Development of a new LDL-based transport system for hydrophobic/amphiphilic drug delivery to cancer cells

International Journal of Pharmaceutics

Volumn 436, Issue 1-2, 2012, Pages 463-471

  Huntosova, Veronika ^a,b   Buzova, Diana ^a   Petrovajova, Dana ^a   Kasak, Peter ^c   Nadova, Zuzana ^a   Jancura, Daniel ^a   Sureau, Franck ^b   Miskovsky, Pavol ^a,d  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

^b University Paris Diderot   (France)

^c POLYMER INSTITUTE   (Slovakia)

^d INTERNATIONAL LASER CENTER   (Slovakia)

Author keywords

Dextran; Drug delivery; Fluorescence; Hypericin; Low density lipoproteins; Photodynamic therapy

Indexed keywords

AMPHOPHILE; DEXTRAN; HYPERICIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG STABILITY; DRUG TARGETING; DRUG TRANSPORT; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE IMAGING; FLUORESCENCE SPECTROSCOPY; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; SOLUBILIZATION;

CELL LINE, TUMOR; DEXTRANS; DRUG CARRIERS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPOPROTEINS, LDL; NEOPLASMS; PERYLENE; RADIATION-SENSITIZING AGENTS;

EID: 84865294301     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.07.005     Document Type: Article

References (44)

1. T.M. Allen, C.B. Hansen, and D.E.L. Demenzes Pharmacokinetics of long-circulating liposomes Adv. Drug Deliv. Rev. 16 1995 267 284
2. M.S. Brown, and J.L. Goldstein Receptor mediated control of cholesterol metabolism Sciences 191 1976 150 154
3. L. Buriankova, D. Buzova, D. Chorvat Jr.; F. Sureau, D. Brault, P. Miskovsky, and D. Jancura Kinetics of hypericin association with low-density lipoproteins Photochem. Photobiol. 87 2011 56 63
4. F. Danhier, O. Feron, and V. Préat To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery J. Controlled Release 148 2010 1315 1346
5. A.N.L. Derycke, and P.A.M. de Witte Liposomes for photodynamic therapy Adv. Drug Deliv. Rev. 56 2004 17 30
6. R.A. Firestone, J.M. Pisano, J.R. Falck, M.M. McPhaul, and M. Krieger Selective delivery of cytotoxic compounds to cells by the LDL pathway J. Med. Chem. 8 1984 1037 1043
7. R.A. Firestone Low-density lipoprotein as a vehicle for targeting antitumor compounds to cancer cells Bioconjugate Chem. 5 1994 105 113
8. P. Gbur, R. Dedic, D. Chorvat Jr.; P. Miskovsky, J. Hala, and D. Jancura Time resolved luminescence and singlet oxygen formation after illumination of the hypericin-low-density lipoprotein complex Photochem. Photobiol. 85 2009 816 823
9. S. Grund, M. Bauer, and D. Fischer Polymers in drug delivery-state of the art and future trends Adv. Eng. Mater. 13 2011 B61 B87
10. T. Hevonoja, M.O. Petikainen, M.T. Hyvonen, P.T. Kovanen, and M. Ala-Korpela Structure of low density lipoprotein (LDL) particles: basis for understanding molecular changes in modified LDL Biochim. Biophys. Acta 1488 2000 189 210
11. V. Huntosova, L. Alvarez, L. Bryndzova, Z. Nadova, D. Jancura, L. Buriankova, S. Bonneau, D. Brault, P. Miskovsky, and F. Sureau Interaction dynamics of hypericin with low-density lipoproteins and U-87 MG cells Int. J. Pharm. 389 2010 32 40
12. H. Jin, J.E. Lovell, J. Chen, K. Ng, W. Cao, L. Ding, Z. Zhang, and G. Zheng Cytosolic delivery of LDL nanoparticle cargo using photochemical internalization Photochem. Photobiol. Sci. 10 2011 810 816
13. G. Jori, and E. Reddi The role of lipoproteins in the delivery of tumour-targeting photosensitizers Int. J. Biochem. 25 1993 1369 1375
14. G. Jori Tumour photosensitizers: approaches to enhance the selectivity and efficiency of photodynamic therapy J. Photochem. Photobiol. B 36 1996 87 93
15. A. Kader, P.J. Davis, M. Kara, and H. Liu Drug targeting using low-density lipoprotein (LDL): physicochemical factors affecting drug loading into LDL particles J. Controlled Release 55 1998 231 243
16. A. Kader, and A. Pater Loading anticancer drugs into HDL as well as LDL has little affect on properties of complexes and enhances cytotoxicity to human carcinoma cells J. Control. Release 80 2002 29 44
17. S. Kascakova, M. Refregiers, D. Jancura, F. Sureau, J.C. Maurizot, and P. Miskovsky Fluorescence spectroscopic study of hypericin-photosensitized oxidation of low-density lipoproteins Photochem. Photobiol. 81 2005 1395 1403
18. S. Kascakova, Z. Nadova, A. Mateasik, J. Mikes, V. Huntosova, M. Refregiers, F. Sureau, J.C. Maurizot, P. Miskovsky, and D. Jancura High level of low-density lipoproteins receptors enhance hypericin uptake by U-87 cells in the presence of LDL Photochem. Photobiol. 84 2008 120 127
19. T. Kiesslich, B. Krammer, and K. Plaetzer Cellular mechanisms and prospective applications of hypericin in photodynamic therapy Curr. Med. Chem. 13 2006 2189 2204
20. M. Kober, K. Pohl, and T. Efferth Molecular mechanisms underlying St. John's wort drug interactions Curr. Drug Metab. 9 2008 1027 1037
21. Y.N. Konan, R. Gurny, and E. Allemann State of the art in the delivery of photosensitizers for photodynamic therapy J. Photochem. Photobiol. B: Biol. 66 2002 89 106
22. G. Lajos, D. Jancura, P. Miskovsky, J.V. Garcia-Ramos, and S. Sanchez-Cortes Interaction of the photosensitizer hypericin with low-density lipoproteins and phosphatidylcholine: a surface enhanced Raman and surface-enhanced fluorescence study J. Phys. Chem. C 113 2009 7147 7154
23. K. Loomis, K. McNeeley, and R.V. Bellamkonda Nanoparticles with targeting, triggered release, and imaging functionality for cancer application Soft Matter 7 2011 839 856
24. M. Masquelier, S. Vitols, and C. Peterson Low-density lipoprotein as a carrier of antitumoral drugs: in vivo fate of drug-human low-density lipoprotein complexes in mice Cancer Res. 46 1986 3842 3847
25. J.C. Maziere, P. Morliere, and R. Santus The role of the low-density lipoprotein receptor pathway in the delivery of lipophilic photosensitizers in the photodynamic therapy of tumors J. Photochem. Photobiol. B 8 1991 351 360
26. P. Miskovsky Hypericin - a new antiviral and antitumor photosensitizer: Mechanism of action and interaction with biological macromolecules Curr. Drug Targets 3 2002 55 84
27. P. Mukherjee, R. Adhikary, M. Halder, J.W. Petrich, and P. Miskovsky Accumulation and interaction of hypericin in low-density lipoproteins - a photophysical study Photochem. Photobiol. 84 2008 706 712
28. N. Nishiyama, Y. Morimoto, W.D. Jang, and K. Kataoka Design and development of dendrimer photosensitizer-incorporated polymeric micelles for enhanced photodynamic therapy Adv. Drug Deliv. Rev. 61 2009 327 338
29. L. Polo, G. Valduga, G. Jori, and E. Reddi Low-density lipoprotein receptors in the uptake of tumour photosensitizers by human and rat transformed fibroblasts Int. J. Biochem. Cell Biol. 34 2002 10 23
30. R. Prassl, and P. Laggner Molecular structure of low density lipoprotein: current status and future challenges Eur. Biophys. J. 38 2009 145 158
31. E. Reddi Role of delivery vehicles for photosensitizers in the photodynamic therapy of tumors J. Photochem. Photobiol. B 37 1997 189 195
32. P.C. Rensen, R.L. de Vrueh, J. Kuiper, M.K. Bijsterbosch, E.A. Biessen, and T.J. van Berkel Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting Adv. Drug Deliv. Rev. 47 2001 251 276
33. M. Samadi-Baboli, G. Favre, P. Canal, and G. Soula Low density lipoprotein for cytotoxic drug targeting: improved activity of elliptinium derivative against B16 melanoma in mice Br. J. Cancer 68 1993 319 326
34. R.E. Serda, B. Godin, E. Blanco, C. Chiappini, and M. Ferrari Multi-stage delivery nano-particle systems for therapeutic applications Biochim. Biophys. Acta 1810 2011 317 329
35. W.M. Sharman, J.E. van Lier, and C.M. Allen Targeted photodynamic therapy via receptor mediated delivery systems Adv. Drug Deliv. Rev. 56 2004 53 76
36. J.M. Shaw, K.V. Shaw, S. Yanovich, M. Iwanik, W.S. Futch, A. Rosowsky, and L.B. Schook Delivery of lipophilic drugs using lipoproteins Ann. N.Y. Acad. Sci. 507 1987 252 271
37. L. Song, H. Li, U. Sunar, J. Chen, I. Corbin, A.G. Yodh, and G. Zheng Naphthalocyanine-reconstituted LDL nanoparticles for in vivo cancer imaging and treatment Int. J. Nanomed. 2 2007 767 774
38. J. Varshosaz Dextran conjugates in drug delivery Expert Opin. Drug Deliv. 5 2012 509 523
39. A.J. Versluis, P.J. van Geel, H. Oppelaar, T.J. van Berkel, and M.K. Bijsterbosch Receptor-mediated uptake of low-density lipoprotein by B16 melanoma cells in vitro and in vivo in mice Br. J. Cancer 4 1996 525 532
40. S. Vitols Uptake of low-density lipoproteins by malignant cells-possible therapeutic implications Cancer Res. 3 1991 488 495
41. S. Vitols, C. Peterson, O. Larsson, P. Holm, and B. Aberg Elevated uptake of low density lipoproteins by human lung cancer tissue in vivo Cancer Res. 52 1992 6244 6247
42. K.M. Wasan, D.R. Brocks, S.D. Lee, K. Sachs-Barrable, and S.J. Thornton Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery Nat. Rev. Drug Discov. 7 2008 84 99
43. B.C. Wilson, and M.S. Patterson The physics, biophysics and technology of photodynamic therapy Phys. Med. Biol. 53 2008 R61 R109
44. G. Zheng, J. Chen, H. Li, and J.D. Glickson Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents Proc. Natl. Acad. Sci. U.S.A. 102 2005 17757 17762