Macroautophagy is deregulated in murine and human lupus T lymphocytes

Autophagy

Volumn 8, Issue 7, 2012, Pages 1113-1123

  Gros, Frédéric ^a,b   Arnold, Johan ^a   Page, Nicolas ^a   Décossas, Marion ^a   Korganow, Anne Sophie ^a,b   Martin, Thierry ^a,b   Muller, Sylviane ^a  

^a INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Lupus prone mice; Macroautophagy; Systemic lupus erythematosus; T lymphocytes

Indexed keywords

CD69 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGOSOME; B LYMPHOCYTE; CELL VACUOLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; HUMAN; IN VIVO STUDY; MACROAUTOPHAGY; MALE; MOUSE; NONHUMAN; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

MURINAE; MUS;

EID: 84865292867     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.20275     Document Type: Article

References (31)

1. Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010; 22:124-31; PMID:20034776; http://dx.doi.org/10.1016/j.ceb.2009.11.014
2. Saitoh T, Akira S. Regulation of innate immune responses by autophagy-related proteins. J Cell Biol 2010; 189:925-35; PMID:20548099; http://dx.doi.org/10.1083/jcb.201002021
3. Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 2007; 39:596-604; PMID:17435756; http://dx.doi.org/10.1038/ng2032
4. Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008; 456:264-8; PMID:18849965; http://dx.doi.org/10.1038/nature07383
5. Alirezaei M, Fox HS, Flynn CT, Moore CS, Hebb AL, Frausto RF, et al. Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis. Autophagy 2009; 5:152-8; PMID:19066443; http://dx.doi.org/10.4161/auto.5.2.7348
6. Harley JB, Alarcón-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, et al. International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN). Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008; 40:204-10; PMID:18204446; http://dx.doi.org/10.1038/ ng.81
7. Orozco G, Eyre S, Hinks A, Bowes J, Morgan AW, Wilson AG, et al. UKRAG consortium. Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis 2011; 70:463-8; PMID:21068098; http://dx.doi.org/10.1136/ard.2010.137174
8. Ruiz-Irastorza G, Ramos-Casals M, Brito-Zeron P, Khamashta MA. Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review. Ann Rheum Dis 2010; 69:20-8; PMID:19103632; http://dx.doi.org/10.1136/ard.2008.101766
9. Perl A. Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren's syndrome. Curr Opin Rheumatol 2009; 21:443-7; PMID:19584730; http://dx.doi.org/10.1097/BOR.0b013e32832efe6b
10. Page N, Gros F, Schall N, Décossas M, Bagnard D, Briand J-P, et al. HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus. Ann Rheum Dis 2011; 70:837-43; PMID:21173017; http://dx.doi.org/10.1136/ard.2010.139832
11. Page N, Gros F, Schall N, Briand JP, Muller S. A therapeutic peptide in lupus alters autophagic processes and stability of MHCII molecules in MRL/lpr B cells. Autophagy 2011; 7:539-40; PMID:21282971; http://dx.doi.org/10.4161/auto. 7.5.14845
12. Monneaux F, Muller S. Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects. Arthritis Res Ther 2009; 11:234; PMID:19591653; http://dx.doi.org/10.1186/ar2711
13. Pua HH, Dzhagalov I, Chuck M, Mizushima N, He YW. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 2007; 204:25-31; PMID:17190837; http://dx.doi.org/10.1084/jem.20061303
14. Arsov I, Adebayo A, Kucerova-Levisohn M, Haye J, MacNeil M, Papavasiliou FN, et al. A role for autophagic protein beclin 1 early in lymphocyte development. J Immunol 2011; 186:2201-9; PMID:21239722; http://dx.doi.org/10. 4049/jimmunol.1002223
15. Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, et al. Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy 2009; 5:625-35; PMID:19276668; http://dx.doi.org/10.4161/auto.5.5.8133
16. Pua HH, Guo J, Komatsu M, He YW. Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol 2009; 182:4046-55; PMID:19299702; http://dx.doi.org/10.4049/jimmunol.0801143
17. Feng CG, Zheng L, Jankovic D, Báfica A, Cannons JL, Watford WT, et al. The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol 2008; 9:1279-87; PMID:18806793; http://dx.doi.org/10.1038/ni.1653
18. Kovacs JR, Li C, Yang Q, Li G, Garcia IG, Ju S, et al. Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Cell Death Differ 2012; 19:144-52; PMID:21660048; http://dx.doi.org/10.1038/cdd. 2011.78
19. Tsokos GC, Mitchell JP, Juang YT. T cell abnormalities in human and mouse lupus: intrinsic and extrinsic. Curr Opin Rheumatol 2003; 15:542-7; PMID:12960478; http://dx.doi.org/10.1097/00002281-200309000-00004
20. Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010; 140:313-26; PMID:20144757; http://dx.doi.org/10.1016/j. cell.2010.01.028
21. Delgado MA, Elmaoued RA, Davis AS, Kyei G, Deretic V. Toll-like receptors control autophagy. EMBO J 2008; 27:1110-21; PMID:18337753; http://dx.doi.org/ 10.1038/emboj.2008.31
22. Xu Y, Jagannath C, Liu XD, Sharafkhaneh A, Kolodziejska KE, Eissa NT. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 2007; 27:135-44; PMID:17658277; http://dx.doi.org/10.1016/j.immuni. 2007.05.022
23. Nambiar MP, Juang YT, Krishnan S, Tsokos GC. Dissecting the molecular mechanisms of TCR zeta chain downregulation and T cell signaling abnormalities in human systemic lupus erythematosus. Int Rev Immunol 2004; 23:245-63; PMID:15204087; http://dx.doi.org/10.1080/08830180490452602
24. Fujita K, Maeda D, Xiao Q, Srinivasula SM. Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation. Proc Natl Acad Sci U S A 2011; 108:1427-32; PMID:21220332; http://dx.doi.org/10.1073/pnas.1014156108
25. Bell BD, Leverrier S, Weist BM, Newton RH, Arechiga AF, Luhrs KA, et al. FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A 2008; 105:16677-82; PMID:18946037; http://dx.doi.org/10.1073/pnas.0808597105
26. Espert L, Denizot M, Grimaldi M, Robert-Hebmann V, Gay B, Varbanov M, et al. Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest 2006; 116:2161-72; PMID:16886061; http://dx.doi.org/10.1172/JCI26185
27. Yuan J, Kroemer G. Alternative cell death mechanisms in development and beyond. Genes Dev 2010; 24:2592-602; PMID:21123646; http://dx.doi.org/10.1101/ gad.1984410
28. Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, et al. The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy 2008; 4:309-14; PMID:18188005
29. Chaturvedi A, Dorward D, Pierce SK. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity 2008; 28:799-809; PMID:18513998; http://dx.doi.org/10.1016/j.immuni.2008.03.019
30. Katz SJ, Russell AS. Re-evaluation of antimalarials in treating rheumatic diseases: re-appreciation and insights into new mechanisms of action. Curr Opin Rheumatol 2011; 23:278-81; PMID:21448012; http://dx.doi.org/10.1097/BOR. 0b013e32834456bf
31. Hubbard VM, Valdor R, Patel B, Singh R, Cuervo AM, Macian F. Macroautophagy regulates energy metabolism during effector T cell activation. J Immunol 2010; 185:7349-57; PMID:21059894; http://dx.doi.org/10.4049/jimmunol. 1000576