Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: A preliminary report

Journal of Orthopaedic Science

Volumn 5, Issue 6, 2000, Pages 600-604

  Orui, Hiroshi ^a   Imaizumi, Satoshi ^a,b   Ogino, Toshihiko ^a   Motoyama, Teiichi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Bone morphogenetic protein 2; MTT assay; Osteosarcoma; Proliferation

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; OSTEOCALCIN;

ARTICLE; BONE DEFECT; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; OSTEOBLAST; OSTEOSARCOMA;

EID: 0034537742     PISSN: 09492658     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007760070012     Document Type: Article

References (29)

1. Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner
2. Skeletal alkaline phosphatase activity as a bone formation index in vitro
3. Enzyme induction, accumulation of collagen, and calcification in implants of bone matrix
4. Expression of bone morphogenetic proteins and receptors in sarcomas
5. Three human osteosarcoma cell lines exhibiting different phenotypic expressions
6. Growth regulation of human prostate cancer cells by bone morphogenetic protein-2
7. Bone morphogenetic protein augumentation grafting of resistant femoral nonunions: A preliminary report
8. Resistant nonunions and partial or complete segmental defects of long bones. Treatment with implants of a composite of human bone morphogenetic protein (BMP) and autolyzed, antigen-extracted, allogenic (AAA) bone
9. Establishment and characterization of a human prostatic carcinoma cell line (PC-3)
10. Relationship of serum levels of pro-type I collagen peptide, pro-type III collagen peptide and type IV 7S collagen with cervical maturation
11. A newly established human osteosarcoma cell line with osteoblastic properties
12. Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo
13. The TGF-β family and its composite receptors
14. Expression of hepatocyte growth factor is up-regulated through activation of a cAMP-mediated pathway
15. Metastasis
16. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
17. Facilitation and suppression of bone metastasis
18. Bone formation in vitro and in nude mice by human osteosarcoma cells
19. Establishment and characterization of human breast cancer cell line, OCUB-1
20. A molecular approach to bone regeneration
21. Bone: Formation by autoinduction
22. Comments on hematogenous metastatic patterns in humans as revealed by autopsy
23. Novel regulators of bone formation: Molecular clones and activities
24. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
25. Establishment and characterization of cell lines derived from a human osteosarcoma
26. Prognostic significance of bone morphogenetic activity in osteosarcoma tissue
27. Immunohistochemical detection of bone morphogenetic proteins in bone and soft-tissue sarcomas
28. Structure, expression, and regulation of the major noncollagenous matrix proteins of bone
29. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage