Demineralized bone matrix as a vehicle for delivering endogenous and exogenous therapeutics in bone repair

Advanced Drug Delivery Reviews

Volumn 64, Issue 12, 2012, Pages 1123-1128

  Holt, Dolly J ^a   Grainger, David W ^a,b  

^a Department of Electrical and Computer Engineering   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Bone regeneration; Cell therapy; Combination device; Controlled release; DBM; Demineralized bone matrix; Drug carrier; Drug delivery; Formulation; Growth factors; Osteoinductive

Indexed keywords

BONE REGENERATION; CELL THERAPY; COMBINATION DEVICES; CONTROLLED RELEASE; DBM; DEMINERALIZED BONE MATRIX; DRUG CARRIER; FORMULATION; GROWTH FACTOR; OSTEOINDUCTIVE;

BIOACTIVITY; BONE CEMENT; DRUG DELIVERY; NUCLEIC ACIDS;

BONE;

ANTIBIOTIC AGENT; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR 1; NOGGIN; OSTEOGENIC PROTEIN 1; OSTEOPONTIN; PLATELET DERIVED GROWTH FACTOR; RECOMBINANT PROTEIN; SIALOPROTEIN; SMALL INTERFERING RNA; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

BIODEGRADABILITY; BONE MATRIX; BONE REMODELING; CELL THERAPY; COMPOSITE MATERIAL; DEMINERALIZED BONE MATRIX; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FRACTURE HEALING; INSTRUMENT STERILIZATION; NONVIRAL GENE DELIVERY SYSTEM; OSSIFICATION; PRIORITY JOURNAL; PROTEIN SECRETION; REVIEW; TRANSGENE;

ANIMALS; BONE AND BONES; BONE DEMINERALIZATION TECHNIQUE; BONE MATRIX; BONE REGENERATION; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; REGENERATIVE MEDICINE;

EID: 84865305021     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.04.002     Document Type: Review

References (57)

1. Gruskin E., Doll B., Futrell F., Schmitz J., Hollinger J. Demineralized bone matrix in bone repair: History and use. Adv. Drug Deliv. Rev. 2012, 64:1063-1077. (this issue).
2. Groessner-Schreiber B., Krukowski M., Lyons C., Osdoby P. Osteoclast recruitment in response to human bone matrix is age related. Mech. Ageing Dev. 1992, 62:143-154.
3. Aaboe M., Pinholt E.M., Schou S., Hjorting-Hansen E. Incomplete bone regeneration of rabbit calvarial defects using different membranes. Clin. Oral Implants Res. 1998, 9:313-320.
4. Schwartz Z., Somers A., Mellonig J.T., Carnes D., Dean D., Cochran D., Boyan B. Ability of demineralized freeze-dried bone allograft to induce new bone formation is dependent on donor age but not gender. J. Periodontol. 1998, 69:470-478.
5. Zhang M., Powers R.M., Wolfinbarger L. A quantitative assessment of osteoinductivity of human demineralized bone matrix. J. Periodontol. 1997, 68:1076-1084.
6. Ranly D.M., Lohmann C.H., Andreacchio D., Boyan B.D., Schwartz Z. Platelet-rich plasma inhibits demineralized bone matrix-induced bone formation in nude mice. J. Bone Joint Surg. Am. 2007, 89:139-147.
7. Salih E., Wang J., Mah J., Fluckiger R. Natural variation in the extent of phosphorylation of bone phosphoproteins as a function of in vivo new bone formation induced by demineralized bone matrix in soft tissue and bony environments. Biochem. J. 2002, 364:465-474.
8. Wildemann B., Kadow-Romacker A., Haas N.P., Schmidmaier G. Quantification of various growth factors in different demineralized bone matrix preparations. J. Biomed. Mater. Res. A 2007, 81:437-442.
9. Pietrzak W.S., Woodell-May J., McDonald N. Assay of bone morphogenetic protein-2, -4, and -7 in human demineralized bone matrix. J. Craniofac. Surg. 2006, 17:84-90.
10. Behnam K., Brochmann E., Murray S. Alkali-urea extraction of demineralized bone matrix removes noggin, an inhibitor of bone morphogenetic proteins. Connect. Tissue Res. 2004, 45:257-260.
11. Urist M.R. Bone: formation by autoinduction. Science 1965, 150:893-899.
12. Urist M.R., Strates B.S. Bone morphogenetic protein. J. Dent. Res. 1971, 50:1392-1406.
13. Peel S.A., Hu Z.M., Clokie C.M. In search of the ideal bone morphogenetic protein delivery system: in vitro studies on demineralized bone matrix, purified, and recombinant bone morphogenetic protein. J. Craniofac. Surg. 2003, 14:284-291.
14. Wu P., Grainger D.W. Drug/device combinations for local drug therapies and infection prophylaxis. Biomaterials 2006, 27:2450-2467.
15. Kimoto T., Hosokawa R., Kubo T., Maeda M., Sano A., Akagawa Y. Continuous administration of basic fibroblast growth factor (FGF-2) accelerates bone induction on rat calvaria-an application of a new drug delivery system. J. Dent. Res. 1998, 77:1965-1969.
16. Lin X., Pena L.A., Zamora P.O., Campion S.L., Takahashi K. Augmentation of demineralized bone matrix (DBM) mineralization by a synthetic growth factor mimetic. J. Orthop. Res. 2006, 24:2051-2058.
17. Lu M., Rabie A.B. The effect of demineralized intramembranous bone matrix and basic fibroblast growth factor on the healing of allogeneic intramembranous bone grafts in the rabbit. Arch. Oral Biol. 2002, 47:831-841.
18. Gombotz W.R., Pankey S.C., Bouchard L.S., Ranchalis J., Puolakkainen P. Controlled release of TGF-beta 1 from a biodegradable matrix for bone regeneration. J. Biomater. Sci. Polym. Ed. 1993, 5:49-63.
19. Moxham J.P., Kibblewhite D.J., Bruce A.G., Rigley T., Gillespy T., Lane J. Transforming growth factor-beta 1 in a guanidine-extracted demineralized bone matrix carrier rapidly closes a rabbit critical calvarial defect. J. Otolaryngol. 1996, 25:82-87.
20. Howes R., Bowness J.M., Grotendorst G.R., Martin G.R., Reddi A.H. Platelet-derived growth factor enhances demineralized bone matrix-induced cartilage and bone formation. Calcif. Tissue Int. 1988, 42:34-38.
21. Chen L., He Z., Chen B., Zhao Y., Sun W., Xiao Z., Zhang J., Yang M., Gao Z., Dai J. Direct chemical cross-linking of platelet-derived growth factor-BB to the demineralized bone matrix improves cellularization and vascularization. Biomacromolecules 2009, 10:3193-3198.
22. Ranly D.M., McMillan J., Keller T., Lohmann C.H., Meunch T., Cochran D.L., Schwartz Z., Boyan B.D. Platelet-derived growth factor inhibits demineralized bone matrix-induced intramuscular cartilage and bone formation. A study of immunocompromised mice. J. Bone Joint Surg. Am. 2005, 87:2052-2064.
23. Emad B., Sherif el M., Basma G.M., Wong R.W., Bendeus M., Rabie A.B. Vascular endothelial growth factor augments the healing of demineralized bone matrix grafts. Int. J. Surg. 2006, 4:160-166.
24. Prisell P.T., Aspenberg P., Wikstrom B., Wredmark T., Norstedt G. Insulin-like growth factor I increases bone formation in old or corticosteroid treated rats. Acta Orthop. Scand. 1997, 68:586-592.
25. Chen B., Lin H., Wang J., Zhao Y., Wang B., Zhao W., Sun W., Dai J. Homogeneous osteogenesis and bone regeneration by demineralized bone matrix loading with collagen-targeting bone morphogenetic protein-2. Biomaterials 2007, 28:1027-1035.
26. Zhang X., Kuroda S., Carpenter D., Nishimura I., Soo C., Moats R., Iida K., Wisner E., Hu F.Y., Miao S., Beanes S., Dang C., Vastardis H., Longaker M., Tanizawa K., Kanayama N., Saito N., Ting K. Craniosynostosis in transgenic mice overexpressing Nell-1. J. Clin. Invest. 2002, 110:861-870.
27. Li W., Lee M., Whang J., Siu R.K., Zhang X., Liu C., Wu B.M., Wang J.C., Ting K., Soo C. Delivery of lyophilized Nell-1 in a rat spinal fusion model. Tissue Eng. A 2010, 16:2861-2870.
28. Siu R.K., Lu S.S., Li W., Whang J., McNeill G., Zhang X., Wu B.M., Turner A.S., Seim H.B., Hoang P., Wang J.C., Gertzman A.A., Ting K., Soo C. Nell-1 protein promotes bone formation in a sheep spinal fusion model. Tissue Eng. A 2011, 17:1123-1135.
29. Lu S.S., Zhang X., Soo C., Hsu T., Napoli A., Aghaloo T., Wu B.M., Tsou P., Ting K., Wang J.C. The osteoinductive properties of Nell-1 in a rat spinal fusion model. Spine J. 2007, 7:50-60.
30. Huang Y.C., Simmons C., Kaigler D., Rice K.G., Mooney D.J. Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther. 2005, 12:418-426.
31. Fang J., Zhu Y.Y., Smiley E., Bonadio J., Rouleau J.P., Goldstein S.A., McCauley L.K., Davidson B.L., Roessler B.J. Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:5753-5758.
32. Wang Y., Grainger D.W. siRNA knock-down of RANK signaling to control osteoclast-mediated bone resorption. Pharm. Res. 2010, 27:1273-1284.
33. Takahashi H., Wang Y., Grainger D.W. Device-based local delivery of siRNA against mammalian target of rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulation. J. Control. Release 2010, 147:400-407.
34. Lin L., Chen L., Wang H., Wei X., Fu X., Zhang J., Ma K., Zhou C., Yu C. Adenovirus-mediated transfer of siRNA against Runx2/Cbfa1 inhibits the formation of heterotopic ossification in animal model. Biochem. Biophys. Res. Commun. 2006, 349:564-572.
35. Shi M., Liu Z.W., Wang F.S. Immunomodulatory properties and therapeutic application of mesenchymal stem cells. Clin. Exp. Immunol. 2011, 164:1-8.
36. Wang J.C., Kanim L.E., Yoo S., Campbell P.A., Berk A.J., Lieberman J.R. Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. J. Bone Joint Surg. Am. 2003, 85-A:905-911.
37. Lieberman J.R., Daluiski A., Stevenson S., Wu L., McAllister P., Lee Y.P., Kabo J.M., Finerman G.A., Berk A.J., Witte O.N. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J. Bone Joint Surg. Am. 1999, 81:905-917.
38. Lindholm T.S., Nilsson O.S., Lindholm T.C. Extraskeletal and intraskeletal new bone formation induced by demineralized bone matrix combined with bone marrow cells. Clin. Orthop. Relat. Res. 1982, 251-255.
39. Supronowicz P., Gill E., Trujillo A., Thula T., Zhukauskas R., Ramos T., Cobb R.R. Human adipose-derived side population stem cells cultured on demineralized bone matrix for bone tissue engineering. Tissue Eng. A 2011, 17:789-798.
40. Lieberman J.R., Le L.Q., Wu L., Finerman G.A., Berk A., Witte O.N., Stevenson S. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J. Orthop. Res. 1998, 16:330-339.
41. Hannallah D., Peng H., Young B., Usas A., Gearhart B., Huard J. Retroviral delivery of Noggin inhibits the formation of heterotopic ossification induced by BMP-4, demineralized bone matrix, and trauma in an animal model. J. Bone Joint Surg. Am. 2004, 86-A:80-91.
42. Lemberg H. Mononucleotide Autologous Stem Cells and Demineralized Bone Matrix in the Treatment of Non Union/Delayed Fractures 2012.
43. Saraf S.K., Yadav A., Nagwani S., Sen M. Decal bone matrix as a local antibiotic delivery vehicle in a MRSA-infected bone model: an experimental study. Indian J Orthop 2010, 44:246-251.
44. Lewis C.S., Supronowicz P.R., Zhukauskas R.M., Gill E., Cobb R.R. Local antibiotic delivery with demineralized bone matrix. Cell Tissue Bank 2012, 13(1):119-127. (Electronic publication ahead of print, 2011 Jan 1).
45. Beardmore A.A., Brooks D.E., Wenke J.C., Thomas D.B. Effectiveness of local antibiotic delivery with an osteoinductive and osteoconductive bone-graft substitute. J. Bone Joint Surg. Am. 2005, 87:107-112.
46. Miclau T., Dahners L.E., Lindsey R.W. In vitro pharmacokinetics of antibiotic release from locally implantable materials. J. Orthop. Res. 1993, 11:627-632.
47. Varlet A., Dauchy P., Hingrez M. Osteogenesis induced by the addition of demineralized bone matrix to plaster pellets with antibiotics. Animal experiment. Rev. Chir. Orthop. Reparatrice Appar. Mot. 1985, 71:73-78.
48. Murugan R., Ramakrishna S. Modification of demineralized bone matrix by a chemical route. J. Mater. Chem. 2004, 14:2041-2045.
49. Kramer S.J., Spadaro J.A., Webster D.A. Antibacterial and osteoinductive properties of demineralized bone matrix treated with silver. Clin. Orthop. Relat. Res. 1981, 154-162.
50. Wong R.W., Rabie A.B. Early healing pattern of statin-induced osteogenesis. Br. J. Oral Maxillofac. Surg. 2005, 43:46-50.
51. Wong R.W., Rabie A.B. Statin-induced osteogenesis uses in orthodontics: a scientific review. World J. Orthod 2006, 7:35-40.
52. Wong R.W., Rabie A.B. Histologic and ultrastructural study on statin graft in rabbit skulls. J. Oral Maxillofac. Surg. 2005, 63:1515-1521.
53. Lima C.E., Calixto J.C., Anbinder A.L. Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats. Braz. Oral Res. 2011, 25:42-48.
54. Galus R., Wlodarski P., Wlodarski K. Influence of fluvastatin on bone formation induced by demineralized bone matrix in mice. Pharmacol. Rep. 2006, 58:443-447.
55. Jakobsen T., Baas J., Bechtold J.E., Elmengaard B., Soballe K. Soaking morselized allograft in bisphosphonate can impair implant fixation. Clin. Orthop. Relat. Res. 2007, 463:195-201.
56. Baas J., Elmengaard B., Jensen T.B., Jakobsen T., Andersen N.T., Soballe K. The effect of pretreating morselized allograft bone with rhBMP-2 and/or pamidronate on the fixation of porous Ti and HA-coated implants. Biomaterials 2008, 29:2915-2922.
57. Aspenberg P., Astrand J. Bone allografts pretreated with a bisphosphonate are not resorbed. Acta Orthop. Scand. 2002, 73:20-23.