Chronic resveratrol administration has beneficial effects in experimental model of type 2 diabetic rats

Endocrine Regulations

Volumn 46, Issue 2, 2012, Pages 83-90

  Soufi, F G ^a   Sheervalilou, R ^b   Vardiani, M ^b   Khalili, M ^b   Alipour, M R ^b  

^a HORMOZGAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Aminotransferase; Diabetes; Hyperglycemia; Oxidative stress; Resveratrol

Indexed keywords

8 ISOPROSTANE; ALBUMIN; CATALASE; CREATININE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEMOGLOBIN A1C; RESVERATROL; SUPEROXIDE DISMUTASE; UREA; ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE PEROXIDASE 1; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ELISA KIT; MALE; METABOLIC REGULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OXIDATIVE STRESS; RAT; SPECTROPHOTOMETRY; WEIGHT CHANGE; ANIMAL; BLOOD; DISEASE MODEL; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; HYPERGLYCEMIA; METABOLISM; WISTAR RAT;

ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; CATALASE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GLUTATHIONE PEROXIDASE; HYPERGLYCEMIA; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; STILBENES; SUPEROXIDE DISMUTASE;

EID: 84865304497     PISSN: 12100668     EISSN: 13360329     Source Type: Journal    
DOI: 10.4149/endo_2012_02_83     Document Type: Article

References (31)

1. Akar F, Pektas MB, Tufan C, Soylemez S, Sepici A, Ulus AT, Gokalp B, Ozturk K, Surucu HS: Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits. Cardiovasc Drugs Ter 25, 119-131, 2011. http://dx.doi.org/10.1007/s10557-010-6255-7
2. Chi TC, Chen W P, Chi TL, Kuo TF, Lee SS, Cheng JT, Su MJ: Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats. Life Sci 80, 1713-1720, 2007. http://dx.doi.org/10.1016/j.lfs.2007.02.002
3. Csiszar A: Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease. Ann N Y Acad Sci 1215, 117-122, 2011. http://dx.doi.org/10.1111/j.1749-6632.2010.05848.x
4. Cottart CH, Nivet-Antoine V, Laguillier-Morizot C, Beaudeux JL: Resveratrol bioavailability and toxicity in humans. Mol Nutr Food Res 54, 7-16, 2010. http://dx.doi.org/10.1002/mnfr.200900437
5. Dailey G: Overall mortality in diabetes mellitus: where do we stand today? Diabetes Technol Ter 13, S65-S74, 2011. http://dx.doi.org/10.1089/dia.2011.0019
6. Davi G, Falco A, Patrono C: Lipid peroxidation in diabetes mellitus. Antioxid Redox Signal 7, 256-268, 2005. http://dx.doi.org/10.1089/ars.2005.7.256
7. Howlett J, Ashwell M: Glycemic response and health: summary of a workshop. Am J Clin Nutr 87, 212S-216S, 2008.
8. Juan ME, Vinardell M P, Planas JM: Te daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. J Nutr 132, 257-260, 2002.
9. Kitada M, Kume S, Imaizumi N, Koya D: Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway. Diabetes 60, 634-643, 2011. http://dx.doi.org/10.2337/db10-0386
10. Kowluru RA, Chan PS: Oxidative stress and diabetic retinopathy. Exp Diabetes Res 2007, Art. ID 43603, 2007. http://dx.doi.org/10.1155/2007/43603
11. Lee SM, Yang H, Tartar DM, Gao B, Luo X, Ye SQ, Zaghouani H, Fang D: Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. Diabetologia 54, 1136-1146, 2011. http://dx.doi.org/10.1007/s00125-011-2064-1
12. Maritim AC, Sanders RA, Watkins JB: Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 17, 24-38, 2003. http://dx.doi.org/10.1002/jbt.10058
13. Masiello P, Broca C, Gross R, Roye M, Manteghetti M, Hillaire-Buys D, Novelli M, Ribes G: Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes 47, 224-229, 1998. http://dx.doi.org/10.2337/diabetes.47.2.224
14. Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts LJ: Increase in circulating products of lipid peroxidation (F2-isoprostane) in smokers. N Engl J Med 332, 1198-1203, 1995. http://dx.doi.org/10.1056/NEJM199505043321804
15. Ndisang JF, Lane N, Syed N, Jadhav A: Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats. Endocrinology 151, 549-560, 2010. http://dx.doi.org/10.1210/en.2009-0471
16. O'Brien RM, Granner DK: Regulation of gene expression by insulin. Biochem J 278, 609-619, 1991.
17. Palsamy P, Subramanian S: Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomed Pharmacother 62, 598-605, 2008. http://dx.doi.org/10.1016/j.biopha.2008.06.037
18. Palsamy P, Subramanian S: Modulatory efects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Chem Biol Interact 179, 356-362, 2009. http://dx.doi.org/10.1016/j.cbi.2008.11.008
19. Palsamy P, Subramanian S: Ameliorative potential of resveratrol on proinfammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic β-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats. J Cell Physiol 224, 423-432, 2010. http://dx.doi.org/10.1002/jcp.22138
20. Palsamy P, Subramanian S: Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal infammatory cytokines via Nrf2-Keap1 signaling. Biochim Biophys Acta 1812, 719-731, 2011.
21. Pitocco D, Zaccardi F, Di Stasio E, Romitelli F, Santini SA, Zuppi C, Ghirlanda G: Oxidative stress, nitric oxide, and diabetes. Rev Diabet Stud 7, 15-25, 2010. http://dx.doi.org/10.1900/RDS.2010.7.15
22. Rains JL, Jain SK: Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 50, 567-575, 2011. http://dx.doi.org/10.1016/j.freeradbiomed.2010.12.006
23. Roghani M, Baluchnejadmojarad T: Mechanisms underlying vascular effect of chronic resveratrol in streptozotocin- diabetic rats. Phytother Res 24, S148-S154, 2010. http://dx.doi.org/10.1002/ptr.3032
24. Salim S, Asghar M, Chugh G, Taneja M, Xia Z, Saha K: Oxidative stress: a potential recipe for anxiety, hypertension and insulin resistance. Brain Res 1359, 178-185, 2010. http://dx.doi.org/10.1016/j.brainres.2010.08.093
25. Schmatz R, Schetinger MR, Spanevello RM, Mazzanti CM, Stefanello N, Maldonado PA, Gutierres J, Correa Mde C, Girotto E, Moretto MB, Morsch VM: Efect of resveratrol on nuleotide degradig enzymes in streptozotocin-induced diabetic rats. Life Sci 84, 345-350, 2009. http://dx.doi.org/10.1016/j.lfs.2008.12.019
26. Sharma S, Kumar A, Arora M, Kaundal RK: Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes. Free Radic Res 43, 400-408, 2009. http://dx.doi.org/10.1080/10715760902801509
27. Sharma S, Misra CS, Arumugam S, Roy S, Shah V, Davis JA, Shirumalla RK, Ray A: Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type-2 diabetes. Phytother Res 25, 67-73, 2011. http://dx.doi.org/10.1002/ptr.3221
28. Su HC, Hung LM, Chen JK: Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin- induced diabetic rats. Am J Physiol Endocrinol Metab 290, E1339-E1346, 2006. http://dx.doi.org/10.1152/ajpendo.00487.2005
29. Szkudelska K, Szkudelski T: Resveratrol, obesity and diabetes. Euro J Pharmachol 635, 1-8, 2010. http://dx.doi.org/10.1016/j.ejphar.2010.02.054
30. Szkudelski T, Szkudelska K: Anti-diabetic effects of resveratrol. Ann N Y Acad Sci 1215, 34-39, 2011. http://dx.doi.org/10.1111/j.1749-6632.2010.05844.x
31. Zhang H, Morgan B, Potter BJ, Ma L, Dellsperger KC, Ungvari Z, Zhang C: Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging. Am J Physiol Heart Circ Physiol 299, H985-H994, 2010. http://dx.doi.org/10.1152/ajpheart.00489.2010