ERK1/2, p38, and JNK regulate the expression and the activity of the three isoforms of the Na +/Ca 2+exchanger, NCX1, NCX2, and NCX3, in neuronal PC12 cells

Journal of Neurochemistry

Volumn 122, Issue 5, 2012, Pages 911-922

  Sirabella, Rossana ^a   Secondo, Agnese ^b   Pannaccione, Anna ^b   Molinaro, Pasquale ^b   Formisano, Luigi ^c   Guida, Natascia ^b   Di Renzo, Gianfranco ^b   Annunziato, Lucio ^a,b   Cataldi, Mauro ^b  

^a IRCCS SDN   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF SANNIO   (Italy)

Author keywords

CREB1; ERK1 2; JNK; p38; Sodium Calcium exchanger (NCX); Sp1

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GENOMIC DNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NERVE GROWTH FACTOR; PROTEASOME; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CALCIUM EXCHANGE PROTEIN 1; SODIUM CALCIUM EXCHANGE PROTEIN 2; SODIUM CALCIUM EXCHANGE PROTEIN 3; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GENE SILENCING; NERVE CELL; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SODIUM CALCIUM EXCHANGE; TRANSCRIPTION INITIATION SITE; UPREGULATION; WHOLE CELL;

ANIMALS; CALCIUM; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CREB-BINDING PROTEIN; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PROTEIN ISOFORMS; RATS; RNA, SMALL INTERFERING; SODIUM-CALCIUM EXCHANGER; SP1 TRANSCRIPTION FACTOR; TIME FACTORS;

EID: 84865312704     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07838.x     Document Type: Article

References (39)

1. 2+ exchanger, from molecular biology to therapeutic perspectives. Pharmacol. Rev. 56, 633-654. (Pubitemid 39658464)
2. 2+ exchanger: a target for therapeutic intervention in cerebral ischemia. in New Strategies in Stroke Intervention: Ionic Transporters, Pumps, and New Channels (, Annunziato L,., ed.), pp. 65-88. Humana Press, a part of Springer Science + Business Media, New York.
3. Atkins C. M., Selcher J. C., Petraitis J. J., Trzaskos J. M., and, Sweatt J. D., (1998) The MAPK cascade is required for mammalian associative learning. Nat. Neurosci. 1, 602-609.
4. Avruch J., (2007) MAP kinase pathways, the first twenty years. Biochim. Biophys. Acta 1773, 1150-1160. (Pubitemid 47125973)
5. Barone F. C., Irving E. A., Ray A. M., et al. (2001) SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. J. Pharmacol. Exp. Ther. 296, 312-321. (Pubitemid 32112455)
6. Borsello T., and, Forloni G., (2007) JNK signalling, a possible target to prevent neurodegeneration. Curr. Pharm. Des. 13, 1875-1886. (Pubitemid 47010160)
7. 2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions. J. Cereb. Blood Flow Metab. 26, 502-517.
8. Condrescu M., Gardner J. P., Chernaya G., Aceto J. F., Kroupis C., and, Reeves J. P., (1995) ATP-dependent regulation of sodium-calcium exchange in Chinese hamster ovary cells transfected with the bovine cardiac sodium-calcium exchanger. J. Biol. Chem. 270, 9137-9146.
9. 2+ exchanger, NCX1 and NCX3, constitute novel additional targets for the prosurvival action of Akt/protein kinase B pathway. Mol. Pharmacol. 73, 727-737. (Pubitemid 351397878)
10. Formisano L., Guida N., Cocco S., Secondo A., Sirabella R., Ulianich L., Paturzo F., Di Renzo G., and, Canzoniero L. M., (2011) The repressor element 1-silencing transcription factor is a novel molecular target for the neurotoxic effect of the polychlorinated biphenyl mixture aroclor 1254 in neuroblastoma SH-SY5Y cells. J. Pharmacol. Exp. Ther. 338, 997-1003.
11. 2+ exchanger expressed in human cell lines. J. Physiol. 548, 677-689. (Pubitemid 36592764)
12. Impey S., McCorkle S. R., Cha-Molstad H., Dwyer J. M., Yochum G. S., Boss J. M., McWeeney S., Dunn J. J., Mandel G., and, Goodman R. H., (2004) Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell 119, 1041-1054. (Pubitemid 40037616)
13. Irving E. A., and, Bamford M., (2002) Role of mitogen- and stress-activated kinases in ischemic injury. J. Cereb. Blood Flow Metab. 22, 631-647. (Pubitemid 34596455)
14. 2+ exchanger 2. Neuron 38, 965-976. (Pubitemid 36782386)
15. Kelleher R. J. 3rd, Govindarajan A., Jung H. Y., Kang H., and, Tonegawa S,. (2004) Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell 116, 467-479. (Pubitemid 38366322)
16. Kvietikova I., Wenger R. H., Marti H. H., and, Gassmann M., (1995) The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site. Nucleic Acids Res. 23, 4542-4550. (Pubitemid 126003251)
17. Lee S. H., Park Y., Yoon S. K., and, Yoon J. B., (2010) Osmotic stress inhibits proteasome by p38 MAPK-dependent phosphorylation. J. Biol. Chem. 285, 41280-41289.
18. Levi A., Biocca S., Cattaneo A., and, Calissano P., (1988) The mode of action of nerve growth factor in PC12 cells. Mol. Neurobiol. 2, 201-226.
19. Miloso M., Scuteri A., Foudah D., and, Tredici G., (2008) MAPKs as mediators of cell fate determination, an approach to neurodegenerative diseases. Curr. Med. Chem. 15, 538-548. (Pubitemid 351516810)
20. 2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage. J. Neurosci. 28, 1179-1184. (Pubitemid 351186355)
21. 2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory. J. Neurosci. 31, 7312-7321.
22. Morooka T., and, Nishida E., (1998) Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells. J. Biol. Chem. 273, 24285-24288. (Pubitemid 28454911)
23. 2+ exchanger gene. Am. J. Physiol. 274, H217-H232.
24. Nozaki K., Nishimura M., and, Hashimoto N., (2001) Mitogen-activated protein kinases and cerebral ischemia. Mol. Neurobiol. 23, 1-19. (Pubitemid 32948270)
25. 2+ exchanger transcripts and proteins in rat brain regions. J. Comp. Neurol. 461, 31-48. (Pubitemid 36578595)
26. Philipson K. D., and, Nicoll D. A., (2000) Sodium-calcium exchange, a molecular perspective. Annu. Rev. Physiol. 62, 111-133.
27. Pignataro G., Gala R., Cuomo O., et al. (2004) Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia. Stroke 35, 2566-2570. (Pubitemid 39458418)
28. Reichardt L. F., (2006) Neurotrophin-regulated signalling pathways. Philos. Trans. R. Soc. Lond. B Biol. Sci. 361, 1545-1564. (Pubitemid 44450210)
29. 2+ exchange. Cell Calcium 34, 19-26. (Pubitemid 36790440)
30. Riccio A., Ahn S., Davenport C. M., Blendy J. A., and, Ginty D. D., (1999) Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 286, 2358-2361. (Pubitemid 30016901)
31. Secondo A., Molinaro P., Pannaccione A., Esposito A., Cantile M., Lippiello P., Sirabella R., Iwamoto T., Di Renzo G., and, Annunziato L., (2011) Nitric oxide stimulates NCX1 and NCX2 but inhibits NCX3 isoform by three distinct molecular determinats. Mol. Pharmacol. 79, 558-568.
32. Turjanski A. G., Vaqué J. P., and, Gutkind J. S., (2007) MAP kinases and the control of nuclear events. Oncogene 26, 3240-3253. (Pubitemid 46763018)
33. Valsecchi V., Pignataro G., Del Prete A., et al. (2011) NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning. Stroke 42, 754-763.
34. Wang J. Q., Tang Q., Parelkar N. K., Liu Z., Samdani S., Choe E. S., Yang L., and, Mao L., (2004) Glutamate signaling to Ras-MAPK in striatal neurons, mechanisms for inducible gene expression and plasticity. Mol. Neurobiol. 29, 1-14. (Pubitemid 39118075)
35. Whitmarsh A. J., (2007) Regulation of gene transcription by mitogen-activated protein kinase signaling pathways. Biochim. Biophys. Acta 1773, 1285-1298. (Pubitemid 47125975)
36. Xing J., Kornhauser J. M., Xia Z., Thiele E. A., and, Greenberg M. E., (1998) Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol. Cell. Biol. 18, 1946-1955. (Pubitemid 28152643)
37. 2+ exchanger expression in adult cardiomyocytes. J. Mol. Cell. Cardiol. 38, 735-743. (Pubitemid 40591738)
38. Yan G. Z., and, Ziff E. B., (1997) Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor. J. Neurosci. 17, 6122-6132. (Pubitemid 27329888)
39. Yang S. H., Sharrocks A. D., and, Whitmarsh A. J., (2003) Transcriptional regulation by the MAP kinase signaling cascades. Gene 320, 3-21. (Pubitemid 37352751)