BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation

International Journal of Cancer

Volumn 131, Issue 8, 2012, Pages 1941-1950

  Wang, Lin ^a   Park, Paul ^a   Zhang, Huina ^a,b   La Marca, Frank ^a   Claeson, Amy ^b   Than, Khoi ^a   Rahman, Shayan ^a   Lin, Chia Ying ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

BMP 2; metastasis; osteogenic differentiation; renal cell carcinoma; Smad

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; BONE MORPHOGENETIC PROTEIN RECEPTOR 1B; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; COLLAGEN TYPE 1; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSCRIPTION FACTOR RUNX2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CANCER STEM CELL; CELL PROLIFERATION; COLLAGEN TYPE 1 GENE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; MOUSE; NONHUMAN; ONCOGENE; OSSIFICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RUNX 2 GENE; TREATMENT RESPONSE;

ANIMALS; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 2; CARCINOMA, RENAL CELL; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; IMMUNOENZYME TECHNIQUES; KIDNEY NEOPLASMS; MICE; MICE, INBRED NOD; MICE, SCID; OSTEOGENESIS; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84865321014     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27444     Document Type: Article

References (41)

1. Siegel R, Ward E, Brawley O, Jemal A,. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61: 212-36.
2. Russo P,. Renal cell carcinoma: presentation, staging, and surgical treatment. Semin Oncol 2000; 27: 160-76. (Pubitemid 30205371)
3. Zekri J, Ahmed N, Coleman RE, Hancock BW,. The skeletal metastatic complications of renal cell carcinoma. Int J Oncol 2001; 19: 379-82.
4. Motzer RJ, Russo P,. Systemic therapy for renal cell carcinoma. J Urol 2000; 163: 408-17. (Pubitemid 30060482)
5. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA,. Novel regulators of bone formation: molecular clones and activities. Science 1988; 242: 1528-34. (Pubitemid 19023695)
6. Hogan BL,. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 1996; 10: 1580-94. (Pubitemid 26268864)
7. Thawani JP, Wang AC, Than KD, Lin CY, La Marca F, Park P,. Bone morphogenetic proteins and cancer: review of the literature. Neurosurgery 2010; 66: 233-46; discussion 46.
8. Nohe A, Keating E, Knaus P, Petersen NO,. Signal transduction of bone morphogenetic protein receptors. Cell Signal 2004; 16: 291-9. (Pubitemid 37542404)
9. Kawabata M, Imamura T, Miyazono K,. Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev 1998; 9: 49-61. (Pubitemid 28280536)
10. Kleeff J, Maruyama H, Ishiwata T, Sawhney H, Friess H, Buchler MW, Korc M,. Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo. Gastroenterology 1999; 116: 1202-16. (Pubitemid 29203031)
11. Langenfeld EM, Calvano SE, Abou-Nukta F, Lowry SF, Amenta P, Langenfeld J,. The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis 2003; 24: 1445-54. (Pubitemid 37160834)
12. Ide H, Yoshida T, Matsumoto N, Aoki K, Osada Y, Sugimura T, Terada M,. Growth regulation of human prostate cancer cells by bone morphogenetic protein-2. Cancer Res 1997; 57: 5022-7. (Pubitemid 27498113)
13. Ghosh-Choudhury N, Ghosh-Choudhury G, Celeste A, Ghosh PM, Moyer M, Abboud SL, Kreisberg J,. Bone morphogenetic protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol-treated MCF-7 human breast cancer cells. Biochim Biophys Acta 2000; 1497: 186-96. (Pubitemid 30618830)
14. Ghosh-Choudhury N, Woodruff K, Qi W, Celeste A, Abboud SL, Ghosh Choudhury G,. Bone morphogenetic protein-2 blocks MDA MB 231 human breast cancer cell proliferation by inhibiting cyclin-dependent kinase-mediated retinoblastoma protein phosphorylation. Biochem Biophys Res Commun 2000; 272: 705-11. (Pubitemid 30420703)
15. Kawamura C, Kizaki M, Yamato K, Uchida H, Fukuchi Y, Hattori Y, Koseki T, Nishihara T, Ikeda Y,. Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3. Blood 2000; 96: 2005-11.
16. Wen XZ, Miyake S, Akiyama Y, Yuasa Y,. BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells. Biochem Biophys Res Commun 2004; 316: 100-6. (Pubitemid 38299134)
17. Beck SE, Jung BH, Fiorino A, Gomez J, Rosario ED, Cabrera BL, Huang SC, Chow JY, Carethers JM,. Bone morphogenetic protein signaling and growth suppression in colon cancer. Am J Physiol Gastrointest Liver Physiol 2006; 291: G135-G145. (Pubitemid 44024671)
18. Brubaker KD, Corey E, Brown LG, Vessella RL,. Bone morphogenetic protein signaling in prostate cancer cell lines. J Cell Biochem 2004; 91: 151-60.
19. Wang L, Park P, Zhang H, La Marca F, Claeson A, Valdivia J, Lin CY,. BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. Cancer Biol Ther 2011; 11: 457-63.
20. Xu P, Qiu M, Zhang Z, Kang C, Jiang R, Jia Z, Wang G, Jiang H, Pu P,. The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo. J Neurooncol 2010; 97: 41-51.
21. Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G, Brem H, Olivi A, Dimeco F, Vescovi AL,. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 2006; 444: 761-5. (Pubitemid 44949605)
22. Wang L, Park P, Lin CY,. Characterization of stem cell attributes in human osteosarcoma cell lines. Cancer Biol Ther 2009; 8: 543-52.
23. Wang L, Park P, Zhang H, La Marca F, Lin CY,. Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. Int J Cancer 2011; 128: 294-303.
24. Vainio S, Karavanova I, Jowett A, Thesleff I,. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 1993; 75: 45-58. (Pubitemid 23306020)
25. Hu X, Zhang X, Qiu S, Yu D, Lin S,. Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. Biochem Biophys Res Commun 2010; 398: 62-7.
26. Le Page C, Puiffe ML, Meunier L, Zietarska M, de Ladurantaye M, Tonin PN, Provencher D, Mes-Masson AM,. BMP-2 signaling in ovarian cancer and its association with poor prognosis. J Ovarian Res 2009; 2: 4.
27. Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007; 1: 555-67. (Pubitemid 350056407)
28. Weber KL, Pathak S, Multani AS, Price JE,. Characterization of a renal cell carcinoma cell line derived from a human bone metastasis and establishment of an experimental nude mouse model. J Urol 2002; 168: 774-9. (Pubitemid 34793361)
29. Waters WB, Richie JP,. Aggressive surgical approach to renal cell carcinoma: review of 130 cases. J Urol 1979; 122: 306-9. (Pubitemid 10226068)
30. Motzer RJ, Russo P, Nanus DM, Berg WJ,. Renal cell carcinoma. Curr Probl Cancer 1997; 21: 185-232.
31. Orui H, Imaizumi S, Ogino T, Motoyama T,. Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report. J Orthop Sci 2000; 5: 600-4. (Pubitemid 32016269)
32. Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T,. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 1994; 127: 1755-66. (Pubitemid 24380911)
33. Yamate J, Kotera T, Kuwamura M, Kotani T,. Potential osteogenic differentiation of cisplatin-resistant rat malignant fibrous histiocytoma-derived cell lines. Exp Toxicol Pathol 2007; 58: 299-309. (Pubitemid 46498719)
34. Reddi AH,. Bone morphogenetic proteins: from basic science to clinical applications. J Bone Joint Surg Am 2001; 83 (Suppl 1): S1-S6.
35. Laflamme C, Curt S, Rouabhia M,. Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation. Arch Oral Biol 2010; 55: 689-701.
36. zur Nieden NI, Kempka G, Ahr HJ,. In vitro differentiation of embryonic stem cells into mineralized osteoblasts. Differentiation 2003; 71: 18-27. (Pubitemid 38230416)
37. Tokunaga K, Ogose A, Endo N, Nomura S, Takahashi HE,. Human osteosarcoma (OST) induces mouse reactive bone formation in xenograft system. Bone 1996; 19: 447-54.
38. Imai N, Iwai A, Hatakeyama S, Matsuzaki K, Kitagawa Y, Kato S, Hokari R, Kawaguchi A, Nagao S, Miyahara T, Itoh K, Miura S,. Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification. Pathol Int 2001; 51: 643-8. (Pubitemid 32947168)
39. Kypson AP, Morphew E, Jones R, Gottfried MR, Seigler HF,. Heterotopic ossification in rectal cancer: rare finding with a novel proposed mechanism. J Surg Oncol 2003; 82: 132-6; disccussion 37. (Pubitemid 36164449)
40. Yamasaki M, Nomura T, Mimata H, Nomura Y,. Involvement of bone morphogenetic protein 2 in ossification of renal cell carcinoma. J Urol 2004; 172: 475-6. (Pubitemid 38900180)
41. Fong S, Chan MK, Fong A, Bowers WJ, Kelly KJ,. Viral vector-induced expression of bone morphogenetic protein 2 produces inhibition of tumor growth and bone differentiation of stem cells. Cancer Gene Ther 2010; 17: 80-5.