Determination of free and protein-bound methadone and its major metabolite EDDP: Enantiomeric separation and quantitation by LC/MS/MS

Clinical Biochemistry

Volumn 38, Issue 12, 2005, Pages 1095-1102

  Etter, M L ^a   George, S ^a   Graybiel, K ^a   Eichhorst, J ^a   Lehotay, D C ^a,b,c  

^a Saskatchewan Health   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c Provincial Laboratory   (Canada)

Author keywords

Chiral chromatography; EDDP; LC MS MS; Methadone; Protein binding; Ultrafiltration

Indexed keywords

2 ETHYLIDINE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; DRUG METABOLITE; METHADONE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; ARTIFICIAL MEMBRANE; CHIRAL CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENANTIOMER; EVAPORATION; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; MEMBRANE RECONSTITUTION; MOLECULAR WEIGHT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SPIKE; ULTRAFILTRATION;

CHROMATOGRAPHY, LIQUID; HUMANS; LINEAR MODELS; MASS SPECTROMETRY; METHADONE; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRROLIDINES; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM;

EID: 29144536234     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2005.09.010     Document Type: Article

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