volumn 331, Issue 2, 2006, Pages 65-71

Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects

Author keywords

Folic acid; Homocysteine; Intervention; Methylenetetrahydrofolate reductase; Riboflavin

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; FATTY ACID; FOLIC ACID; HOMOCYSTEINE; RIBOFLAVIN;

EID: 33646100519     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000441-200602000-00011     Document Type: Article
Times cited : (15)

References (31)
  • 1
    • 0036092467 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: Current evidence and future prospects
    • Mangoni AA, Jackson SHD. Homocysteine and cardiovascular disease: current evidence and future prospects. Am J Med 2002;112:556-65.
    • (2002) Am J Med , vol.112 , pp. 556-565
    • Mangoni, A.A.1    Jackson, S.H.D.2
  • 2
    • 0033620779 scopus 로고    scopus 로고
    • Homocysteine and vascular disease
    • Hankey GJ, Eikelboom JW. Homocysteine and vascular disease. Lancet 1999;354:407-19.
    • (1999) Lancet , vol.354 , pp. 407-419
    • Hankey, G.J.1    Eikelboom, J.W.2
  • 3
    • 0032771090 scopus 로고    scopus 로고
    • Folic acid and homocyst(e)ine metabolic defects and the risks of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review
    • Ray JG, Laskin CA. Folic acid and homocyst(e)ine metabolic defects and the risks of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review. Placenta 1999;20:519-29.
    • (1999) Placenta , vol.20 , pp. 519-529
    • Ray, J.G.1    Laskin, C.A.2
  • 4
    • 0033547813 scopus 로고    scopus 로고
    • Homocyst(e)ine, diet, and cardiovascular disease. A statement for healthcare professionals from the Nutrition Committee, American Heart Association
    • Malinow MR, Bostom AG, Krauss RM. Homocyst(e)ine, diet, and cardiovascular disease. A statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 1999;99:178-82.
    • (1999) Circulation , vol.99 , pp. 178-182
    • Malinow, M.R.1    Bostom, A.G.2    Krauss, R.M.3
  • 5
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • Selhub J, Jacques PF, Wilson PW, et al. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993;270:2693-98.
    • (1993) JAMA , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Wilson, P.W.3
  • 6
    • 0028028118 scopus 로고
    • Vitamin requirements for the treatment of hyperhomocysteinemia in humans
    • Ubbink JB, Vermaak WJ, van der Merwe A, et al. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr 1994;124:1927-33.
    • (1994) J Nutr , vol.124 , pp. 1927-1933
    • Ubbink, J.B.1    Vermaak, W.J.2    Van Der Merwe, A.3
  • 7
    • 17344370074 scopus 로고    scopus 로고
    • Vitamin supplementation reduces blood homocysteine levels: A controlled trial in patients with venous thrombosis and healthy volunteers
    • den Heijer M, Brouwer IA, Bos GMJ, et al. Vitamin supplementation reduces blood homocysteine levels: a controlled trial in patients with venous thrombosis and healthy volunteers. Arterioscler Thromb Vasc Biol 1998;18:356-61.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 356-361
    • Den Heijer, M.1    Brouwer, I.A.2    Bos, G.M.J.3
  • 8
    • 0033869703 scopus 로고    scopus 로고
    • Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetrahydrofolate reductase C677T polymorphism
    • Hustad S, Ueland PM, Vollset SE, et al. Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism. Clin Chem 2000;46:1065-71.
    • (2000) Clin Chem , vol.46 , pp. 1065-1071
    • Hustad, S.1    Ueland, P.M.2    Vollset, S.E.3
  • 9
    • 0036171590 scopus 로고    scopus 로고
    • The relationship between riboflavin and plasma total homocysteine in the Framingham offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene
    • Jacques PF, Kalmbach R, Bagley PJ, et al. The relationship between riboflavin and plasma total homocysteine in the Framingham offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. J Nutr 2002;132:283-8.
    • (2002) J Nutr , vol.132 , pp. 283-288
    • Jacques, P.F.1    Kalmbach, R.2    Bagley, P.J.3
  • 10
    • 0036076711 scopus 로고    scopus 로고
    • Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: Implications for riboflavin requirements
    • McNulty H, McKinley MC, Wilson B, et al. Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements. Am J Clin Nutr 2002;76:436-41.
    • (2002) Am J Clin Nutr , vol.76 , pp. 436-441
    • McNulty, H.1    McKinley, M.C.2    Wilson, B.3
  • 11
    • 18344387513 scopus 로고    scopus 로고
    • Riboflavin is a determinant of total homocysteine plasma concentration in end-stage renal disease patients
    • Skoupy S, Fodinger M, Veitl M, et al. Riboflavin is a determinant of total homocysteine plasma concentration in end-stage renal disease patients. J Am Soc Nephrol 2002;13: 1331-7.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1331-1337
    • Skoupy, S.1    Fodinger, M.2    Veitl, M.3
  • 12
    • 0037305374 scopus 로고    scopus 로고
    • Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype
    • Moat SJ, Ashfield-Watt PAL, Powers HJ, et al. Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype. Clin Chem 2003;49:295-302.
    • (2003) Clin Chem , vol.49 , pp. 295-302
    • Moat, S.J.1    Ashfield-Watt, P.A.L.2    Powers, H.J.3
  • 13
    • 0031785822 scopus 로고    scopus 로고
    • Effect of pyridoxine or riboflavin supplementation on plasma homocysteine levels in women with oral lesions
    • Lakshmi AV, Ramalakshmi BA. Effect of pyridoxine or riboflavin supplementation on plasma homocysteine levels in women with oral lesions. Natl Med J India 1998;1:171-2.
    • (1998) Natl Med J India , vol.1 , pp. 171-172
    • Lakshmi, A.V.1    Ramalakshmi, B.A.2
  • 14
    • 0036738023 scopus 로고    scopus 로고
    • Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status
    • McKinley MC, McNulty H, McPartlin J, et al. Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status. Euro J Clin Nutr 2002;56:850-6.
    • (2002) Euro J Clin Nutr , vol.56 , pp. 850-856
    • McKinley, M.C.1    McNulty, H.2    McPartlin, J.3
  • 15
    • 0028926633 scopus 로고
    • Measurement of homocysteine in the prediction of arteriosclerosis
    • Fortin LJ, Genest J Jr. Measurement of homocysteine in the prediction of arteriosclerosis. Clin Biochem 1995;28:155-62.
    • (1995) Clin Biochem , vol.28 , pp. 155-162
    • Fortin, L.J.1    Genest Jr., J.2
  • 16
    • 0017293933 scopus 로고
    • Evaluation of methods of coenzyme activation of erythrocyte enzymes for deficiency of vitamin B1, B2, and B6
    • Bayoumi RA, Rosalki SB. Evaluation of methods of coenzyme activation of erythrocyte enzymes for deficiency of vitamin B1, B2, and B6. Clin Chem 1976;22:327-35.
    • (1976) Clin Chem , vol.22 , pp. 327-335
    • Bayoumi, R.A.1    Rosalki, S.B.2
  • 17
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-3.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 18
    • 0022569576 scopus 로고
    • The effect of riboflavin deficiency on methylenetetrahydrofolate reductase (NADPH) (EC1.5.1.20) and folate metabolism in the rat
    • Bates CJ, Fuller NJ. The effect of riboflavin deficiency on methylenetetrahydrofolate reductase (NADPH) (EC1.5.1.20) and folate metabolism in the rat. Br J Nutr 1986;55:455-64.
    • (1986) Br J Nutr , vol.55 , pp. 455-464
    • Bates, C.J.1    Fuller, N.J.2
  • 19
    • 0024378545 scopus 로고
    • Two interconnected B vitamins: Riboflavin and pyridoxine
    • McCormick DB. Two interconnected B vitamins: riboflavin and pyridoxine. Physiol Rev 1989;69:1170-98.
    • (1989) Physiol Rev , vol.69 , pp. 1170-1198
    • McCormick, D.B.1
  • 20
    • 0035929601 scopus 로고    scopus 로고
    • Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for cloning and mapping of NADPH-dependent methionine synthase activation
    • Olteanu H, Banerjee R. Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for cloning and mapping of NADPH-dependent methionine synthase activation. J Biol Chem 2001;276:35558-63.
    • (2001) J Biol Chem , vol.276 , pp. 35558-35563
    • Olteanu, H.1    Banerjee, R.2
  • 21
    • 0035116352 scopus 로고    scopus 로고
    • Determinants of plasma total homocysteine concentration in the Framingham offspring cohort
    • Jacques PF, Bostom AG, Wilson PWF, et al. Determinants of plasma total homocysteine concentration in the Framingham offspring cohort. Am J Clin Nutr 2001;73:613-21.
    • (2001) Am J Clin Nutr , vol.73 , pp. 613-621
    • Jacques, P.F.1    Bostom, A.G.2    Wilson, P.W.F.3
  • 22
    • 16544368401 scopus 로고    scopus 로고
    • Frequent consumption of milk, yogurt, cold breakfast cereals, peppers, and cruciferous vegetables and intakes of dietary folate and riboflavin but not vitamin B-12 and B-6 are inversely associated with serum total homocysteine concentrations in the US population
    • Ganji V, Kafai M. Frequent consumption of milk, yogurt, cold breakfast cereals, peppers, and cruciferous vegetables and intakes of dietary folate and riboflavin but not vitamin B-12 and B-6 are inversely associated with serum total homocysteine concentrations in the US population. Am J Clin Nutr 2004;80:1500-7.
    • (2004) Am J Clin Nutr , vol.80 , pp. 1500-1507
    • Ganji, V.1    Kafai, M.2
  • 23
    • 2242477014 scopus 로고    scopus 로고
    • Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomized trials
    • Homocysteine Lowering Trials' Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials. BMJ 1998;316:894-8.
    • (1998) BMJ , vol.316 , pp. 894-898
  • 24
    • 0036330367 scopus 로고    scopus 로고
    • Folic acid fortification, folate status and plasma homocysteine
    • Rader JI. Folic acid fortification, folate status and plasma homocysteine. J Nutr 2002;132:S2466-70.
    • (2002) J Nutr , vol.132
    • Rader, J.I.1
  • 25
    • 0036147706 scopus 로고    scopus 로고
    • The history and future of food fortification in the United States: A public health perspective
    • Backstrand JR. The history and future of food fortification in the United States: a public health perspective. Nutr Rev 2002;60:15-26.
    • (2002) Nutr Rev , vol.60 , pp. 15-26
    • Backstrand, J.R.1
  • 26
    • 0030027668 scopus 로고    scopus 로고
    • Relationship between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
    • Jacques PF, Bostom AG, Williams RR, et al. Relationship between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996;93:7-9.
    • (1996) Circulation , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3
  • 27
    • 0029974036 scopus 로고    scopus 로고
    • Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 μmol/L): The Hordaland Homocysteine Study
    • Guttormsen AB, Ueland PM, Nesthus I, et al. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 μmol/L): the Hordaland Homocysteine Study. J Clin Invest 1996;98:2174-83.
    • (1996) J Clin Invest , vol.98 , pp. 2174-2183
    • Guttormsen, A.B.1    Ueland, P.M.2    Nesthus, I.3
  • 28
    • 0742324549 scopus 로고    scopus 로고
    • Effects of the interaction between the C677T 5,10-methelenetetrahydrofolate reductase polymorphism and serum B vitamins on homocysteine levels in pregnant women
    • Kim KN, Kim KJ, Chang N. Effects of the interaction between the C677T 5,10-methelenetetrahydrofolate reductase polymorphism and serum B vitamins on homocysteine levels in pregnant women. Eur J Clin Nutr 2004;58:10-6.
    • (2004) Eur J Clin Nutr , vol.58 , pp. 10-16
    • Kim, K.N.1    Kim, K.J.2    Chang, N.3
  • 29
    • 0042920823 scopus 로고    scopus 로고
    • Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation
    • Stern LL, Shane B, Bagley PJ, et al. Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation. J Nutr 2003;133:2716-20.
    • (2003) J Nutr , vol.133 , pp. 2716-2720
    • Stern, L.L.1    Shane, B.2    Bagley, P.J.3
  • 30
    • 0346726185 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genomic stability in cultured human lymphocyte
    • Kimura M, Umegaki K, Higuchi M, et al. Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genomic stability in cultured human lymphocyte. J Nutr 2004;134:48-56.
    • (2004) J Nutr , vol.134 , pp. 48-56
    • Kimura, M.1    Umegaki, K.2    Higuchi, M.3
  • 31
    • 0036223735 scopus 로고    scopus 로고
    • Is folate a promising agent in the prevention and treatment of cardiovascular disease in patients with renal failure?
    • De Vriese AS, Verbeke F, Schrijvers BF, et al. Is folate a promising agent in the prevention and treatment of cardiovascular disease in patients with renal failure? Kidney Int 2002;61:1199-209.
    • (2002) Kidney Int , vol.61 , pp. 1199-1209
    • De Vriese, A.S.1    Verbeke, F.2    Schrijvers, B.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.