LC-MS/MS techniques for high-volume screening of drugs of abuse and target drug quantitation in urine/blood matrices

Methods in Molecular Biology

Volumn 902, Issue , 2012, Pages 29-41

  Eichhorst, Jeff C ^a   Etter, Michele L ^a   Hall, Patricia L ^a   Lehotay, Denis C ^a  

^a Saskatchewan Disease Control Laboratory   (Canada)

Author keywords

Chromatography; Drugs of abuse; GC MS; LC MS MS; Screening; Tandem mass spectrometry; Toxicology

Indexed keywords

DRUG; STREET DRUG;

ARTICLE; BLOOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; METABOLISM; METHODOLOGY; SOLID PHASE EXTRACTION; SUBSTANCE ABUSE; TANDEM MASS SPECTROMETRY; URINE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HIGH-THROUGHPUT SCREENING ASSAYS; PHARMACEUTICAL PREPARATIONS; SOLID PHASE EXTRACTION; STREET DRUGS; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY;

EID: 84865309170     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-934-1_3     Document Type: Article

References (14)

1. Jemal M (2000) High-throughput quantitative bioanalysis by LC/MS/MS. Biomed Chromatogr 14:422-429
2. Weinmann W et al (2001) Fast con fi rmation of 11-nor-9-carboxy-Delta(9)- tetrahydrocannabinol (THC-COOH) in urine by LC/MS/MS using negative atmospheric-pressure chemical ionisation (APCI). Forensic Sci Int 121:103-107
3. Maralikova B, Weinmann W (2004) Con fi rmatory analysis for drugs of abuse in plasma and urine by high-performance liquid chromatography-tandem mass spectrometry with respect to criteria for compound identi fi cation. J Chromatogr B: Analyt Technol Biomed Life Sci 811:21-30
4. Mueller CA et al (2005) Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library searching. Rapid Commun Mass Spectrom 19:1332-1338
5. Wineker R (2008) Immunoassays continue to improve, expand and evolve. American Association for Clinical Chemistry, Washington, DC, pp 1-9
6. Mortier KA et al (2002) Determination of paramethoxyamphetamine and other amphetaminerelated designer drugs by liquid chromatography/sonic spray ionization mass spectrometry. Rapid Commun Mass Spectrom 16:865-870
7. Abraham TT et al (2007) Simultaneous GC-EI-MS determination of Delta9-tetrahydrocannabinol, 11-hydroxy-Delta9-tetrahydrocannabinol, and 11-nor-9-carboxy-Delta9-tetrahydrocannabinol in human urine following tandem enzyme-alkaline hydrolysis. J Anal Toxicol 31:477-485
8. Kushnir MM et al (2005) Assessing analytical speci fi city in quantitative analysis using tandem mass spectrometry. Clin Biochem 38:319-327
9. Mallet CR, Lu Z, Mazzeo JR (2004) A study of ion suppression effects in electrospray ionization from mobile phase additives and solidphase extracts. Rapid Commun Mass Spectrom 18:49-58
10. Taylor PJ (2005) Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. Clin Biochem 38:328-334
11. Tiller PR, Romanyshyn LA, Neue UD (2003) Fast LC/MS in the analysis of small molecules. Anal Bioanal Chem 377:788-802
12. Hopfgartner G, Husser C, Zell M (2002) High-throughput quanti fi cation of drugs and their metabolites in biosamples by LC/MS/MS and CE-MS/MS: possibilities and limitations. Ther Drug Monit 24:134-143
13. Etter ML et al (2005) Determination of free and protein-bound methadone and it's major metabolite EDDP: enatiomeric separation and quantitation by LC/MS/MS. Clin Biochem 38:1095-1102
14. Eichhorst JC et al (2009) Drugs of abuse testing by tandem mass spectrometry: a rapid, simple method to replace immunoassays. Clin Biochem 42:1531-1542